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| 1 | 免耕条件下秸秆还田对冬小麦-夏玉米轮作系统土壤呼吸及土壤水热状况的影响显示文摘【目的】研究免耕条件下秸秆还田对旱地冬小麦-夏玉米轮作系统土壤呼吸及土壤水热状况的影响。【方法】2011年10月至2014年9月,在陕西杨凌设置秸秆全量还田+施肥(S1F1)、秸秆全量还田+不施肥(S1F0)、秸秆半量还田+施肥(S1/2F1)、秸秆半量还田+不施肥(S1/2F0)、秸秆不还田+施肥(S0F1)、秸秆不还田+不施肥(S0F0)6种不同耕作处理的3年定位试验,测定并分析不同耕作处理下土壤呼吸、土壤水热状况、作物产量、土壤耕作层有机碳含量的差异。【结果】在冬小麦生育期内,各处理土壤呼吸速率均呈先下降后升高再下降的趋势;在夏玉米生育期内,各处理土壤呼吸速率均表现为先升高后下降的趋势。同一生育期内各处理土壤呼吸平均速率及呼吸总量依次为S1F1>S1/2F1>S1/2F0>S0F1>S1F0>CK,同种作物不同生育期之间,各处理土壤生育期呼吸总量有逐年降低的趋势。整个研究周期内,土壤温度的变化趋势与每月平均气温的变化趋势相似,不同处理在同一生育期内的土壤温度变化趋势相近,且各处理生育期土壤平均温度均随土壤深度的增加而降低;不同秸秆还田处理冬季土壤温度均高于对照,但生育期土壤平均温度均低于对照。土壤含水量随土壤深度的增加而降低,但受降雨影响,不同轮作周期之间的土壤含水量波动较大,各处理同一生育期的土壤平均含水量均表现为S1F0>S1F1>S1/2F0>S1/2F1>CK>S0F1,且不同秸秆还田处理的土壤含水量与对照间的差异均显著(P<0.05);土壤温度能够解释土壤呼吸速率变化的32.5%—60.4%,土壤含水量能够解释土壤呼吸速率变化的38.4%—82.5%,不同土层深度间,5 cm土层的温度与土壤呼吸的拟合度性最高,而10—20 cm土层的含水量与土壤呼吸的拟合度最高。相同年份内,不同处理冬小麦和夏玉米产量均表现为S1F1>S1F0>S1/2F1>S0F1>S1/2F0>CK,这个研究周期内,冬小麦产量逐年增加,夏玉米在前两季表现为增产,但受极端炎热天气的影响,第三季的产量明显降低。单季作物收获后,各处理同一土层深度的有机碳含量均表现为S1F1>S1/2F1>S1F0>S1/2F0>S0F1>CK。且不同秸秆还田处理的土壤有机碳含量逐年升高。【结论】长期免耕秸秆还田能够有效降低农田土壤碳排放、提高农田土壤水分利用率及冬季土壤温度、提高作物产量及土壤有机碳含量。不同秸秆还田处理间以S1F0处理的效果最优。 | 王维钰 乔博 Kashif AKHTAR 袁率 任广鑫 冯永忠 | 2016 | 中国农业科学2016，49，11： | 47 |
| 2 | 免耕条件下秸秆还田与施肥对小麦-玉米轮作系统土壤养分和酶活性的影响显示文摘为研究免耕条件下秸秆还田与施肥对小麦-玉米轮作系统土壤养分和酶活性的影响,于西北农林科技大学校内试验地进行试验,设3个秸秆还田水平:秸秆全量还田、秸秆半量还田、秸秆不还田,施肥和不施肥2个施肥水平,共6个处理,以秸秆不还田+不施肥作为对照,研究秸秆还田与施肥对小麦-玉米轮作系统一年内两季不同作物收获期0~40 cm土层土壤养分含量和土壤酶活性的影响。结果表明,冬小麦和夏玉米收获期土壤不论是0~20 cm还是20~40 cm土层,秸秆全量还田+施肥和秸秆半量还田+施肥处理相比秸秆不还田+不施肥均能增加土壤有机碳、碱解氮、速效磷和速效钾的含量,并且高于秸秆还田+不施肥处理;秸秆全量还田+施肥处理下的冬小麦土壤脲酶、碱性磷酸酶、过氧化氢酶和蔗糖酶的活性比秸秆不还田+不施肥处理的0~20 cm土层分别提高92.34%,87.91%,4.94%,62.41%;对于夏玉米而言,秸秆全量还田+施肥相比秸秆不还田+不施肥处理的0~20 cm土层提高了土壤脲酶、碱性磷酸酶、蔗糖酶和过氧化氢酶,分别提高了68.54%,49.11%,149.84%,10.38%。可见,土壤脲酶、碱性磷酸酶、过氧化氢酶和蔗糖酶在秸秆全量还田+施肥的处理下活性最高,并且土壤脲酶与全氮和碱解氮相关性最好,碱性磷酸酶与全氮、速效钾和速效磷的相关性比较好,过氧化氢酶与速效钾和速效磷的相关性比较好,蔗糖酶与有机碳的相关性比较好,且均呈正相关。以上结果表明,秸秆还田配施化肥可以提高土壤质量。 | 刘兰清 杨晨璐 王维钰 孔德杰 KASHIF Akhtar 任广鑫 冯永忠 杨改河 | 2017 | 华北农学报2017，32，6： | 17 |
| 3 | Indoleamine 2,3-dioxygenase: As a potential prognostic marker and immunotherapeutic target for hepatocellular carcinoma显示文摘Tumor cells induce an immunosuppressive microen-vironment which leads towards tumor immune escape. Understanding the intricacy of immunomodulation by tumor cells is essential for immunotherapy. Indoleamine 2,3-dioxygenase(IDO) is an immunosuppressive enzyme which mediates tumor immune escape in various cancers including hepatocellular carcinoma(HCC). IDO up-regulation in HCC may lead to recruitment of regulatory T-cells into tumor microenvironment and therefore inhibit local immune responses and promote metastasis. HCC associated fibroblasts stimulate natural killer cells dysfunction through prostaglandin E2 and subsequently IDO promotes favorable condition for tumor metastasis. IDO up-regulation induces immuno-suppression and may enhance the risk of hepatitis C virus and hepatitis B virus induced HCC. Therefore, IDO inhibitors as adjuvant therapeutic agents may have clinical implications in HCC. This review proposes future prospects of IDO not only as a therapeutic target but also as a prognostic marker for HCC. | Kashif Asghar Asim Farooq Bilal Zulfiqar Muhammad Usman Rashid | 2017 | World Journal of Gastroenterology2017，23，13： | 16 |
