|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 宏观经济水资源规划多目标决策分析方法研究及应用显示文摘本文是将区域水资源规划纳入到宏观经济/环境系统中,应用多目标技术进行整体研究,使决策者可通过宏观经济水资源规划多目标决策分析模型的操作和运行,看到在不同策略下区域宏观经济、环境等目标与水资源规划关系的全貌.在该方法研究中,作者完成了这一方法的软件编制和开发工作,实现了决策分析过程的计算机化。 | 翁文斌 蔡喜明 史慧斌 王浩 米柯森(ARI M.MICHELSEN) 巴格(JONA BARGUR) | 1995 | 水利学报1995，27，2： | 73 |
| 2 | 地表自然过程排汞研究进展及展望显示文摘地表自然过程排汞包括了自然源排汞过程和先前排放的汞沉降到地表后的再排放过程。已有证据显示,地表自然过程向大气的排汞量可能远大于人为活动直接向大气的排汞量。准确确定自然过程汞的释放通量,不仅对正确评价目前减少人为活动向大气排汞对全球环境汞污染的影响程度具有重要的意义,而且可为全球大气汞的减排政策的制定提供重要科学理论依据。本综述通过对国内外地表自然排放源相关文献的调研分析发现:由于缺少可靠的观测技术、对地表与大气间汞交换过程和机理的准确认识及大气汞沉降对地表自然排汞过程影响的认识还不清楚,因此目前还难以准确估算地表自然过程向大气的排汞量。近年来,随着技术手段的进步,已具备了开展地表自然排汞及先前排汞沉降后的再释放过程、机理和通量研究的可行性。地表自然过程排汞的研究将是汞的生物地球化学循环演化研究领域的前沿之一。 | 冯新斌 付学吾 SOMMAR Jonas LIN Jery 商立海 仇广乐 | 2011 | 生态学杂志2011，30，5： | 15 |
| 3 | Alveolar echinococcosis-spreading disease challenging clinicians: A case report and literature review显示文摘Human alveolar echinococcosis (AE) is a potentially deadly disease; recent studies have shown that the endemic area of Echinococcus multilocularis , its causative agent, is larger than previously known. This disease has low prevalence and remains underreported in Europe. Emerging clinical data show that diagnostic difficulties are still common. We report on a 76-year old patient suffering from AE lesions restricted to the left lobe of the liver who underwent a curative extended left hemihepatectomy. Prior to the resection a liver biopsy under the suspicion of an atypical malignancy was performed. After the intervention he developed a pseudoaneurysm of the hepatic artery that was successfully coiled. Surprisingly, during surgery, the macroscopic appearance of the tumour revealed a growth pattern that was rather typical for cystic echinococcosis (CE), i.e. , a gross tumour composed of multiple large vesicles with several centimeters in diameter. In addition, there were neither extensive adhesions nor infiltrations of the neighboring pancreas and diaphragm as was expected from previous imaging results. The unexpected diagnosis of AE was confirmed by definite histopathology, specific polymerase chain reaction and serology results. This is a rare case of unusual macroscopic presentation of AE that posed immense diagnostic challenges and had an eventful course. To our knowledge this is the first case of an autochthonous infection in this particular geographic area of Germany, the federal state of Saxony. This report may provide new hints for an expanding area of risk for AE and emphasizes the risk of complications in the scope of diagnostic procedures and the limitations of modern radiological imaging. | Georgi Atanasov Christoph Benckert Armin Thelen Dennis Tappe Matthias Frosch Dieter Teichmann Thomas FE Barth Christian Wittekind Stefan Schubert Sven Jonas | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 4 | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth显示文摘AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.METHODS: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western blots.RESULTS: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined treatment.CONCLUSION: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus. | Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 5 | Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature显示文摘Xanthogranulomatous 胆汁(XGC ) 是胆囊的破坏煽动性的疾病,很少包含邻近的机关并且模仿国王先进胆囊癌。诊断在病理学的检查以后仅仅通常是可能的。46 42 岁的女人被指我们包含肝核,正确的肝脑叶,恰好结肠的弯曲,和十二指肠的怀疑的胆囊癌症的中心。刷细胞学获得了由内视镜后退胆管造影术(ERC ) 出现了高级发育异常。病人经历了团的在团体切除术,由正确叶切除术,正确的半结肠切除术,和部分十二指肠的切除术组成。出人意料地揭示的病理学的检查一 XGC.Only,为有邻近的机关的直接参与的 XGC 的扩大外科的切除术的六个案例到目前为止被报导了。在这些情况中,与癌给 XGC 的可能的共存,恶意不能被排除,甚至在细胞学和 intraoperative 冰冻切片调查以后。在结论,由于源于在另外的方面上包围机关的高度好攻击的煽动性的侵略的一个方面和可能的复杂并发症上的胆囊癌的差的预后,它似乎这些案例应该被当作恶性瘤直到不那样证明。临床医生们应该包括 XGC 在之中可能微分在肝核群众诊断。 | Antonino Spinelli Guido Schumacher Andreas Pascher Enrique Lopez-Hanninen Hussain Al-Abadi Christoph Benckert Igor M Sauer Johann Pratschke Ulf P Neumann Sven Jonas Jan M Langrehr Peter Neuhaus | 2006 | World Journal of Gastroenterology2006，12，14： | 13 |
