|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia显示文摘AIM To study liver stiffness(LS) during pregnancy and its association with complications during pregnancy.METHODS In this observational, diagnostic study, 537 pregnant women were prospectively enrolled at the Department of Obstetrics and Gynecology, University hospital Heidelberg and Salem Medical Center. LS was measured using the Fibroscan device(Echosens, Paris) in all women and in 41 cases 24 h after delivery. Clinical and morphological data were recorded and abdominal ultrasound and standard laboratory tests were performed. No complications were observed in 475 women(controls) while preeclampsia and intrahepatic cholestasis of pregnancy(ICP) developed in 22 and 40 women, respectively.RESULTS In controls, LS increased significantly from initially 4.5 ± 1.2 kPa in the second trimester to 6.0 ± 2.3 kPa(P < 0.001) in the third trimester. In the third trimester, 41% of women had a LS higher than 6 kPa. Elevated LS in controls was significantly correlated with alkaline phosphatase, leukocytes, gestational age and an increase in body weight and body mass index(BMI). In women with pregnancy complications, LS was significantly higher as compared to controls(P < 0.0001). Moreover, in multivariate analysis, LS was an independent predictor for preeclampsia with an odds ratio of 2.05(1.27-3.31) and a cut-off value of 7.6 kPa. In contrast, ICP could not be predicted by LS. Finally, LS rapidly decreased in all women within 24 h after delivery from 7.2 ± 3.3 kPa down to 4.9 ± 2.2 kPa(P < 0.001).CONCLUSION During pregnancy, LS significantly and reversibly increases in the final trimester of pregnant women without complications. In women with preeclampsia, LS is significantly elevated and an independent noninvasive predictor. | Franziska J Ammon Anna Kohlhaas Omar Elshaarawy Johannes Mueller Thomas Bruckner Christof Sohn Gabriele Fluhr Herbert Fluhr Sebastian Mueller | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 2 | Divergent evolution of plant NBS-LRR resistance gene homologues in dicot and cereal genomes 显示文摘 | Pan Q L Wendel J Fluhr R | 2000 | Journal of Molecular Evolution2000，50，： | 1 |
| 3 | Rapid transcriptome changes induced by cytosolic Ca2+ transients reveal ABRErelated sequences as Ca2+-responsive cis elements in Arabidopsis显示文摘 | Kaplan B Davydov O Knight H Galon Y Knight M R Fluhr R Frommc H | | 0，，： | 1 |
| 4 | Short- term glucocorticoid treatment compromi- ses both permeability barrier homeostasis and stratum comeum integrity: Inhibition of epidermal lipid synthesis accounts for functional abnormalities显示文摘 | Kao JS Fluhr JW Man MQ | 2003 | J Invest Der- matol2003，120，3： | 1 |
| 5 | Calcium requirement for ethylene-dependent responses显示文摘 | Raz V Fluhr R | 1992 | Plant Cell1992，4，： | 1 |
| 6 | Is human chorionic gonadotropin directly involved in the regulation of human imp|antation显示文摘 | Lieht P Fluhr H Neuwinger J | 2007 | Mol Cell Endocrinol2007，269，： | 1 |
| 7 | Divergent evolution of plant NBS-LRR resistance gene homologues in dicot and cereal genomes显示文摘 | Pan Q Wendel J Fluhr R | 2000 | J Mol Evol2000，50，： | 1 |
| 8 | Air flow atdifferent temperatures increases sodium lauryl sulphate-induced barrier disruption and irritation in vivo显示文摘 | Fluhr JW Praessler J Akengin A | 2005 | Br JDermatol2005，152，6： | 1 |
| 9 | The role of calcium and activated oxygen as signals for controlling cross-adaptation显示文摘 | Bowler C Fluhr R L | 2000 | Trends in Plant Science2000，5，： | 1 |
| 10 | Antifungal and antibacterial properties of a silver-loaded cellulosic fiber显示文摘 | Hipier U C Eisner P Fluhr J W | 2006 | J Biomed Mater Res2006，77，1： | 1 |
| 11 | An RFLP marker in to- mato linked to the Fusarium oxysDorum resistance gene I-2 显示文摘 | Sarfatti M Katan J Fluhr R | 1989 | TAG Theoretical and Applied Genetics1989，78，： | 1 |
| 12 | Full-body skin mapping for six bio- physical parameters: baseline values at 16 anatomical sites in 125 hu- man subjects显示文摘 | Kleesz P Darlenski R Fluhr JW | 2011 | Skin pharmacology and physiology2011，25，1： | 1 |
| 13 | An RFLP marker in tomat:linked to the Fusarium oxysporum resistance gene 12显示文摘 | Sarfatti M Katan J Fluhr R | 1989 | TAG1989，78，： | 1 |
| 14 | Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum comeum integrity: Inhibition of epidermal lipid synthesis accounts for functionalabnormalities 显示文摘 | Kao JS Fluhr JW Man MQ | 2003 | J Invest Dermatol2003，120，3： | 1 |
| 15 | Alternative splicing modulation by a LAMMER kinase impinges on developmental and transcriptome expression显示文摘 | Savaldi-Goldstein S Aviv D Davydov O Fluhr R | | 0，，04： | 1 |
| 16 | Pre - Study protocol MagPEP: A multi- centre randomized controlled trial of magnesiumsulphate in the prevention of post - ERCP pancreatitis 显示文摘 | Fluhr G Mayerle J Weber E | 2013 | BMC Gastroenterol2013，13，1： | 1 |
| 17 | The role of calcium and activated cxygens as signals for controlling cross-adaptaion显示文摘 | BOWLER C FLUHR R | 2000 | Trends Plant Science2000，，5： | 1 |
| 18 | German S2k guideline fur the therpy of pathological scars ( hypertrophic scars and keloids) 显示文摘 | Nast A Eming S Fluhr J | 2012 | J Dtsch Dernmtol Ges2012，10，10： | 1 |
| 19 | Topical liver Ⅹ receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate显示文摘 | Fluhr JW Crumrine D Man MQ | 2005 | J Invest Dermatol2005，125，6： | 1 |
| 20 | Divergent evolution of plant NBS-LRR resistance gene homologues in dicot and cereal ge- nomes 显示文摘 | PAN Q WENDEL J FLUHR R | 2000 | J Mol Evol2000，50，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员