| 4 | Parameters effect on heterogeneous photocatalysed degradation of phenolin aqueous dispersion of TiO_2显示文摘Photocatalytic degradation of phenol selected as model compound of organic pollutant had been investigated in aqueous titanium dioxide (TiO2) dispersion under UV irradiation. The effects of various parameters such as pH, catalyst concentration, phenol concentration, anions, metal ions, electron acceptors, and surfactants on the photocatalytic degradation of phenol were investigated. The degradation kinetics was determined by the change in phenol concentration employing UV-Vis spectrometry as a function of irradiation time. The degradation kinetics of phenol follows pseudo first-order kinetics. The results showed a significant dependence of the photocatalytic degradation of phenol on the functional parameters. The probable promising roles of the additives on the degradation process were discussed. | KASHIF Naeem | 2009 | Journal of Environmental Sciences2009，21，4： | 15 |
| 5 | Functional gastrointestinal disorders and gut-brain axis: What does the future hold?显示文摘Despite their high prevalence, lack of understanding of the exact pathophysiology of the functional gastrointestinal disorders has restricted us to symptomatic diagnostic tools and therapies. Complex mechanisms underlying the disturbances in the bidirectional communication between the gastrointestinal tract and the brain have a vital role in the pathogenesis and are key to our understanding of the disease phenomenon. Although we have come a long way in our understanding of these complex disorders with the help of studies on animals especially rodents, there need to be more studies in humans, especially to identify the therapeutic targets. This review study looks at the anatomical features of the gut-brain axis in order to discuss the different factors and underlying molecular mechanisms that may have a role in the pathogenesis of functional gastrointestinal disorders. These molecules and their receptors can be targeted in future for further studies and possible therapeutic interventions. The article also discusses the potential role of artificial intelligence and machine learning and its possible role in our understanding of these scientifically challenging disorders. | Kashif Mukhtar Hasham Nawaz Shahab Abid | 2019 | World Journal of Gastroenterology2019，25，5： | 15 |
| 6 | 趋化性细胞因子受体CXCR4在大肠癌的表达及其临床意义显示文摘目的:探讨趋化性细胞因子受体CXCR4在大肠癌中的表达及其与预后的关系.方法:收集67例大肠癌患者手术标本,采用免疫组织化学方法检测肿瘤组织中CXCR4蛋白的表达和微血管密度,分析CXCR4的表达水平与临床病理特征和生存的关系.结果:大肠癌组织中CXCR4蛋白表达阳性率为56.7%(38/67),与患者的性别、年龄、肿瘤部位、T分期和病理类型无相关性(P>0.05),与淋巴结转移、临床分期、微血管密及生存相关.N0,N1和N2期CXCR4的阳性率分别为40.6%,68.2%,76.9%(P<0.05);Ⅰ+Ⅱ期和Ⅲ期CXCR4的阳性率分别为39.4%,73.5%(P<0.05).低MVD组CXCR4的阳性率显著低于高MVD组(36.4%vs74.3%,P<0.01);CXCR4阳性组较CXCR4阴性组有较高的复发/转移率(47.4%vs24.1%,P<0.05)和较低的3a无病生存率(32.6%vs71.3%,P<0.05).结论:CXCR4可能促进大肠癌的侵袭和转移以及血管生成并影响其预后. | 张孟贤 Kashif Iqbal 于世英 | 2007 | 世界华人消化杂志2007，15，7： | 13 |
