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| 1 | Experimental study on the feasibility and safety of radiofrequency ablation for secondary splenomagely and hypersplenism显示文摘AIM: To assess the feasibility and safety of radiofrequency ablation (RFA) in treatment of secondary splenomagely and hypersplenism.METHODS: Sixteen healthy mongrel dogs were randomly divided into two groups, group Ⅰ (n=4) and group Ⅱ (n=12).Congestive splenomegaly was induced by ligation of splenic vein and its collateral branches in both groups. At the end of 3rd week postoperation, RFA in spleen was performed in group Ⅱ via laparotomy, complications of RFA were observed,CT scan was performed and the spleens were obtained.The radiofrequency (RF) thermal lesions and histopathology of spleen were examined regularly.RESULTS: No complication or death was observed in both groups; CT revealed that the splenomegaly lasted over 2months after ligation of splenic vein; the segmental RF lesions included hyperintense zone of coagulative necrosis and more extensive peripheral hypointense infarcted zone, the latter was called 'bystander effect'. The infarcted zone would be absorbed and subsequently disappeared in 4-6 weeks after RFA accompanied with shrinkage of the remnant spleen.The fundamental histopathological changes of splenic lesions caused by RF thermal energy included local coagulative necrosis, peripheral thrombotic infarction zone, subsequent tissue absorption and fibrosis in the zone of thrombotic infarction, the occlusion of vessels in remnant viable spleen,deposition of extensive fibrous protein, and disappearance of congestive splenic sinusoid - 'splenic carnification'. Those pathologic changes were underline of shrinkage of spleen.CONCLUSION: It is feasible and safe to perform RFA in spleen to treat experimental splenomegaly and hypersplenism. The RFA could be safely performed clinically via laparotomy or laparoscopic procedure while spleen was strictly separated from surrounding organs. | Quan-DaLiu Kuan-ShengMa Zhen-PingHe JunDing Xue-QuanHuang Jia-HongDong | 2003 | World Journal of Gastroenterology2003，9，4： | 25 |
| 2 | Endoscopic sphincterotomy in the treatment of cholangiopancreatic diseases显示文摘AIM: To investigate the therapeutic effect of endoscopicsphincterotomy (EST) in the treatment of choledocholithiasis and stenosing papillitis.METHODS: A total of 1 026 patients undergoing EST during July 1983 to May 2003 at the institute were retrospectively analyzed. Chronic pancreatitis was diagnosed in 63 (6.1%),cholecystolithiasis and choledocholithiasis in 549 (53.5%),stones in residual biliary duct in 249 (24.3%), stenosing papillitis in 228 (22.2%). In patients with simple stenosing papillitis, most incisions were within 0.5-1 cm in length. As for patients with chronic pancreatitis simultaneously, selective pancreatic sphincterotomy was performed, and incision was within 0.5-0.8 cm in length. For stones less than 1 cm, incision was from 1 to 1.5 cm, and for those larger than 1 cm, incision ranged from 1.5 to 3 cm. For stones more than 2 cm in diameter, detritus basket rather than simple incision was chosen. RESULTS: Of the 798 patients with choledocholithiasis, 764 (93.5%) had successful stone clearance, 215 (94.3%)out of 228 cases of stenosing papillitis were cured totally, while 63 had chronic pancreatitis developed from stenosing papillitis, 57 (90.1%) had sound remission of symptoms, though membranous stenosis emerged in 13 of 57 which was treated with balloon dilatation. After the operation, only 21 cases (2.1%) had complications such as severe pancreatitis and incision bleeding. None of the patients died.CONCLUSION: EST is an ideal surgical management with mini-invasion in the treatment of choledocholithiasis and stenosing papillitis. | Zhi-HuaLi MinChen Ji-KuiLiu JunDing Jia-HongDong | 2005 | World Journal of Gastroenterology2005，11，17： | 23 |
