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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | Numerical calculation of flow and isotope separation for SF6 gas centrifuge显示文摘 | KAI T HASEGAWA K | 2000 | J Nucl Sci Technol2000，37，2： | 1 |
| 3 | Treatment for extrahepatic metastasis of hepatocellular carcinoma following suecessful hepatic resection 显示文摘 | Aramaki M Kawano K Kai T | 1999 | Hepato Gastroenterol1999，46，4： | 1 |
| 4 | C66 fullerene encaging a scandium dimer显示文摘 | Wang C R Kai T Tomiyama T | 2000 | Nature2000，408，6811： | 1 |
| 5 | The stem cell niche: theme and-variations 显示文摘 | Ohlstein B Kai T Dccetto E | 2004 | Curr Opin Cell Biol2004，16，6： | 1 |
| 6 | Selection of DNA aptamers with affinity for pro-gastrin-releasing peptide(pro GRP),a tumor marker for small cell lung cancer显示文摘 | Mie M Kai T Le T | 2013 | Appl Biochem Biotechnol2013，169，1： | 1 |
| 7 | Stem cells find their niche显示文摘 | SPRADLING A DRUMMOND-BARBOSA D KAI T | 2001 | Nature2001，414，6859： | 1 |
| 8 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，6： | 1 |
| 9 | En- hanced uniaxial anisotropy and two-step magnetization process along the hard axis of polycrystalline NiFe/NiO bilayers 显示文摘 | Zhao T Fujiwara H Zhang K Hou C Kai T | 2001 | Physical Review B2001，65，01： | 1 |
| 10 | Expressing of the OsPll geBe, cloned from rice roots using cDNA microarray, rapidly responds to phosphorus 显示文摘 | Wasaki J Ryoma Y T Shinano T Kai M Osaki M | 2003 | New Phytologist2003，158，2： | 1 |
| 11 | Studies on the optimization of stem hull form based on a potential flow solver 显示文摘 | SUZUKI K Z KAI H S KASHIWABARA S T | 2005 | Marine Science and Technology2005，10，： | 1 |
| 12 | Stem cells find their Niche显示文摘 | Spradling A Drummodn Barrosa D Kai T | | 0，，6859： | 1 |
| 13 | Stem cells find their niche 显示文摘 | Spradling A Drummond-Barbosa D Kai T | 2001 | Nature2001，414，6859： | 1 |
| 14 | Hydrophobic PVDF hollowfiber membranes with narrowpore size distribution and ultra-thin skin for the freshwater produetion through membrane distillation显示文摘 | Wang Kai Yu Chung T S Gryta M | 2008 | Chem Eng Sci2008，63，： | 1 |
| 15 | Decomposition of China’s Regional IneQualities显示文摘 | Kai Yuen T Sui | 1993 | Journal of Comparative Economics1993，，17： | 1 |
| 16 | Synthesis and characterization of Mg2B2Os显示文摘 | Qasrawi A F Kayed T S Mergen A et aI | 2005 | Materials Research Bulletin2005，40，4： | 1 |
| 17 | Water channels and water canales in the gill of the freshwater mussel,Ligumia subrostrata: ultrastructure and histochemistry 显示文摘 | KAYS W T SILVERMAN H DITZ T H | 1990 | J Exp Zool1990，254，： | 1 |
| 18 | Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites显示文摘 | Wenjie T Kai Z David JS | 2004 | JVI2004，78，3： | 1 |
| 19 | Microstructure dependence of compactibility of rapidly solidified Ti - rich TiM alloy powders produced by plasma rotating electrode process显示文摘 | Nishida M Morizono Y Kai T | 1997 | Materials Transactions1997，38，4： | 1 |
| 20 | Measurement of the two-dimensional magnetostriction and the vector magnetic property for a non-oriented electrical steel sheet under stress显示文摘 | Kai Y Todaka T Enokizono M | 2012 | Journal of Applied Physics2012，111，7： | 1 |
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