| 7 | Prevalence of gastric varices and results of sclerotherapy with N-butyl 2 cyanoacrylate for controlling acute gastric variceal bleeding显示文摘AIM: To study the prevalence, predictors and control of bleeding following N-butyl 2 cyanoacrylate (NBC) sclerotherapy of gastric varix (GV). METHODS: We analyzed case records of 1436 patients with portal hypertension, who underwent endoscopy during the past five years for variceal screening or upper gastrointestinal (GI) bleeding. Fifty patients with bleeding GV underwent sclerotherapy with a mean of 2 mL NBC for control of bleeding. Outcome parameters were primary hemostasis (bleeding control within the first 48 h), recurrent bleeding (after 48 h of esophago- gastro-duodenoscopy) and in-hospital mortality were analyzed. RESULTS: The prevalence of GV in patients with portal hypertension was 15% (220/1436) and the incidence of bleeding was 22.7% (50/220). Out of the 50 bleeding GV patients, isolated gastric varices (IGV-I) were seen in 22 (44%), gastro-oesophageal varices (GOV) on lesser curvature (GOV-Ⅰ) in 16 (32%), and GOV on greater curvature (GOV-Ⅱ) in 15 (30%). IGV-Ⅰ was seen in 44% (22/50) patients who had bleeding as compared to 23% (39/170) who did not have bleeding (P < 0.003). Primary hemostasis was achieved with NBC in all patients. Re-bleeding occurred in 7 (14%) patients after 48 h of initial sclerotherapy. Secondary hemostasis was achieved with repeat NBC sclerotherapy in 4/7 (57%). Three patients died after repeat sclerotherapy, one during transjugular intrahepatic portosystemic stem shunt (TIPSS), one during surgery and one due to uncontrolled bleeding. Treatment failure-related mortality rate was 6% (3/50). CONCLUSION: GV can be seen in 15% of patients withportal hypertension and the incidence of bleeding is 22.7%. NBC is highly effective in controlling GV bleeding. In hospital mortality of patients with bleeding GV is 6%. | Khalid Mumtaz Shahid Majid Hasnain A Shah Kashif Hameed Ashfaq Ahmed Saeed Hamid Wasim Jafri | 2007 | World Journal of Gastroenterology2007，13，8： | 12 |
| 8 | 利用虚拟平扫降低冠状动脉CT血管造影辐射剂量的可行性研究显示文摘目的探讨利用双层探测器光谱CT冠状动脉CT血管造影(CCTA)钙化积分的虚拟平扫成像(VNC)降低扫描辐射剂量的可行性。方法回顾性分析2019年3月至2020年8月在南京大学医学院附属鼓楼医院双层探测器光谱CT行CCTA扫描的122例患者资料。记录每位患者的CT容积剂量指数(CTDIvol)、剂量长度乘积(DLP)及有效剂量(E)。记录检查时间。在后处理工作站中, 基于CCTA的光谱基数据(SBI)生成VNC图像。2名医师分别独立评价左前降支(LAD)、左回旋支(LCx)、右冠状动脉(RCA)真实平扫(TNC)及VNC的钙化积分(CS;NC, CS;NC)并做Pearson相关性分析, 得到校正系数λ, 各分支校正系数分别记为λLAD、λLCx、λRCA, 总体冠状动脉(Total)的平均校正系数记为λAVG。校正后VNC的CS(CCS;NC)=λ× CS;NC。采用重复测量单因素方差分析比较CS;NC、CCS;NC的差异;采用Bland-Altman法分析评价CS;NC、CCS;NC一致性。结果获得CS平扫的辐射剂量为0.69 mSv。心电门控冠状动脉CTA扫描的辐射剂量为6.47 mSv, 总的辐射剂量为7.16 mSv。利用基于双层探测器光谱CT冠状动脉CTA的VNC图像替代TNC图像获得CS, 可省去CTA前的平扫, 减少10.6%的总辐射剂量及39%的检查时间。LAD、LCx、RCA及Total的CS;NC, CS;NC差异有统计学意义(t=6.75、5.33、4.99、6.60, P < 0.05), 相关性良好(R2=0.929、0.896、0.958、0.918, λ=2.18、1.18、2.15、2.07)。LAD和RCA的CS;NC、平均系数CCS;NC及分支系数CCS;NC的差异均无统计学意义(P > 0.05)。LCx的CS;NC、平均系数CCS;NC及分支系数CCS;NC差异有统计学意义(F=10.94, P<0.05)。组内两两比较:CS;NC与平均系数CCS;NC及平均系数CCS;NC与分支系数CCS;NC差异有统计学意义(t=3.21、3.43, P<0.05), LCx的CS;NC与及分支系数CCS;NC无统计学差异(P>0.05)。结论利用双层探测器光谱CT的VNC技术可以从CCTA图像中准确评价冠状动脉CS, 有望代替冠状动脉常规CT平扫, 从而有效降低患者辐射剂量及减少扫描时间。 | 陈文萍 尹克杰 李茗 康丽娜 余鸿鸣 梁静 吴敏 Dar Kashif 陈杏彪 盛志洪 牡丹 | 2022 | 中华放射医学与防护杂志2022，42，1： | 11 |
