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| 1 | The willow genome and divergent evolution from poplar after the common genome duplication显示文摘 | Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin | 2014 | Cell Research2014，24，10： | 28 |
| 2 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 3 | How we can improve patients’comfort after Milligan- Morgan open haemorrhoidectomy显示文摘AIM:To demonstrate the value of Diosmin(flavonidic fraction)in the management of post-haemorhoidectomic symptoms.METHODS:Eighty-six consecutive patients with grades ⅢandⅣacute mixed hemorrhoids admitted to the Anorectal Surgical Department of First Affiliated Hospital,Xinjiang Medical University from April 2009 to April 2010,were enrolled in this study.An observerblinded,randomized trial was conducted to compare post-haemorhoidectomic symptoms with use of Diosmin flavonidic fraction vs placebo.Eighty-six patients were randomly allocated to receive Diosmin flavonidic fraction 500 mg for 1 wk(n=43)or placebo(n=43).The Milligan-Morgan open haemorrhoidectomy was performed by a standardized diathermy excision method.Pain,bleeding,heaviness,pruritus,wound edema and mucosal discharge were observed after surgery.The postoperative symptoms and hospitalization time were recorded.RESULTS:The mean age of the Diosmin group and controls was 53.2 and 51.3 years,respectively.In Diosmin group,haemorrhoid piles were of the third degree in 33 patients and the fourth degree in 10;and in the control group,29 were of the third degree and 14 were of the fourth degree.There was no statistically significance in age,gender distribution,degree and number of excised haemorrhoid piles,and the mean duration of haemorrhoidal disease between the two groups.There was a statistically significant improvement in pain,heaviness,bleeding,pruritus from baseline to the 8th week after operation(P<0.05).Patients taking Diosmin had a shorter hospitalization stay after surgery(P< 0.05).There was also a significant improvement on the proctoscopic appearance(P<0.001).However,there was no statistical difference between the two groups in terms of wound mucosal discharge.Two patients experienced minor bleeding at the 8th week in Diosmin group,and underwent surgery.CONCLUSION:Diosmin is effective in alleviating postoperational symptoms of haemorrhoids.Therefore,it should be considered for the initial treatment after haemorrhoid surgery.However,further prospective randomized trials are needed to confirm the findings of this study. | Ma-Mu-Ti-Jiang A ba-bai-ke-re Hong-Guo Huang Wen-Ni Re Kai Fan Hui Chu Er-Ha-Ti Ai Mai-Mai-Ti-Tu-Er-Xun KE Li-Mu Yi-Rui Wang Hao Wen | 2011 | World Journal of Gastroenterology2011，17，11： | 13 |
| 4 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 5 | Source identification, contamination status and health risk assessment of heavy metals from road dusts in Dhaka, Bangladesh显示文摘In this study, concentrations of Cr, Mn, Ni, Cu, Zn, Cd and Pb were determined in road dusts collected from different locations in Dhaka to assess source, contamination status and health risk. Energy-dispersive X-ray fluorescence spectroscopy and energy-dispersive X-ray spectroscopy were used to determine Cr, Mn, Ni, Cu, Zn, Cd and Pb and their mean concentrations were 162.27 ± 29.46, 721.18 ± 180.14, 35.65 ± 12.55, 104.56 ± 128.33, 515.32 ± 321.90,BDL, and 342.82 ± 591.20 mg/kg, respectively. Among the heavy metals, highest concentrations of Cu, Zn and Pb were found at urban sites-7(municipal waste dumping) and 8(medical waste incineration). Highest concentration of Cr followed by Cu and Zn was found at site-5(Tejgaon, urban). Principal component