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| 1 | Retinopathy of prematurity: Past, present and future显示文摘Retinopathy of prematurity(ROP) is a vasoproliferative disorder of the retina occurring principally in new born preterm infants. It is an avoidable cause of childhood blindness. With the increase in the survival of preterm babies, ROP has become the leading cause of preventable childhood blindness throughout the world. A simple screening test done within a few weeks after birth by an ophthalmologist can avoid this preventable blindness. Although screening guidelines and protocols are strictly followed in the developed nations, it lacks in developing economies like India and China, which have the highest number of preterm deliveries in the world. The burden of this blindness in these countries is set to increase tremendously in the future, if corrective steps are not taken immediately. ROP first emerged in 1940 s and 1950 s, when it was called retrolental fibroplasia. Several epidemics of this disease were and are still occurring in different regions of the world and since then a lot of research has been done on this disease. However, till date very few comprehensive review articles covering all the aspects of ROP are published. This review highlights the past, present and future strategies in managing this disease. It would help the pediatricians to update their current knowledge on ROP. | Parag K Shah Vishma Prabhu Smita S Karandikar Ratnesh Ranjan Venkatapathy Narendran Narendran Kalpana | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 13 |
| 2 | Antioxidant activity and phenol and flavonoid contents of eight medicinal plants from Western Nepal显示文摘OBJECTIVE: The purpose of this study was to evaluate the antioxidant activity, phenolic and flavonoids contents of selected medicinal plants form the Western region of Nepal.METHODS: The antioxidant activity of selected medicinal plants were determined by using 2, 2-diphenyl-1-picrylhydrazyl radical scavenging activity; total ferric ion reducing ability through spectroscopic analysis. The content of total phenols was determined using Folin-Ciocalteu reagent, whereas Aluminum chloride colorimetric method was used for flavonoid determination.RESULTS: Extracts of Syzygium Operculatus(87%),Astilbe Rivularis(83%) and Mallotus Philippnensis(88%) showed significant free radical scavenging activity with effective concentration(EC50) close to that of ascorbic acid. Syzygium Operculatus(96%),Astilbe Rivularis(97%) and Mallotus Philippnensis(97%) had potent reducing power in concentration dependent fashion. Those plant extract with higher free radical scavenging and ferric reducing effect also showed the greater content of both phenols and flavonoids, suggesting the correlation between polyphenolic content and antioxidant activity. Those plant extracts which showed better antioxidant activity assays, also demonstrated higher total phenol and flavonoid contents. These three plants showed the presence of higher amount of phenols and flavonoids.CONCLUSION: This study may provide the scientific basis for the traditional use of those plants and may provide valuable idea for further research. | Lalita Subedi Sunita Timalsena Pabitra Duwadi Ritu Thapa Anita Paudel Kalpana Parajuli | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 8 |
| 3 | MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer显示文摘 | Fanyin Meng Roger Henson Hania Wehbe–Janek Kalpana Ghoshal Samson T. Jacob Tushar Patel | 2007 | Gastroenterology2007，，2： | 6 |
