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| 1 | Predisposing factors for positive D-Xylose breath test for evaluation of small intestinal bacterial overgrowth:A retrospective study of 932 patients显示文摘AIM: To investigate, in the largest cohort to date, patient characteristics and associated risk factors for developing small intestinal bacterial overgrowth(SIBO) using the D-Xylose breath test(XBT).METHODS: We performed a retrospective crosssectional study to analyze patient characteristics who underwent the XBT for evaluation of SIBO. Diagnostic testing with the XBT was performed based on a clinical suspicion for SIBO in patients with symptoms of bloating, abdominal pain, abdominal distension, weight loss, diarrhea, and/or constipation. Consecutive electronicmedical records of 932 patients who completed the XBT at the University of Florida between 2005 and 2009 were reviewed. A two-way Analysis of Variance(ANOVA) was used to test for several associations including age, gender, and body mass index(BMI) with a +XBT. A two-way ANOVA was also performed to control for the differences and interaction with age and between genders. A similar analysis was repeated for BMI. Associations between medical conditions and prior surgical histories were conducted using the Mantel-Haenszel method for 2 by 2 contingency tables, stratified for gender. Reported odds ratio estimates reflect the odds of the prevalence of a condition within the +XBT group to that of the-XBT group. P values of less than 0.05(two-sided) were considered statistically significant.RESULTS: In the 932 consecutive eligible subjects studied, 513 had a positive XBT. A positive association was found between female gender and a positive XBT(P = 0.0025), and females with a positive test were, on average, greater than 5 years older than those with a negative test(P = 0.024). The mean BMI of positive XBT subjects was normal(24.5) and significantly lower than the subjects with a negative XBT(29.5)(P = 0.0050). A positive XBT was associated with gastroesophageal reflux disease(GERD)(OR = 1.35; 95%CI: 1.02-1.80, P = 0.04), peptic ulcer disease(PUD)(OR = 2.61; 95%CI: 1.48-4.59, P < 0.01), gastroparesis(GP)(OR = 2.04; 95%CI: 1.21-3.41, P < 0.01) and steroid use(OR = 1.35; 95%CI: 1.02-1.80, P = 0.01). Irritable bowel syndrome, independent protonpump inhibitor(PPI) usage, or previous abdominal surgery was not significantly associated with a positive XBT. No single subdivision by gender or PPI use was associated with a significant difference in the odds ratios between any of the subsets. CONCLUSION: Female gender, lower BMI, steroid use, PUD, GERD(independent of PPI use), and GP were more prevalent in patients with SIBO, determined by a positive XBT. Increasing age was associated with SIBO in females, but not in males. | Richard A Schatz Qing Zhang Nilesh Lodhia Jonathan Shuster Phillip P Toskes Baharak Moshiree | 2015 | World Journal of Gastroenterology2015，21，15： | 4 |
