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| 1 | A carbazole-hemicyanine dye based ratiometric fluorescent probe for selective detection of bisulfite(HSO_3^-)in cells and C. elegans显示文摘Bisulfite(HSO_3) is an important sulfur dioxide(SO_2) derivative, which plays a major role in many physiological processes and is also closely associated with a variety of diseases. Thus the development of highly selective and sensitive fluorescent probes is essential to detect HSO_3 in living cells. In this work,we report the synthesis and analysis of a ratiometric fluorescent probe for selective detection of HSO_3 based on the 1,4-nucleophilic addition reaction with the carbazole as an electron donor(D) and aldehyde group as an electron acceptor(A). The addition of HSO_3 and other ions to our probe can be observed by UV vis and fluorescence spectrometry. Our investigation proved that the probe is highly selective and sensitive for HSO_3 and ratiometric changes. Moreover, the probe has good cell permeability and was successfully applied to the detection of exogenous HSO_3 in Hela cells and C. elegans. | Keying Bi Rui Tan Ruiting Hao Lanxi Miao Yanqi He Xianghua Wu Junfeng Zhang Rui Xu | 2019 | Chinese Chemical Letters2019，30，3： | 1 |
| 2 | Cancer Cell:利用脑瘤对胆固醇的需求或可开发出癌症治疗的新方法显示文摘最近路德维希癌症研究所的研究人员发表了一项研究进展,他们发现了成胶质细胞瘤的一个代谢弱点,并在研究中揭示了如何利用这个弱点开发潜在治疗方法。成胶质细胞瘤是一种侵袭性强并且不可治愈的脑癌类型。研究人员发现成胶质细胞瘤细胞向细胞内转入大量胆固醇以维持细胞存活。可以利用处于临床开发阶段的药物分子特异且有效地削弱这一维持癌细胞存活的机制。相关研究结果发表在国际学术期刊Cancer Cell上。 | Genaro R. Villa Jonathan J. Hulce Ciro Zanca Junfeng Bi Shiro Ikegami Gabrielle L. Cahill Yuchao Gu Kenneth M. Lum Kenta Masui Huijun Yang Xin Rong Cynthia Hong Kristen M. Turner Feng Liu Gary C. Hon David Jenkins Michael Martini Aaron M. Armando Oswald Quehenberger Timothy F. Cloughesy Frank B. Furnari Webster K. Cavenee Peter Tontonoz Timothy C. Gahman Andrew K. Shiau Benjamin F. Cravatt Paul S. Mischel | 2016 | 现代生物医学进展2016，16，35： | 1 |
| 3 | A novel FGFR1 inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis显示文摘Glioblastoma(GBM)is a malignant brain tumor that grows quickly,spreads widely,and is resistant to treatment.Fibroblast growth factor receptor(FGFR)1 is a receptor tyrosine kinase that regulates cellular processes,including proliferation,survival,migration,and dif-ferentiation.FGFR1 was predominantly expressed in GBM tissues,and FGFR1 expression was negatively correlated with overall survival.We rationally designed a novel small molecule CYY292,which exhibited a strong affinity for the FGFR1 protein in GBM cell lines in vitro.CYY292 also exerted an effect on the conserved Ser777 residue of FGFR1.CYY292 dose-depen-dently inhibited cell proliferation,epithelial-mesenchymal transition,stemness,invasion,and migration in vitro by specifically targeting the FGFR1/AKT/Snail pathways in GBM cells,and this effect was prevented by pharmacological inhibitors and critical gene knockdown.In vivo experiments revealed that CYY292 inhibited U87MG tumor growth more effectively than AZD4547.CYY292 also efficiently reduced GBM cell proliferation and increased survival in orthotopic GBM models.This study further elucidates the function of FGFR1 in the GBM and reveals the effect of CYY292,which targets FGFR1,on downstream signaling pathways directly reducing GBM cell growth,invasion,and metastasis and thus impairing the recruitment,activation,and function of immune cells. | Yanran Bi Ruiling Zheng Jiahao Hu Ruiqing Shi Junfeng Shi Yutao Wang Peng Wang Wenyi Jiang Gyudong Kim Zhiguo Liu Xiaokun Li Li Lin | 2024 | Genes & Diseases2024，11，1： | 0 |
| 4 | The genomic characteristics and pathogenicity of a mammalian orthoreovirus within a new lineage from wild pika in plateau显示文摘Emerging and re-emerging viruses from wild animals have seriously threatened the health of humans and domesticated animals in recent years.Herein,we isolated a new mammalian orthoreovirus(MRV),Pika/MRV/GCCDC7/2019(PMRV-GCCDC7),in the Qinghai-Tibet Plateau wild pika(Ochotona curzoniae).Though the PMRVGCCDC7 shows features of a typical reovirus with ten gene segments arranged in 3:3:4 in length,the virus belongs to an independent evolutionary branch compared to other MRVs based on phylogenetic tree analysis.The results