| 3 | Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)has become one of the most prominent causes of chronic liver diseases and malignancies.However,few therapy has been approved.Radix Bupleuri(RB)is the most frequently used herbal medicine for the treatment of liver diseases.In the current study,we aim to systemically evaluate the therapeutic effects of saikosaponin A(SSa)and saikosaponin D(SSd),the major bioactive monomers in RB,against NAFLD and to investigate the underlying mechanisms.Our results demonstrated that both SSa and SSd improved diet-induced NAFLD.Integrative lipidomic and transcriptomic analysis revealed that SSa and SSd modulated glycerolipid metabolism by regulating related genes,like Lipe and Lipg.SSd profoundly suppressed the fatty acid biosynthesis by downregulating Fasn and Acaca expression and promoted fatty acid degradation by inducing Acox1 and Cpt1 a expression.Bioinformatic analysis further predicted the implication of master transcription factors,including peroxisome proliferator-activated receptor alpha(PPARα),in the protective effects of SSa and SSd.These results were further confirmed in vitro in mouse primary hepatocytes.In summary,our study uncoded the complicated mechanisms underlying the promising anti-steatosis activities of saikosaponins(SSs),and provided critical evidence inspiring the discovery of innovative therapies based on SSa and SSd for the treatment of NAFLD and related complications. | Xiaojiaoyang Li Junde Ge Yajing Li Yajie Cai Qi Zheng Nana Huang Yiqing Gu Qi Han Yunqian Li Rong Sun Runping Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 4 | Spatial and temporal dynamics of phytoplankton and bacterioplankton biomass in Sanya Bay, northern South China Sea显示文摘The composition of phytoplankton and the dynamics of phytoplankton and bacterioplankton biomass (PB and BB, respectively) of Sanya Bay, South China Sea, were determined. A total of 168 species (67 genera) phytoplankton were identified, including Bacillariophyta (diatom, 128 species), Pyrrophyta (35 species), Cyanophyta (3 species), and Chrysophyta (2 species). Annual average abundance of phytoplankton was 1.2 × 107 cells/m3, with the highest abundance in autumn, and the lowest in summer. Annual average diversity index (H ) and evenness (J) values were 3.96 and 0.70, respectively. Average chlorophyll-a was 2.5 mg/m3, and the average PB was 124 mg C/m3, with the highest value in autumn. Surface PB was higher than the bottom, except for summer. Annual mean bacterioplankton abundance and BB were 6.9 × 1011 cells/m3 and 13.8 mg C/m3, respectively. The highest BB was found in summer, followed by winter, spring, and autumn. Surface BB was higher than bottom all year round. The spatial distribution patterns of PB and BB were very similar with the highest biomass in the estuary, and decreased seaward, primarily due to the terrestrial input from the Sanya River and influx of oceanic water. The main factor influencing PB and BB was dissolved inorganic nitrogen (DIN). Other factors such as temperature, which is above 22°C throughout the year, had a negligible impact. The correlation between BB and PB was significant (P < 0.01). The annual average ratio of BB/PB was 0.12 (0.06-0.15). Phytoplankton primary production was one of the most important factors in controlling the distribution of bacterioplankton. | ZHOU Weihua | 2009 | Journal of Environmental Sciences2009，21，5： | 11 |
| 5 | Thermoluminescence dating of the ancient Chinese porcelain using a regression method of saturation exponential in pre-dose technique显示文摘This paper studies the thermoluminescence (TL) dating of the ancient por- celain using a regression method of saturation exponential in the pre-dose technique. The experimental results show that the measured errors are 15% (±1σ) for the paleodose and 17% (±1σ) for the annual dose respectively, and the TL age error is 23% (±1σ) in this method. The larger Chinese porcelains from the museum and the nation-wide collectors have been dated by this method. The results show that the certainty about the authenticity testing is larger than 95%, and the measurable porcelains make up about 95% of the por- celain dated. It is very successful in discrimination for the imitations of ancient Chinese porcelains. This paper describes the measured principle and method for the paleodose of porcelains. The TL ages are dated by this method for the 39 shards and porcelains from past dynasties of China and the detailed data in the measurement are reported. | WANG Weida XIA Junding ZHOU Zhixin | 2006 | Science China(Technological Sciences)2006，49，2： | 11 |
| 6 | Toosendanin increases free-Ca^(2+) concentration in NG108-15 cells υia L-type Ca^(2+) channels显示文摘AIM: To examine if toosendanin (TSN) affects intracellular free-Ca2+ concentration ([Ca2+]i) in neuroblastomagliomahybrid cells (NG108-15 cells). METHODS: The [Ca2+]i was determined by laser-scanning confocal microscopicimaging technique in which Fluo-3 was used as Ca2+ indicator. RESULTS: TSN induced an increase in resting[Ca2+]i and in high K+-evoked Ca2+ transient in differentiated NG108-15 cells. The TSN-induced increase in [Ca2+]iwas dose-dependent and disappeared in CdCl2-, nifedipine-containing or Ca2+-free solution, and appeared afterwashing out the Ca2+ channel blockers or adding Ca2+. CONCLUSION: TSN increased [Ca2+]i in differentiatedNG108-15 cells. The [Ca2+]i enhancement was due to the influx of extracellular Ca2+ and related to L-type Ca2+channels. | Tong-huiXU junDING Yu-liangSHI | 2004 | Acta Pharmacologica Sinica2004，25，5： | 8 |
