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| 1 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 2 | Systematic Identification of the Light-quality Responding Anthocyanin Synthesis-related Transcripts in Petunia Petals显示文摘Previous studies have shown that high light intensity can induce anthocyanin synthesis(AS)in petunia plants.To identifywhich kind of light quality plays a role in inducing such metabolic process,and what transcripts participate in controlling it,we carried out whole-transcriptome sequencing and analysis of petunia petals treated with different light-quality conditions.Among the red and white light treatments,a total of 2205 differentially expressed genes and 15,22,and 20 differentially expressed circRNAs,miRNAs,and lncRNAs,were identified respectively.The AS-related genes,including the structural genes CHSj,F3H,F35H,DFR,and ANS,and the regulatory genes AN4,DPL,PHZ and MYBx were found to be downregulated under red light condition compared with their levels under white light condition.Furthermore,the light photoreceptor Cryptochrome 3(CRY3)and a series of light-dependent genes,such as PIF,HY5,andBBXs,were also determined to respond to the light treatments.The anthocyanin contents in early petunia petals under red light were significantly lower than that under white and blue light.The results of qRT-PCR further confirmed the expression pattern of some AS-related and light-response genes in response to different light quality.Yeast two-hybrid results showed that the key elements in the light signal pathway,HY5 can interact with BBX19,BBX24 and BBX25.And PHZ,the important AS regulator can induce anthocyanin synthesis in response to blue light quality fromtransient expression analysis in petunia petals.These findings presented here not only deepen our understanding of how light quality controls anthocyanin synthesis,but also allow us to explore potential target genes for improving pigment production in petunia flower petals. | Zhenzhu Fu Hongquan Shang Hui Jiang Jie Gao Xiaoyu Dong Huijuan Wang Yanmin Li Limin Wang Jing Zhang Qingyan Shu Yacong Chao Menglan Xu Rui Wang Liangsheng Wang Hechen Zhang | 2020 | Horticultural Plant Journal2020，6，6： | 7 |
| 3 | Recent development on COX-2 inhibitors as promising anti-inflammatory agents:The past 10 years显示文摘Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins.Two cyclooxygenases are described,the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2,for which the target inhibitors are the non-steroidal anti-inflammatory drugs(NSAIDs).Prostaglandins are a class of lipid compounds that mediate acute and chronic inflammation.NSAIDs are the most frequent choices for treatment of inflammation.Nevertheless,currently used anti-inflammatory drugs have become associated with a variety of adverse effects which lead to diminished output even market withdrawal.Recently,more studies have been carried out on searching novel selective COX-2 inhibitors with safety profiles.In this review,we highlight the various structural classes of organic and natural scaffolds with efficient COX-2 inhibitory activity reported during 2011-2021.It will be valuable for pharmaceutical scientists to read up on the current chemicals to pave the way for subsequent research. | Zhiran Ju Menglan Li Junde Xu Daniel C.Howell Zhiyun Li Fen-Er Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 4 |
