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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 2 | Novel DNA vaccine based on hepatitis B virus core gene induces specific immune responses in Balb/c mice显示文摘AIM: To investigate the immunogenicity of a novel DNA vaccine,pSW3891/HBc, based on HBV core gene in Balb/c mice.METHODS: A novel DNA vaccine, pSW3891/HBc, encoding HBV core gene was constructed using a vector plasmid pSW3891. Balb/c mice were immunized with either pSW3891/HBc or empty vector DNA via gene gun. IgG anti-HBc responses in mouse sera were demonstrated by ELISA. Specific cytotoxicity of cytotoxic T lymphocytes (CTLs) of mice was quantitatively measured by lactate dehydrogenase release assay.RESULTS: HBcAg was expressed effectively in 293T cell line transiently transfected with pSW3891/HBc. Strong IgG anti-HBc responses were elicited in mice immunized with pSW3891/HBc. The end-point titers of anti-HBc reached the highest 1:97 200, 4 wk after the third immunization. The specific CTL killing with the highest specific lysis reached 73.25% at effector:target ratio of 20:1 in mice that received pSW3891/HBc DNA vaccine.CONCLUSION: pSW3891/HBc vaccination elicits specific anti-HBc response and induces HBc-specific CTL response in immunized Balb/c mice. | Yi-Ping Xing Zu-Hu Huang Shi-Xia Wang Jie Cai Jun Li Te-Hui W Chou Shan Lu | 2005 | World Journal of Gastroenterology2005，11，29： | 7 |
| 3 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 4 | Clinical outcome after management of unprotected left main in-stent restenosis after bare metal or drug-eluting stents显示文摘也的背景培植赤裸的金属 stent (BMS ) 或 drug-eluting stent (DES ) 与没有防卫的左主要狭窄(UPLMS ) 为病人在每天实践被使用了。仍然有数据 regading 的缺乏 UPLMS in-stent 狭窄(ISR ) 的随后的结果。在 stenting 被包括以后,现在的学习与 UPLMS ISR 在 BMS 或 DES.Methods 病人的培植以后在 determing 瞄准了 UPLMS ISR 病人的临床的结果。主要端点是累积主要不利心脏的事件(向) ,包括心脏的死亡,心肌的梗塞(Ml ) ,和目标容器 revascularization (TVR ).Results UPLMS ISR 率 14.8%(n=73, 15.7% 在 BMS 以后, 14.5% 为 DES ) 在以后平均(3.89 | CHEN Shao-liang XU Bo Gary Mintz YE Fei ZHANG Jun-jie KAN Jing SUN Xue-wen ZHANG Ai-ping CHEN Jin-guo QIAN Jun Kwan Tak W | 2010 | Chinese Medical Journal2010，，7： | 3 |
| 5 | Use of ADME studies to confirm the safety of ε-polylysine as a preservative in food显示文摘 | Jun Hiraki Takafumi Ichikawa Shin-ichi Ninomiya Hideaki Seki Katsumi Uohama Hiroshi Seki Shigemi Kimura Yukio Yanagimoto James W Barnett | 2003 | Regulatory Toxicology and Pharmacology2003，，2： | 2 |
| 6 | Chemical design of nanoparticle probes for high-performance magnetic resonance imaging显示文摘 | JUN Y W LEE J H CHEON J | 2008 | Angsw Chem Int Ed Engl2008，47，28： | 1 |
| 7 | Reproducing kernel particle methods 显示文摘 | LIU W K JUN S ZGABG Y F | 1995 | International Journal for Numerical Methods in Fluids1995，20，： | 1 |
| 8 | Polyolefin/Polystyrene In Situ Compatibilization Using Fridel-Crafts Alkylation 显示文摘 | Jun S Y Baker W E | 1997 | J Appl Polym Sci1997，65，： | 1 |
| 9 | Combining singu points and orientation im information for fingeqll classification 显示文摘 | Li Jun Yau Weiyan W Han | 2008 | Part Recognition2008，41，： | 1 |
| 10 | Discrimination and prediction of multiple beef freshness indexes based on electronic nose 显示文摘 | Xuezhen H Jun W Hai Z | 2012 | Sensors and Actuators B-Chemical2012，161，1： | 1 |
| 11 | The diarrhoeogenic and antidiarrhoeal bidirectional effects of rhubarb and its potential mechanism 显示文摘 | Qin Y Wang J B Jun W | 2011 | J Ethnopharmacol2011，133，3： | 1 |
| 12 | Leaching behavior of tin from Sn-Fe alloys in sodium hydroxide solutions 显示文摘 | Jun W S Yun P S Lee E C | 2004 | Hydrometallurgy2004，73，12： | 1 |
| 13 | 查看详情显示文摘 | Vishwanathan V Jun K W Kim J W Roh H S | | 0，，： | 1 |
| 14 | Carbon nanotubes and nanotube composites for nonlinear optical devices显示文摘 | Wang Jun Chen Yu Blau W J | 2009 | Journal of Materials Chemistry2009，19，40： | 1 |
| 15 | Long persistence of EV71 specific nu- cleotides in respiratory and feces samples of the patients with Hand- Foot-Mouth disease after recovery显示文摘 | Jun H XJ M JF W | 2010 | BMC Infect Dis2010，10，10： | 1 |
| 16 | Composite Branding Alliances:An Investigation of Extension and Feedback Effects显示文摘 | PARK C W JUN S Y SCHOCKER A | 1996 | Journal of Marketing Research1996，33，4： | 1 |
| 17 | Reproducing kernel Particle methods显示文摘 | LIU W K JUN S ZHANG Y F | 1995 | International Journal for Numerical Methods in Fluids1995，，20： | 1 |
| 18 | Bioinspired construction of Mg-Li alloys surfaces with stable superhydrophobicity and improved corrosion resistance 显示文摘 | Liu K S Zhang M Jin Z Jun W | 2008 | Applied Physics Letters2008，92，18： | 1 |
| 19 | Reproducing kernel particle methods for structural dynamics 显示文摘 | LUY W K JUN S Li S | 1995 | International Journal for Numerical Methods in Engineering1995，38，： | 1 |
| 20 | Combined promotional effect of CO2 and Ni on Co/Mn/Br^-catalyst in the liquid-phase oxidation of p-xylene显示文摘 | David R B Jun K W Jin S | 2002 | Catal Lett2002，81，： | 1 |
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