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| 1 | The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase显示文摘 | Thomas F Franke Sung-Il Yang Tung O Chan Ketaki Datta Andrius Kazlauskas Deborah K Morrison David R Kaplan Philip N Tsichlis | 1995 | Cell1995，，5： | 2 |
| 2 | Do statins reduce hepatitis C RNA titers during routine clinical use?显示文摘AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral titers.RESULTS: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy. | Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan | 2009 | World Journal of Gastroenterology2009，15，40： | 2 |
| 3 | Biofilm formation as microbial development 显示文摘 | O 'Toole G Kaplan H B Kolter R | 2000 | Annu Rev Micmbiol2000，54，： | 1 |
| 4 | Primary bipolar hemiprosthesis for unstable intertrochanteric fractures显示文摘 | Rodop O Kira A Kaplan H | 2002 | Int Orthop2002，26，4： | 1 |
| 5 | Primary bipolar hemiprosthesis for unstable intertro chanteric fractures 显示文摘 | Rodop O Kiral A Kaplan H | 2002 | Int Ortho p2002，26，4： | 1 |
| 6 | The management of acute cholecystitis in elderly patiengts 显示文摘 | Hafif A Gut man M Kaplan O | 1991 | Am Surg1991，57，10： | 1 |
| 7 | Management of breast fibroadenomas显示文摘 | Greenberg R Skomiek Y Kaplan O | 1998 | J Gen Intem Med1998，13，9： | 1 |
| 8 | Rapid transcriptome changes induced by cytosolic Ca2+ transients reveal ABRErelated sequences as Ca2+-responsive cis elements in Arabidopsis显示文摘 | Kaplan B Davydov O Knight H Galon Y Knight M R Fluhr R Frommc H | | 0，，： | 1 |
| 9 | Exogenous nitric oxide triggers classic ischemic preconditioning by preventing intracellular Ca2+ overload in cardiomyocytes显示文摘 | Rickover O Zinman T Kaplan D | 2008 | Cell Calcium2008，43，4： | 1 |
| 10 | Octreotide for treatment of postope-rative alimentary tract fistulas显示文摘 | Paran H Neufld D Kaplan O | 2007 | World J Surg2007，19，3： | 1 |
| 11 | Biofilm formation as microbial development显示文摘 | O'Toole G Kaplan H B Kolter R | 2000 | Annu Rev Microbiol2000，54，： | 1 |
| 12 | Foot and mouth disease virus infected but not vaccinated cattle develop antibodies against recombinant 3AB1 nonstructural protein显示文摘 | Silberstein E Kaplan G Taboga O | 1997 | Arch Virol1997，142，： | 1 |
| 13 | A new framework for service supply chains显示文摘 | Baltacioglu T Ada E Kaplan M D Yurt O and Kaplan Y C | 2007 | The Service Industries Journal2007，27，2： | 1 |
| 14 | Biofilm formation as microbial development 显示文摘 | O'Toole G Kaplan HB Kolter R | 2000 | Annu Rev Microbiol2000，54，： | 1 |
| 15 | Sequential or simultaneous, same- day anterior decompression and posterior stabilization in the management of vertebral osteomyelitis of the lumbar spine 显示文摘 | Safran O Rand N Kaplan L | 1998 | Spine1998，23，17： | 1 |
| 16 | Biofilm formation as microbial development 显示文摘 | O' Toole G Kaplan HB Kolter R | 2000 | Annu Rev Microbiol2000，54，1： | 1 |
| 17 | Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38 α MAPK显示文摘 | EBEL M E AWE O KAPLAN M H | 2015 | The Journal of Immunology2015，194，12： | 1 |
| 18 | Acceleration of retarded growth in children with Gaucher disease after treatment with alglucerase? 显示文摘 | Kaplan P Mazur A Manor O | 1996 | J Pediatr1996，129，1： | 1 |
| 19 | primary bipolar hemiprosthesis for unstable intertrochanterie fractures 显示文摘 | Rodop O kiral A Kaplan H | 2002 | Int Ortbop2002，26，4： | 1 |
| 20 | Mechanical Stimulation Promotes Osteogenic Differentiation of Human Bone Marrow Stromal Cells on 3-D Partially Demineralized Bone Scaffolds In Vitro显示文摘 | J. R. Mauney S. Sjostorm J. Blumberg R. Horan J. P. O’Leary G. Vunjak-Novakovic V. Volloch D. L. Kaplan | 2004 | Calcified Tissue International2004，，5： | 1 |
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