| 7 | Traffic Prediction in 3G Mobile Networks Based on Multifractal Exploration显示文摘Traffic prediction plays an integral role in telecommunication network planning and network optimization. In this paper, we investigate the traffic forecasting for data services in 3G mobile networks. Although the Box-Jenkins model has been proven to be appropriate for voice traffic (since the arrival of calls follows a Poisson distribution), it has been demonstrated that the Internet traffic exhibits statistical self-similarity and has to be modeled using the Fractional AutoRegressive Integrated Moving Average (FARIMA) process. However, a few studies have concluded that the FARIMA process may fail in modeling the Internet traffic. To this end, we conducted experiments on the modeling of benchmark Internet traffic and found that the FARIMA process fails because of the significant multifractal characteristic inherent in the traffic series. Thereafter, we investigate the traffic series of data services in a 3G mobile network from a province in China. Rich multifractal spectra are found in this series. Based on this observation, an integrated method combining the AutoRegressive Moving Average (ARMA) and FARIMA processes is applied. The obtained experimental results verify the effectiveness of the integrated prediction method. | Yanhua Yu Meina Song Yu Fu Junde Song | 2013 | Tsinghua Science and Technology2013，18，4： | 6 |
| 8 | 类胰岛素生长因子信号途径及其对脊椎动物生长和发育的调控作用:以斑马鱼为模式动物的新进展显示文摘类胰岛素生长因子(包括IGF-Ⅰ和IGF-Ⅱ)是进化上保守性很强的多肽.IGFs对脊椎动物的生长和早期发育有极其重要的调控作用. IGF的生理作用是由IGF受体中介并受几个分泌性的IGF结合蛋白调节.本文主要介绍了以斑马鱼为模式动物, 用基因敲除、转基因动物和培养细胞系等现代实验方法对IGF信号途径的最新研究进展,综述了IGF配体、受体和结合蛋白的结构特点、基因表达和调节和生物学功能.此外,也对斑马鱼作为模式动物的许多优点进行了探讨[动物学报 49(4):421~431,2003]. | CunmingDUAN JunDING PeterJ.SCHLUETER YunLI JunbinZHANG TriciaL.ROYER | 2003 | 动物学报2003，49，4： | 6 |
| 9 | The bacterial diversity in surface sediment from the South China Sea显示文摘16S rDNA sequencing results from this study and literatures demonstrate that sediment bacteria in the South China Sea (SCS) were very diverse,which contained 22 of the 24 phyla of bacteria investigated from marine sediment,however,it was very imbalance among stations.So bacterial diversity from 15 samples which covered a wide range of sediment types from 20 to 3 888 m in depth was studied in DGGE (denature gradient gel electrophoresis) in this paper.The DGGE results indicate that both sediment bacterial diversity and diversity difference among stations were significant.Thirty representative and differential fingerprints among samples were recovered and sequenced,phylogenetic analysis indicates that they may belong to Proteobacteria (α-,β-,γ-,δ-,ε-),Planctomycetes,Firmicutes,Chloroflexi,Acidobacteria,Actinobacteria,Nitrospirae,Gemmatimonadetes,candidate division WS3 and so on,of which,Gemmatimonadetes and candidate division WS3 bacteria were first detected in SCS sediment.This study also shows that bacterial diversity analysis based on DGGE was more potential than traditional 16S rDNA clone library in multiple sample analysis. | WANG Guanghua DONG Junde LI Xiang SUN Huimin | 2010 | Acta Oceanologica Sinica2010，29，4： | 5 |
| 10 | Recent development on COX-2 inhibitors as promising anti-inflammatory agents:The past 10 years显示文摘Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins.Two cyclooxygenases are described,the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2,for which the target inhibitors are the non-steroidal anti-inflammatory drugs(NSAIDs).Prostaglandins are a class of lipid compounds that mediate acute and chronic inflammation.NSAIDs are the most frequent choices for treatment of inflammation.Nevertheless,currently used anti-inflammatory drugs have become associated with a variety of adverse effects which lead to diminished output even market withdrawal.Recently,more studies have been carried out on searching novel selective COX-2 inhibitors with safety profiles.In this review,we highlight the various structural classes of organic and natural scaffolds with efficient COX-2 inhibitory activity reported during 2011-2021.It will be valuable for pharmaceutical scientists to read up on the current chemicals to pave the way for subsequent research. | Zhiran Ju Menglan Li Junde Xu Daniel C.Howell Zhiyun Li Fen-Er Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 4 |
