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| 1 | 基于DEM的陕北黄土高原典型地貌分形特征研究显示文摘应用分形理论与方法,结合陕北黄土高原1∶5万DEM数据,通过河网分形维数和稳定性系数计算,研究了陕北黄土地貌空间分布特征。结果表明:(1)陕北黄土高原不同地貌类型分形结构复杂程度各异,表现出不同大小的水系分维值和稳定性系数,其中,黄土峁状、梁状丘陵沟壑区地貌结构最为复杂,分维值最大,稳定性系数最小。黄土残塬、黄土塬区分维值次之。黄土—风沙过渡区地形结构简单,地势相对平坦,分维值最低,稳定性程度最高。(2)以分形参数作为定量化指标进行黄土地貌特征研究是可行的,DEM数据集是研究过程中的核心和基础。分形值所描述的分形特征与地貌类型、地质结构等有一定的相关性。此外,对分形几何的地学机理还需要进一步分析。 | 蔡凌雁 汤国安 熊礼阳 Kamila Justyna Lis 谢婷 李亚平 | 2014 | 水土保持通报2014，34，3： | 18 |
| 2 | Insulin resistance,adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C显示文摘AIM:to analyze adipokine concentrations,insulin resistance and hepatic expression of suppressor of cytokine signaling 3(SOCS-3)in patients with chronic hepatitis C genotype 1 with normal body weight,glucose and lipid profile.METHODS:The study group consisted of 31 patients with chronic hepatitis C and 9 healthy subjects.Total levels of adiponectin,leptin,resistin,visfatin,omentin,osteopontin and insulin were measured using an ELISA kit.The hepatic expression of SOCS-3 was determined by the use of the reverse transcription polymerase chain reaction method.RESULTS:Homeostasis model assessment for insulin resistance(HOMA-IR)values were significantly higher in hepatitis C virus(HCV)infected patients without metabolic disorders compared to healthy controls(2.24 vs 0.59,P=0.0003).Hepatic steatosis was observed in 32.2%of patients with HCV infection and was found in patients with increased HOMA-IR index(2.81 vs1.99,P=0.05)and reduced adiponectin level(5.96vs 8.37,P=0.04).Inflammatory activity(G≥2)was related to increased osteopontin concentration(34.04vs 23.35,P=0.03).Advanced liver fibrosis(S≥2)was associated with increased levels of omentin and osteopontin(436.94 vs 360.09,P=0.03 and 32.84 vs20.29,P=0.03)and reduced resistin concentration(1.40 vs 1.74,P=0.047).No correlations were reported between adipokine profile,HOMA-IR values and hepatic expression of the SOCS-3 gene.CONCLUSION:We speculated that no relationship between adipokines and HOMA-IR values may indicate that HCV can induce insulin resistance itself.Some adipokines appear to be biochemical markers of steatosis,inflammation and fibrosis in patients with chronic HCV infection. | Kamila Wójcik Elzbieta Jabonowska Aleksandra Omulecka Anna Piekarska | 2014 | World Journal of Gastroenterology2014，20，30： | 8 |
| 3 | The influence of potassium to mineral fertilizers on the maize health显示文摘Field experiments(2009–2011) were conducted at the Department of Agronomy at Poznań University of Life Sciences on the fields of the Research Institute in Swadzim. We evaluated the health of maize plants of two types, depending on the variations in mineral fertilization. The conducted research recorded the occurrence of pests such as oscinella frit(Oscinella frit L.) and the European corn borer(Pyrausta nubilalis Hbn.). Diseases recorded during the research included two pathoagenes: Fusarium(Fusarium ssp.) and corn smut(Ustilago maydis Corda). It was shown that the meteorological conditions during the maize vegetation had a significant influence on the occurrence of pests. Adding potassium to mineral fertilizers increased the maize resistance to Fusarium. Cultivation of 'stay-green' cultivar shall be considered as an element of in-tegrated maize protection. The occurrence of oscinella frit was correlated with the occurrence of Fusarium as well as the occurrence of the European corn borer for both examined cultivars. | Jan Bocianowski Piotr Szulc Anna Tratwal Kamila Nowosad Dariusz Piesik | 2016 | Journal of Integrative Agriculture2016，15，6： | 4 |