| 6 | 复合材料薄板在低速冲击下的破坏分析:试验和数值方法显示文摘在冲击荷载作用下,复合层压板破坏过程中有很多并发现象,因此,复合层压板的动力性能十分复杂。当采用复合材料结构时,对于接触和较大的位移导致的纤维破坏、分层、模具破裂、塑性变形应给予重视。对碳纤维环氧树脂加固的层压复合薄板进行低速冲击下的研究。采用荷载时间序列、位移时间序列、能量时间序列以及来自NDE的图像,分析叠加系列和能量响应的影响。当层压复合薄板受到低速外来目标的冲击时,由压痕试验结果与动力学的结果比较,验证了迟滞效应。采用希尔模型和ABAQUS软件中由UMAT补充的材料模型,通过有限元分析以模拟压痕试验的破坏机制。 | Volnei Tita Jonas de Carvalho Dirk Vandepitte | 2008 | 钢结构2008，23，9： | 12 |
| 7 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 8 | Exchange flux of total gaseous mercury between air and natural water surfaces in summer season显示文摘The exchanges of mercury between surface and air are of significance in the biogeochemical cycling of Hg in the environment, but there are still few reliable data on air/surface exchange in aquatic systems. Field measurement campaigns over seawater surface at Kristineberg Marine Research Station (KMRS) and over Hovg?rds?n River surface at Knobesholm in southwestern Sweden were conducted to measure mercury flux using a dynamic flux chamber technique coupled with automatic mercury vapor-phase analyzers. Both sites show net emissions during summer time. Mercury fluxes measured over both river and seawater surfaces exhibit a consistently diurnal pattern with maximum fluxes during the daytime period and minimum fluxes during the nighttime period. At freshwater site, mercury flux is strongly correlated with the intensity of net solar radiation, and negatively correlated with relative humidity. A typical exponential relationship between mercury flux and water temperature was observed at freshwater measurement site. At seawater site, a strong correlation between mercury flux and intensity of solar radiation was obtained. The driving force of mercury emission from water surface to air is the super-saturation of dissolved gaseous mercury in aqueous phase. | 冯新斌 Jonas Sommar Katarina Grdfeldt OliverLindqvist | 2002 | Science China Earth Sciences2002，45，3： | 10 |
| 9 | 斯德哥尔摩的拥挤收费政策——政策实施5年后的效果、接受度及经验启示显示文摘根据2006年拥挤收费政策试运行结束后的公民投票结果,2007年,斯德哥尔摩正式实施了该政策。讨论了其至2011年6月首个5年内的政策实施效果。结果表明,受到外部因素影响,由收费引起的交通减少量随时间推移稍有增加。2008年的清洁汽车免税措施可显著提高销售量。结合最新研究成果和瑞典的经验,讨论了公众接受度和政治接受度。得到的结论是:拥挤收费对交通系统的主客观影响,以及环境和政治态度,是公众支持拥挤收费的基础;同时,为了获得政治支持,必须要进行体制改革、解决权力问题。最后,简要讨论了拥挤收费的实施对瑞典交通规划进程的可能影响。 | Maria Brjesson Jonas Eliasson Muriel B.Hugsson Karin Brundell-Freij 刘莹 蔡静 | 2012 | 城市交通2012，10，2： | 10 |
| 10 | Defining the advantages and exposing the limitations of endoscopic variceal ligation in controlling acute bleeding and achieving complete variceal eradication显示文摘BACKGROUND Bleeding esophageal varices(BEV)is a potentially life-threatening complication in patients with portal hypertension with mortality rates as high as 25%within six weeks of the index variceal bleed.After control of the initial bleeding episode patients should enter a long-term surveillance program with endoscopic intervention combined with non-selectiveβ-blockers to prevent further bleeding and eradicate EV.AIM To assess the efficacy of endoscopic variceal ligation(EVL)in controlling acute variceal bleeding,preventing variceal recurrence and rebleeding and achieving