| 11 | Effect of the endoparasitoid Campoletis chlorideae on phenoloxidase activity in Helicoverpa armigera hemo-lymph显示文摘Endoparasitoid wasps can develop inside permissive host due to their ability to overcome or to evade the host’s cellular and humoral immune response. Oviposition of Campoletis chlorideae (Hymenoptera: Ichneumonidae) in larvae of Helicoverpa armigera (Lepidoptera) was accompanied by inhibition of phenoloxidase (PO) activity and melanization reaction in host hemolymph in vitro. PO activity in host plasma was decreased about 83% 48 h post para-sitization. A similar result was found when the host insect was injected with 0.5 wasp equivalent calyx fluid. This indicated that the calyx fluid was concerned with suppression of PO activity after parasitization. Furthermore, the prophen-oloxidase (proPO) in host haemocytes could be activated by bovine trypsin in unparasitized insects, while it could not be activated in parasitized or calyx fluid-injected host. The results suggested that inhibition of PO activity by parasitization was related to the calyx fluid of Campoletis chlorideae, and the components of calyx | Lihong Yin Chenzhu Wang Junde Qin | 2001 | Chinese Science Bulletin2001，46，21： | 4 |
| 12 | High-resistance controlled yielding supporting technique in deep-well oil shale roadways显示文摘In order to avoid the deep-well oil shale roadway being deformed, damaged, or difficult to maintain after excavating and supporting in Haishiwan coal mine, this paper has analyzed the characteristics of the deformed roadway and revealed its failure mechanism by taking comprehensively the methods of field geological investigation, displacement monitoring of surrounding rock, rock properties and hydration properties experiments and field application tests. Based on this work, the high-resistance controlled yielding supporting principle is proposed, which is: to ‘‘resist'' by high pre-tightening force and high stiffness in the early stage, to ‘‘yield'' by making use of the controlled deformation of a yielding tube in the middle stage, and to ‘‘fix'' by applying total-section Gunite in the later stage. A high-resistance controlled yielding supporting technique of ‘‘high pre-tightening force yielding anchor bolt + small-bore pre-tightening force anchor cable + rebar ladder beam + rhombic metal mesh + lagging gunite'' has been established, and industrial on site testing implemented. The practical results show that the high-resistance controlled yielding supporting technique can effectively control the large deformation and long-time rheology of deep-well oil shale roadways and can provide beneficial references for the maintenance of other con-generic roadways. | Yu Yang Bai Jianbiao Wang Xiangyu Wang Junde Xue Shizhi Xu Ke | 2014 | International Journal of Mining Science and Technology2014，24，2： | 3 |
| 13 | An ideal topology type convergent theorem on scale effect algebras显示文摘The famous Antosik-Mikusinski convergent theorem on the Abel topological groups has very extensive applications in measure theory, summation theory and other analysis fields. In this paper, we establish the theorem on a class of effect algebras equipped with the ideal topology. This paper shows also that the ideal topology of effect algebras is a useful topology in studying the quantum logic the- ory. | WU JunDe ZHOU XuanChang Minhyung CHO | 2007 | Science in China(Series F)2007，50，1： | 2 |
| 14 | Spatial variability of cyanobacterial community composition in Sanya Bay as determined by DGGE fingerprinting and multivariate analysis显示文摘The cyanobacterial communities in the surface and bottom waters of Sanya Bay were investigated on April 24 and 25,2010.Flow cytometry showed that the total cyanobacterial abundance in the surface and bottom layers ranged from 0.7×10 4 to 2.38×10 4 cells mL-1 and from 1×10 4 to 1.8×10 4 cells mL-1,respectively.Cyanobacterial diversity was analyzed using a molecular fingerprinting technique called denaturing gradient gel electrophoresis(DGGE),followed by DNA sequencing.The results were then interpreted through multivariate statistical analysis.Differences in the compositions of cyanobacterial communities were observed in the surface and bottom waters at the same station,with some bands obtained from both the surface and bottom layers,whereas some bands were present only in one layer.The predominant cyanobacterial species of the excised DGGE bands were related to Synechococcus or Synechococcus-like species(56.2%).Other phylogenetic groups identified included