| 4 | Trefoil factor-3 is not a useful marker of mucosal healing in Crohn's disease treated with anti-TNF-α antibodies显示文摘AIM To evaluate whether repeated serum measurements of trefoil factor-3(TFF-3)can reliably reflect mucosal healing(MH)in Crohn’s disease(CD)patients treated with anti-tumor necrosis factor-α(anti-TNF-α)antibodies.METHODS Serum TFF-3 was measured before and after antiTNF-αinduction therapy in 30 CD patients.The results were related to clinical,biochemical and endoscopic parameters.MH was defined as a≥50%decrease in Simple Endoscopic Score for Crohn’s disease(SES-CD).RESULTS SES-CD correlated significantly with CD clinical activity and several standard biochemical parameters(albumin,leukocyte and platelet counts,C-reactive protein,erythrocyte sedimentation rate,fibrinogen).In contrast,SES-CD did not correlate with TFF-3(P=0.54).Moreover,TFF-3 levels did not change significantly after therapy irrespectively of whether the patients achieved MH or not.Likewise,TFF-3 did not correlate with changes in fecal calprotectin,which has been proposed as another biochemical marker of mucosal damage in CD.CONCLUSION Serum TFF-3 is not a convenient and reliable surrogate marker of MH during therapy with TNF-αantagonists in CD. | Piotr Eder Kamila Stawczyk-Eder Katarzyna Korybalska Natasza Czepulis Joanna Luczak Liliana Lykowska-Szuber Iwona Krela-Kazmierczak Krzysztof Linke Janusz Witowski | 2017 | World Journal of Gastroenterology2017，23，1： | 3 |
| 5 | GDF-15 Level Correlates with CMKLR1 and VEGF-A in Tumor-free Margin in Colorectal Cancer显示文摘Colorectal cancer(CRC)is the third most frequently diagnosed cancer worldwide,responsible for over 880000 deaths each year.Growth/differentiation factor 15(GDF-15)is reported to be a promising diagnostic and prognostic factor in CRC.It induces pleiotropic effects in tumor cells:proliferation,sternness,invasion and metastasis.Some studies indicate that GDF-15 may stimulate angiogenesis in malignant neoplasms.However,it has not been investigated in CRC yet.The aim of our study was to determine the level of GDF-15 and the concentrations of hypoxia-inducible factor-la(HIF-1α),VEGF-A and chemokine-like receptor 1(CMKLR1)in tumor and margin specimens of CRC in relation to histological grade and TNM staging.The study comprised 33 samples of tumor and margin tissues obtained from CRC patients.To assess the concentration of GDF-15,HIF-1α,VEGF-A and CMKLR1,commercially available enzyme-linked immunosorbent assay(ELISA)kits were used.We found significantly increased levels of GDF-15 and CMKLR1 in tumor tissue compared to margin tissue and higher concentrations of HIF-1α and VEGF-A in margin tissue than in tumor tissue.The levels of GDF-15 and HIF-1α were significantly correlated with VEGF-A and CMKLR1 in margin tissue.In CRC,the increased level of GDF-15 might stimulate angiogenesis through upregulation of HIF-1α,VEGF A and CMKLR1 expression.Our study is the first one to reveal the correlation between the levels of GDF-15 and CMKLR1 in CRC.The elevated levels of HIF-1α and VEGF-A in tumor-free margin tissues suggest that noncancer cells in the tumor microenvironment are an important source of proangiogenic factors. | Sylwia Mielcarska Kamila Stopifnska Miriam Dawidowicz Agnieszka Kula Pawel Kicamer Alicja Prawdric Senkowska Ewa Nowakowska Zajde Katarzyna Walkiewicz Dariusz Waniczek Elzbieta Swietochowska | 2021 | Current Medical Science2021，41，3： | 3 |