of cellular susceptibility,species tropism,and replication kinetics of PMRV-GCCDC7 indicated the virus could infect four human cell lines(A549,Huh7,HCT,and LoVo)and six non-human cell lines,including Vero-E6,LLCMK2,BHK-21,N2a,MDCK,and RfKT cell,derived from diverse mammals,i.e.monkey,mice,canine and bat,which revealed the potential of PMRV-GCCDC7 to infect a variety of hosts.Infection of BALB/c mice with PMRVGCCDC7 via intranasal inoculation led to relative weight loss,lung tissue damage and inflammation with the increase of virus titer,but no serious respiratory symptoms and death occurred.The characterization of the new reovirus from a plateau-based wild animal has expanded our knowledge of the host range of MRV and provided insight into its risk of trans-species transmission and zoonotic diseases. | Kexin Zong Yuanyuan Guo Jingdong Song Maoshun Liu Junfeng Hao Jie Zhang Xin Li Shiyan Zhu Shuting Huo Ziqian Xu Peipei Liu Yingze Zhao Yuhai Bi Jiapeng Qu George F.Gao Jun Liu | 2023 | Virologica Sinica2023，38，6： | 0 |
| 5 | Low-thermal-budget Au-free ohmic contact to an ultrathin barrier AlGaN/GaN heterostructure utilizing a micro-patterned ohmic recess显示文摘A pre-ohmic micro-patterned recess process,is utilized to fabricate Ti/Al/Ti/TiN ohmic contact to an ultrathin-barrier(UTB)AlGaN/GaN heterostructure,featuring a significantly reduced ohmic contact resistivity of 0.56Ω·mm at an alloy temperature of 550℃.The sheet resistances increase with the temperature following a power law with the index of +2.58,while the specific contact resistivity decreases with the temperature.The contact mechanism can be well described by thermionic field emission(TFE).The extracted Schottky barrier height and electron concentration are 0.31 eV and 5.52×10^(18) cm^(−3),which suggests an intimate contact between ohmic metal and the UTB-AlGaN as well as GaN buffer.A good correlation between ohmic transfer length and the micro-pattern size is revealed,though in-depth investigation is needed.A preliminary CMOS-process-compatible metal-insulator-semiconductor high-mobility transistor(MIS-HEMT)was fabricated with the proposed Au-free ohmic contact technique. | Wen Shi Sen Huang Xinhua Wang Qimeng Jiang Yixu Yao Lan Bi Yuchen Li Kexin Deng Jie Fan Haibo Yin Ke Wei Yankui Li Jingyuan Shi Haojie Jiang Junfeng Li Xinyu Liu | 2021 | Journal of Semiconductors2021，42，9： | 0 |
| 6 | TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance显示文摘分成三部分的主题(修剪) 家庭蛋白质是戒指手指包含域,多域蛋白质在许多生物过程含有。包括 TRIM-9, MID1 和 MID2,整齐的蛋白质的 TRIM-9/C-I 亚科的成员有 neuronal 功能并且与神经病学的疾病被联系。为了探索 C-I 的功能是否整修蛋白质,在无脊椎动物被保存,我们分析了 Caenorhabditis elegans 和果蝇 trim-9 异种。C。elegans trim-9 异种在雌雄同体的腹的指导展出缺点特定的神经原(HSN ) 和触摸神经原 AVM。进一步基因的分析显示 TRIM-9 参予 UNC-6-UNC-40 吸引力小径。UNC-40 的不对称的分发在 trim-9 异种在 HSN 开发期间是正常的。然而, MIG-10 的不对称的本地化, UNC-40 的一个下游的受动器,在 trim-9 异种被废除。这些结果建议 TRIM-9 工作在 UNC-40 小径的 MIG-10 在上游。而且,我们证明在 vitro 的 TRIM-9 展览 E3 ubiquitin ligase 活动和这项活动为在 vivo 的 TRIM-9 功能是重要的。另外,我们发现果蝇 trim-9 为一组感觉神经原轴突的中线吸引力被要求。Netrin/UNC-6 受体的在表示上穿破在 trim-9 异种压制指导缺点。我们的学习在 UNC-40/Frazzled-mediated UNC-6/Netrin 吸引力小径揭示 TRIM-9 的 evolutionarily 保存的功能。 | Song Song Qinglan Ge Jinbo Wang Haiyang Chen Sanyuan Tang Junfeng Bi Xia Li Qi Xie Xun Huang | 2011 | Journal of Genetics and Genomics2011，38，1： | 0 |
| 7 | New understandings on gas accumulation and major exploration breakthroughs in subsalt Ma 4 Member of Ordovician Majiagou Formation,Ordos Basin,NW China显示文摘Geological conditions and main controlling factors of gas accumulation in subsalt Ma 4 Member of Ordovician Majiagou Formation are examined based on large amounts of drilling,logging and seismic data.The new understandings on the control of paleo-uplift over facies,reservoirs and accumulations are reached:(1)During the sedimentary period of Majiagou Formation,the central paleo-uplift divided the North China Sea in central-eastern of the basin from the Qinqi Sea at southwest margin of the basin,and controlled the deposition of the thick hummocky grain beach facies dolomite on platform margin of Ma 4 Member.Under the influence of the evolution of the central paleo-uplift,the frame of two uplifts alternate with two sags was formed in the central-eastern part of the basin,dolomite of inner-platform beach facies developed in the underwater low-uplift zones,and marl developed in the low-lying areas between uplifts.