| 9 | 煤炭腐植酸作为土壤改良剂对土壤物理性质和小麦产量的影响显示文摘在巴基斯坦旁遮普的波特瓦地区(33°N,74°E),集约化土壤耕作,土壤侵蚀和低量作物残体的投入是导致土壤结构退化的原因。结构不稳定的土壤很容易受到侵蚀,反过来,土壤侵蚀又会造成作物产量的下降。因此,为了改善土壤的物理性状,在巴基斯坦旁遮普的干旱地区进行了田间试验。试验地点位于大学(拉瓦尔品第PMAS干旱农业大学)研究农场的园区内。2种不同等级(实验室级和商品级)的腐植酸(HA)各分8个水平,施用2年,处理分别为HL_0(对照,不施腐植酸),HL_1 10 kg HA/hm^2,HL_2 20 kg HA/hm^2,HL_3 30 kg HA/hm^2,HL_4 60 kg HA/hm^2,HL_5 90 kg HA/hm^2,HL_6 120 kg HA/hm^2和HL_7 150 kg HA/hm^2,各处理同时配合施用N-P-K(120-90-60 kg/hm^2)。试验期间,检测土壤总有机碳、饱和导水率、团聚体稳定性、容重、土壤含水量和作物产量。试验结果表明,腐植酸能通过影响土壤总有机碳、饱和导水率、团聚体稳定性、容重和土壤含水量等指标来改善土壤的物理性状。2年试验结果均表现为,实验室级的腐植酸比商品级的腐植酸能更好地改善土壤物理性状,从而提高小麦产量。2种不同级别的腐植酸各施用水平与对照相比,差异均显著。在120 kg/hm^2和150 kg/hm^2的腐植酸施用水平下,大多数指标均显示出了相似的结果,因此,从经济角度考虑,120 k g/hm^2的腐植酸用量为最佳施用量。 | Ijaz Ahmad Safdar Ali Khalid Saifullah Khan Fayyazul Hassan Kashif Bashir 何一通 孙志梅 | 2016 | 腐植酸2016，，3： | 10 |
| 10 | Influence of supports on photocatalytic degradation of phenol and 4-chlorophenol in aqueous suspensions of titanium dioxide显示文摘The photocatalytic degradation of phenol and 4-chlorophenol (4-CP) in aqueous suspensions with the use of titanium dioxide (TiO2 ) under UV irradiation was examined. The effects of different supporting materials mixed physically with TiO2 were studied to achieve maximum degradation efficiency. Among the three supports, namely activated carbon (AC), silica (SiO2 ) and zeolite (ZSM-5), all exhibited paramount efficiency for degradation of phenol and 4-CP and was better than TiO2 alone. The optimum concentration was found to be 50 mg for all supporting materials. The efficiency order of the three supports was as follows: AC > ZSM-5 > SiO2 , respectively. Whilst, the degradation of phenol and 4-CP was improved from 70.6% to 87.6% and 80.6% to 89.7%, respectively, within 120 min photocatalysis in the presence of optimal amount of AC. The degradation was also comparatively enhanced in the presence of cheaper rice husk and the activity was closed to ZSM-5 and lower than AC. | Kashif Naeem Feng Ouyang | 2013 | Journal of Environmental Sciences2013，25，2： | 8 |
| 11 | Simultaneous removal of Cd(II)and As(III)from co-contaminated aqueous solution byα-FeOOH modified biochar显示文摘A novelα-FeOOH modified wheat straw biochar(α-FeOOH@BC)was developed and the findings of the current study showed thatα-FeOOH@BC is an efficient material for the simultaneous removal of cations(Cd(II))and anions(As(III))from aqueous solutions.The SEM,FTIR,and XRD analysis proved thatα-FeOOH@BC was covered byα-FeOOH.In the single adsorption system,the maximum adsorption capacities ofα-FeOOH@BC for Cd(II)and As(III)were 62.9 and 78.3 mg/g,respectively.In the dual adsorption system,the maximum adsorption capacities ofα-FeOOH@BC for Cd(II)and As(III)dropped to 39.3 and 67.2 mg/g,respectively.The adsorption capacities of Cd(II)and As(III)byα-FeOOH@BC were much higher by BC andα-FeOOH both in single and dual adsorbate system.The adsorption results were well fitted by the Langmuir and pseudo-second-order kinetics models.The Cd(II)and As(III)co-adsorption onα-FeOOH@BC had a competitive effect,and the dominant adsorption mechanisms were co-precipitation and ion exchange.Our study showed thatα-FeOOH@BC could be an effective remediation material for Cd(II)and As(III)co-adsorption from aqueous environment. | Sihang Zhu Ting Qu Muhammad Kashif Irshad Jianying Shang | 2020 | Biochar2020，2，1： | 7 |