| 4 | Integrin β4 was downregulated on the airway epithelia of asthma patients显示文摘流上皮的功能的动态平衡的上皮的房间和损失是的航线气喘的主要病理学的特征;然而,位于这些病理下面的机制仍然保持阴暗。我们的以前的工作证明在 integrin 的 5 flanking 区域有三个变化地点 4 在气喘病人,它与 integrin 的减少的表示被相关 4 在外部白血球。Integrin 4 是航线 epithelia 上的一个重要结构的粘附分子保留上皮的房间的结构的粘附。在这个工作,我们进一步表明了 4 表示是的那 integrin 在气喘病人的航线 epithelia 的 downregulated。探查在 integrin 的 imbalanced 表示之间的关系 4 并且航线的机能障碍在气喘的上皮的房间, integrin 4 由 integrin 是在人的支气管的上皮房间(16HBE14O ) 的 silenced 4 小介入的 RNA lentivirus 向量。在 integrin 的 silencing 之上 4, 16HBE14O 房间显示出减少的增长和创伤修理。大多数房间被显示在 integrin 以后在 G1 阶段被逮捕 4 silencing,和增加的 apoptosis 在 integrin 4 沉默房间被导致。在摘要,我们的结果提供了引人注目的证据那 integrin 4 涉及结构的正直和航线的功能的动态平衡上皮的房间。它是可能的 4 在气喘航线 epithelia 上贡献的 integrin 的那 downregulation 航线的结构的混乱和机能障碍上皮的房间。 | Chi Liu Yang Xiang Huijun Liu Yun Li Yurong Tan Xiaolin Zhu DanZeng Menglan Li Liwen Zhang Xiaoqun Qin | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 4 |
| 5 | Combining chlorination and sulfuration strategies for high-performance all-small-molecule organic solar cells显示文摘Three small-molecule donors based on dithieno [2,3-d:2’,3 ’-d’]-benzo[1,2-b:4,5-b’] dithiophene(DTBDT)unit were designed and synthesized by side chain regulation with chlorinated or/and sulfurated substitutions(namely ZR1,ZR1-Cl,and ZR1-S-Cl respectively),along with a crystalline non-fullerene acceptor IDIC-4 Cl with a chlorinated 1,1-dicyanomethylene-3-indanone(IC) end group.Energy levels,molar extinction coefficients and crystallinities of three donor molecules can be effectively altered by combining chlorination and sulfuration strategies.Especially,the ZR1-S-Cl exhibited the best absorption ability,lowest higher occupied molecular orbital(HOMO) energy level and highest crystallinity among three donors,resulting in the corresponding all-small-molecule organic solar cells to produce a high power conversion efficiency(PCE) of 12.05% with IDIC-4 Cl as an acceptor. | Ruimin Zhou Chen Yang Wenjun Zou Muhammad Abdullah Adil Huan Li Min Lv Ziyun Huang Menglan Lv Jianqi Zhang Kun Lu Zhixiang Wei | 2021 | Journal of Energy Chemistry2021，30，1： | 3 |
| 6 | Development of a widely targeted volatilomics method for profiling volatilomes in plants显示文摘Volatile organic compounds play essential roles in plant environment interactions as well as determining the fragrance of plants.Although gas chromatography-mass spectrometry-based untargeted metabolo-mics is commonly used to assess plant volatiles,it suffers from high spectral convolution,low detection sensitivity,a limited number of annotated metabolites,and relatively poor reproducibility.Here,we report a widely targeted volatilomics(WTV)method that involves using a“targeted spectra extraction”algorithm to address spectral convolution,constructing a high-coverage MS2 spectral tag library to expand volatile annotation,adapting a multiple reaction monitoring mode to improve sensitivity,and using regression models to adjust for signal drift.The newly developed method was used to profile the volatilome of rice grains.Compared with the untargeted method,the newly developed WTV method shows higher sensitivity(for example,the signal-to-noise ratio of guaicol increased from 4.1 to 18.8),high annotation coverage(the number of annotated volatiles increased from 43 to 132),and better reproducibility(the number of volatiles in quality control samples with relative standard deviation value below 30.0%increased from 14 to 92 after normalization).Using the WTV method,we studied the metabolic responses of tomato to environmental stimuli and profiled the volatilomes of different rice accessions.The results identified benzothiazole as a potential airborne signal priming tomato plants for enhanced defense and 2-nonanone and 2-heptanone as novel aromatic compounds contributing to rice fragrance.These case studies suggest that the widely targeted volatilomics method is more efficient than those currently used and may considerably promote plant volatilomics studies. | Honglun Yuan Guangping Cao Xiaodong Hou Menglan Huang Pengmeng Du Tingting Tan Youjin Zhang Haihong Zhou Xianqing Liu Ling Liu Yiding Jiangfang Yufei Li Zhenhuan Liu Chuanying Fang Liqing Zhao Alisdair R.Fernie Jie Luo | 2022 | Molecular Plant2022，15，1： | 2 |
