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| 1 | Innate immunity and hepatocarcinoma:Can toll-likereceptors open the door to oncogenesis?显示文摘Hepatocarcinoma(HCC) is a highly prevalent cancer worldwide and its inflammatory background was established long ago.Recent studies have shown that innate immunity is closely related to the HCC carcinogenesis.An effective innate immunity response relies on the tolllike receptors(TLR) found in several different liver cells which,through different ligands and many signaling pathways can elicit,not only a pro-inflammatory but also an oncogenic or anti-oncogenic response.Our aim was to study the role of TLRs in the liver oncogenesis and as a consequence their value as potential therapeutic targets.We performed a systematic review of PubMed searching for original articles studying the relationship between HCC and TLRs until March 2015.TLR2 appears to be a fundamental stress-sensor as its absence reveals an augmented tendency to accumulate DNAdamages and to cell survival.However,pathways are still not fully understood as TLR2 up-regulation was also associated to enhanced tumorigenesis.TLR3 has a wellknown protective role influencing crucial processes like angiogenesis,cell growth or proliferation.TLR4 works as an interesting epithelial-mesenchymal transition's inducer and a promoter of cell survival probably inducing HCC carcinogenesis even though an anti-cancer role has already been observed.TLR9's influence on carcinogenesis is also controversial and despite a potential anticancer capacity,a pro-tumorigenic role is more likely.Genetic polymorphisms in some TLRs have been found and its influence on the risk of HCC has been reported.As therapeutic targets,TLRs are already in use and have a great potential.In conclusion,TLRs have been shown to be an interesting influence on the HCCs microenvironment,with TLR3 clearly determining an antitumour influence.TLR4 and TLR9 are considered to have a positive relationship with tumour development even though,in each of them anti-tumorigenic signals have been described.TLR2 presents a more ambiguous role,possibly depending on the stage of the inflammationHCC axis. | Jorge AndréGomes Lopes Marta Borges-Canha Pedro Pimentel-Nunes | 2016 | World Journal of Hepatology2016，8，3： | 12 |
| 2 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 3 | Long-term riskof mortality after acute kidney injury in patientswith sepsis: a contemporary analysis 显示文摘 | Lopes JA Fernandes P Jorge S | 2010 | BMC Nephrol2010，11，1： | 1 |
| 4 | The Construction Sector and Economic Development: the 'Bon curve'显示文摘 | Les Ruddock Jorge Lopes | 2006 | Construction Management and Economics2006，24，7： | 1 |
| 5 | Acute renal failure in severely burned patients显示文摘 | Lopes J A Jorge S Neves F C | 2007 | Resuscitation2007，73，2： | 1 |
| 6 | Distributed planning and control systems for the virtual enterprise: organizational requirements and development life-cycle显示文摘 | Antonio Lucas Soares Americo Lopes Azevedo Jorge Pinho de Sousa | 2000 | Journal of Intelligent Manufacturing2000，11，： | 1 |
| 7 | Acute renal failure in severely burned patients显示文摘 | Lopes J A Jorge S Neves F C | 2007 | Resuscitation2007，73，2： | 1 |
| 8 | Acute renal failure in patients with sepsis显示文摘 | Lopes JA Jorge S Resina C | 2007 | Crit Care2007，11，2： | 1 |
| 9 | Polyphenol oxidase activity, phenolic acid composition and browning in cashew apple ( Anacardium occidentale , L.) after processing显示文摘 | Christiane Queiroz Antonio Jorge Ribeiro da Silva Maria Lúcia Mendes Lopes Eliane Fialho Vera Lúcia Valente-Mesquita | 2010 | Food Chemistry2010，，1： | 1 |
| 10 | Acute renal failure in severely burned patients 显示文摘 | Lopes JA Jorge S Neves FC | 2007 | Resuscitation2007，73，2： | 1 |
| 11 | Acute kidney injury in intensive care unit patients:a comparison between the RIFLE and the Acute Kidney Injury Network classifications 显示文摘 | Lopes JA Femandes P Jorge S | 2008 | Crit Care2008，12，4： | 1 |
| 12 | The effect of etching tittle on dentin demineralization显示文摘 | Jorge Perdigao Manuela Lopes | 2001 | QuiutessenceInt2001，32，： | 1 |
| 13 | Acute renal failure in patients with sepsis显示文摘 | Lopes J A Jorge S Resina C | 2007 | Crit Care2007，11，2： | 1 |
| 14 | Contemporary analysis of the influence of acute kidney injury after reduced intensity conditioning haematopoietic celltransplantation on long-term survival 显示文摘 | Lopes JA Go tfalves S Jorge S | 2008 | Bone Marrow Transplant2008，42，9： | 1 |
| 15 | Prognostic utility of RIFLE for acute renal failure in patients with sepsis 显示文摘 | Lopes JA Jorge S Resina C | 2007 | Crit Care2007，11，2： | 1 |
| 16 | Acute kidney injury in intensive care unit patients:a comparison between the RIFLE and the Acute Kidney Injury Network classifications显示文摘 | Lopes JA Femandes P Jorge S Gon(c)alves S Alvarez A Costa e Silva Z | | 0，，： | 1 |
| 17 | Acute kidney injury in intensive care unit patients:a comparison between the RIFLE and the Acute Kidney Injury Network classifications显示文摘 | Lopes J A Fernandes P Jorge S | | 0，，04： | 1 |
| 18 | Sepsis as a major determinant of outcome incritically ill HIV/AIDS patients: don’ I forget acute kidney injury显示文摘 | Lopes JA Jorge S | 2012 | Crit Care2012，16，6： | 1 |
| 19 | Posterior reversi- ble encephalopathy syndrome (PRES) and chronic kidney disease 显示文摘 | Jorge S Lopes J A De Almeida E | 2007 | Nefrologia2007，27，5： | 1 |
| 20 | Seismic Resistance of Earth Construction in Portugal显示文摘 | Maria Idália Gomes Mário Lopes Jorge de Brito | | 0，，33： | 1 |
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