(2)From the central paleo-uplift to the east margin of the basin,the dolomite in the Ma 4 Member gradually becomes thinner and turns into limestone.The lateral sealing of the limestone sedimentary facies transition zone gives rise to a large dolomite lithological trap.(3)During the late Caledonian,the basin was uplifted as a whole,and the central paleo-uplift was exposed and denuded to various degrees;high-quality Upper Paleozoic Carboniferous-Permian coal measures source rocks deposited on the paleo-uplift in an area of 60000 km^(2),providing large-scale hydrocarbon for the dolomite lithological traps in the underlying Ma 4 Member.(4)During the Indosinian-Yanshanian stage,the basin tilted westwards,and central paleo-uplift depressed into an efficient hydrocarbon supply window.The gas from the Upper Paleozoic source rock migrated through the high porosity and permeability dolomite in the central paleo-uplift to and accumulated in the updip high part;meanwhile,the subsalt marine source rock supplied gas through the Caledonian faults and micro-fractures as a significant supplementary.Under the guidance of the above new understandings,two favorable exploration areas in the Ma 4 Member in the central-eastern basin were sorted out.Two risk exploration wells were deployed,both revealed thick gas-bearing layer in Ma 4 Member,and one of them tapped high production gas flow.The study has brought a historic breakthrough in the gas exploration of subsalt Ma 4 Member of Ordovician,and opened up a new frontier of gas exploration in the Ordos Basin. | HE Haiqing GUO Xujie ZHAO Zhenyu XI Shengli WANG Jufeng SONG Wei REN Junfeng WU Xingning BI He | 2022 | Petroleum Exploration and Development2022，49，3： | 0 |
| 8 | Corrigendum to'A novel FGFR1 inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis'[Genes&Diseases 11(2024)479-494]显示文摘The authors regret that in Figure 3C,the Western Blot(WB)image representing GAPDH levels was mistakenly chosen as the same image for ERK(indicated by the red dotted-line rectangle).We have attached the original WB strip for GAPDH to demonstrate that this was an unintentional error in image selection.Additionally,we noticed that the Transwell images in the two upper panels of the right column in Figure 4J are misleading due to errors in image selection.We have attached the original data to show that this was also an unintentional error.We assure you that these two corrections do not alter the scientificconclusionof thearticle. | Yanran Bi Ruiling Zheng Jiahao Hu Ruiqing Shi Junfeng Shi Yutao Wang Peng Wang Wenyi Jiang Gyudong Kim Zhiguo Liu Xiaokun Li Li Lin | 2024 | Genes & Diseases2024，11，3： | 0 |
| 9 | Fluorine-defects induced solid-state red emission of carbon dots with an excellent thermosensitivity显示文摘Up to date,solid-state carbon dots(CDs)with bright red fluorescence have scarcely achieved due to aggregation-caused quenching(ACQ)effect and extremely low quantum yield in deep-red to near infrared region.Here,we report a novel fluorine-defects induced solid-state red fluorescence(λ_(em)=676 nm,the absolute fluorescence quantum yields is 4.17%)in fluorine,nitrogen and sulfur co-doped CDs(F,N,S-CDs),which is the first report of such a long wavelength emission of solid-state CDs.As a control,CDs without fluorine-doping(N,S-CDs)show no fluorescence in solid-state,and the fluorescence quantum yield/emission wavelength of N,S-CDs in solution-state are also lower/shorter than that of F,N,S-CDs,which is mainly due to the F-induced defect traps on the surface/edge of F,N,S-CDs.Moreover,the solid-state F,N,S-CDs exhibit an interesting temperature-sensitive behavior in the range of 80-420 K,with the maximum fluorescence intensity at 120 K,unveiling its potential as the temperature-dependent fluorescent sensor and the solid-state light-emitting device adapted to multiple temperatures. | Haizhen Ding Jiahui Xu Lei Jiang Chen Dong Qi Meng Sajid ur Rehman Junfeng Wang Zhishen Ge Vladimir Yu.Osipov Hong Bi | 2021 | Chinese Chemical Letters2021，32，11： | 0 |
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