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88篇 您的检索式:作者名="Junyi Yang"
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1Contribution of the Compass satellite navigation system to global PNT users显示文摘As one of the four global satellite navigation systems,Compass not only enhances satellite visibility and availability for positioning,navigation and timing (PNT) for users in China and the surrounding areas,but also improves PNT precision for global users.The improvements in satellite visibility and the dilution of precision are analyzed under GNSS compatibility and interoperation conditions.The contribution of the Compass satellite navigation system to global users,especially the benefits that users can acquire from the combination of Compass,GPS,GLONASS,and Galileo navigation systems,is analyzed using simulation data.YANG YuanXi LI JinLong XU JunYi TANG Jing GUO HaiRong HE HaiBo 2011Chinese Science Bulletin2011,56,26:90
2Preliminary assessment of the navigation and positioning performance of BeiDou regional navigation satellite system显示文摘BeiDou regional navigation satellite system(BDS)also called BeiDou-2 has been in full operation since December 27,2012.It consists of 14 satellites,including 5 satellites in Geostationary Orbit(GEO),5 satellites in Inclined Geosynchronous Orbit(IGSO),and 4 satellites in Medium Earth Orbit(MEO).In this paper,its basic navigation and positioning performance are evaluated preliminarily by the real data collected in Beijing,including satellite visibility,Position Dilution of Precision(PDOP)value,the precision of code and carrier phase measurements,the accuracy of single point positioning and differential positioning and ambiguity resolution(AR)performance,which are also compared with those of GPS.It is shown that the precision of BDS code and carrier phase measurements are about 33 cm and 2 mm,respectively,which are comparable to those of GPS,and the accuracy of BDS single point positioning has satisfied the design requirement.The real-time kinematic positioning is also feasible by BDS alone in the opening condition,since its fixed rate and reliability of single-epoch dual-frequency AR is comparable to those of GPS.The accuracy of BDS carrier phase differential positioning is better than 1 cm for a very short baseline of 4.2 m and 3 cm for a short baseline of 8.2 km,which is on the same level with that of GPS.For the combined BDS and GPS,the fixed rate and reliability of single-epoch AR and the positioning accuracy are improved significantly.The accuracy of BDS/GPS carrier phase differential positioning is about 35 and 20%better than that of GPS for two short baseline tests in this study.The accuracy of BDS code differential positioning is better than 2.5 m.However it is worse than that of GPS,which may result from large code multipath errors of BDS GEO satellite measurements.YANG YuanXi LI JinLong WANG AiBing XU JunYi HE HaiBo GUO HaiRong SHEN JunFei DAI Xian 2014Science China Earth Sciences2014,57,1:125
3GNSS receiver autonomous integrity monitoring(RAIM)algorithm based on robust estimation显示文摘Integrity is significant for safety-of-life applications. Receiver autonomous integrity monitoring(RAIM) has been developed to provide integrity service for civil aviation. At first,the conventional RAIM algorithm is only suitable for single fault detection, single GNSS constellation. However, multiple satellite failure should be considered when more than one satellite navigation system are adopted. To detect and exclude multi-fault, most current algorithms perform an iteration procedure considering all possible fault model which lead to heavy computation burden. An alternative RAIM is presented in this paper based on multiple satellite constellations(for example, GPS and Bei Dou(BDS) etc.) and robust estimation for multi-fault detection and exclusion, which can not only detect multi-failures,but also control the influences of near failure observation. Besides, the RAIM algorithm based on robust estimation is more efficient than the current RAIM algorithm for multiple constellation and multiple faults. Finally, the algorithm is tested by GPS/Bei Dou data.Yuanxi Yang Junyi Xu 2016Geodesy and Geodynamics2016,7,2:15
