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219篇 您的检索式:作者名="Jun Di"
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1Current pattern of Chinese dialysis units: a cohort study in a representative sample of units显示文摘ZHOU Qiu-gen JIANG Jian-ping WU Sheng-jie TIAN Jian-wei CHEN Jiang-hua YU Xue-qing CHEN Ping-yan MEI Chang-lin XIONG Fei SHI Wei ZHOU Wei LIU Xu-sheng SUN Shi-ren XIE Di LIU Jun XU Xin HOU Fan-fan 2012Chinese Medical Journal2012,,19:69
2Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients显示文摘Background:A patient’s infectivity is determined by the presence of the virus in different body fluids,secretions,and excreta.The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease(COVID-19)remain unclear.This study analyzed the clearance time and factors influencing 2019 novel coronavirus(2019-nCoV)RNA in different samples from patients with COVID-19,providing further evidence to improve the management of patients during convalescence.Methods:The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20,2020 to February 10,2020 were collected retrospectively.The reverse transcription polymerase chain reaction(RT-PCR)results for patients’oropharyngeal swab,stool,urine,and serum samples were collected and analyzed.Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive(minimum 24 h sampling interval)negative RT-PCR results for viral RNA from oropharyngeal swabs.The effects of cluster of differentiation 4(CD4)+T lymphocytes,inflammatory indicators,and glucocorticoid treatment on viral nucleic acid clearance were analyzed.Results:In the 292 confirmed cases,66 patients recovered after treatment and were included in our study.In total,28(42.4%)women and 38 men(57.6%)with a median age of 44.0(34.0-62.0)years were analyzed.After in-hospital treatment,patients’inflammatory indicators decreased with improved clinical condition.The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5(6.0-11.0)days.By February 10,2020,11 convalescent patients(16.7%)still tested positive for viral RNA from stool specimens and the other 55 patients’stool specimens were negative for 2019-nCoV following a median duration of 11.0(9.0-16.0)days after symptom onset.Among these 55 patients,43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs,with a median delay of 2.0(1.0-4.0)days.Results for only four(6.9%)urine samples were positive for viral nucleic acid out of 58 cases;viral RNA was still present in three patients’urine specimens after throat swabs were negative.Using a multiple linear regression model(F=2.669,P=0.044,and adjusted R2=0.122),the analysis showed that the CD4+T lymphocyte count may help predict the duration of viral RNA detection in patients’stools(t=-2.699,P=0.010).The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(15 days vs.8.0 days,respectively;t=2.550,P=0.013)and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(20 days vs.11 days,respectively;t=4.631,P<0.001).There was no statistically significant difference in inflammatory indicators between patients with positive fecal viral RNA test results and those with negative results(P>0.05).Conclusions:In brief,as the clearance of viral RNA in patients’stools was delayed compared to that in oropharyngeal swabs,it is important to identify viral RNA in feces during convalescence.Because of the delayed clearance of viral RNA in the glucocorticoid treatment group,glucocorticoids are not recommended in the treatment of COVID-19,especially for mild disease.The duration of RNA detection may relate to host cell immunity.Yun Ling Shui-Bao Xu Yi-Xiao Lin Di Tian Zhao-Qin Zhu Fa-Hui Dai Fan Wu Zhi-Gang Song Wei Huang Jun Chen Bi-Jie Hu Sheng Wang En-Qiang Mao Lei Zhu Wen-Hong Zhang Hong-Zhou Lu 2020Chinese Medical Journal2020,,9:58
3BMP-6 inhibits microRNA-21 expression in breast cancer through repressing 6EF1 and AP-1显示文摘Jun Du Shuang Yang Di An Fen Hu Wei Yuan Chunli Zhai Tianhui Zhu 2009Cell Research2009,19,4:44
4Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices.Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng 2016Light(Science & Applications)2016,5,1:36
5Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human显示文摘A novel H7N9 influenza A virus has been discovered as the causative identity of the emerging acute respiratory infection cases in Shanghai,China.This virus has also been identified in cases of infection in the neighboring area Hangzhou City in Zhejiang Province.In this study,epidemiologic,clinical,and virological data from three patients in Hangzhou who were confirmed to be infected by the novel H7N9 influenza A virus were collected and analyzed.Human respiratory specimens and chicken feces from a contacted free market were tested for influenza virus by real-time reverse transcription PCR(RT-PCR) and sequencing.The clinical features of the three cases were similar featured with high fever and severe respiratory symptoms;however,only one of the patients died.A certain degree of diversity was observed among the three Hangzhou viruses sequenced from human samples compared with other reported H7N9 influenza A viruses.The sequences of the novel avian-origin H7N9 influenza viruses from Hangzhou City contained important amino acid substitutions related to human adaptation.One of the Hangzhou viruses had gained a novel amino acid substitution(Q226I) in the receptor binding region of hemagglutinin.More importantly,the virus sequenced from the chicken feces had a 627E substitution in the PB2 protein instead of the mammalian-adapted 627K substitution that was found in the PB2 proteins from the Hangzhou viruses from the three patients.Therefore,the newly-emerging H7N9 virus might be under adaptation pressure that will help it 'jump' from avian to human hosts.The significance of these substitutions needs further exploration,with both laboratory experiments and extensive field surveillance.LI Jun YU XinFen PU XiaoYing XIE Li SUN YongXiang XIAO HaiXia WANG FenJuan DIN Hua WU Ying LIU Di ZHAO GuoQiu LIU Jun PAN JingCao 2013Science China(Life Sciences)2013,56,6:32
6SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu 2016Cell Research2016,26,2:32
7Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment显示文摘Pu Li Jing-Xuan Shan Xue-Hua Chen Di Zhang Li-Ping Su Xiu-Ying Huang Bei-Qin Yu Qiao-Ming Zhi Cheng-Long Li Ya-Qing Wang Sara Tomei Qu Cai Jun Ji Jian-Fang Li Lotfi Chouchane Ying-Yan Yu Fang-Zhen Sun Zhi-Heng Xu Bing-Ya Liu Zheng-Gang Zhu 2015Cell Research2015,25,5:24
8Comparison of membrane fouling during short-term filtration of aerobic granular sludge and activated sludge显示文摘氧气的小粒的污泥被栽培采用定序批空运反应堆的内部传播。关于短期的膜在氧气的小粒的污泥系统和活性污泥系统之间犯规的对比的实验被调查。膜肮脏蚂蚁被 Fourier 变换也描绘红外线(FTIR ) 光谱学技术。结果证明氧气的小粒的污泥有优秀脱氮能力;TN 的移动效率能到达 90% 。氧气的小粒的污泥能减轻有效地犯规的膜。氧气的小粒的污泥的稳定的膜流动是两次像活性污泥系统的一样。另外,氧气的小粒的污泥能导致严重的膜,这被发现堵住毛孔然而,活性污泥能引起犯规的严重蛋糕。肮脏蚂蚁的主要部件作为蛋白质和多糖材料包括被识别。ZHOU Jun YANG Feng-lin MENG Fan-gang AN Peng WANG Di 2007Journal of Environmental Sciences2007,19,11:18
9Characteristics of elemental carbon and organic carbon in PM_(10) during spring and autumn in Chongqing,China显示文摘PM10 (particulate matter with aerodynamic diameter less than 10 m) samples were collected simultaneously at nine urban sites and one urbanbackground site during two intensive observation campaigns in 2006. Concentrations of elemental carbon (EC) and organic carbon (OC) in PM10were analyzed using an element analyzer. The characteristics regarding spatial and seasonal distribution patterns of OC and EC concentrations andtheir contributions to PM10 mass, as well as correlation between OC and EC, were investigated in detail. The average OC and EC concentrationsfor urban sites were 57.5 ± 20.8 and 8.3 ± 3.9 g/m3, respectively, both being around three times higher than those for urban background site. As awhole, EC concentrations did not show distinct seasonal variations, though OC concentrations were generally higher in autumn than in spring. Forurban sites, total carbonaceous aerosol (TCA) accounted for 33.2% in spring and 35.0% in autumn of PM10 mass. The OC and EC concentrationswere found significantly correlated to each other both in spring and in autumn, implying the existence of similar emission sources such as coalcombustion. The OC/EC ratios generally exceeded 2.0, indicating the presence of secondary organic carbon (SOC), whose estimated concentrationfor urban Chongqing was 26.7 and 39.4 g/m3, accounting for 48.9 and 61.9% of the total OC observed in the samples, in spring and in autumn,respectively.Di Ye Qi Zhao Changtan Jiang Jun Chen Xiaoxing Meng 2007China Particuology2007,5,4:17
10Two new diarylheptanoids from the pericarps of Juglans regia L.显示文摘二新周期的 diarylheptanoids juglanin A (1 ) 和 juglanin B (2 ) 从 Juglans regia L 的果皮被孤立。他们的结构被各种各样的分光镜的方法包括 2D NMR 技术阐明(舒适, HMQC, HMBC, NOESY ) 并且 HR-ESIMS。Jun Xi Liu Duo Long Di Xin Yi Huang Chen Li 2007Chinese Chemical Letters2007,18,8:14
