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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | Effect of Qinling granule in treatment of 102 patients with chronic hepatitis B显示文摘EfectofQinlinggranuleintreatmentof102patientswithchronichepatitisBHUANGZhengMing1,YANGXinBo1,CAOWenBin1,ZHOUYiJun2andLULi... | HUANG Zheng Ming 1, YANG Xin Bo 1, CAO Wen Bin 1, ZHOU Yi Jun 2 and LU Li Yan 2 1Department of Pharmacology, Chinese PLA Beijing Medical School, Beijing 100071, China 2Chinese PLA 184 Hospital, Yingtan 350000, Jiangxi Province, Ch | 1998 | World Journal of Gastroenterology1998，4，1： | 7 |
| 3 | Design and Simulation of Flow Field for Bone Tissue Engineering Sca old Based on Triply Periodic Minimal Surface显示文摘A novel method was proposed to design the structure of a bone tissue engineering scafold based on triply periodic minimal surface.In this method,reverse engineering software was used to reconstruct the surface from point cloud data.This method overcomes the limitations of commercially available software packages that prevent them from generating models with complex surfaces used for bone tissue engineering scafolds.Additionally,the fluid feld of the scafolds was simulated through a numerical method based on fnite volume and the cell proliferation performance was evaluated via an in vitro experiment.The cell proliferation and the mass flow evaluated in a bioreactor further verifed the flow feld simulated using computational fluid dynamics.The result of this study illustrates that the pressure value drops rapidly from 0.103 Pa to 0.011 Pa in the y-axis direction and the mass flow is unevenly distributed in the outlets.The mass flow in the side outlets is observed to be approximately 24.3 times higher thanthe bottom.Importantly,although the mean value of wall shear stress is signifcantly more than 0.05 Pa,there is stil a large area with a suitable shear stress below 0.05 Pa where most cells can proliferate well.The result shows that th inlet velocity 0.0075 m/s is suitable for cell proliferation in the scafold.This study provides an insight into the design analysis,and in vitro experiment of a bone tissue engineering scafold. | Zhen Wang Chuanzhen Huang Jun Wang Peng Wang Shisheng Bi Ch Asad Abbas | 2019 | Chinese Journal of Mechanical Engineering2019，32，2： | 2 |
| 4 | Therapeutic effects of human umbili- cal cord blood-derived mesenchymal stem cells alter intrathecal ad- ministration by lumbar puncture in a rat model of cerebral ischemia 显示文摘 | Lim JY Jeong CH Jun JA | 2011 | Stem Cell Res Ther2011，2，5： | 1 |
| 5 | A new cochlear prosthet- ic system with an implanted DSP 显示文摘 | MAI S P ZHANG CH JUN C | 2008 | Journal of Semi- conductor2008，29，9： | 1 |
| 6 | Posterior direct decompression and fusion of the lower thoracic and lumbar fractures with neurological deficit显示文摘 | Jun DS Yu CH Ahn BG | 2011 | Asian Spine J2011，5，3： | 1 |
| 7 | Barrier properties of TiN/TiSi2 bilayers formed by two-step rapid thermal conversion process for Cu diffusion barrier显示文摘 | Kim YT Jun CH Kim DY | 1999 | Thin Solid Films1999，347，2： | 1 |
| 8 | Self-assembly and guest binding of nickel ( II ) macrocyclic complex with pentyl groups and cis,cis-l,3,5-cyclohexanetricarboxylic acid显示文摘 | Ji Hye Parka Ah Rim Jeongb Jong Won Shinb Maeng Jun Jeongb Chan Sik Ch~ Kil Sik Mina | 2015 | Inorganic Chemistry Communications2015，，57： | 1 |
| 9 | Meta-analysis of the association between HLA-DRB1 allele and rheumatoid arthritis susceptibility in Asian populations 显示文摘 | Jun KR Choi SE Cha CH | 2007 | J Korean Med Sci2007，22，6： | 1 |
| 10 | ULK-Atgl3-FIP200 complexesmediate mTOR signaling to the autophagy machinery显示文摘 | Jung CH Jun CB Ro SH | 2009 | Mol Biol ce112009，20，7： | 1 |
| 11 | A new loss function-based method for multlresponse optimization 显示文摘 | Ko YH Kim KJ Jun CH | 2005 | Journal of quality technology2005，37，1： | 1 |
| 12 | AKAP12 induces apoptotic cell death in human fibrosarcoma cells by regulating CDKI-cyclin D1 and caspase-3 activity显示文摘 | Yoon DK Jeong CH Jun HO | 2007 | Cancer Lett2007，254，1： | 1 |
| 13 | ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery 显示文摘 | June CH Jun CB Ro SH | 2009 | Mol Biol Cell2009，20，7： | 1 |
| 14 | Synthesis of Cycloalkanones from Dienes and Allylamines through C H and C C Bond Activation Catalyzed by a Rhodium(I)Complex显示文摘 | Lee DY Kim IJ Jun CH | 2002 | Angew Chem Int Ed2002，41，16： | 1 |
| 15 | C-H and C-C Bond Activation of Primary Amines through Dehydrogenation and Transimination显示文摘 | Jun CH Chung KY Hong JB | 2001 | Org Lett2001，3，5： | 1 |
| 16 | Involvement of caspase-3-like protease in the mechanism oI cell death following focally evoked limbic seizures显示文摘 | David CH Jun C Roger PS | 2000 | J Neurochem2000，74，： | 1 |
| 17 | ULK- Atgl3 - FIP200 comple- xes mediate mTOR signaling to the autophagy machinery 显示文摘 | Jung CH Jun CB Ro SH | 2009 | Mol Biol Cell2009，20，7： | 1 |
| 18 | Therapeutic effects of human umbilical cord blood-derived mesenchymal stem ceils after intrathecal administration by lumbar puncture in a rat model of cerebral isch- emia 显示文摘 | Lim JY Jeong CH Jun JA | 2011 | Stem Cell Res Ther2011，2，5： | 1 |
| 19 | Digital video transcoding 显示文摘 | XIN Jun LIN Ch C W SUN Ming-ting | 2005 | Proceedings of the IEEE2005，93，1： | 1 |
| 20 | Demomtration of a magnetic and catalytic Co@Pt nanoparticle as a dual-function nanoplatform显示文摘 | CH Jun YJ Park YR Yeon | 2006 | Chem Commun2006，15，： | 1 |
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