4Palladium Nanoparticle-Graphene Hybrids as Active Catalysts for the Suzuki Reaction显示文摘Graphene has been successfully modified with palladium nanoparticles in a facile manner by reducing palladium acetate [Pd(OAc)2] in the present of sodium dodecyl sulfate (SDS), which is used as both surfactant and the reducing agent. The palladium nanoparticle-graphene hybrids (Pd-graphene hybrids) are characterized by high- resolution transmission electron microscopy, atomic force microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and energy dispersive X-ray spectroscopy. We demonstrate that the Pd-graphene hybrids can act as an efficient catalyst for the Suzuki reaction under aqueous and aerobic conditions, with the reaction reaching completion in as little as 5 min. The influence of the preparation conditions on the catalytic activities of the hybrids is also investigated.Yang Li Xiaobin Fan Junjie Qi Junyi Ji Shulan Wang Guoliang Zhang Fengbao Zhang 2010Nano Research2010,3,6:10
5Dissecting the Genetic Basis of Grain Shape and Chalkiness Traits in Hybrid Rice Using Multiple Collaborative Populations显示文摘Junyi Gong Jiashun Miao Yan Zhao Qiang Zhao Qi Feng Qilin Zhan Benyi Cheng Junhui Xia Xuehui Huang Shihua Yang Bin Han 2017Molecular Plant2017,10,10:8
6Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients.Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin 2021Cellular & Molecular Immunology2021,18,2:8
7Integrity analysis of COMPASS and other GNSS combined navigation显示文摘The integrity requirement should be satisfied when GNSS is used in aviation.There are now two ways for integrity monitoring,that is,receiver autonomous integrity monitoring(RAIM) and GNSS integrity channel(GIC) based on augmentation system.The rapid development of the Beidou satellite navigation system(COMPASS) will significantly improve the satellite geometry.Besides,the effects of first order ionosphere delay will be mitigated by the combination of GNSS multi-frequency signals.The availability of RAIM will be enhanced,which makes it possible to provide a worldwide seamless integrity service for aviation by using RAIM.The contribution of COMPASS to the availability of RAIM is analyzed by simulation;and the integrity requirement of which aviation approaching phrase can be satisfied when using COMPASS single system and its combination with other satellite navigation system is analyzed.Moreover,the influence of user range accuracy(URA) of COMPASS on integrity performance is discussed.XU JunYi YANG YuanXi LI JinLong HE HaiBo GUO HaiRong 2013Science China Earth Sciences2013,56,9:8
8Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells(MSCs)显示文摘Cartilage injuries caused by arthritis or trauma pose formidable challenges for effective clinical management due to the limited intrinsic proliferative capability of chondrocytes.Autologous stem cell-based therapies and transgene-enhanced cartilage tissue engineering may open new avenues for the treatment of cartilage injuries.Bone morphogenetic protein 2(BMP2)induces effective chondrogenesis of mesenchymal stem cells(MSCs)and can thus be explored as a potential therapeutic agent for cartilage defect repair.However,BMP2 also induces robust endochondral ossification.Although the precise mechanisms through which BMP2 governs the divergence of chondrogenesis and osteogenesis remain to be fully understood,blocking endochondral ossification during BMP2-induced cartilage formation may have practical significance for cartilage tissue engineering.Here,we investigate the role of Sox9-donwregulated Smad7 in BMP2-induced chondrogenic differentiation of MSCs.We find that overexpression of Sox9 leads to a decrease in BMP2-induced Smad7 expression in MSCs.Sox9 inhibits BMP2-induced expression of osteopontin while enhancing the expression of chondrogenic marker Col2a1 in MSCs.Forced expression of Sox9 in MSCs promotes BMP2-induced chondrogenesis and suppresses BMP2-induced endochondral ossification.Constitutive Smad7 expression inhibits BMP2-induced chondrogenesis in stem cell implantation assay.Mouse limb explant assay reveals that Sox9 expands BMP2-stimulated chondrocyte proliferating zone while Smad7 promotes BMP2-intitated hypertrophic zone of the growth plate.Cell cycle analysis indicates that Smad7 induces significant early apoptosis in BMP2-stimulated MSCs.Taken together,our results strongly suggest that Sox9 may facilitate BMP2-induced chondrogenesis by downregulating Smad7,which can be exploited for effective cartilage tissue engineering.Chen Zhao Wei Jiang Nian Zhou Junyi Liao Mingming Yang Ning Hu Xi Liang Wei Xu Hong Chen Wei Liu Lewis L.Shi Leonardo Oliveira Jennifer Moriatis Wolf Sherwin Ho Aravind Athiviraham H.M.Tsai Tong-Chuan He Wei Huang 2017Genes & Diseases2017,4,4:7