| 4 | Curcumin induces differentiation of embryonic stem cells through possible modulation of nitric oxide-cyclic GMP pathway显示文摘Curcumin,an active ingredient of dietary spice used in curry,has been shown to exhibit anti-oxidant,anti-inflammatory and anti-proliferative properties.Using EB directed differentiation protocol of H-9 human em-bryonic stem(ES)cells;we evaluated the effect of cur-cumin(0-20μmol/L)in enhancing such differentiation.Our results using real time PCR,western blotting and immunostaining demonstrated that curcumin signifi-cantly increased the gene expression and protein levels of cardiac specific transcription factor NKx2.5,cardiac troponin I,myosin heavy chain,and endothelial nitric oxide synthase during ES cell differentiation.Further-more,an NO donor enhanced the curcumin-mediated induction of NKx2.5 and other cardiac specific proteins.Incubation of cells with curcumin led to a dose depend-ent increase in intracellular nitrite to the same extent as giving an authentic NO donor.Functional assay for second messenger(s)cyclic AMP(cAMP)and cyclic GMP(cGMP)revealed that continuous presence of cur-cumin in differentiated cells induced a decrease in the baseline levels of cAMP but it significantly elevated baseline contents of cGMP.Curcumin addition to a cell free assay significantly suppressed cAMP and cGMP degradation in the extracts while long term treatment of intact cells with curcumin increased the rates of cAMP and cGMP degradation suggesting that this might be due to direct suppression of some cyclic nucleo-tide-degrading enzyme(phosphodiesterase)by curcu-min.These studies demonstrate that polyphenol curcu-min may be involved in differentiation of ES cells partly due to manipulation of nitric oxide signaling. | Kalpana Mujoo Lubov ENikonoff Vladislav G Sharin Nathan SBryan Alexander YKots Ferid Murad | 2012 | Protein & Cell2012，3，7： | 5 |
| 5 | 硼酸铝晶须增强铝基复合材料的显微组织、力学性能和磨损性能显示文摘通过传统的粉末冶金技术制备不同含量硼酸铝晶须(ABOw)(5%, 10%, 15%,质量分数)增强的商业纯铝基复合材料,并对其显微组织特征和力学性能进行研究。采用粉末冶金方法有效混合铝粉和ABOw,将混合粉冷压后在600℃下烧结。通过光学显微镜(OM)、扫描电子显微镜(SEM)、能谱分析(EDS)、透射电子显微镜(TEM)和X射线衍射(XRD)对烧结后的复合材料进行显微组织表征,测定复合材料的孔隙率随ABOw含量的变化,研究ABOw含量变化对复合材料的力学性能,包括硬度、抗弯强度和抗压强度的影响,及复合材料在恒定载荷下、不同滑动距离下的干滑动磨损行为。结果表明,当ABOw含量为10%(质量分数)时,复合材料具有最大的抗弯强度和抗压强度,分别为172 MPa和324 MPa,并且硬度得到改善,约为HV 40.2。但是,随着ABOw含量的进一步增加,性能降低。含10%ABOw复合材料的耐磨性能也得到显著提高。Al-10%ABOw复合材料优异的综合性能归因于其具有良好的界面结合性能、低的孔隙率和好的组织均匀性。 | Neeraj PANDEY ICHAKRABARTY Kalpana BARKANE NSMEHTA MRMAJHI | 2020 | Transactions of Nonferrous Metals Society of China2020，30，7： | 5 |
| 6 | 2010女性急性单纯性膀胱炎和肾盂肾炎临床治疗指南(摘译)显示文摘美国感染病学会、欧洲临床微生物与感染病学会共同组织专家对1999年美国感染病学会单纯性尿路感染的指南进行了更新。2010指南更新的重点是治疗女性急性单纯性膀胱炎和肾盂肾炎,仅适用于无已知尿道畸形或合并症的绝经前及未妊娠的女性患者。作者就指南的主要内容进行摘译。 | 刘辉(译) 刘树元(译) kalpana gupta thomas m.hooton richard colgan loren g.miller gregory j.moran anthony j.schaeffer david e.soper lindsay e.nicolle kurt g.naber bjorn wullt raul raz | 2016 | 转化医学杂志2016，5，2： | 4 |
| 7 | Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians显示文摘AIM To investigate the association of NFKB1 gene-94 ATTG insertion/deletion(rs28362491) polymorphism with inflammatory markers and risk of diabetic nephropathy in Asian Indians.METHODS A total of 300 subjects were recruited(100 each), normoglycemic,(NG); type 2 diabetes mellitus(T2DM) without any complications(DM) and T2 DM with diabetic nephropathy [DM-chronic renal disease(CRD)]. Analysis was carried out by polymerase chain reaction-restriction fragment length polymorphism and ELISA. Pearson's correlation, analysis of variance and logistic regression wereused for statistical analysis.RESULTS The allelic frequencies of-94 ATTG insertion/deletion were 0.655/0.345(NG), 0.62/0.38(DM) and 0.775/0.225(DM-CRD). The-94 ATTG ins allele was associated with significantly increased levels of urinary monocyte chemoattractant protein-1(u MCP-1); u MCP-1(P = 0.026) and plasma tumor necrosis factor-alpha(TNF-α); TNF-α(P = 0.030) and almost doubled the risk of diabetic nephropathy(OR = 1.91, 95%CI: 1.080-3.386, P = 0.025).CONCLUSION-94 ATTG ins/ins polymorphism might be associated with increased risk of developing nephropathy in Asian Indian subjects with diabetes mellitus. | Amar Gautam Stuti Gupta Mohit Mehndiratta Mohini Sharma Kalpana Singh Om P Kalra Sunil Agarwal Jasvinder K Gambhir | 2017 | World Journal of Diabetes2017，8，2： | 4 |