| 7 | High electron mobility fluorinated indacenodithiophene small molecule acceptors for organic solar cells显示文摘Indacenodithiophene(IDT)derivatives are kinds of the most representative and widely used cores of small molecule acceptors(SMAs)in organic solar cells(OSCs).Here we systematically investigate the influence of end-group fluo rination density and position on the photovoltaic properties of the IDT-based SMAs IDIC-nF(n=0,2,4).The absorption edge of IDIC-nF red-shifts with theπ-πstacking and crystallinity improvement,and their electronic energy levels downshift with increasing n.Due to the advantages of J_(sc)and FF as well as acceptable V_(oc),the difluorinated IDIC-2 F acceptor based OSCs achieve the highest power conversion efficiency(PCE)of 13%,better than the OSC devices based on IDIC and IDIC-4 F as acceptors.And the photovoltaic performance of the PTQ10:IDIC-2 F OSCs is insensitive to the active layer thickness:PCE still keep high values of 12.00%and 11.46%for the devices with active layer thickness of 80 and 354 nm,respectively.This work verifies that fine and delicate modulation of the SMAs molecular structure could optimize photovoltaic performance of the corresponding OSCs.Meanwhile,the thickness-insensitivity property of the OSCs has potential for large-scale and printable fabrication technology. | Fei Pan Xiaojun Li Song Bai Tianhao Liu Xian Wei Yingfen Li Shanshan Chen Changduk Yang Xiwen Chen Menglan Lv Yongfang Li | 2021 | Chinese Chemical Letters2021，32，3： | 1 |
| 8 | Single-wall carbon nanotube-containing cathode interfacial materials for high performance organic solar cells显示文摘Water/alcohol soluble cathode interfacial materials(CIMs)are playing important roles in optoelectronic devices such as organic light emitting diodes,perovskite solar cells and organic solar cells(OSCs).Herein,n-doped solution-processable single-wall carbon nanotubes(SWCNTs)-containing CIMs for OSCs are developed by dispersing SWCNTs to the typical CIMs perylene diimide(PDI)derivatives PDIN and PDINO.The Raman and X-ray photoelectron spectroscopy(XPS)measurement results illustrate the ndoped behavior of SWCNTs by PDIN/PDINO in the blend CIMs.The blended and n-doped SWCNTs can tune the work function and enhance the conductivity of the PDI-derivative/SWCNT(PDI-CNT)composite CIMs,and the composite CIMs can regulate and down-shift the work function of cathode,reduce the charge recombination,improve the charge extraction rate and enhance photovoltaic performance of the OSCs.High power conversion efficiency(PCE)of 17.1%and 17.7%are obtained for the OSCs based on PM6:Y6 and ternary PM6:Y6:PC_(71) BM respectively with the PDI-CNTcomposites CIMs.These results indicate that the ndoped SWCNT-containing composites,like other n-doped nanomaterials such as zero dimensional fullerenes and two dimensional graphenes,are excellent CIMs for OSCs and could find potential applications in other optoelectronic devices. | Fei Pan Song Bai Tianhao Liu Dianyong Tang Xian Wei Xiwen Chen Menglan Lv Yongfang Li | 2021 | Science China Chemistry2021，64，4： | 1 |
| 9 | Self-assembly of Pyrene-modified Rhomboidal Metalloden- drimers via Directional Metal-ligand Bonding Approach显示文摘设计并且经由方向性的 metal-ligand 的修改分核的长斜方形的 metallodendrimers R1R6 自己组装结合的途径被描述。由采用包含分核 120 敺搠獩牴扩瑵潩 ? 景 ? 偄华 ? 敷敲搠瑥牥業敮 ? 祢搠湹浡捩氠杩? | Menglan He Qing Han Jiuming He Quanjie Li Zeper Abliz Hongwei Tan Lin Xu Haibo Yang | 2013 | Chinese Journal of Chemistry2013，31，5： | 1 |
| 10 | Identification ofvolatile flavor compounds in Chinese Sinkiang camel-naizi using differentsolid phase microextraction fibers显示文摘 | LI Ning ZHENG Fuping LIANG Menglan | 2010 | Food Science andBiotechnology2010，19，4： | 1 |