9A new approach to dual-band polarimetric radar remote sensing image classification显示文摘It is very important to efficiently represent the target scattering characteristics in applications of polarimetric radar remote sensing. Three probability mass functions are introduced in this paper for target representation: using similarity parameters to describe target average scattering mechanism, using the eigenvalues of a target coherency matrix to describe target scattering randomness, and using radar received power to describe target scattering intensity. The concept of cross-entropy is employed to measure the difference between two scatterers based on the probability mass functions. Three parts of difference between scatterers are measured separately as the difference of average scattering mechanism, the difference of scattering randomness and the difference of scattering intensity, so that the usage of polarimetric data can be highly efficient and flexible. The supervised/unsupervised image classification schemes and their simplified versions are established based on the minimum cross-entropy principle. They are demonstrated to have better classification performance than the maximum likelihood classifier based on the Wishart distribution assumption, both in supervised and in unsupervised classification.XU Junyi YANG Jian PENG Yingning 2005Science in China(Series F)2005,48,6:7
10The use of fire at Zhoukoudian:evidence from magnetic susceptibility and color measurements显示文摘In order to provide direct evidence for the use of fire by humans at Locality 1,Zhoukoudian,we examine the burnt and unburnt sediments of newly excavated area in Layer 4 by detailed measurements of magnetic susceptibility,color,and diffuse reflectance spectrum.Results show that the magnetic susceptibility and redness of the burnt sediments are remarkably higher than those of other areas on the same level:up to*22 times for magnetic susceptibility and*3 times for redness of those of the adjacent unburnt sediments.Fine-grained(superparamagnetic/stable single-domain)magnetite and hematite grains make dominant contributions to the distinctly high values of magnetic susceptibility and redness in the burnt sediments.Diffuse reflectance spectroscopy results show that the burnt sediments contain more hematite than those of other areas and localities 2 and 3.High-temperature magnetic susceptibility measurements demonstrate that the burnt sediments have been heated above 700°C.Those changes in low-frequency magnetic susceptibility and redness are impossibly resulted from natural fires,thus most likely signaling the human activities of controlled use of fire.However,further work is needed to confirm whether or not these heat-affected sediments were produced in situ.Yan Zhang Zhengtang Guo Chenglong Deng Shuangquan Zhang Haibin Wu Chunxia Zhang Junyi Ge Deai Zhao Qin Li Yang Song Rixiang Zhu 2014Chinese Science Bulletin2014,59,10:6
11Nitrated and parent PAHs in the surface water of Lake Taihu,China:Occurrence,distribution,source,and human health risk assessment显示文摘Nitrated polycyclic aromatic hydrocarbons(NPAHs)have toxic potentials that are higher than those of their corresponding parent polycyclic aromatic hydrocarbons(PAHs)and thus have received increasing attention in recent years.In this study,the occurrence,distribution,source,and human health risk assessment of 15 NPAHs and 16 PAHs were investigated in the surface water from 20 sampling sites of Lake Taihu during the dry,normal,and flood seasons of 2018.The PAH concentrations ranged from 255 to 7298 ng/L and the NPAH concentrations ranged from not-detected(ND)to 212 ng/L.Among the target analytes,2-nitrofluorene(2-n Flu)was the predominant NPAH,with a detection frequency ranging from 85%to 90%and a maximum concentration of 56.2 ng/L.The three-ringed