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| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | Antenna-assisted picosecond control of nanoscale phase transition in vanadium dioxide显示文摘Nanoscale devices in which the interaction with light can be configured using external control signals hold great interest for next-generation optoelectronic circuits.Materials exhibiting a structural or electronic phase transition offer a large modulation contrast with multi-level optical switching and memory functionalities.In addition,plasmonic nanoantennas can provide an efficient enhancement mechanism for both the optically induced excitation and the readout of materials strategically positioned in their local environment.Here,we demonstrate picosecond all-optical switching of the local phase transition in plasmonic antenna-vanadium dioxide(VO_(2))hybrids,exploiting strong resonant field enhancement and selective optical pumping in plasmonic hotspots.Polarization-and wavelength-dependent pump–probe spectroscopy of multifrequency crossed antenna arrays shows that nanoscale optical switching in plasmonic hotspots does not affect neighboring antennas placed within 100 nm of the excited antennas.The antenna-assisted pumping mechanism is confirmed by numerical model calculations of the resonant,antenna-mediated local heating on a picosecond time scale.The hybrid,nanoscale excitation mechanism results in 20 times reduced switching energies and 5 times faster recovery times than a VO_(2) film without antennas,enabling fully reversible switching at over two million cycles per second and at local switching energies in the picojoule range.The hybrid solution of antennas and VO_(2) provides a conceptual framework to merge the field localization and phase-transition response,enabling precise,nanoscale optical memory functionalities. | Otto L Muskens Luca Bergamini Yudong Wang Jeffrey M Gaskell Nerea Zabala CH de Groot David W Sheel Javier Aizpurua | 2016 | Light(Science & Applications)2016，5，1： | 5 |
| 3 | Photonic gas sensors exploiting directly the optical properties of hybrid carbon nanotube localized surface plasmon structures显示文摘Weinvestigate the modification of the optical properties of carbon nanotubes(CNTs)resulting from a chemical reaction triggered by the presence of a specific compound(gaseous carbon dioxide(CO_(2)))and show this mechanism has important consequences for chemical sensing.CNTs have attracted significant research interest because they can be functionalized for a particular chemical,yielding a specific physical response which suggests many potential applications in the fields of nanotechnology and sensing.So far,however,utilizing their optical properties for this purpose has proven to be challenging.We demonstrate the use of localized surface plasmons generated on a nanostructured thin film,resembling a large array of nano-wires,to detect changes in the optical properties of the CNTs.Chemical selectivity is demonstrated using CO_(2) in gaseous form at room temperature.The demonstrated methodology results additionally in a new,electrically passive,optical sensing configuration that opens up the possibilities of using CNTs as sensors in hazardous/explosive environments. | Thomas Allsop Raz Arif Ron Neal Kyriacos Kalli Vojtěch Kundrát Aleksey Rozhin Phil Culverhouse David J Webb | 2016 | Light(Science & Applications)2016，5，1： | 3 |
| 4 | Modulators of neuronal cell death in epilepsy显示文摘 | David CH Brona MM | 2008 | Neurosciences2008，8，1： | 1 |
| 5 | Effect of atropine and/or physostigmine on cerebral acetylcholine in rats poisoned with Soman显示文摘 | Larrel WH William CH David LS | 1978 | Life Sci1978，22，10： | 1 |
| 6 | AtbZIP34 is required for Arabidopsis pollen wall patterning and the control of several metabolic pathways in developing pollen显示文摘 | Antónia Gibalová David Reňák Katarzyna Matczuk Nikoleta Dupl’áková David Cháb David Twell David Honys | 2009 | Plant Molecular Biology2009，，5： | 1 |
| 7 | Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors 显示文摘 | Michael MM David CH | 1992 | Cancer1992，69，9： | 1 |
| 8 | CT of Dry Skulls with Craniofacial Deformi ties:Accuracy of Three-Dimensional Reconstruction显示文摘 | David CH Paul LT | 1985 | Radiology1985，157，1： | 1 |
| 9 | Dual- site right ventricular and left ventricular pacing in a patient with left ventricular systolic dys- function and atrial fibrillation using a standard CRT - D device 显示文摘 | David CH Vipin K Amit H | 2013 | Journal of the Saudi Heart Association2013，25，3： | 1 |
| 10 | Type I error rates from mixed effects model repeated measures versus fixed effects ANOVAwith missing values imputed via Last Observation Carried Forward 显示文摘 | Mallinckredt CH Clark WS David SR | 2001 | Drug Information J2001，35，4： | 1 |
| 11 | Composition Dependence of the Ultraviolet Absorption Edge in Lithium Tantalate显示文摘 | David C Tunyagi A | 2003 | JApp Phys2003，93，5： | 1 |
| 12 | Propofo exerts protective effects on the acute lung injury in duced by endotoxin in rats显示文摘 | Chu CH David Liu D Hsu YH | 2007 | Pulm Pharmacol T her2007，20，5： | 1 |
| 13 | Influence of post dimension on stress distribution in dentin显示文摘 | David CH Ana MA James ML | 1996 | Prosthet Dent1996，75，2： | 1 |
| 14 | Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis 显示文摘 | Jonathan CC Darid JG David W CH | 2001 | J Mol Cell Cardiol2001，33，： | 1 |
| 15 | The comparative role of AP1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by TGFβ-1显示文摘 | Marie CH David AY Jasmine G | 2003 | J Biol Chem2003，278，10： | 1 |
| 16 | Propofol exerts protective effects on the acute lung injury induced by endotoxin in rats 显示文摘 | Chu CH David Liu D Hsu YH | 2007 | Pulm Pharmacol Ther2007，20，5： | 1 |
| 17 | Geographical and taxonomic biases in invasion ecology显示文摘 | Petr Py?ek David M. Richardson Jan Pergl Vojtěch Jaro?ík Zuzana Sixtová Ewald Weber | 2008 | Trends in Ecology & Evolution2008，，5： | 1 |
| 18 | Influence of post dimension on stress distribution in dentin显示文摘 | David CH Ana MA James ML | 1996 | Prosthet Dent1996，75，2： | 1 |
| 19 | The use of TaqMan RT - PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models显示文摘 | Andrew DM David CH Simon JR | 2000 | J Neuroscience Methods2000，98，1： | 1 |
| 20 | The Nicloas Andry Award: Comparative results of cemented and cemendess total hip arthroplasty显示文摘 | Ikorabeck CH Robert BB Mulliken BD Naresh N Andereas L Peter T David F | 1996 | Clinical Orthopaedics and Related Research1996，325，： | 1 |
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