| 11 | Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF)is a chronic fatal lung disease with a median survival time of 3–5 years.Inaccurate diagnosis,limited clinical therapy and high mortality together indicate that the development of effective therapeutics for IPF is an urgent need.In recent years,it was reported that DDRs are potential targets in anti-fibrosis treatment.Based on previous work we carried out further structure modifications and led to a more selective inhibitor 47 by averting some fibrosis-unrelated kinases,such as RET,AXL and ALK.Extensive profiling of compound 47 has demonstrated that it has potent DDR1/2 inhibitory activities,low toxicity,good pharmacokinetic properties and reliable in vivo anti-fibrosis efficacy.Therefore,we confirmed that discoidin domain receptors are promising drug targets for IPF,and compound 47 would be a promising candidate for further drug development. | Qi Wang Bixi Tang Dandan Sun Ying Dong Yinchun Ji Huanyu Shi Liwei Zhou Yueyue Yang Menglan Luo Qian Tan Lin Chen Yue Dong Cong Li Rongrong Xie Yi Zang Jingkang Shen Bing Xiong Jia Li Danqi Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 12 | High-yielding rice variety Zhong 83-49显示文摘The early season indica rice variety Zhong83-49 was developed in 1981 as one of theF_7 breeding lines by selections from IR24/Yuanfengzao(F_6)//Zhuke 2.After various tri-als and tests,Zhong 83-49 has been proved to be | WU Menglan ZHAO Meiling ZHUANG Jieyun MA Liangyong LI Ximing CNRRI,Hangzhou 310006,China | 1991 | Chinese Rice Research Newsletter1991，，2： | 0 |
| 13 | Benzaldehyde lyase-catalyzed enantioselective C-C bond formation and cleavage:A review显示文摘Benzaldehyde lyase(BAL)is an enzyme which was originally found from Pseudomonas fluorescens biovar I.It has long been used in the formation of a C-C bond.BAL can exclusively yield(R)-enantioselective products from the synthesis ofα-hydroxy ketones and has so far been explored as an important enzyme to prepare the corresponding intermediate of pharmaceuticals.Due to its substrate spectrum and stereospecificity,this enzyme extends the synthetic potential for carboligations appreciably.In this review,we highlight the biotransformation applications of BAL in recent years,some of which have achieved intriguing results and provided the theoretical basis for drug development and industrial purpose in the future. | Zhiran Ju Junde Xu Zhiyun Li Jingjie Fang Menglan Li Daniel C.Howell FenEr Chen | 2022 | Green Synthesis and Catalysis2022，3，4： | 0 |
| 14 | Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection显示文摘Zika virus(ZIKV)evolves non-structural proteins to evade immune response and ensure efficient replication in the host cells.Cholesterol metabolic enzyme 7-dehydrocholesterol reductase(DHCR7)was recently reported to impact innate immune responses in ZIKV infection.However,the vital non-structural protein and mechanisms involved in DHCR7-mediated viral evasion are not well elucidated.In this study,we demonstrated that ZIKV infection facilitated DHCR7 expression.Notably,the upregulated DHCR7 in turn facilitated ZIKV infection and blocking DHCR7 suppressed ZIKV infection.Mechanically,ZIKV non-structural protein 4B(NS4B)interacted with DHCR7 to induce DHCR7 expression.Moreover,DHCR7 inhibited TANK-binding kinase 1(TBK1)and interferon regulatory factor 3(IRF3)phosphorylation,which resulted in the reduction of interferon-beta(IFN-β)and interferon-stimulated genes(ISGs)productions.Therefore,we propose that ZIKV NS4B binds to DHCR7 to repress TBK1 and IRF3 activation,which in turn inhibits IFN-βand ISGs,and thereby facilitating ZIKV evasion.This study broadens the insights on how viral non-structural proteins antagonize innate immunity to facilitate viral infection via cholesterol metabolic enzymes and intermediates. | Weijie Chen Yukun Li Xiuling Yu Zhenwei Wang Wenbiao Wang Menglan Rao Yongkui Li Zhen Luo Qiwei Zhang Jinbiao Liu Jianguo Wu | 2023 | Virologica Sinica2023，38，1： | 0 |
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