| 2 | “双盲、安慰剂对照交叉设计研究植物药对于进食量、饱腹感、体重减轻及氧化应激的影响”的研究方案(英文)显示文摘背景:植物性治疗药物作为一种重要且尚未被完全开发的药用资源,可能有助于热量控制从而产生长期的减重功效。从藤黄果(Garcinia combogia Desr.)中提取的羟基柠檬酸可能通过影响与饱腹有关的神经通路而减少摄食量和减轻体重。方法与设计:本研究为双盲、安慰剂对照、交叉设计试验,共计划纳入48名超重或肥胖的健康受试者(体重指数25.0~39.9 kg/m^2,年龄50~70岁),研究两种剂量藤黄果来源的羟基柠檬酸对摄食量、饱腹感、体重减轻及氧化应激水平的影响。摄食量作为主要结局指标,根据受试者在测量日的早餐、午餐和晚餐的摄食量计算。与平行设计的研究相比,本研究所使用的受试者数量将大大减少。讨论:本研究选择藤黄果来源的羟基柠檬酸为研究对象是因为该药物能够安全地减少摄食量、减轻体重和降低氧化应激水平。我们将会在研究过程中探讨其可能的作用机制和安全指标。 | Stephen D.Anton Jonathan Shuster Christiaan Leeuwenburgh | 2011 | 中西医结合学报2011，9，11： | 2 |
| 3 | Fibril formation of 1,3 : 2,4-di (3,4-dimethylbenzylidene) sorbitol in a polypropylene melt 显示文摘 | Jonathan Lipp Michael Shuster Ann E Terry | 2006 | Langmuir2006，22，14： | 1 |
| 4 | The Effects of Varying Local Anesthetic Concentration and Volume on Continuous Popliteal Sciatic Nerve Blocks: A Dual-Center, Randomized, Controlled Study显示文摘 | Brian M. Ilfeld Vanessa J. Loland J C. Gerancher Anupama N. Wadhwa Elizabeth M. Renehan Daniel I. Sessler Jonathan J. Shuster Douglas W. Theriaque Rosalita C. Maldonado Edward R. Mariano | 2008 | Anesthesia & Analgesia2008，，2： | 1 |
| 5 | The spectrum of pyruvate dehydrogenase complex deficiency: Clinical, biochemical and genetic features in 371 patients显示文摘 | Kavi P. Patel Thomas W. O’Brien Sankarasubramon H. Subramony Jonathan Shuster Peter W. Stacpoole | 2012 | Molecular Genetics and Metabolism2012，，3： | 1 |
| 6 | The spectrum of pyruvate dehydrogenase complex deficiency: Clinical, biochemical and genetic features in 371 patients显示文摘 | Kavi P. Patel Thomas W. O’Brien Sankarasubramon H. Subramony Jonathan Shuster Peter W. Stacpoole | 2011 | Molecular Genetics and Metabolism2011，，1： | 1 |
| 7 | CC genotype donors for the interleukin‐28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant显示文摘 | Roberto J. Firpi Huijia Dong Virginia C. Clark Consuelo Soldevila‐Pico Giuseppe Morelli Roniel Cabrera Oxana Norkina Jonathan J. Shuster David R. Nelson Chen Liu | 2012 | Liver Int2012，，1： | 1 |
| 8 | 局部麻醉药浓度和剂量对持续锁骨下神经阻滞的影响:一项多中心、随机、单盲、对照研究显示文摘背景目前尚不明确局部麻醉药浓度或药物总剂量是否是连续外周神经阻滞效果最主要的决定性因素。此前仅有一项关于胭窝坐骨神经阻滞的研究,该研究报道了使用高容量较低浓度罗哌卡因发生肢体感觉完全阻滞的概率远远高于低容量较高浓度罗哌卡因,但上述现象是否仅限于腘窝处的坐骨神经,或者说是否因解剖部位变化而异尚不清楚。因此,本研究的检验假设定为:在连续锁骨下臂丛阻滞中,以不同的浓度和速率注射总量相等的罗哌卡因,可以产生相似的阻滞效果。方法选择拟行肘关节远端、中等疼痛骨科手术患者,经喙突入路放置锁骨下臂丛阻滞导管。患者经随机分组确定手术后第2天应用罗哌卡因神经周围镇痛的方法:浓度0.2%组(背景剂量8ml/h,单次追加量4ml)或0.4%组(背景剂量4ml/h,单次追加量2ml)。两组患者每小时持续注入罗哌卡因的总量均为16mg,每30分钟可能还有患者自控的追加剂量8mg。主要观察指标为自手术后次日早晨开始的24小时内患侧肢体完全无感觉的发生率,次要观察指标是镇痛效果和患者的满意度。结果给予0.4%罗哌卡因(n=27)的患者发生肢体无感觉的平均次数(标准差)为1.8(1.6)次,而给予0.2%罗哌卡因(n=23)的患者为0.6(0.9),评估差异为1.2次,95%可信区间0.5~1.9次(P=0.001)。手术后镇痛满意度(评分0—10分,10分为最高分)在0.2%罗哌卡因组得分的中位数(25%~75%百分位数)为10.0分(8.0~10.0),0.4%罗哌卡因组为7.0分(5.3~8.9)。镇痛效果两组相近。结论在连续锁骨下神经阻滞时,除了注射局麻药物总量之外,药物的浓度和容量是另两种影响神经周围镇痛辫果的因素。容量偏小而浓度略高的罗哌卡因产生肢体完全无感觉的概率较高,这一结果与此前关于连续胭窝坐骨神经阻滞的研究结果相反。局麻药浓度与容量之间的关系相当复杂,且随置管部位的不同而异。 | Brian M. Ilfeld Linda T. Le Joanne Ramjohn Vanessa J. Loland Anupama N. Wadhwa J. C. Gerancher Elizabeth M. Renehan Daniel I. Sessler Jonathan J. Shuster Douglas W. Theriaque Rosalita C. Maldonado Edward R. Mariano 周璐璐(译) 包睿(译) 邓小明(校) | 2010 | 麻醉与镇痛2010，，1： | 0 |
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