| 8 | δ-Opioid receptor as a potential therapeutic target for ischemic stroke显示文摘Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels.Despite having advancement in the use of thrombolytic and clot removal medicine,significant numbers of stroke patients are still left out without option for treatment.In this review,we summarize recent research work on the activation ofδ-opioid receptor as a strategy for treating ischemic stroke-caused neuronal injury.Moreover,as activation ofδ-opioid receptor by a non-peptidicδ-opioid receptor agonist also modulates the expression,maturation and processing of amyloid precursor protein andβ-secretase activity,the potential role of these effects on ischemic stroke caused dementia or Alzheimer’s disease are also discussed. | Kalpana Subedi Hongmin Wang | 2020 | Neural Regeneration Research2020，15，1： | 3 |
| 9 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 10 | Nitrate regulates rhizobial and mycorrhizal symbiosis in common bean(Phaseolus vulgaris L.)显示文摘Nitrogen‐limited conditions are considered to be a prerequisite for legume‐rhizobial symbiosis, but the effects of nitrate‐rich conditions on symbiotic status remain poorly understood. We addressed this issue by examining rhizobial(Rhizobim tropici) and arbusclarmycorrhizal(Glomus intraradices) symbiosis in Phaseolus vulgaris L. cv. Negro Jamapa under nitrate pre‐incubation and continuous nitrate conditions. Our results indicate that nitrate pre‐incubation, independent of the concentration, did not affect nodule development. However, the continuous supply of nitrate at high concentrations impaired nodule maturation and nodule numbers. Low nitrate conditions, in addition to positively regulating nodule number, biomass, and nitrogenase activity, also extended the span of nitrogen‐fixing activity. By contrast, for arbuscular mycorrhizae, continuous 10 and 50mmol/L nitrate increased the percent root lengthcolonization, concomitantly reduced arbuscule size, and enhanced ammonia transport without affecting phosphate transport. Therefore, in this manuscript, we have proposed the importance of nitrate as a positive regulator in promoting both rhizobial and mycorrhizal symbiosis in the common bean. | Kalpana Nanjareddy Lourdes Blanco Manoj‐Kumar Arthikala Xochitl Alvarado Affantrange Federico Sánchez Miguel Lara | 2014 | Journal of Integrative Plant Biology2014，56，3： | 3 |
| 11 | Role of microRNA‐155 at early stages of hepatocarcinogenesis induced by choline‐deficient and amino acid–defined diet in C57BL/6 mice显示文摘 | Bo Wang Sarmila Majumder Gerard Nuovo Huban Kutay Stefano Volinia Tushar Patel Thomas D. Schmittgen Carlo Croce Kalpana Ghoshal Samson T. Jacob | 2009 | Hepatology2009，，4： | 3 |