analysis revealed that anthropogenic activities are the potential sources for Cr, Ni, Cu, Zn and Pb while earth crust for Mn. Pollution index and pollution load index results suggested that all the sites were contaminated and/or degraded by Cr, Cu, Zn and Pb except sites-9(urban), 10(sub-urban), 11(rural) while sites-7 and 8(urban) were extremely degraded. For noncarcinogenic health risk, hazard quotient values for dermal were higher compared to that of inhalation/ingestion. Though hazard index values were less than 1 at all the sites, these were at least one order of magnitude higher for children group than that of adult group, thus the children group may face more noncarcinogenic health risk at sites -7 and 8. Values of incremental lifetime cancer risk were from 10to 10showed no carcinogenic health risk by road dusts contaminated with the heavy metals. | Aklima Nargis Ahsan Habib Md Nazrul Islam Kai Chen Md Shafiqul Islam Sarker A N M Al-Razee Wenbin Liu Guorui Liu Minggang Cai | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 6 | Effectiveness of circumferential endoscopic mucosal resection with a novel tissue-anchoring device显示文摘AIM: To evaluate the efficacy of circumferential endoscopic mucosal resection (EMR) with a tissue-anchoring device in comparison to forceps precut EMR and conventional endoscopic submucosal dissection (ESD). METHODS: The study was designed as a prospective, randomized, ex vivo study. Fresh ex vivo specimens were harvested from adult white Yorkshire pigs weighing 30-50 kg. Seventy-five standardized, artificial lesions measuring 3 cm × 3 cm were created by methy- lene blue tattoo at the greater curvature in fresh ex vivo stomachs using the EASIE-R simulator platform (Endosim LLC, Berlin, MA, United States). The three advanced endoscopists performed the three resection techniques such as circumferential EMR using the tissue-anchoring device (TA-EMR), forceps precut EMR (FP-EMR), and endoscopic submucosal dissection. The endoscopists and the type of cutting methods were determined randomly by grouped randomized selection.The resection bed was grossly inspected to determine whether the lesion was resected 'en-bloc ' (defined as no remaining mucosal tattoo remaining on specimen). The resection bed was also probed for evidence of perforation. The procedural time of circumferential resection, submucosal dissection, and injection frequency were recorded by an independent observer.RESULTS: All 75 created lesions were successfully resected by three advanced endoscopists using the three techniques. The mean ± SD size of resected specimens (long axis) were 39.5 ± 5.6 mm, 36.5 ± 7.3 mm, and 44.6 ± 5.6 mm for TA-EMR, FP-EMR, and ESD respectively. The overall mean dissection time of both the TA- EMR and FP-EMR was significant shorter than ESD (TA- EMR: 5.1 ± 3.3 min, FP-EMR: 3.5 ± 2.0 min vs ESD: 15.8 ± 9.5 min, P < 0.001, P < 0.001). The overall mean total procedure time of both the tissue-anchoring and forceps circumferential EMR was significantly shorter than ESD (TA-EMR: 17.5 ± 6.0 min, FP-EMR: 16.6 ± 6.6 min vs ESD: 28.6 ± 13.9 min, P < 0.001, P < 0.001). The en-bloc resection rate of ESD was 100% (25/25) and the en-bloc resection rate of the TA-EMR (84.0%, 21/25) was higher than for the FP-EMR (60.0%, 15/25), yet not statistically significant (P = 0.18). The perforation rate of each technique was 8.0% (2/25). CONCLUSION: TA-EMR appears to be quicker than ESD, and there was a trend towards improved en bloc resection rate with the TA-EMR when compared to the FP-EMR. | Yunho Jung Masayuki Kato Jongchan Lee Mark A Gromski Ram Chuttani Kai Matthes | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，6： | 3 |
