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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Linked decreases in liver ki- nase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes 显示文摘 | Petursson F Husa M June R | 2013 | Arthritis Res Ther2013，15，4： | 1 |
| 3 | Dynamic model- ing of large - scale mageto theological damper systems for civil engineering applications 显示文摘 | Yang G Q Spencer B F June H J | 2004 | Journal of Engineering Mechanics2004，130，9： | 1 |
| 4 | High self control predicts good adjustment,less pathology,better grades,and interpersonal success显示文摘 | June T P Roy B F Luzio B A | | 0，，02： | 1 |
| 5 | Satellite observations of the microwave emissivity of a semi-arid land surface显示文摘 | June C Morland David I F Grimes T J Hewison | 2001 | Remote Sensing of Environment2001，77，1： | 1 |
| 6 | The Estimation of Land Surface Emissivities at 24GHz to 157GHz Using Remotely Sensed Aircraft Data显示文摘 | June C Morland David I F Grimes George Dugdale | 2000 | Remote Sensing of Environment2000，73，2： | 1 |
| 7 | High Self Control Predicts Good Adjustment, Less Pathology, Better Grades, and Interpersonal Success 显示文摘 | JUNE T P ROY B F LUZIO B A | 2004 | Journal of Personality2004，72，2： | 1 |
| 8 | High self control Predicts good adjustment, less Pathology, better grades, and Interpersonal Success显示文摘 | JUNE T P BOY B F LUZIO B A | 2004 | J Personality2004，72，2： | 1 |
| 9 | High self control predicts good adjustment,less pathology,better grades,and interpersonal success显示文摘 | June T P Roy B F Luzio B A | | 0，，02： | 1 |
| 10 | Creatine kinase isoenzyme BB creased in serum and tumor tissue of patients with giant cell tumor of bone显示文摘 | June F Saburou Y Keiko Y | 1994 | Clin Biochem1994，40，： | 1 |
| 11 | Spectral properties of sums of certain Kronecker products显示文摘 | JUNE F JAMES L | 2009 | Linear Algebra and Its Applications2009，431，： | 1 |
| 12 | Identification of Abscisic Acid,Indole-3-Acetic Acid,Jasmonic Acid,Indole-3-Acetonitrile,Methyl Jasmonate and Gibberellins in Developing,Dormant and Stratified Seeds of Ash(Fraxinus Excelsior)显示文摘 | Patrick S B June M T William E F | 2002 | Plant GrowthRegulation2002，37，： | 1 |
| 13 | Per- sistent calcium elevation correlates with the induction of surface immunoglobulin-mediated B cell DNA syn- thesis显示文摘 | YAMADA H JUNE C H FINKELMAN F | 1993 | J Exp Med1993，177，6： | 1 |
| 14 | High self control pre-dicts good adjustment,less pathology,better grades,and interpersonal success显示文摘 | June T P Roy B F Luzio B A | 2004 | Journal of Personality2004，72，2： | 1 |
| 15 | Transforming growth faetor-β isoforms and the induction of bone formation: implications for reconstructive craniofacial surgery显示文摘 | Ugo R Carlo F June T | 2009 | Craniofac Surg2009，20，5： | 1 |
| 16 | Buried pipe modeling with initial imperfections显示文摘 | Junes A Villarraga Jose F Rodriguez Cora Martinez | 2004 | Journal of PressureVessel Technology2004，126，： | 1 |
| 17 | Detection limit of CIostridium botulinum spores in dried mushroom samples sourced from China 显示文摘 | Pradeep K M June P Clare F | 2013 | Int J Food Microbio12013，166，1： | 1 |
| 18 | Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor– α and negatively with adiponectin levels in obese adolescents显示文摘 | Fábio Santos Lira Jose Cesar Rosa Ronaldo Vagner dos Santos Daniel Paulino Venancio June Carnier Priscila de Lima Sanches Claudia Maria Oller do Nascimento Aline de Piano Lian Tock Sergio Tufik Marco Túlio de Mello Ana R. Damaso Lila Missae Oyama | 2011 | Metabolism2011，，3： | 1 |
| 19 | Fast discriminative visual codebooks using randomized clustering forests 显示文摘 | Moosmann F Triggs B June F | 2007 | Advances in Neural Information Processing Systems2007，19，： | 1 |
| 20 | Buried Pipe Modeling With Initial Imperfections显示文摘 | Junes A Villarraga Jose F Rodriguez Cora Mart inez | 2004 | Journal of Pressure Vessel Technology2004，，5： | 1 |
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