| 12 | Clinacanthus nutans:a review of the medicinal uses,pharmacology and phytochemistry显示文摘Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bites,lesions caused by herpes simplex virus,diabetes,and gout in Malaysia.Indonesia.Thailand and China.Phylochemieal investigations documented the varied contents of bioaclive compounds from litis plant namely flavonoids,glycosides,glycoglyeerolipids.cerebrosides and monoacylmonogalatosylglycerol.The pharmacological experiment proved that various types of extracts and pure compounds from this species exhibited a broad range of biological properties such as anti-inflammatory,antiviral,antioxidant,and anti-diabetic activities.The lindings of toxicity study showed that extracts from this plant did not show any toxicity thus it can be used as strong therapeutic agents for specific diseased conditions.However,further experiments on chemical components and their mode of action showing biological activities are required to elucidate the complete phytochemical profile and assess to confirm their suitability tor future drugs.This review summarizes the medicinal uses,phytochemistry and pharmacology of this plant in order to explore its therapeutic potential and gaps necessitating for prospected research work. | Md.Ariful Alam Sahena Ferdosh Kashif Ghafoor Md.Abdul Hakim Abdul Shukor Juraimi Alfi Khatib Md.Zaidul I.Sarker | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 7 |
| 13 | 预防心包积水综合征所造成的损失显示文摘家禽饲养场中如果生物安全措施不到位,某些疾病就很可能发生,心包积水综合征就是这样一种疾病。为使心包积水综合征处于受控状态,接种合适的疫苗是必须的。 | 张贤群 Muhammad Kashif Saleemi | 2010 | 国外畜牧学(猪与禽)2010，，5： | 7 |
| 14 | An extended treatment protocol with pegylated interferon and ribavirin for hepatitis C recurrence after liver transplantation显示文摘AIM: To evaluate the efflicacy and tolerability of an extended treatment protocol and to determine the predictors of sustained virological response (SVR) after liver transplantation (LT).METHODS: Between August 2005 and November 2008, patients with recurrent hepatitis C virus (HCV) after LT were selected for treatment if liver biopsy showed at least grade 2 inflammation and/or stage 2 flibrosis. All patients were to receive pegylated interferon (PEG)/regimens combining ribavirin (RBV) for an additional 48 wk after HCV undetectability.RESULTS: Extended protocol treatment was initiated in thirty patients. Overall, 73% had end of treatmentresponse and 60% had SVR. Nineteen patients completed treatment per protocol, of them, sixteen (84%) had end of treatment response, and fourteen (74%) achieved SVR. Both early virological response and 24-week virological response were individually associated with SVR but this association was not signif icant on multivariate analysis. Eleven patients (37%) discontinued therapy due to adverse effects. Cytopenias were the most common and most severe adverse effect, and required frquent growth factor use, dose adjustments and treatment cessations. The risk of rejection was not increased.CONCLUSION: Recurrent HCV after LT can be safely treated with extended virological responseguided therpy using PEG/RBV, but requires close monitoring for treatment-related adverse effects, particularly cytopenias. | Nikroo Hashemi Victor Araya Kashif Tufail Laxmi Thummalakunta Eyob Feyssa Ashaur Azhar Mumtaz Niazi Jorge Ortiz | 2011 | World Journal of Hepatology2011，3，7： | 7 |
