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| 1 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 2 | New endoscopic approaches in IBD显示文摘Recent advances in endoscopic imaging techniques have revolutionized the diagnostic approach of patients with inflammatory bowel disease(IBD).New,emerging endoscopic imaging techniques visualized a plethora of new mucosal details even at the cellular and subcellular level.This review offers an overview about new endoscopic techniques,including chromoendoscopy,magnification endoscopy,spectroscopy,confocal laser endomicroscopy and endocytoscopy in the face of IBD. | Helmut Neumann Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 3 | First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy显示文摘We present the case of a 53-year-old woman with long-standing ulcerative colitis and severe, steroid-dependent disease course unresponsive to treatment with azathioprine, methotrexate, anti-TNF antibodies(infliximab, adalimumab) and tacrolimus, who refused colectomy as a therapeutic option. As the pro-inflammatory cytokine interleukin-6(IL-6) had been identified as a crucial regulator in the immunopathogenesis of inflammatory bowel diseases, we treated the patient with biweekly intravenous infusions of an anti-IL-6R antibody(tocilizumab) for 12 wk. However, no clinical improvement of disease activity was noted. In fact, endoscopic, histological and endomicroscopic assessment demonstrated exacerbation of mucosal inflammation and ulcer formation upon anti-IL-6R therapy. Mechanistic studies revealed that tocilizumab treatment failed to suppress intestinal IL-6 production, impaired epithelial barrier function and induced production of pro-inflammatory cytokines such as TNF, IL-21 and IFN-γ. Inhibition of IL-6 by tocilizumab had no clinical benefit in this patient with intractable ulcerative colitis and even led to exacerbation of mucosal inflammation. Our findings suggest that anti-IL-6R antibody therapy may leadto aggravation of anti-TNF resistant ulcerative colitis. When targeting IL-6, the differential responsiveness of target cells has to be taken into account, as IL-6 on the one side promotes acute and chronic mucosal inflammation via soluble IL-6R signaling but on the other side also strongly contributes to epithelial cell survival via membrane bound IL-6R signaling. | Raja Atreya Ulrike Billmeier Timo Rath Jonas Mudter Michael Vieth Helmut Neumann Markus F Neurath | 2015 | World Journal of Gastroenterology2015，21，45： | 5 |
| 4 | 当前围手术期处理模式:北欧五国结直肠外科医生调查显示文摘 | Kristoffer Lassen Pascal Hannemann Olle Ljungqvist Ken Fearon Cornelis H C Dejong Maarten F von Meyenfeldt Jonatan Hausel Jonas Nygren Jens Andersen Arthur Revhaug 王东 | 2005 | 英国医学杂志中文版2005，8，6： | 3 |
| 5 | Anti-CD18 attenuates deleterious effects of cardio-pulmonary bypass and hypothermic circulatory arrest in piglets显示文摘 | Aoki M Jonas RA Nomura F | 1995 | J Card Surg1995，10，： | 1 |
| 6 | Surface effects in metal microclusters显示文摘 | Jiang P Jona F Marcus P M | 1987 | Phys Rev1987，36，： | 1 |
| 7 | Poly (3,4-ethylenedioxythiophene) and its derivatives:Past,present,and future显示文摘 | Groenendaal B L Jonas F Freitag D | 2000 | Adv Mater2000，12，： | 1 |
| 8 | 显示文摘 | Groenend B L Jonas F Freitage D | 2000 | Adv Mater2000，12，： | 1 |
| 9 | Monitoring glaucoma progression with visual evoked potentials of the blue-sensitive pathway显示文摘 | HORN F K JONAS J B BUDDE W M | 2002 | Invest Ophthalmol Vis Sci2002，43，6： | 1 |
| 10 | Finlay Microbial interactions in the mycorrhizosphere and their significance for sustainable agriculture显示文摘 | Jonas F Johansson Leslie R | 2004 | FEMS Microbiology Ecology2004，48，： | 1 |
| 11 | Jackson & Schuler revisited: A meta-analysis of the relationshipsbe- tween role ambiguity, role conflict and job performance显示文摘 | ALEXANDER T Mohr JONAS F Puck | 2006 | Journal of Management2006，26，2： | 1 |
| 12 | Design of a surveillance system of antibiotic use and bacterial resistance in German intensivecare units(SARI)显示文摘 | Meyer E Jonas D Schwab F | 2003 | Infection2003，31，4： | 1 |
| 13 | Comprehensive approach to modeling and simulation of photovohaic arrays 显示文摘 | MARCELO G V JONAS R G ERNESTO R F | 2009 | IEEE Transactions on Power Electronics2009，24，5： | 1 |
| 14 | Current issues in recrystallization:a review显示文摘 | DOHERTY R D HUGHES D A HUMPHREYS F J JONAS J J JENSEN D J KASSNER M E KING W E MCNELLEY T R MCQUEEN H J ROLLETT A D | 1997 | Materials Science and Engineering A1997，238，1： | 1 |
| 15 | Comprehensive approach to modeling and simulation of photovoltaic arrays显示文摘 | Marcelo G V Jonas R G Ernesto R F | 2009 | IEEE transactions on power electronics2009，24，5： | 1 |
| 16 | Filtering of high modal frequencies for stable real-time explicit integration of deformable objects using finite element method显示文摘 | IKER A BASIL F JONAS S | | 0，，2： | 1 |
| 17 | 显示文摘 | Groenendal B L Jonas F Freitage D | 2004 | Adv Mater2004，12，： | 1 |
| 18 | 显示文摘 | Groenendaal L Jonas F Freitag D | 2000 | Adv Mater2000，12，： | 1 |
| 19 | A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model 显示文摘 | Henderson WR Jr Tang LO Chu SJ Tsao SM Chiang GK Jones F Jonas M Pae C Wang H Chi EY | 2002 | Am J Respir Crit Care Med2002，165，1： | 1 |
| 20 | Technical applications for conductive polymers显示文摘 | Jonas F Heywang G | | 0，，8： | 1 |
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