| 12 | Considering the Fault Dependency Concept with Debugging Time Lag in Software Reliability Growth Modeling Using a Power Function of Testing Time显示文摘自从 1970 年代初,巨大的生长在软件可靠性生长建模的研究被看见了。一般来说,软件可靠性生长模型(SRGM ) 对在软件开发测试的迟了的阶段适用,他们能提供怎么改进软件产品的可靠性的有用信息。很多 SRGM 在文学被建议了代表时间依赖者差错鉴定 / 移动现象;仍然新的模型正在被建议那能适合很多可靠性生长曲线。经常,数学模型什么时候被开发,被假定检测差错立即被改正。因为移开一个检测差错的时间取决于人员的差错,技巧和经验的复杂性,这个假设不能在实践是现实主义的,调试的队,的尺寸这种技术等等。因此,检测差错不必立即被移开,并且它可以落后由一个延期效果因素的差错察觉过程。在这篇论文,我们首先考察不同软件可靠性生长模型怎么被开发了,在差错察觉过程剩余差错内容的数字依赖于不仅而且在严峻的时间的地方,并且看这些模型怎么能用一个延期效果因素作为推迟的差错察觉模型由是 reinterpreted 。基于严峻的时间概念的力量功能,我们建议在软件假定差错的二种类型的存在的四新 SRGM:领先、依赖的差错。领先的差错是能在被观察的失败之上被移开的那些。然而,依赖差错被领先的差错掩盖并且在相应的带差错与一调试时间被移开以后,能仅仅被移开落后。这些模型在真实软件错误数据上被测试了显示出它合适的、预兆的有效性和适用性的美德。关键词非同类的泊松过程 - 差错相关性 - 领先的差错 - 依赖差错 - 延期效果 V. B。Singh 从设计学院的 M.M.M 收到了 M.C.A 度, Gorakhpur, U.P,印度。他是在在艺术和商业的德里学院的计算机科学系的一个讲师,德里的大学,德里,印度。一会儿,他是在德里的大学的一个博士候选人,德里。他出版了九篇研究论文。他的研究兴趣包括软件测试并且软件可靠性设计。Kalpana Yadav 收到了 M.Tech。在来自大师 Jambheshwar 大学的计算机科学和工程, Hissar,印度。她是在在因迪拉·甘地工学院的计算机科学系的一个讲师,大师 Gobind Singh Indraprastha 大学,德里,印度。一会儿,她是在 Jiwaji 大学的一个博士候选人, Gwalior。她出版了九篇研究论文。她的研究兴趣包括软件测试并且软件可靠性设计。Reecha Kapur 是在数学和计算机申请的系的一个研究学者, Bundelkhand 大学, Jhansi,印度。她从 Bundelkhand 大学在数学做了波斯特毕业, Jhansi,印度。她出版了三篇研究论文。她的研究兴趣在软件可靠性包括有瑕疵的调试模型,它软件测试上的效果花费。V.S. S。Yadavalli 在 1982 从印度工学院收到了他的博士学位。他是一个教授工业与在比勒陀利亚的大学的系统工程。他在可靠性理论上出版了超过 90 篇研究论文,排队理论,库存理论,软件可靠性,人力计划,在 ISI 当模特儿的 econometric 在可靠性,微电子学和可靠性上相信了象 IEEE 交易一样的杂志,随机的分析和应用程序,系统科学的国际杂志,运作的研究,应用数学与计算的亚太杂志,南非的计算机杂志,工业工程的南非的杂志, Interna 他在 Opertional 研究的亚太杂志的编委,管理动力学,工业工程的南非的杂志。他最近在马奎斯被列出了鈥 ?(第 23 编辑) 。他的研究兴趣包括可靠性理论,排队理论,库存理论,软件可靠性,计划的人力,并且 econometric 建模。 | V.B.Singh Kalpana Yadav Reecha Kapur V.S.S.Yadavalli | 2007 | International Journal of Automation and computing2007，4，4： | 3 |
| 13 | Chemical composition and antioxidant capacity of the aqueous extract of Phellodendron amurense显示文摘The aqueous extract of Phellodendron amurense Rupr.(Amur Cork Tree) provides a rich source of antioxidants and chemical compounds, and can be used for food and wood preservative materials.In this study, we characterized the chemical composition of this extract by GC and GC/MS.The antioxidant capacity was evaluated using a variety of antioxidant assays(superoxide radical,hydroxyl radical, nitric oxide radical, and DPPH radical scavenging activity).Additionally, total polyphenolic content was determined.Phenolic acids and acetone derivatives were major compounds of the extract capable of scavenging the DPPH free radical and reducing ferric ions.DPPH and ferric ion reduction results were strongly correlated with total phenolic content of the extract which also exhibited strong nitric oxide, hydroxyl radical scavenging and superoxide anion radical scavenging activities. | Natarajan Velmurugan Duraisamy Kalpana Jae Young Cho Yang Soo Lee | 2018 | Journal of Forestry Research2018，29，4： | 3 |
| 14 | A hybrid weed optimized coverage path planning technique for autonomous harvesting in cashew orchards显示文摘A coverage path planning algorithm is proposed for discrete harvesting in cashew orchards.The main challenge in such an orchard is the collection of fruits and nuts lying on the floor.The manual collection of fruits and nuts is both time consuming and labour intensive.The scenario begs for automated collection of fruits and nuts.There are methods developed in research for continuous crop fields,but none for discrete coverage.The problem is visualized as a graph traversal problem and paths for autonomous maneuvering are generated.A novel Mahalanobis distance based partitioning approach for performing coverage is introduced.The proposed path planner was able to achieve a mean coverage of 52.78 percentage with a deviation of 18.95 percentage between the best and worst solutions.Optimization of the generated paths is achieved through a combination of local and global search techniques.This was implemented by combining a discrete invasive weed optimization technique with an improved 2-Opt operator.A case study is formulated for the fruit picking operations in the orchards of Puducherry.The performance of the proposed algorithm is benchmarked against existing methods and also with performance metrics such as convergence rate,convergence diversity and deviation ratio.The convergence rate was observed to be 99.97 percent and 97.83 percent for a dataset with 48 and 442 nodes respectively.The deviation ratio was 0.02 percent and 2.16 percent,with a convergence diversity of 1.18 percent and 30.14 percent for datasets with 48 and 442 nodes.The achieved solutions was on par with the global best solutions achieved so far for the test datasets. | Kalaivanan Sandamurthy Kalpana Ramanujam | 2020 | Information Processing in Agriculture2020，7，1： | 3 |