| 15 | 毛棉苗期抗旱性状的QTL定位显示文摘【目的】通过分析毛棉苗期抗旱相关性状的数量性状位点(Quantitative trait locus,QTL),以期检测稳定的主效QTL,促进栽培品种抗旱性状遗传改良及提高抗旱育种效率。【方法】以四倍体野生种毛棉(Gossypium tomentosum)和陆地棉品种中棉所12(CCRI 12)的种间杂种F2及其F2:3家系为研究材料,用于基因型分型的F2有188个系,用于表型分型的F2:3家系有149个株系。分别在干旱胁迫和正常灌水2个环境下调查表型数据。采用复合区间作图法对F2:3家系苗期相关性状抗旱系数进行QTL定位。【结果】对苗期相关性状抗旱系数的QTL定位分析,共得到16个QTL,其中与株高、叶片数、叶绿素含量、脯氨酸含量、丙二醛含量抗旱系数相关的QTL分别有5个、1个、3个、3个、4个,分布在13条染色体上。来自毛棉的5个加性QTL分别为qSHDC-19-1、qSHDC-19-2、qSLNDC-5-1、qMDADC-24-1、qMDADC-24-2,其加性效应值为0.10~0.22,解释变异9.4%~25.8%。【结论】这些与抗旱相关的QTL有助于棉花抗旱分子标记辅助选择。 | 郑巨云 George Oluoch Khan Muhammad Kashif Riaz 周忠丽 王星星 蔡小彦 李雪源 王春英 王玉红 刘方 王坤波 | 2017 | 棉花学报2017，29，1： | 6 |
| 16 | Advances in fungal-assisted phytoremediation of heavy metals:A review显示文摘Trace metals such as manganese(Mn),copper(Cu),zinc(Zn),and iron(Fe)are essential for many biological processes in plant life cycles.However,in excess,they can be toxic and disrupt plant growth processes,which is economically undesirable for crop production.For this reason,processes such as homeostasis and transport control of these trace metals are of constant interest to scientists studying heavily contaminated habitats.Phytoremediation is a promising cleanup technology for soils polluted with heavy metals.However,this technique has some disadvantages,such as the slow growth rate of metal-accumulating plant species,low bioavailability of heavy metals,and long duration of remediation.Microbial-assisted phytoremediation is a promising strategy for hyperaccumulating,detoxifying,or remediating soil contaminants.Arbuscular mycorrhizal fungi(AMF)are found in association with almost all plants,contributing to their healthy performance and providing resistance against environmental stresses.They colonize plant roots and extend their hyphae to the rhizosphere region,assisting in mineral nutrient uptake and regulation of heavy metal acquisition.Endophytic fungi exist in every healthy plant tissue and provide enormous services to their host plants,including growth enhancement by nutrient acquisition,detoxification of heavy metals,secondary metabolite regulation,and enhancement of abiotic/biotic stress tolerance.The aim of the present work is to review the recent literature regarding the role of AMF and endophytic fungi in plant heavy metal tolerance in terms of its regulation in highly contaminated conditions. | Muhammad KHALID Saeed UR-RAHMAN Danial HASSANI Kashif HAYAT Pei ZHOU Nan HUI | 2021 | Pedosphere2021，31，3： | 6 |