11Inhibition of PI3K/Akt/m TOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro显示文摘The activation of the PI3K/AKT/m TOR pathway plays a key role in ovarian cancer tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the possible mechanism that PI-103, a dual inhibitor of phosphatidylinositide 3-kinase and m TOR, enhances the sensitivity of SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy. The results showed that PI-103 could significantly increase the sensitivity of SKVO3/DDP cells to cisplatin through inhibiting the activation of PI3K/Akt/m TOR signaling pathway and inducing cell cycle arrest and apoptosis.Yunlang Cai Xiaoqiang Tan Jun Liu Yang Shen Di Wu Mulan Ren Peilin Huang Dandan Yu 2014Chinese Journal of Cancer Research2014,26,5:11
12Commissioning progress of the FAST显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) was completed with its main structure installed on September 25, 2016, after which it entered the commissioning phase. This paper aims to introduce the commissioning progress of the FAST over the past two years. To improve its operational reliability and ensure effective observation time, FAST has been equipped with a real-time information system for the active reflector system and hierarchical commissioning scheme for the feed support system, which ultimately achieves safe operation of the two systems. For meeting the high-performance indices, a highprecision measurement system was set up based on the effective control methods that were implemented for the active reflector system and feed support system. Since the commissioning of the FAST, a low-frequency ultra-wideband receiver and 19-beam1.05-1.45 GHz receiver have been mainly used. Telescope efficiency, pointing accuracy, and system noise temperature were completely tested and ultimately achieved the acceptance indices of the telescope. The FAST has been in the process of national acceptance preparations and has begun to search for pulsars. In the future, it will still strive to improve its capabilities and expand its application prospects.Peng Jiang YouLing Yue HengQian Gan Rui Yao Hui Li GaoFeng Pan JingHai Sun DongJun Yu HongFei Liu NingYu Tang Lei Qian JiGuang Lu Jun Yan Bo Peng ShuXin Zhang QiMing Wang Qi Li Di Li 2019Science China(Physics,Mechanics & Astronomy)2019,62,5:11
13A de novo Genome of a Chinese Radish Cultivar显示文摘Here, we report a high-quality draft genome of a Chinese radish(Raphanus sativus) cultivar. This draft contains 387.73 Mb of assembled scaffolds, 83.93% of the scaffolds were anchored onto nine pseudochromosomes and 95.09% of 43 240 protein-coding genes were functionally annotated. 184.75 Mb(47.65%) of repeat sequences was identified in the assembled genome. By comparative analyses of the radish genome against 10 other plant genomes, 2 275 genes in 780 gene families were found unique to R. sativus. This genome is a good reference for genomic study and of great value for genetic improvement of radish.ZHANG Xiaohui YUE Zhen MEI Shiyong QIU Yang YANG Xinhua CHEN Xiaohua CHENG Feng WU Zhangyan SUN Yuyan JING Yi LIU Bo SHEN Di WANG Haiping CUI Na DUAN Yundan WU Jian WANG Jinglei GAN Caixia WANG Jun WANG Xiaowu LI Xixiang 2015Horticultural Plant Journal2015,1,3:10
14Relationship between linguistic functions and cognitive functions in a clinical study of Chinese patients with post-stroke aphasia显示文摘YU Zeng-zhi JIANG Shu-jun BI Sheng LI Jun LEI Di SUN Li-ling 2013Chinese Medical Journal2013,,7:10
15Computational and experimental analysis of Mach 2 air flow over a blunt body with plasma aerodynamic actuation显示文摘According to the mechanism of the arc plasma heating effect,and from a phenomenological perspective of view,the plasma actuation was simplified as heating energy injected into the supersonic flow field for the numerical research on controlling detached shock of the blunt body in non-center symmetrical positions.Besides,experimental research on the form and strength of detached shock wave control by plasma aerodynamic actuation in non-center symmetrical positions was conducted in a high-speed shock tunnel(M=2).The results showed that the detached distance of shock wave increased and the strength of normal shock wave ahead of the detached shock wave reduced when plasma actuation was applied.The control effect was greatly improved after the magnetic field was applied and the effect of upwind-direction flow was the best one.When the upwind-direction flow was applied with 1000 V voltage actuation,the distance of detached shock wave would increase from 3.4 to 7.6 mm and the time average strength of normal shock wave was weaken by 5.5%.At last,the mechanism of plasma actuation on controlling the detached shock wave was briefly analyzed.SUN Quan CHENG BangQin LI YingHong KONG WeiSong LI Jun ZHU YiFei JIN Di 2013Science China(Technological Sciences)2013,56,4:9
