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| 1 | Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer显示文摘Breast cancer is the leading cause of death among women worldwide.Chemoprevention and chemotherapy play beneficial roles in reducing the incidence and mortality of cancer.Epidemiological and experimental studies showed that naturally-occurring antioxidants present in the diet may act as anticancer agents.Identifying the abnormalities of cellular energy metabolism facilitates early detection and management of breast cancer.The present study evaluated the effect of tangeretin on cellular metabolic energy fluxes in 7,12-dimethylbenz(a)anthracene(DMBA)-induced proliferative breast cancer.The results showed that the activities of glycolytic enzymes significantly increased in mammary tissues of DMBA-induced breast cancer bearing rats.The gluconeogenic tricarboxylic acid(TCA) cycle and respiratory chain enzyme activities significantly decreased in breast cancer-bearing rats.In addition,proliferating cell nuclear antigen(PCNA) was highly expressed in breast cancer tissues.However,the activities of glycolytic enzymes were significantly normalized in the tangeretin pre- and post-treated rats and the TCA cycle and respiratory chain enzyme activities were significantly increased in tangeretin treated rats.Furthermore,tangeretin down-regulated PCNA expression on breast cancerbearing rats.Our study demonstrates that tangeretin specifically regulates cellular metabolic energy fluxes in DMBA-induced breast cancer-bearing rats. | Kuppusamy Periyasamy Venkatachalam Sivabalan Kuppusamy Baskaran Kannayiram Kasthuri Dhanapal Sakthisekaran | 2016 | The Journal of Biomedical Research2016，30，2： | 3 |
| 2 | Identification of Shewanella baltica as the most important H2S-producing species during iced storage of Danish marine fish显示文摘 | BIRTE F V KASTHURI V MASATAKA S | | 0，，11： | 1 |
| 3 | Carbon monoxide poisoning显示文摘 | Mehta SR Niyogi M Kasthuri AS | 2001 | J AssocPhys India2001，49，： | 1 |
| 4 | Malignant hepatic tumours in children:incidence,clinical features and aetiology显示文摘 | Mann JR Kasthuri N Raafat F | 1990 | Paediatr Perinat Epidemiol1990，4，3： | 1 |
| 5 | Role of tissue factor in cancer显示文摘 | Kasthuri RS Taubman MB Mackman N | 2009 | J Clin Oncol2009，27，29： | 1 |
| 6 | Ro|e of tissue factor in cancer 显示文摘 | Kasthuri R S Taubman M B Mackman N | 2009 | J Clin Oncol2009，27，29： | 1 |
| 7 | A novel molluscan sigma-like glutathione S-transferase from Manila clam, Ruditapes philippinarum : Cloning, characterization and transcriptional profiling显示文摘 | Navaneethaiyer Umasuthan Kasthuri Saranya Revathy Youngdeuk Lee Ilson Whang Cheol Young Choi Jehee Lee | 2012 | Comparative Biochemistry and Physiology Part C2012，，4： | 1 |
| 8 | First molluscan theta-class Glutathione S-Transferase: Identification, cloning, characterization and transcriptional analysis post immune challenges显示文摘 | Kasthuri Saranya Revathy Navaneethaiyer Umasuthan Youngdeuk Lee Cheol Young Choi Ilson Whang Jehee Lee | 2012 | Comparative Biochemistry and Physiology Part B (-)2012，，1： | 1 |
| 9 | Biological Synthesis of Silver and Gold Nanoparticlas Using Apiin as Reducing Agent 显示文摘 | KASTHURI J VEERAPANDIAN S RAJENDIRAN N | 2009 | Colloids and Surfaces B:Biointerfaces2009，68，： | 1 |
| 10 | Role of tissue factor in cancer显示文摘 | Kasthuri RS Taubman MB Mackman N | 2009 | J Clin Oncol2009，27，25： | 1 |
| 11 | Validation of the use of self-repor- ted hearing loss and the hearing handicap inventory for elder- ly among rural Indian elderly population显示文摘 | Deepthi R Kasthuri A | 2012 | Archives of Ger- ontology and Geriatrics2012，55，： | 1 |
| 12 | Role of tissue factor in cancer显示文摘 | Kasthuri RS Taubman MB Mackman N | 2009 | J Clin Oncol2009，27，29： | 1 |
| 13 | Validation of the use of self-repor- ted hearing loss and the hearing handicap inventory for elderly among rural Indian elderly population 显示文摘 | Deepthi R Kasthuri A | 2012 | Arch Gerontol Geriatr2012，55，： | 1 |
| 14 | Role of tissue factor in cancer显示文摘 | KASTHURI RS TAUBMAN MB MACKMAN N | 2009 | J Clin Oncol2009，27，29： | 1 |
| 15 | Production of Bioflocculant by Staphylococcus cohnii ssp. from Palm Oil Mill Effluent (POME)显示文摘 | Yee-Shian Wong Soon-An Ong Tjoon-Tow Teng L. Aminah Kasthuri Kumaran | 2012 | Water, Air, & Soil Pollution2012，，7： | 1 |
| 16 | Role of tissue factor in cancer显示文摘 | Kasthuri RS Taubman MB Mackman N | 2009 | J Clin Oncol2009，27，29： | 1 |
| 17 | Role of tissue factor in cancer 显示文摘 | Kasthuri RS Taubman MB Mackman N | 2009 | J Clin Oncol2009，27，29： | 1 |
| 18 | Phyllanthin-as- sisted biosynthesis of silver and gold nanoparticles:a no- vel biological approach 显示文摘 | Kasthuri J Kathiravan K Rajendiran N | 2009 | Journal of Nanoparticle Re search2009，11，5： | 1 |
| 19 | Biological synthesis of silver and gold nanoparticles using apiin as reducing agent 显示文摘 | Kasthuri J Veerapandian S Rajendiran N | 2009 | Colloids and Surfaces B : Biointerfaces2009，68，1： | 1 |
| 20 | Validation of the use of self-reportedhearing loss and the hearing handicap inventory for elderly a-mong rural Indian elderly population显示文摘 | Deepthi R Kasthuri A | 2012 | Arch Gerontol Geri-atr2012，55，： | 1 |
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