Chroococcidiopsis(6.3%),Cyanobium(6.3%) and some unclassified cyanobacteria(31.2%).A redundancy analysis(RDA) was conducted to reveal the relationships between the cyanobacterial community composition and environmental factors.Analysis results showed that the spatial variations in the cyanobacterial community composition in surface waters was significantly related to chlorophyll a(Chla),the biochemical oxygen demand(BOD),nitrate and phosphate(P<0.05).Meanwhile,the spatial variations in the bottom waters was significantly affected by nitrate,nitrite,and phosphate(P<0.05).Environmental parameters could explain 99.3% and 58.3% of the variations in the surface and bottom layers,respectively. | LING Juan ZHANG YanYing DONG JunDe WANG YouShao HUANG Hui CHEN Lei HUANG XiaoFang LONG LiJuan ZHANG Si | 2013 | Chinese Science Bulletin2013，58，9： | 2 |
| 15 | Joint Optimization of Satisfaction Index and Spectrum Efficiency with Cache Restricted for Resource Allocation in Multi-Beam Satellite Systems显示文摘Dynamic resource allocation(DRA) is a key technology to improve system performances in GEO multi-beam satellite systems. And, since the cache resource on the satellite is very valuable and limited, DRA problem under restricted cache resources is also an important issue to be studied. This paper mainly investigates the DRA problem of carrier resources under certain cache constraints. What's more, with the aim to satisfy all users' traffic demands as more as possible, and to maximize the utilization of the bandwidth, we formulate a multi-objective optimization problem(MOP) where the satisfaction index and the spectrum efficiency are jointly optimized. A modified strategy SA-NSGAII which combines simulated annealing(SA) and non-dominated sorted genetic algorithm-II(NSGAII) is proposed to approximate the Pareto solution to this MOP problem. Simulation results show the effectiveness of the proposed algorithm in terms of satisfaction index, spectrum efficiency, occupied cache, and etc. | Pei Zhang Xiaohui Wang Zhiguo Ma Junde Song | 2019 | China Communications2019，16，2： | 2 |
| 16 | QoS prediction algorithm used in location-aware hybrid Web service显示文摘Quality-of-Service(QoS) describes the non-functional characteristics of Web services. As such, the QoS is a critical parameter in service selection, composition and fault tolerance, and must be accurately determined by some type of QoS prediction method. However, with the dramatic increase in the number of Web services, the prediction failure caused by data sparseness has become a critical challenge. A new ‘hybrid user-location-aware prediction based on weighted Adamic-Adar(WAA)'(HUWAA) was proposed. The implicit neighbor search was optimized by incorporating location factors. Meanwhile, the ability of the improved algorithms to solve the data sparsity problem was validated in experiments on public real world datasets. The new algorithm outperforms the existing of item-based pearson correlation coefficient(IPCC), user-based pearson correlation coefficient(UPCC) and Web service recommender system(WSRec) algorithms. | E Haihong Tong Junjie Song Meina Song Junde | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，1： | 2 |
| 17 | Image retrieval based on color distribution entropy显示文摘 | Junding Sun Ximin Zhang Jiangtao Cui Lihua Zhou | 2006 | Pattern Recognition Letters2006，，10： | 2 |
| 18 | Impact of Sino-US Trade Friction on Import and Export Trade Pattern of Soybean in Heilongjiang显示文摘Under the background of Sino-US trade friction,soybean,as an important variety in the important and export trade of agricultural products,has become a key bargaining chip. After the Ministry of Commerce of China announced the counter list of agricultural products including soybean,the price fluctuations of domestic soybean and related agricultural products are rapidly expanding. Under the background of SinoUS trade friction,taking the soybean-producing areas in Heilongjiang as an example,the impact of Sino-US trade friction on the important and export pattern of soybean in Heilongjiang was explored to provide a certain theoretical basis for the development of soybean industry in Heilongjiang. | Junde HAN Junjie SONG Tianzhen QI | 2019 | Asian Agricultural Research2019，11，3： | 2 |
| 19 | Purification and characterization of antioxidative peptides from protein hydrolysate of lecithin-free egg yolk显示文摘 | Park PJ Jund WK Nam KS | | 0，，： | 1 |
| 20 | 查看详情显示文摘 | Hefang W Ligong C Guoyi B Dezhi L Yang L Xilong Y Yuecheng Z Junde X | | 0，，： | 1 |
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