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| 1 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 2 | I-IBV life cycle is restricted in mouse hepatocytes .~xpressing human NTCP显示文摘 | Hanjie Li Qiuyu Zhuang Yuze Wang Tianyi'ng Zhang Jinghua Zhao Yali Zhang Junfang Zhang Yi Lin Quan Yuan Ningshao Xia Jiahuai Han | 2014 | Cellular & Molecular Immunology2014，11，2： | 14 |
| 3 | Analysis and improvement of missile three-loop autopilots显示文摘The non-minimum phase feature of tail-controlled missile airframes is analyzed.Three selection strategies for desired performance indexes are presented.An acceleration autopilot design methodology based on output feedback and optimization is proposed.Performance and robustness comparisons between the two-loop and classical three-loop topologies are made.Attempts to improve the classical three-loop topology are discussed.Despite the same open-loop structure,the classical three-loop autopilot shows distinct characteristics from a two-loop autopilot with PI compensator.Both the two-loop and three-loop topologies can stabilize a static unstable missile.However, the finite actuator resource is the crucial factor dominating autopilot function. | Lin Defu Fan Junfang Qi Zaikang Mou Yu | 2009 | Journal of Systems Engineering and Electronics2009，20，4： | 10 |
| 4 | Research and Practice of Dynamic Network Security Architecture for IaaS Platforms显示文摘Network security requirements based on virtual network technologies in IaaS platforms and corresponding solutions were reviewed.A dynamic network security architecture was proposed,which was built on the technologies of software defined networking,Virtual Machine(VM)traffic redirection,network policy unified management,software defined isolation networks,vulnerability scanning,and software updates.The proposed architecture was able to obtain the capacity for detection and access control for VM traffic by redirecting it to configurable security appliances,and ensured the effectiveness of network policies in the total life cycle of the VM by configuring the policies to the right place at the appropriate time,according to the impacts of VM state transitions.The virtual isolation domains for tenants’VMs could be built flexibly based on VLAN policies or Netfilter/Iptables firewall appliances,and vulnerability scanning as a service and software update as a service were both provided as security supports.Through cooperation with IDS appliances and automatic alarm mechanisms,the proposed architecture could dynamically mitigate a wide range of network-based attacks.The experimental results demonstrate the effectiveness of the proposed architecture. | Lin Chen Xingshu Chen Junfang Jiang Xueyuan Yin Guolin Shao | 2014 | Tsinghua Science and Technology2014，19，5： | 6 |
| 5 | Efficient transformation and expression of gfp gene in the edible mushroom Pleurotus nebrodensis显示文摘An efficient transformation method mediated by PEG-protoplasts was developed for the newly commercial edible mushroom Pleu- rotus nebrodensis. Two plasmids were used to co-transform protoplasts of P. nebrodensis. One plasmid is pAN7-1 containing a positive selectable marker gene hph conferring hygromycin B resistance. Another plasmid is pBlue-GFP containing a reporter gene gfp conferring green fluorescent protein. PCR and Southern blot analysis showed that hph gene or/and gfp gene were integrated into the genome of P. nebrodensis transformants. The transformation efficiency of the positive selectable marker gene hph was 3 transformants per microgram of plasmid pAN7-1 DNA, which was about 30 times higher than that previously reported in thoroughly studied Pleurotus species such as Pleurotus ostreatus. The transformation efficiency of the reporter gene gfp was 9 transformants per microgram of plasmid pBlu-GFP DNA. The co-transformation efficiency was 23.68%. This is the first report that a 'reporter' gene, green fluorescent protein gene can be successfully stably expressed in this Pleurotus species. | Junfang Lin Mingyao Zheng Jie Wang Wei Shu Liqiong Guo | 2008 | Progress in Natural Science:Materials International2008，18，7： | 5 |
| 6 | Farmland mercury contamination in the vicinity of an organic chemical factory in Guizhou,China显示文摘This study assesses the level of contamination of Hg in farmland soils along the irrigating channel down-stream from Guizhou Organic Chemical Factory (GOCF),where metallic mercury is used as a catalyst to produce acetic acid. The total input of mercury into the environment,as announced by GOCF,is 140 t in the past 30 years (1971-2000). Sampling sites were chosen based on the distance from the source of pollution—the chemical factory. A total of 39 samples were collected from the study area and analyzed for total mercury concentrations and methyl mercury concentrations. The characteristics of vertical and horizontal distributions of total mercury and methyl mer-cury in the study area (farmland) are described in this paper. Much attention was paid to the transformation of inor-ganic Hg into organic mercury species in soils as well. The results showed that the farmland has been heavily con-taminated by Hg. Land cultivation activity,land utilization style and distance from the pollution source could be the dominant factors controlling the distribution of THg and MeHg. It is observed that active transformation of inorganic Hg into organic mercury species (MeHg) usually takes place in paddy soils. | ZHANG Junfang QU Liya FENG Xinbin ZHANG Wei GUO Yanna LIN Kai LI Mei | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 3 |