and four-ringed NPAHs and PAHs comprised the majority of the detected compounds.In terms of seasonal variation,the highest levels of the NPAHs and PAHs were in the dry season and flood season,respectively.Diagnostic ratio analysis indicated that the prime source of NPAHs was direct combustion,whereas in the case of PAHs the contribution was predominantly from a mixed pattern including pollution from unburned petroleum and petroleum combustion.The human health risk of NPAHs and PAHs was evaluated using a lifetime carcinogenic risk assessment model.The carcinogenic risk level of the targets ranged from 2.09×10^(-7)to 5.75×10^(-5)and some surface water samples posed a potential health risk.Jijie Kong Yuxuan Dai Mengshu Han Huan He Jiapeng Hu Junyi Zhang Junzhe Shi Qiming Xian Shaogui Yang Cheng Sun 2021Journal of Environmental Sciences2021,33,4:6
12NON-YELLOWING2 (NYE2), a Close Paralog of NYE1, Plays a Positive Role in Chlorophyll Degradation in Arabidopsis显示文摘Wu, Shouxin Li, Zhongpeng Yang, Lifeng Xie, Zuokun Chen, Junyi Zhang, Wei Liu, Tianqi Gao, Shan Gao, Jiong Zhu, Yihua Xin, Jiwen Ren, Guodong Kuai, Benke 2016Molecular Plant2016,9,4:6
13Self-powered electrochromic devices with tunable infrared intensity显示文摘Triboelectric nanogenerator(TENG) is an efficient way to convert ambient mechanical energy into electricity to power up portable electronics.In this work,a flexible infrared electrochromical device(IR-ECD)with stable performances was assembled with a TENG for building self-powered infrared detector with tunable intensity.As driven by TENG,the electrochromic device could be operated in the mid-IR region due to the reversible electrochromic reactions.An average infrared reflectance contrast of 46% was achieved in 8–14 lm regions and as well a clear thermal image change can be observed.This work indicates that the TENG-driven infrared electrochromical device has potential for use in self-powered camouflage and thermal control.Jiangman sun xiong pu Chunyan Jiang Chunhua Du Mengmeng Liu Yang Zhang Zhitian Liu Junyi Zhai Weiguo Hu Zhong Lin Wang 2018Science Bulletin2018,63,12:6
14Whole-genome resequencing of Osmanthus fragrans provides insights into flower color evolution显示文摘Osmanthus fragrans is a well-known ornamental plant that has been domesticated in China for 2500 years.More than 160 cultivars have been found during this long period of domestication,and they have subsequently been divided into four cultivar groups,including the Yingui,Jingui,Dangui,and Sijigui groups.These groups provide a set of materials to study genetic evolution and variability.Here,we constructed a reference genome of O.fragrans‘Liuyejingui’in the Jingui group and investigated its floral color traits and domestication history by resequencing a total of 122 samples,including 119 O.fragrans accessions and three other Osmanthus species,at an average sequencing depth of 15×.The population structure analysis showed that these 119 accessions formed an apparent regional cluster.The results of linkage disequilibrium(LD)decay analysis suggested that varieties with orange/red flower color in the Dangui group had undergone more artificial directional selection;these varieties had the highest LD values among the four groups,followed by the Sijigui,Jingui,and Yingui groups.Through a genome-wide association study,we further identified significant quantitative trait loci and genomic regions containing several genes,such as ethylene-responsive transcription factor 2 and Arabidopsis pseudoresponse regulator 2,that are positively associated with petal color.Moreover,we found a frameshift mutation with a 34-bp deletion in the first coding region of the carotenoid cleavage dioxygenase 4 gene.This frameshift mutation existed in at least one site on both alleles in all varieties of the Dangui group.The results from this study shed light on the genetic basis of domestication in woody plants,such as O.fragrans.Hongguo Chen Xiangling Zeng Jie Yang Xuan Cai Yumin Shi Riru Zheng Zhenqi Wang Junyi Liu Xinxin Yi Siwei Xiao Qiang Fu Jingjing Zou Caiyun Wang 2021Horticulture Research2021,8,1:5