| 7 | Polarized sorting and trafficking in epithelial cells显示文摘在在形成的上皮的房间结果的表面膜的蛋白质和类脂化合物的极化的分发一顶端并且一个 basolateral 领域,它被紧密的连接分开。上皮的极性的产生和维护要求保证正确排序和货物分子的 vectorial 交货的精致的机制。这个动态过程包含与排序机械和运输搬运人的形成排序信号的相互作用。这里,我们在在上皮的房间排序极化的地里考察最近的进展。我们特别在顶端的排序加亮类脂化合物椽子的角色。 | Xinwang Cao Michal A Surma Kai Simons | 2012 | Cell Research2012，22，5： | 2 |
| 8 | First Imported Case of SARS-CoV-2 Omicron Subvariant BA.4-Guangdong Province,China,May 4,2022显示文摘On April 29,2022,a flight arrived at Baiyun International Airport,Guangzhou City,Guangdong Province,and departed from Amsterdam Schiphol Airport,Netherlands.After the first test of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleic acid at the Baiyun International Airport,all passengers were admitted to a quarantine hotel for a routine 14-day medical observation.On April 30,one of the passengers(a 20-year-old Chinese female)was reported positive for coronavirus disease 2019(COVID-19),and then a nasopharyngeal swab sample was immediately retested on May 1 and reported positive. | Qianfang Guo Changcheng Wu Aiping Deng Jingtao Liang Xiang Zhao Ruhan A Jiajun Liu Fangzhu Ouyang Jing Xu Shen Huang Yang Song Lirong Zou Xiaoling Deng Kai Nie Baisheng Li | 2022 | China CDC weekly2022，4，40： | 2 |
| 9 | Histone H3 lysine 4 monomethylation modulates long- range chromatin interactions at enhancers显示文摘在 enhancers 和倡导者之间的远程的染色质相互作用为在哺乳动物和另外的 metazoans 的许多发展地控制的基因的抄写是必要的。当前,把远侧的 enhancers 连接到他们的特定的目标倡导者的准确机制尚待充分被阐明。这里,我们证明 4 monomethylation (H3K4me1 )(MLL3/4 ) 和 histone methyltransferases MLL3 和 MLL4 玩的提高特定的 histone H3 离氨酸在这个过程的一个活跃角色。我们在区分老鼠表明那胚胎的干细胞,在 enhancers 的 H3K4me1 的 MLL3/4-dependent 免职与染色质相互作用的增加的层次相关,而这 histone 修正的损失在区别期间在基因激活导致染色质相互作用和缺点的减少的层次。H3K4me1 便于 Cohesin 建筑群的招募,染色质组织的一个已知的管理者到在 vitro 并且在 vivo 的染色质,提供潜在的机制让 MLL3/4 支持在 enhancers 和倡导者之间的染色质相互作用。一起拿,我们的结果在在哺乳动物的房间在 enhancers 安排远程的染色质相互作用为 MLL3/4-dependent H3K4me1 支持一个角色。 | Jian Yan Shi-An A Chen Andrea Local Tristin Liu Yunjiang Qiu Kristel M Dorighi Sebastian Preissl Chloe M Rivera Chaochen Wang Zhen Ye Kai Ge Ming Hu Joanna Wysocka Bing Ren | 2018 | Cell Research2018，28，2： | 2 |
| 10 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 11 | Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple re- ceptors显示文摘 | Heddini A Pettersson F Kai O | 2001 | Infect Immun2001，69，9： | 1 |
| 12 | Source and tectonic implications of tonalite-trondhjemite magmatism in the Klarnath Mountains 显示文摘 | Barnes C G Petersen S W Kistler R W Murray R Kays M A | 1996 | Contrib Mineral Petrol1996，123，1： | 1 |
| 13 | Fresh isolates from children with severe Plasmodium faleiparum malaria bind to multiple reeeptors显示文摘 | Heddini A Pettersson F Kai O | 2001 | Infeet Immun2001，69，9： | 1 |
| 14 | Self-consiructed e-lectrically conductive bacterial networks 显示文摘 | Nakamura R Kai F Okamoto A | 2009 | AngewandteChemie International Edition2009，48，3： | 1 |
| 15 | Optimal torque control of fault-tolerant permanent magnet brushless machines显示文摘 | WANG Jia-bin KAIS A HOWE D | 2003 | IEEE Transactions on Magnet-ics2003，39，5： | 1 |
| 16 | Periodic waves and their limits for the Camassa-Holm equation显示文摘 | LIU Z R KAYED A M CHEN C | 2006 | International Journal of Bifurcation and Chaos2006，16，8： | 1 |