| 7 | Control of static unstable airframes显示文摘The challenge and control problems of static unstable missiles are presented. The steady-state benefits of static instability are illustrated, while the corresponding control challenge is described both by the characteristic lag of airframe and the increment of necessary control usage. Control limitation led by unstable zero-pole pair is analyzed for preliminary design and evaluation. Linear control strategy is examined wherein two and three loop acceleration autopilots with different control usages are developed using an optimal control approach combined with frequency domain constraint. The weights selection and relation with system performance are detailed. Then the nonlinear backstepping recursive method is detailed to determine how well it is able to follow command and its engineering feasibility. The results show that a static unstable missile is controllable, while the actuator bandwidth is the crucial limited factor. There should be a compromise between overall performance and actuator payment. | Junfang Fan Defu Lin Zhong Su Qing Li | 2010 | Journal of Systems Engineering and Electronics2010，21，6： | 2 |
| 8 | A Noncovalently Fused-Ring Asymmetric Electron Acceptor Enables Efficient Organic Solar Cells显示文摘Main observation and conclusion Recently,the asymmetric nonfullerene acceptors(NFAs)with acceptor-donor-acceptor(A-D-A)structure have been developed rapidly,especially for the modification of asymmetric core,asymmetric side chains and asymmetric end groups.In this work,a novel asymmetric A-D-π-A type NFA with a noncovalently fused-ring core named PIST-4F is synthesized,containing an indacenodithieno[3,2-b]dithiophene(IDT),two strong electron-withdrawing end groups and an alkylthio-substituted thiopheneπ-bridge.Benefiting from the S···S noncovalent interaction between the sulfur atom onπ-bridge and the adjacent thiophene in IDT,the PIST-4F presents nearly planar geometry and extended conjugated area,resulting in the optimized electronic properties,charge transport,and film morphology compared to the symmetric NFA PI-4F.As a result,PM6:PIST-4F-based devices achieve a higher power conversion efficiency(PCE)of 13.8%,while the PM6:PI-4F-based devices only show a PCE of 7.1%.Notably,the PM6:PIST-4F-based devices processed with nonhalogen solvent toluene exhibit an excellent PCE as high as 13.1%.These results indicate that PIST-4F is an effective acceptor for high-efficiency organic solar cells. | Ji Lin Qing Guo Qi Liu Junfang Lv Haiyan Liang Yang Wang Lei Zhu Feng Liu Xia Guo Maojie Zhang | 2021 | Chinese Journal of Chemistry2021，39，10： | 1 |
| 9 | Satellite-observed variability of phytoplankton size classesassociated with a cold eddy in the South China Sea显示文摘 | LIN JUNFANG CAO WENXI WANG GUIFEN 2014 | 2014 | MarinePollution Bulletin2014，83，1： | 1 |
| 10 | Composition of transgenic Volvariella volvacea tolerant to cold stress is equivalent to that of conventional control显示文摘 | WANG Jie GUO Liqiong LIN Junfang | 2009 | J Agile Food Chem2009，57，6： | 1 |
| 11 | Non - volatile components of several novel species of edible fungi in China显示文摘 | Guo Liqiong Lin Junyang Lin Junfang | 2007 | Food Chemistry2007，100，2： | 1 |
| 12 | Non-volatile components of several novel species of edible fungi显示文摘 | GUO Liqiong LIN Junyang Lin Junfang | 2007 | China Food Chemistry2007，100，： | 1 |
| 13 | Successful bortezomib treatment in combination with dexamethasone andthalidomide for previously untreated epidural plasmacytoma显示文摘 | Zhiyong Zeng Ling Zheng Junfang Lin Junmin Chen | 2012 | Oncology Letters2012，，3： | 1 |
| 14 | Bortezomib for patients with previously untreated multiple myeloma: a systematic review and meta-analysis of randomized controlled trials显示文摘 | Zhiyong Zeng Junfang Lin Junmin Chen | 2013 | Annals of Hematology2013，，7： | 1 |
| 15 | Screening for bacterial enzymes synthesizing GPR119 agonist in cAMP-responsive cells显示文摘G protein-coupled receptor 119(GPR119),encoded by human GPR119 gene,is considered as a novel member of cannabinoid receptors.GPR119 is expressed predominantly in the pancreas and gastrointestinal tract of rodents and humans,as well as in the brain of rodents.GPR119 has also been shown to regulate incretin and insulin hormone secretion.Activation of GPR119 causes a reduction in food intake and lowers gain of body weight in rats[1].Targeting GPR119 with specific agonists has thus been attempted as a novel strategy to treat obesity and diabetes[2–4].In addition,GPR119 also plays an important role in bone metabolism,thus making GPR119 a potential target for bone resorption-associated diseases[5]. | Junfang Jia Yun Chen Lin Xu Yun Yang Xingxing Xu Hongyu Ding Caiwei Jia Hong Gao Pengxiang Guo Ronggui Hu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 0 |
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