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| 1 | Entire hemithorax irradiation following complete resection in patients with Stage II–III invasive thymoma显示文摘 | Minoru Uematsu Hiroshi Yoshida Makoto Kondo Jun Itami Kazuo Hatano Kouichi Isobe Hisao Ito Kouichi Kobayashi Yutaka Yamaguchi Atsushi Kubo | 1996 | International Journal of Radiation Oncology Biology Physics1996，，2： | 1 |
| 2 | Long-term results of radiotherapy for intracranial germinoma: a multi-institutional retrospective review of 126 patients显示文摘 | Kazuhiko Ogawa Naoto Shikama Takafumi Toita Katsumasa Nakamura Takashi Uno Hiroshi Onishi Jun Itami Yasumasa Kakinohana Takao Kinjo Yoshihiko Yoshii Hisao Ito Sadayuki Murayama | 2004 | International Journal of Radiation Oncology, Biology, Physics2004，，3： | 1 |
| 3 | Hypofractionated Stereotactic Radiotherapy (HypoFXSRT) for Stage I Non-small Cell Lung Cancer: Updated Results of 257 Patients in a Japanese Multi-institutional Study显示文摘 | Hiroshi Onishi Hiroki Shirato Yasushi Nagata Masahiro Hiraoka Masaharu Fujino Kotaro Gomi Yuzuru Niibe Katsuyuki Karasawa Kazushige Hayakawa Yoshihiro Takai Tomoki Kimura Atsuya Takeda Atsushi Ouchi Masato Hareyama Masaki Kokubo Ryusuke Hara Jun Itami Kaz | 2007 | Journal of Thoracic Oncology ( Suppl )2007，，7： | 1 |
| 4 | Induction chemotherapy with docetaxel,cisplatin and fluorouracil followed by concurrent chemoradiotherapy for unresectable sinonasal undifferentiated carcinoma: Two cases of report显示文摘BACKGROUND Sinonasal undifferentiated carcinoma(SNUC) is a rare aggressive tumor that is often unresectable. Optimal treatment for patients with unresectable,locally advanced SNUC(LA-SNUC) has not been established,and the patient outcome remains poor. We report two cases of unresectable LA-SNUC in which induction chemotherapy with docetaxel,cisplatin and fluorouracil(TPF) followed by radiotherapy with concurrent cisplatin(CCRT),a standard treatment option for locally advanced head and neck cancer,demonstrated promising outcomes.CASE SUMMARY A 39-year-old man presented with tearing and pain in the right eye. A biopsy of the tumor invading the sinonasal cavities,right orbit and cranial base confirmed the diagnosis of LA-SNUC. Induction TPF chemotherapy induced remarkable tumor shrinkage and rapidly improved the symptoms. He subsequently received CCRT and achieved complete remission of the disease. The other case is a 21-year-old man who presented with worsening vision. The unresectable tumor involving the nasal septum and cranial base was pathologically diagnosed as SNUC. TPF chemotherapy followed by CCRT yielded complete remission of the disease with preserved visual function. Both patients have been disease-free for44 mo.CONCLUSION Induction TPF chemotherapy followed by CCRT may remarkably improve the outcomes in LA-SNUC patients. | Sho Watanabe Yoshitaka Honma Naoya Murakami Hiroshi Igaki Taisuke Mori Hidekazu Hirano Natsuko Okita Hirokazu Shoji Satoru Iwasa Atsuo Takashima Ken Kato Kenya Kobayashi Fumihiko Matsumoto Seiichi Yoshimoto Jun Itami Narikazu Boku | 2019 | World Journal of Clinical Cases2019，7，6： | 0 |
| 5 | Effects of a Single Bolus Intravenous Dose of Tramadol on Minimum Alveolar Concentration( MAC) of Sevoflurane in Dogs显示文摘Tramadol is an atypical opioid analgesic widely used in small animal practice.This study was designed to determine the effect of a single intravenous (IV) dose of tramadol on the minimum alveolar concentration (MAC) of sevoflurane in dogs.Six beagle dogs were anesthetized twice to determine the sevoflurane MAC with or without an administration of tramadol (4 mg/kg,IV) at 7-days interval.The sevoflurane MAC was determined using a tail clamp method in each dog ventilated with positive pressure ventilation.The tramadol administration produced a significant reduction in the sevoflurane MAC by 22.3 ± 12.2% (1.44 ± 0.28% with tramadol versus 1.86 ± 0.29% without tramadol,P =0.010).This MAC reduction had been determined from 122 ± 19 to 180 ± 41 min following the tramadol administration.During this period,the plasma concentrations of tramadol and its metabolite,O-desmethyltramadol (M1),decreased from 429 ± 64 to 332 ± 55 ng/mL and from 136 ± 24 to 114 ± 68 ng/mL,respectively,but these changes were not statistically significant (P = 0.070 for tramadol and P = 0.716 for M1).There was no significant difference in heart rate,mean arterial blood pressure and SpO2between the control and tramadol treatment.The dogs that received tramadol treatment sometimes breathed spontaneously.Therefore,their respiratory rates significantly increased and PETCO2decreased during the MAC determination.In conclusion,the single IV dose of tramadol produced a significant reduction in the sevoflurane MAC in dog. | Takaharu Itami Tomoohito Ishizuka Jun Tamura Sho Fukui Kenjirou Miyoshi Kazuto Yamashita | 2012 | 畜牧与兽医2012，44，S2： | 0 |
| 6 | Dose escalation of external beam radiotherapy for high-risk prostate cancerdImpact of multiple high-risk factor显示文摘Objective:To retrospectively investigate the treatment outcomes of external beam radiotherapy with androgen deprivation therapy(ADT)in high-risk prostate cancer in three radiotherapy dose groups.Methods:Between 1998 and 2013,patients with high-risk prostate cancer underwent threedimensional conformal radiotherapy or intensity-modulated radiotherapy of 66 Gy,72 Gy,or 78 Gy with ADT.Prostate-specific antigen(PSA)relapse was defined using the Phoenix definition.PSA relapse-free survival(PRFS)was evaluated in each radiotherapy dose group.Moreover,high-risk patients were divided into H-1(patients with multiple high-risk factors)and H-2(patients with a single high-risk factor)as risk subgroups.Results:Two hundred and eighty-nine patients with a median follow-up period of 77.3 months were analyzed in this study.The median duration of ADT was 10.1 months.Age,Gleason score,T stage,and radiotherapy dose influenced PRFS with statistical significance both in univariate and multivariate analyses.The 4-year PRFS rates in Group-66 Gy,Group-72 Gy and Group-78 Gy were 72.7%,81.6%and 90.3%,respectively.PRFS rates in the H-1 subgroup differed with statistical significance with an increasing radiotherapy dose having a more favorable PRFS,while PRFS rates in H-2 subgroup did not differ with increase in radiotherapy dose.Conclusion:Dose escalation for high-risk prostate cancer in combination with ADT improved PRFS.PRFS for patients in the H-1 subgroup was poor,but dose escalation in those patients was beneficial,while dose escalation in the H-2 subgroup was not proven to be effective for improving PRFS. | Rei Umezawa Koji Inaba Satoshi Nakamura Akihisa Wakita Hiroyuki Okamoto Keisuke Tsuchida Tairo Kashihara Kazuma Kobayashi Ken Harada Kana Takahashi Naoya Murakami Yoshinori Ito Hiroshi Igaki Keiichi Jingu Jun Itami | 2019 | Asian Journal of Urology2019，6，2： | 0 |
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