16Prevalence and drug resistance characteristics of carbapenem-resistant Enterobacteriaceae in Hangzhou, China显示文摘与在开发国家的抗菌剂代理人的滥用,增加 carbapenem 抵抗的 Enterobacteriaceae (CRE ) 的数字吸引了可观的公共担心。回顾的研究在东南中国在 Hangzhou,调查流行的中国和 CRE 的药抵抗特征从一所第三级的医院基于 242 CRE 紧张被进行。细菌的种类被识别。抗菌剂危险性被肉汤 microdilution 方法或 epsilometer 测试检验。抵抗 -lactamase 基因被聚合酶链反应识别并且定序。遗传型被种系发生的分析调查。Klebsiella pneumoniae 和 Escherichia coli 分别地是种类的最流行的类型,与在 71.9% 紧张和 21.9% 的出现。所有紧张展出了高抵抗(>70%) 对酮抗菌素, ciprofloxacin, trimethoprimsulfamethoxazole,和 nitrofurantoin 但是对 tigecycline (0.8%) 和 minocycline (8.3%) 的展出低抵抗。多于二种 -lactamase 基因怀有的 123 紧张的一个总数。 bla KPC-2 , bla SHV-11 , bla TEM-1 ,和 bla CTX-M-14 是占优势的遗传型与60.3%,61.6%,43.4%,和16.5%的察觉率,分别地,并且与在不同国家的参考序列是高度相同的,显示潜在的水平传播。IMP-4 是在这研究的最经常的班 B metallo-lactamases。在结论,连续监视和有效预防应该被强调减少 CRE 的传播。Yan Yang Jian Chen Di Lin Xujian Xu Jun Cheng Changgui Sun 2018Frontiers of Medicine2018,12,2:8
17Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations.Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu 2022Cell Research2022,32,1:8
18Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes.ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin 2018Biomedical and Environmental Sciences2018,31,6:8
19LSECtin on tumor-associated macrophages enhances breast cancer sternness via interaction with its receptor BTN3A3显示文摘Macrophages have bee n suggested to con tribute to con structing a cancer stem cell(CSC)niche.However,whether and how macrophages regulate the activity of CSCs through juxtacrine signaling are poorly understood.Here we report LSECtin,a transmembrane protein highly expressed on tumor-associated macrophages(TAMs),enhances sternness of breast cancer cells(BCCs).We identified BTN3A3,a B7 family member with previously unknown functions as the receptor for LSECtin on BCCs responsible for stemness-promoting effect of LSECtin.In mice bearing human tumor xenografts,either macrophage-specific ablation of LSECtin or silencing of BTN3A3 in BCCs decreased CSC frequency and tumor growth.Admixture of LSECtin-positive macrophages increased the tumorigenic activity of BCCs dependent on BTN3A3.Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 mAb has a therapeutic effect on breast cancer.These findings define a juxtacrine signaling mechanism by which TAMs promote cancer stemness.Targeting this axis in the CSC niche may provide potential therapies to breast cancer.Di Liu Qian Lu Xing Wang Jun Wang Ning Lu Zefei Jiang Xiaopeng Hao Jianbin Li Jing Liu Pengbo Cao Guilin Peng Yuandong Tao Dianyuan Zhao Fuchu He Li Tang 2019Cell Research2019,29,5:8
20Hexagonal boron nitride adsorbent: Synthesis, performance tailoring and applications显示文摘Hexagonal boron nitride(h-BN),with unique structural and properties,has shown enormous potentitoward variety of possible applications.By virtue of partially-ionic character of BN chemical bonds anusually large specific surface area,h-BN-related nanostructures exhibit appealing adsorption propertiewhich can be widely applied for separation and purification towards energy and environment treatmenIn this review,recent progress in designing h-BN micro,nano-structure,controlled synthesis,performancoptimizing as well as energy and environment-related adsorption applications are summarized.Strategieto tailor the h-BN can be classified as morphology control,element doping,defect control and surfacmodification,focusing on how to optimize the adsorption performance.In order to insight the intrinsimechanism of tuning strategies for property optimization,the significant adsorption applications of h-Btowards hydrogen storage,CO2 capture,pollutants removal from water and adsorption desulfurization arpresented.Jun Xiong Jun Di Wenshuai Zhu Huaming Li 2020Journal of Energy Chemistry2020,29,1:7
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