| 6 | Long-term follow-up of children and adolescents with primary sclerosing cholangitis and autoimmune sclerosing cholangitis显示文摘BACKGROUND: Sclerosing cholangitis(SC) is a chronic cholestatic hepatobiliary disease with uncertain long-term prognosis in pediatric patients. This study aimed to evaluate longterm results in children with SC according to the types of SC.METHODS: We retrospectively followed up 25 children with SC over a period of 4-17 years(median 12). The diagnosis of SC was based on biochemical, histological and cholangiographic findings. Patients fulfilling diagnostic criteria for probable or definite autoimmune hepatitis at the time of diagnosis were defined as having autoimmune sclerosing cholangitis(ASC); other patients were included in a group of primary sclerosing cholangitis(PSC). The incidence of the following complications was studied: obstructive cholangitis, portal hypertension, advanced liver disease and death associated with the primary disease.RESULTS: Fourteen(56%) patients had PSC and 11(44%) had ASC. Patients with ASC were significantly younger at the time of diagnosis(12.3 vs 15.4 years, P=0.032) and had higher Ig G levels(22.7 vs 17.2 g/L, P=0.003). The mentioned complications occurred in 4(16%) patients with SC, exclusively in the PSC group: one patient died from colorectal cancer, one patient underwent liver transplantation and two patients, in whom severe bile duct stenosis was present at diagnosis, were endoscopically treated for acute cholangitis. Furthermore, twoother children with ASC and 2 children with PSC had elevated aminotransferase levels. The 10-year overall survival was 95.8% in all patients, 100% in patients without complicated liver disease, and 75.0% in patients with complications.CONCLUSION: In children, ASC is a frequent type of SC, whose prognosis may be better than that in patients with PSC. | Vratislav Smolka Eva Karaskova Oksana Tkachyk Kvetoslava Aiglova Jiri Ehrmann Kamila Michalkova Michal Konecny Jana Volejnikova | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，4： | 2 |
| 7 | Effect of CD14/TLR4 antagonist on GnRH/LH secretion in ewe during central inflammation induced by intracerebroventricular administration of LPS显示文摘Background: Immune stress induced by lipopolysaccharide(LPS) influences the gonadotropin-releasing hormone(GnRH)/luteinizing hormone(LH) secretion. Presence of LPS interacting Toll-like receptor(TLR) 4 in the hypothalamus may enable the direct action of LPS on the GnRH/LH secretion. So, the aim of the study was to investigate the influence of intracerebroventricular(icv) injection of TLR4 antagonist on GnRH/LH secretion in anestrous ewes during LPS-induced central inflammation. Animals were divided into three groups icv-treated with: Ringer-Locke solution, LPS and TLR4 antagonist followed by LPS.Results: It was demonstrated that TLR4 antagonist reduced LPS-dependent suppression of GnRH gene expression in the preoptic area and in the medial basal hypothalamus, and suppression of receptor for GnRH gene expression in the anterior pituitary gland. It was also shown that TLR4 antagonist reduced suppression of LH release caused by icv injection of LPS. Central administration of LPS stimulated TLR4 gene expression in the medial basal hypothalamus.Conclusions: It was indicated that blockade of TLR4 prevents the inhibitory effect of centrally acting LPS on the GnRH/LH secretion. This suggests that some negative effects of bacterial infection on the hypothalamic-pituitary-gonadal axis activity at the hypothalamic level may be caused by central action of LPS acting through TLR4. | Karolina Haziak Andrzej Przemyslaw Herman Karolina Wojtulewicz Bartosz Pawlina Kamila Paczesna Joanna Bochenek Dorota Tomaszewska-Zaremba | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 2 |
| 8 | How to treat male breast cancer 显示文摘 | Kamila C Jenny B Per H | 2007 | Breast2007，16，2： | 1 |
| 9 | Characterization of Borderline Oxacillin-Resistant Staphylococcus aureus Isolated from Food of Animal Origin显示文摘 | Bystron Jaroslaw Podkowik Magdalena Korzekwa Kamila Lis Elzbieta Molenda Jerzy Bania Jacek | 2010 | Journal of Food Protection2010，，7： | 1 |