| 15 | Nasopharyngeal carcinoma in the Northeastern states of India显示文摘Nasopharyngeal cancer (NPC) is a rare disease in most parts of the world, except for Southeast Asia, some parts of North Africa and the Arctic. It is mostly seen in people of Chinese origin. In India, NPC is also rare, except for the Hill States of Northeast India, particularly Nagaland, Manipur, and Mizoram. The striking feature of NPC in Northeast India is that the incidence ranges over the complete spectrum from the lowest (as 0.5/100 000 to 2.0/100 000 among Caucasoid) to the highest (as ~20/100 000 among Cantonese/Zhongshan dialect Chinese). The age-adjusted rate of NPC in Kohima district of Nagaland State is 19.4/100 000, which is among the highest recorded rates. By contrast, in Assam, one of the so-called Hill States but not itself a hilly state, NPC is much less common. The Northeastern region is distinguished by a preponderance of the Tibeto-Burman languages and by variable mongoloid features among peoples of the region. The nature of the migratory populations who are presumed to be bearers of the mongoloid risk is unknown, but these NPC occurrence features provide an outstanding opportunity for NPC risk investigation, such as that of the hypothesis of Wee et al. for westward displacement of Chinese aborigines following the last glacial maximum. | Amal Chandra Kataki Malcolm J. Simons Ashok Kumar Das Kalpana Sharma Narinder Kumar Mehra | 2011 | Chinese Journal of Cancer2011，30，2： | 2 |
| 16 | 具有精准结构Zr-O及Zr/Ti-O纳米团簇的深共熔溶剂热合成(英文)显示文摘近年来,深共熔溶剂热作为一种绿色合成方法被广泛用于多种杂化功能材料的合成。在本研究中,这一合成方法被引入到多核Zr-和Zr/Ti-O纳米团簇的制备,成功获得被邻菲罗啉、苯酚等共轭配体修饰的Zr_6以及Ti_(11)Zr_4团簇。此方法将为具有精准结构信息的被较多发色团包覆的纳米团簇的合成开辟新的技术路线。此外,光催化分解水产氢实验结果表明,由于具有不同的簇核环境,这两种纳米团簇表现出不同的分散性及与之相关的产氢活性。因此,该研究也为探索金属氧簇材料的结构-性能关系以及结构设计原则提供了借鉴。 | NARAYANAM Nagaraju CHINTAKRINDA Kalpana 方伟慧 张磊 张健 | 2018 | 物理化学学报2018，34，7： | 2 |
| 17 | MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer显示文摘 | Fanyin Meng Roger Henson Hania Wehbe–Janek Kalpana Ghoshal Samson T. Jacob Tushar Patel | 2007 | Gastroenterology2007，，2： | 2 |
| 18 | Acetyl- l -Carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats显示文摘 | Kalpana Barhwal Shashi Bala Singh Sunil Kumar Hota K. Jayalakshmi G. Ilavazhagan | 2007 | European Journal of Pharmacology2007，，1： | 2 |
| 19 | 氨化碳纳米管接枝生物分子(蛋白质和DNA)(英文)显示文摘报告-种氨基功能化处理的多壁碳纳米管(f-MWCNTs)用于生物分子〔如牛血浆蛋白素(BSA)蛋白质及脱氧核醣核酸(DNA)〕的接枝处理高效方法。以苯—二茂铁喷入氩氛炉于~850℃裂解制得MWCNTs,,而后向纳米管表面导入羧基化合物,再以氨基基团对MWCNTs,进行功能化处理。该过程包括:乙二胺与羧基基团直接结合,经酰胺化引入胺基基团。对制得的MWCNTs、f-MWCNTs以及由BSA蛋白质和DNA接枝的氨化f-MWCNTs等样品,采用SEM、TEM、FTIR进行表征。结果表明:生物分子(BSA蛋白质和DNA)接枝于氨化的f-MWCNTs。 | Kalpana Awasthi D.P. Singh Sunil Singh D. Dash O.N. Srivastava | 2009 | 新型炭材料2009，24，4： | 2 |
| 20 | Synthesis of 5-benzylidene-3-(3-fluoro-4-yl-morpholin-4-yl-phenylimino)-thiazolidin-4-one derivatives catalyzed by [BmIm] OH and their anti-microbial activity显示文摘一系列新奇 5-benzylidene-3-(3-fluoro-4-yl-morpholin-4-yl-phenylimino ) thiazolidin-4-one 衍生物被综合使用[bmIm ] 哦作为催化剂并且为他们的抗菌剂和抗真菌的活动被测试。显示出的这些混合物对测试的微生物在 vitro 节制活动。 | Sudhakar G.Patil Rahul R.Bagul Mangesh S.Swami Nandini Kotharkar Kalpana Darade | 2011 | Chinese Chemical Letters2011，22，8： | 2 |
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