| 17 | Concomitant-chemoradiotherapy-associated oral lesions in patients with oral squamous-cell carcinoma显示文摘Objective:Oral squamous-cell carcinoma(OSCC)accounts for >90% of oral cancers affecting adults mostly between the fourth to seventh decades of life.The most common OSCC treatment is concomitant chemoradiotherapy(CCRT)having both locoregional and distant control,but CCRT has acute and chronic toxic effects on adjacent normal tissue.This study aimed to determine the side effects of CCRT on the oral mucosa and to characterize the clinicopathology of oral lesions in patients with OSCC.Methods:This descriptive,cross-sectional study was certified by the Ethical Review Committee(UHS/Education/126-12/2728)of the University of Health Sciences,Lahore,Pakistan.OSSC patients(n=81)with various histological subtypes,grades,and stages were recruited,and findings on their oral examination were recorded.These patients received 70,90,and 119 Gy of radiotherapy dosages in combination with the chemotherapy drugs cisplatin and 5-fluorouracil.Data were analyzed using SPSS 20.0.Results:The most common presentation of OSCC was a nonhealing ulcer(63%) involving tongue(55.6%).Clinical findings included mucositis(92.6%)and xerostomia of mild,moderate,and severe degrees in 11.1%,46.9%,and 35.8% cases,respectively.Ulcers(87.7%),palpable lymph nodes(64.2%),limited mouth opening(64.2%)and fistula(40.7%) were also observed.In females,the association of radiotherapy dosage with limited mouth opening,xerostomia,and histological grading was statistically significant(P<0.05).The association of chemotherapy drugs with xerostomia(P=0.003)was also statistically significant.Conclusions:CCRT induced mucositis,xerostomia,and trismus in patients with OSCC. | Sadia Minhas Muhammad Kashif Wasif Altaf Nadeem Afzal Abdul Hanan Nagi | 2017 | Cancer Biology & Medicine2017，14，2： | 6 |
| 18 | Pre-course student performance prediction with multi-instance multi-label learning显示文摘Dear editor,Studying courses is one of the most basic and important tasks for college students.For each new course,the initial period of learning is crucial for students,and seriously influences subsequent learning activities.However,given a large number of classes in universities,it has become impossible for teachers to keep track of the individual performance of each student.In these circumstances,it is desirable to predict each student’s performance on a certain course prior to its commencement. | Yuling MA Chaoran CUI Xiushan NIE Gongping YANG Kashif SHAHEED Yilong YIN | 2019 | Science China(Information Sciences)2019，62，2： | 5 |
| 19 | Genetic analysis of yield and fiber quality traits in upland cotton(Gossypium hirsutum L.) cultivated in different ecological regions of China显示文摘Background:Cotton is an important fiber crop worldwide.The yield potential of current genotypes of cotton can be exploited through hybridization.However,to develop superior hybrids with high yield and fiber quality traits,information of genetic control of traits is prerequisite.Therefore,genetic analysis plays pivotal role in plant breeding.Results:In present study,North Carolina II mating design was used to cross 5 female parents with 6 male parents to produce 30 intraspecific F1cotton hybrids.All plant materials were tested in three different ecological regions of China during the year of 2016-2017.Additive-dominance-environment(ADE)genetic model was used to estimate