| 10 | Knowledge about cervical cancer among Polish and Finnish female students显示文摘 | Kinga Kuczkowska Kamila Jankowiak-Siuda Zbigniew Wronkowski | 2011 | European Journal of Obstetrics and Gynecology2011，，2： | 1 |
| 11 | Effect of Regional Citrate Anticoagulation on Thrombogenicity and Biocompatibility During CVVHDF显示文摘 | Kamila Polanská Karel Opatrny Richard Rokyta Ale&scaron Krou&zcaron ecky Ladislav Vit Eduard Kasal | 2006 | Renal Failure2006，，： | 1 |
| 12 | Determination of malachite green and leucomalachite green residues in water using liquid chromatography with visible and fluorescence detection and confirmation by tandem mass spectrometry 显示文摘 | Kamila M Andrzej P Jan Z | 2008 | Journal of Chromatography A2008，1207，12： | 1 |
| 13 | Antimicrobial and healing activity of Kefir and Kefiranextract 显示文摘 | Kamila L R Lucelia Rita G C Jose Carlos T C | 2005 | International Journal of Antimicrobial Agents2005，25，： | 1 |
| 14 | Determination of malachite green and leucomalachite green in carp muscle by liquid chromatography with visible and fluorescence detection 显示文摘 | Kamila M Andrzej P Jan Z | 2005 | Journal of Chromatography A2005，1089，12： | 1 |
| 15 | Trophoblast interferon and pregnancy显示文摘 | Kristina J D Kamila D Anthony F | 2001 | Reproduction2001，121，： | 1 |
| 16 | Invariance Image Analysis Using Modified Zernike Moments 显示文摘 | Kamila N K Mahapatra S Nanda S | 2005 | Pattern Recognition Letters2005，26，： | 1 |
| 17 | Generation of dendritic cells from human peripheral blood monocytes-comparison of different culture media显示文摘 | Nataliya Tkachenko Kamila Wojas | 2005 | Folia Histochem Cytobiol2005，43，1： | 1 |
| 18 | Regional characterization of a hamster–sheep somatic cell hybrid panel显示文摘 | Kamila Tabet-Aoul Laurent Schibler Daniel Vaiman Anne Oustry-Vaiman Isabelle Lantier Nadhira Saidi-Mehtar Edmond-Paul Cribiu Frédéric Lantier | 2000 | Mammalian Genome2000，，1： | 1 |
| 19 | Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy显示文摘Evasion of apoptosis is a hallmark of cancer,attributed in part to overexpression of the antiapoptotic protein B-cell lymphoma 2(Bcl-2).In a variety of cancer types,including lymphoma,Bcl-2 is overexpressed.Therapeutic targeting of Bcl-2 has demonstrated efficacy in the clinic and is the subject of extensive clinical testing in combination with chemotherapy.Therefore,the development of co-delivery systems for Bcl-2 targeting agents,such as small interfering RNA(siRNA),and chemotherapeutics,such as doxorubicin(DOX),holds promise for enabling combination cancer therapies.Lipid nanoparticles(LNPs)are a clinically advanced nucleic acid delivery system with a compact structure suitable for siRNA encapsulation and delivery.Inspired by ongoing clinical trials of albumin-hitchhiking doxorubicin prodrugs,here we developed a DOX-siRNA co-delivery strategy via conjugation of doxorubicin to the surface of siRNAloaded LNPs.Our optimized LNPs enabled potent knockdown of Bcl-2 and efficient delivery of DOX into the nucleus of Burkitts'lymphoma(Raji)cells,leading to effective inhibition of tumor growth in a mouse model of lymphoma.Based on these results,our LNPs may provide a platform for the co-delivery of various nucleic acids and DOX for the development of new combination cancer therapies. | Kamila Butowska Xuexiang Han Ningqiang Gong Rakan El-Mayta Rebecca MHaley Lulu Xue Wenqun Zhong Wei Guo Karin Wang Michael J.Mitchell | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 20 | Analyti- cal procedure for the determination of chlortetracycline and 4 - epi -chlortetracycline in pig kidneys显示文摘 | Posyniak ArLdrzej Mitrowska Kamila Zmudzki Jan | 2005 | Journal of Chromatography A2005，1088，： | 1 |
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