| 17 | Genomic Surveillance for SARS-CoV-2 Variants of Concern from Imported COVID-19 Cases-the Mainland of China,2021显示文摘Introduction:After the epidemic in Wuhan City was brought under control in 2020,local outbreaks of coronavirus disease 2019(COVID-19)in the mainland of China were mainly due to imported COVID-19 cases.The ongoing evolution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has continued to generate new variants.Some have been designated as variants of concern(VOCs)by the World Health Organization(WHO).To better assess the role of imported SARS-CoV-2 surveillance and the prevalence of VOCs in 2021,the genomic surveillance data of SARS-CoV-2 from imported COVID-19 cases of 2021 in the mainland of China were analyzed.Methods:The analyses included the number of sequence submissions,time of sequence deposition,and time of detection of the VOCs in order to determine the timeliness and sensitivity of the surveillance.The proportions of VOCs were analyzed and compared with data from the Global Initiative of Sharing All Influenza Data(GISAID).Results:A total of 3,355 sequences of imported cases were submitted from 29 provincial-level administrative divisions,with differences in the number of sequence submissions and median time of sequence deposition.A total of 2,388 sequences with more than 90%genomic coverage were used for lineage analysis.The epidemic trend from Alpha to Delta to Omicron in imported cases was consistent with that in the GISAID.In addition,VOCs from imported cases were usually identified after WHO designation and before causing local outbreaks.Conclusions:The global distribution of SARSCoV-2 VOCs changed rapidly in 2021.Robust genomic surveillance of the imported SARS-CoV-2 in the mainland of China is of great significance.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the etiological agent of coronavirus disease 2019(COVID-19),is constantly mutating under the different circumstances of global transmission(1).The emerging SARS-CoV-2 variants may have potential adverse impacts on epidemic traits and severity.To some extent,it is also capable of escaping natural and vaccine-induced immunity(2–3).Some of them were designated as variants of concern(VOCs)by the World Health Organization(WHO)(4).Therefore,robust surveillance is essential to assess the evolution of viruses in real time.After the epidemic in Wuhan City was brought under control in 2020,several COVID-19 outbreaks in the mainland of China have been proven to relate to SARS-CoV-2 contaminated cold-chain products(5–7),while most were caused by transmission through imported cases on flights,at isolation facilities,or in designated hospitals(8–9).Therefore,genomic surveillance for SARS-CoV-2 from imported cases is of great significance for monitoring the risk of different variants that were imported into the mainland of China,assessing the risk of importation-associated domestic spread,and helping guide public health interventions.On March 17,2020,the China CDC released a notice and launched genomic surveillance for SARS-CoV-2 from imported COVID-19 cases nationwide.The laboratories of provincial CDCs were required to conduct SARS-CoV-2 whole-genome sequencing for samples from imported cases and submit the genomic sequences to the China CDC in time.This study includes the analysis of genomic surveillance data of imported SARS-CoV-2 cases of 2021 from the mainland of China. | Yenan Feng Xiang Zhao Zhixiao Chen Kai Nie Zeyuan Yin Ying Xia Ji Wang Peihua Niu Ruhan A Lili Li Dayan Wang Wenjie Tan Xuejun Ma Shiwen Wang Huanyu Wang George F.Gao Cao Chen Wenbo Xu | 2022 | China CDC weekly2022，4，31： | 1 |
| 18 | Stem cells find their niche显示文摘 | SPRADLING A DRUMMOND-BARBOSA D KAI T | 2001 | Nature2001，414，6859： | 1 |
| 19 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，6： | 1 |
| 20 | Dexamethasone suppresses mucus production and MUC-2 and MUC-5AC gene expression by NCI-H292 cells显示文摘 | Kai H Yoshitake K Hisatsune A | 1996 | Am J Physiol1996，271，31： | 1 |
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