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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Selective electrochemical production of hydrogen peroxide at zigzag edges of exfoliated molybdenum telluride nanoflakes显示文摘The two-electron reduction of molecular oxygen represents an effective strategy to enable the green,mild and on-demand synthesis of hydrogen peroxide.Its practical viability,however,hinges on the development of advanced electrocatalysts,preferably composed of non-precious elements,to selectively expedite this reaction,particularly in acidic medium.Our study here introduces 2H-MoTe2 for the first time as the efficient non-precious-metal-based electrocatalyst for the electrochemical production ofhydrogen peroxide in acids.We show that exfoliated 2H-MoTe2 nanoflakes have high activity(onset overpotential〜140 mV and large mass activity of 27 A g^-1 at 0.4 V versus reversible hydrogen electrode),great selectivity(H2O2 percentage up to 93%)and decent stability in 0.5 M H2SO4.Theoretical simulations evidence that the high activity and selectivity of 2H-MoTe2 arise from the proper binding energies of HOO*and O*at its zigzag edges that jointly favor the two-electron reduction instead of the four-electron reduction of molecular oxygen. | Xuan Zhao Yu Wang Yunli Da Xinxia Wang Tingting Wang Mingquan Xu Xiaoyun He Wu Zhou Yafei Li Jonathan NColeman Yanguang Li | 2020 | National Science Review2020，7，8： | 3 |
| 3 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 4 | Comparison of cocaine and lignocaine as intranasal local anaesthetics显示文摘 | Jonathan DA Violaris NS | 1988 | J Laryngol Otol1988，1，7： | 1 |
| 5 | Endorectal Advancement Flap显示文摘 | Nelly Mizrahi Steven D. Wexner Oded Zmora Giovanna Da Silva Jonathan Efron Eric G. Weiss Anthony M. Vernava Juan J. Nogueras | 2002 | Diseases of the Colon & Rectum2002，，12： | 1 |
| 6 | Inflammatory markers,adiponectin, and risk of type 2 diabetes in the pima indian 显示文摘 | Jonathan Krakoff Tohru Funahashi Cone DA | 2003 | Diabetes Care2003，26，4： | 1 |
| 7 | Wolfe Estimation of the incidence of stroke using a capture - recapture model including covariates显示文摘 | Kate TiUing Jonathan AC Sterne Charles DA | 2001 | Int J Epidemiol2001，30，： | 1 |
| 8 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 1 |
| 9 | Risk of worsening renal function with nesiritide in patients with acutly decompensated heart failure 显示文摘 | Jonathan SB Hal AS Keith DA | 2005 | Circulation2005，111，： | 1 |
| 10 | Sonotubometry:its role in childhood glue ear显示文摘 | Jonathan DA | 1989 | Clin Otolaryngol Allied Sci1989，14，2： | 1 |
| 11 | Comparison of hear ing thresholds obtained with Baha preoperative assessment tools and those obtained with the osseointegrated implant显示文摘 | Heywood RL Patel PM Jonathan DA | 2011 | Ear Nose Throat J2011，90，： | 1 |
| 12 | Comparison of cocaine and lignocaine as intranasal local anesthesia显示文摘 | Jonathan DA Violaris NS | 1988 | J Zaryngol Otol1988，102，7： | 1 |
| 13 | Practical cost-based approach for the voltage ancillary service显示文摘 | Edson Luiz da Silva Jonathan J Hedgecock | 2001 | IEEE Trans on PWRS2001，16，4： | 1 |
| 14 | Biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium Propionibacterium acnes显示文摘 | Richard DA Jonathan AZ Daniel KY | 2011 | NewBiotechnol2011，28，1： | 1 |
| 15 | Risk of worsening renal function with nesiritide in patients with acuty decompensated heart failure显示文摘 | Jonathan SB Hal AS Keith DA | 2005 | Circulation2005，111，12： | 1 |
| 16 | Injury-elicited differential transcriptional regulation of phospholipid growth factor receptors in the cornea 显示文摘 | Wang DA Du HM Jonathan H | 2002 | Am J Physiol cell Physiol2002，283，： | 1 |
| 17 | Risk of worsening renal function with nesiritide in patients with acutly decompensated heart failure显示文摘 | Jonathan SB Hal AS Keith DA | 2005 | Circulation2005，111，： | 1 |
| 18 | Risk of worsening renal function with nesiritide in patients with acute decompensated heart failure显示文摘 | Jonathan SB Hal AS Keith DA | | 0，，12： | 1 |
| 19 | Comparing different domains of analysis for the characterisation of N-glycans on monoclonal antibodies显示文摘With the size of the biopharmaceutical market exponentially increasing,there is an aligned growth in the importance of data-rich analyses,not only to assess drug product safety but also to assist drug development driven by the deeper understanding of structure/function relationships.In monoclonal antibodies,many functions are regulated by N-glycans present in the constant region of the heavy chains and their mechanisms of action are not completely known.The importance of their function focuses analytical research efforts on the development of robust,accurate and fast methods to support drug development and quality control.Released N-glycan analysis is considered as the gold standard for glycosylation characterisation;however,it is not the only method for quantitative analysis of glycoform heterogeneity.In this study,ten different analytical workflows for N-glycan analysis were compared using four monoclonal antibodies.While observing good comparability between the quantitative results generated,it was possible to appreciate the advantages and disadvantages of each technique and to summarise all the observations to guide the choice of the most appropriate analytical workflow according to application and the desired depth of data generated. | Sara Carillo Raquel Peerez-Robles Craig Jakes Meire Ribeiro da Silva Silvia Millan Martín Amy Farrell Natalia Navas Jonathan Bones | 2020 | Journal of Pharmaceutical Analysis2020，10，1： | 1 |
| 20 | Crohn's disease and clinical management today:How it does?显示文摘Crohn’s Disease(CD)is an Inflammatory Bowel Disease and is characterized by an immune-mediated nature.Its etiology results from the interaction between genetic,enviromental and microbial factors.Regarding pathophysiology,it involves high levels of interleukin(IL)-12,IL-17,and Th1 profile,along with loss of tolerance mechanisms,an increase in pro-inflammatory interleukins,beyond the possibility to affect any part of the gastrointestinal tract.Its symptoms include abdominal pain,chronic diarrhea,weight loss,anorexia,and fatigue,as well as blood in the stool or rectum.Additionally,conditions comprising musculoskeletal,cutaneous,ocular,hepatic,and hematological alterations may be associated with this scenario and extra-intestinal presentation,such as erythema nodosum,anterior uveitis,osteoporosis,and arthritis can also occur.Today,clinical history,exams as fecal calprotectin,ileocolonocopy,and capsule endoscopy can be performed in the diagnosis investigation,along with treatments to induce and maintain remission.In this sense,anti-inflammatory drugs,such as corticosteroids,immunomodulators,and biological agents,as well as surgery and non-pharmacological interventions plays a role in its therapy.The aim of this review is to bring more current evidence to clinical management of CD,as well as to briefly discuss aspects of its pathophysiology,surveillance,and associated disorders. | Ronaldo Teixeira da Silva Júnior Jonathan Santos Apolonio Jessica Oliveira de Souza Nascimento Bruna Teixeira da Costa Luciano Hasimoto Malheiro Marcel Silva Luz Lorena Sousa de Carvalho Cleiton da SilvaSantos Fabrício Freire de Melo | 2023 | World Journal of Methodology2023，13，5： | 0 |
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