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| 1 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | Study of the planar optical fiber Bragg grating hydrophone probe with acceleration compensation显示文摘自从一个平面光 FBG 水中听音器的探查加速反应,是很明显的并且在正常上有不利影响在水下声学的压力察觉,采用一项加速赔偿措施的一个加速不敏感性方法这里被介绍。结果显示由利用这个方法,相等的压力产量适用由当结构的敏感从 28 fm/Pa 减少到 20 fm/Pa 时,然而,回声频率从 6.2 kHz 稍微增加到 6.5 kHz。改进动态频率特征的增加的回声频率帮助,并且当结构的敏感被减少时,它能被补偿由改进光 FBG 动态波长讯问敏感。光 FBG 水中听音器的系统敏感被它的波长讯问敏感和并非探查结构敏感主要决定。因此,加速赔偿方法将有宽广实际应用。 | WANG Junjie DING Tengjiao JIANG Desheng XIE Guanmo HUANG Junbin | 2011 | Chinese Journal of Acoustics2011，30，2： | 1 |
| 3 | Purification and characterization of acetylcholinesterase from brain tissues of Oreochromis aurea and its application in environmental pesticide monitoring显示文摘Acetylcholinesterase(AChE)plays an important role in enzyme-based detection of pesticides in the environment.In this paper,AChE from the Triton X-100 extract of brain tissues of Oreochromis aurea was purified by(NH4)2SO4 fractional precipitation,Sephadex G-100 gel filtration,and DEAE-cellulose ion exchange chromatography.Certain biochemical characterizations of the purified enzyme and inhibition of pesticides on the enzyme were also studied.The specific activity of this purified enzyme was 20.628 U/mg protein,fold of purification was 139,and recovery was 22.1%.The optimal temperature of this enzyme was between 35-40℃,and optimal pH was between 7.5-8.0.The Michaelis constant(Km)for acetylthiocholine iodide was 0.183 mmol/L.The enzyme activity was inhibited by excess substrate,and optimal substrate concentration was 6 mmol/L.Four pesticides(di-chlorvos,phoxim,triazophos,and methomyl)exhibited strong inhibitions on this enzyme with IC50 less than 5 μg/mL.This study suggests that Oreochromis aurea(tilapia)could be a good enzyme source for pesticide monitoring in water environments. | YunHua Ding XiaoMin Wu JunBin Fang | 2011 | Research in Cold and Arid Regions2011，3，4： | 1 |
| 4 | Sm-MnO_(x)catalysts for low-temperature selective catalytic reduction of NO_(x)with NH_(3):Effect of precipitation agent显示文摘A series of Sm-Mn mixed oxide catalysts were prepared via precipitation using various precipitants,namely Na_(2)CO_(3)(NH_(4))_(2)CO_(3),and NH_(3)·H_(2)O,and evaluated for the selective catalytic reduction(SCR)of NO_(x)with NH_(3)at low temperatures.Various characterisation techniques were used to determine the physicochemical properties of the catalysts,and it is found that their catalytic performance is greatly influenced by the nature of the precipitation agent used.It is found that Sm_(0.1)Mn-Na_(2)CO_(3)and Sm_(0.1)Mn-(NH_(4))_(2)CO_(3)exhibit superior catalytic performance in the SCR reaction to that of Sm_(0.1)Mn-NH_(3)·H_(2)O due to an abundance of surface acid sites,high surface concentration of Mn^(4+),and high NO oxidation capacity.From in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFT)analysis,we conclude that the Sm-Mn catalysts follow both Eley-Rideal and Langmuir-Hinshelwood mechanisms,and that the Eley-Rideal mechanism is dominant at elevated temperatures. | Junbin Ding Xinwei Yang Aiyong Wang Can Yang Yanglong Guo Yun Guo Li Wang Wangcheng Zhan | 2022 | Journal of Rare Earths2022，40，8： | 1 |
| 5 | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys显示文摘Neurological manifestations are frequently reported in the COVID-19 patients.Neuromechanism of SARS-CoV-2 remains to be elucidated.In this study,we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19.In rhesus monkey,SARS-CoV-2 invades the CNS primarily via the olfactory bulb.Thereafter,viruses rapidly spread to functional areas of the central nervous system,such as hippocampus,thalamus,and medulla oblongata.The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons,microglia,and astrocytes in the CNS.Consistently,SARS-CoV-2 infects neuro-derived SK-N-SH,glial-derived U251,and brain microvascular endothelial cells in vitro.To our knowledge,this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model,which provides important insights into the CNS-related pathogenesis of SARS-CoV-2. | Li Jiao Yun Yang Wenhai Yu Yuan Zhao Haiting Long Jiahong Gao Kaiyun Ding Chunxia Ma Jingmei Li Siwen Zhao Haixuan Wang Haiyan Li Mengli Yang Jingwen Xu Junbin Wang Jing Yang Dexuan Kuang Fangyu Luo Xingli Qian Longjiang Xu Bin Yin Wei Liu Hongqi Liu Shuaiyao Lu Xiaozhong Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 6 | Structure-function integrated magnesium alloys and their composites显示文摘Magnesium-based materials not only exhibit desirable characteristics such as low density and high specific strength, but also possess exceptional functional properties, including high damping capacity, high thermal conductivity, high electromagnetic interference shielding capacity, flame retardancy, and dissolvability. However, achieving a balance between strength and functional properties remains a significant challenge in Mg alloys community. Typically, strength depends on the pinning effect of defects, such as solute atoms and second phases,which hinder dislocation motion. On the other hand, optimal functional properties usually necessitate relative perfect crystal structures, as the presence of solute atoms and second phases can have adverse effects on damping capacity and thermal conductivity. Balancing these conflicting requirements is difficult. The trade-off between strength and functional properties of the Mg alloys should be broken to meet the urgent need in aerospace, automotive, 3C(computers, communications, and consumer electronics) and energy industries for high performance structural-functional integrated Mg-based materials. This review summarizes recent progress in understanding the mechanisms and influencing factors for the functional properties of Mg alloys. The mechanisms underlying the trade-off between strength and functional properties of Mg alloys is discussed. The latest developed structural-functional integrated Mg alloys and their composites are summarized, including high strength Mg-based materials with high damping capacity/high thermal conductivity/strong electromagnetic shielding capability/excellent flame-resistance/high dissolution rate. The future works of developing structure-function integrated Mg-based materials are proposed. | Junbin Hou Ding Li Zejia Liu Zhikang Ji Shoufu Guan Chongchao Li Xiaoguang Qiao Igor S.Golovin Mingyi Zheng | 2023 | Journal of Magnesium and Alloys2023，11，10： | 0 |
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