15Exploration of presence/absence variation and corresponding polymorphic markers in soybean genome显示文摘This study was designed to reveal the genome‐wide distribution of presence/absence variation(PAV) and to establish a database of polymorphic PAV markers in soybean. The 33 soybean whole‐genome sequences were compared to each other with that of Williams 82 as a reference genome. A total of 33,127 PAVs were detected and 28,912 PAV markers with their primer sequences were designed as the database NJAUSoyPAV_1.0. The PAVs scattered on whole genome while only 518(1.8%) overlapped with simple sequence repeats(SSRs) in BARCSOYSSR_1.0database. In a random sample of 800 PAVs, 713(89.13%) showed polymorphism among the 12 differential genotypes. Using 126 PAVs and 108 SSRs to test a Chinese soybean germplasm collection composed of 828 Glycine soja Sieb. et Zucc. and Glycine max(L.) Merr. accessions, the per locus allele number and its variation appeared less in PAVs than in SSRs. The distinctness among alleles/bands of PCR(polymerase chain reaction) products showed better in PAVs than in SSRs, potential in accurate marker‐assisted allele selection. The association mapping results showed SSR t PAV was more powerful than any single marker systems.The NJAUSoyPAV_1.0 database has enriched the source of PCR markers, and may fit the materials with a range of per locus allele numbers, if jointly used with SSR markers.Yufeng Wang Jiangjie Lu Shouyi Chen Liping Shu Reid G.Palmer Guangnan Xing Yan Li Shouping Yang Deyue Yu Tuanjie Zhao Junyi Gai 2014Journal of Integrative Plant Biology2014,56,10:5
16Structural Asymmetry of Dorsolateral Prefrontal Cortex Correlates with Depressive Symptoms: Evidence from Healthy Individuals and Patients with Major Depressive Disorder显示文摘In this study,we investigated the role of structural asymmetry of the dorsolateral prefrontal cortex(DLPFC) in the continuum of depression from healthy individuals to patients.Structural magnetic resonance imaging was performed in 70 patients with major depressive disorder(MDD),49 matched controls,and 349 healthy university students to calculate structural asymmetry indexes of the DLPFC.First-episode,treatment-naive MDD patients showed a relatively lower asymmetry index than healthy controls,and their asymmetry index was negatively correlated with the depressive symptoms.This abnormality was normalized by antidepressants in medicated MDD patients.Furthermore,the asymmetry index was negatively correlated with the depressive symptoms in university students;this was replicated at two time points in a subgroup of students,suggesting good test–retest reliability.Our findings are consistent with previous studiesthat support the imbalance hypothesis of MDD and suggest a potential structural basis underlying the functional asymmetry of the DLPFC in depression.In future,the structural index of the DLPFC may become a potential biomarker to evaluate individuals' risk for the onset of MDD.Wei Liu Yu Mao Dongtao Wei Junyi Yang Xue Du Peng Xie Jiang Qiu 2016Neuroscience Bulletin2016,32,3:4
17Self-powered acoustic source Iocator in underwater environment based on organic film triboelectric nano-generator显示文摘Aifang Yu Ming Song Yan Zhang Yang Zhang Libo Chen Junyi Zhai Zhong Lin Wang 2015Nano Research2015,8,3:4
18The Main Ecological Issues of Water-Level -Fluctuating Zone and The strategies in Three Gorges Reservoir Area显示文摘Weici Su Jinping Liu Hua Yang Junyi Zhang 2010Journal of Environmental Science and Engineering2010,4,1:4
19Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC.Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu 2019Cancer Biology & Medicine2019,16,3:4
20Comparison of the water quality of the surface microlayer and subsurface water in the Guangzhou segment of the Pearl River, China显示文摘在表面 microlayer (SML ) 优秀的水和在广州的表面下的水(SSW ) 珀尔分割河,发育营养正常促进剂在中国的城市的河节,被分析。滋养的集中,重金属和细菌的空间、时间的动力学在整个 2010 在每月的样品从二个采样地点被检验。当全部的磷和 orthophosphate 分别地是 0.5 mg/L 和 0.1 mg/L 时,全部的氮,氨,硝酸盐和亚硝酸根的吝啬的集中比 7.0 mg/L, 3.1 mg/L, 1.1 mg/L 和 0.3 mg/L 高。这些结果显示水质量富于矿物质和发育营养正常促进剂。Mn 和 Fe 的吝啬的集中比 0.013 mg/L 高;并且 Ni, Cr 和 Pb 比 0.001 mg/L 高。吝啬的集中在 Mn 的顺序 > Fe > Ni > Pb > Cr。在广州片断的重金属的集中是比在中国和世界健康组织的表面水质量标准的限制低的() ,但是比在世界淡水的中部的价值高。细菌的密度从 3.30 潳瑵敨獡整湲瀠牡 ? 景琠敨猠畯桴牥 ? 楑杮慨 ?LIU Qing HU Xiaojuan JIANG Jiangluan ZHANG Junyi WU Zhihui YANG Yufeng 2014Journal of Geographical Sciences2014,24,3:3
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