the genetic effects and genotypic and phenotypic correlation of yield and fiber quality traits.Results showed that yield traits except lint percentage were mainly controlled by genetic and environment interaction effects,whereas lint percentage and fiber quality traits were determined by main genetic effects.Moreover,dominant and additiveen vironine nt in teraction effects had more influence on yield traits,whereas additive and domi nance-e nviron ment interaction effects were found to be predominant for fiber traits.Broad-sense and its interaction heritability were significant for all yield and most of fiber quality traits.Narrow-sense and its interaction heritability were non-significant for boll number and seed cotton yield.Correlation analysis indicated that seed cotton yield had significant positive correlation with other yield attributes and non-significant with fiber quality traits.All fiber quality traits had signiflcant positive correlation with each other except micronaire.Conclusions:Results of current study provide important information about genetic control of yield and fiber quality traits.Further,this study identified that parental lines,e.g.,SJ48-1,ZB-1,851-2,and DT-8 can be utilized to improve yield and fiber quality traits in cotton. | SHAHZAD Kashif LI Xue QI Tingxiang GUO Liping TANG Huini ZHANG Xuexian WANG Hailin ZHANG Meng ZHANG Bingbing QIAO Xiuqin XING Chaozhu WU Jianyong | 2019 | Journal of Cotton Research2019，2，2： | 5 |
| 20 | Prevention of macrovascular complications in patients with type 2 diabetes mellitus: Review of cardiovascular safety and efficacy of newer diabetes medications显示文摘Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications has been very frustrating for clinicians involved in care of patients with diabetes mellitus (DM). Highly publicized controversy surrounding cardiovascular (CV) safety of rosiglitazone resulted in major changes in United States Food and Drug Administration policy in 2008 regarding approval process of new antidiabetic medications, which has resulted in revolutionary data from several large CV outcome trials over the last few years. All drugs in glucagon-like peptide-1 receptor agonist (GLP-1 RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitor classes have shown to be CV safe with heterogeneous results on CV efficacy. Given twofold higher CV disease mortality in patients with DM than without DM, GLP-1 RAs and SGLT-2-inhibitors are important additions to clinician’s armamentarium and should be second line-therapy particularly in patients with T2DM and established atherosclerotic CV disease or high risks for CV disease. Abundance of data and heterogeneity in CV outcome trials results can make it difficult for clinicians, particularly primary care physicians, to stay updated with all the recent evidence. The scope of this comprehensive review will focus on all major CV outcome studies evaluating CV safety and efficacy of GLP-1 RAs and SGLT-2 inhibitors. | Ravi Kant Kashif M Munir Arshpreet Kaur Vipin Verma | 2019 | World Journal of Diabetes2019，10，6： | 5 |
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