complete eradication of esophageal varices(EV)in patients who present with BEV.METHODS A prospectively documented single-center database was used to retrospectively identify all patients with BEV who were treated with EVL between 2000 and 2018.Control of acute bleeding,variceal recurrence,rebleeding,eradication and survival were analyzed using Baveno assessment criteria.RESULTS One hundred and forty patients(100 men,40 women;mean age 50 years;range,21-84 years;Child-Pugh grade A=32;B=48;C=60)underwent 160 emergency and 298 elective EVL interventions during a total of 928 endoscopy sessions.One hundred and fourteen(81%)of the 140 patients had variceal bleeding that was effectively controlled during the index banding procedure and never bled again from EV,while 26(19%)patients had complicated and refractory variceal bleeding.EVL controlled the acute sentinel variceal bleed during the first endoscopic intervention in 134 of 140 patients(95.7%).Six patients required balloon tamponade for control and 4 other patients rebled in hospital.Overall 5-d endoscopic failure to control variceal bleeding was 7.1%(n=10)and four patients required a salvage transjugular intrahepatic portosystemic shunt.Index admission mortality was 14.2%(n=20).EV were completely eradicated in 50 of 111 patients(45%)who survived>3 mo of whom 31 recurred and 3 rebled.Sixteen(13.3%)of 120 surviving patients subsequently had 21 EV rebleeding episodes and 10 patients bled from other sources after discharge from hospital.Overall rebleeding from all sources after 2 years was 21.7%(n=26).Sixty-nine(49.3%)of the 140 patients died,mainly due to liver failure(n=46)during follow-up.Cumulative survival for the 140 patients was 71.4%at 1 year,65%at 3 years,60%at 5 years and 52.1%at 10 years.CONCLUSION EVL was highly effective in controlling the sentinel variceal bleed with an overall 5-day failure to control bleeding of 7.1%.Although repeated EVL achieved complete variceal eradication in less than half of patients with BEV,of whom 62%recurred,there was a significant reduction in subsequent rebleeding. | Jake Krige Eduard Jonas Urda Kotze Christo Kloppers Karan Gandhi Hisham Allam Marc Bernon Sean Burmeister Mashiko Setshedi | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，10： | 10 |
| 11 | Structure and evolution of the continental margin off Norway and the Barents Sea显示文摘 | Jan Inge Faleide Filippos Tsikalas AsbjФrn Breivik Rolf Mjelde Oliver Ritzmann Фyvind Engen Jonas Wilson Olav Eldholm | 2008 | Episodes2008，31，1： | 8 |
| 12 | Ambulatory blood-pressure monitoring, antihypertensive therapy and the risk of fall injuries in elderly hypertensive patients显示文摘BackgroundFall 损害是普通的在之中老。这研究的目的是调查是否血压模式由 24-h 测量了监视的回廊血压( ABPM ),或跟随 24-h ABPM 的 antihypertensive 治疗的增强,可以在高血压的老 patients.MethodsIn 与秋天损害被联系回顾的研究,是的基于社区的老病人(年龄 70 年)指了 24-h ABPM 在一个年 post-ABPM 以内为秋天损害被评估。我们比较了临床的特征, 24-h ABPM 模式和高血压的治疗追随者 24-h ABPM 的增强,在有或没有秋天 injury.ResultsOverall 的病人之间 1032 个高血压的老病人被评估。(5.3%) 55 在跟随 ABPM 的一年有一个秋天损害事件。有秋天损害的病人显著地更老,并且与以前的下降的更高的率。更低的 24-h 心脏舒张的血压(到 2014 年 12 月的 67.3 2011 年 1 月) , 1164 个病人作为有尖锐大动脉的解剖被识别。corr?? | Michael Jonas Rasisa Kazarski Gil Chemin | 2018 | Journal of Geriatric Cardiology2018，15，4： | 8 |
| 13 | 长蛸对几个环境因子的耐受能力及栖息习性研究显示文摘研究了长蛸成体的栖息习性及对水体环境的盐度、温度、pH的耐受能力。通过设置红砖搭穴、瓦片搭穴、石块搭穴和白塑料管作为长蛸的隐蔽场所,使用控温电热棒和冰袋调温并保持水温,用NaOH和HCl调节水体的pH值,加食盐或淡水调配水体的盐度。试验结果表明,长蛸喜栖于砖、瓦、石块下,以瓦片为最佳隐蔽场所;喜欢泥质底,有钻泥打洞现象;适宜盐度为16.3-27.3,最适盐度为18.3-24.3;适宜温度为10-31℃,最适温度为12-27℃;适宜pH为6.2-9.7,最适为6.7-9.2。 | Jonas Wiza Ng’ambi 陈武 王春琳 张晓梅 李来国 徐军超 | 2010 | 水产科学2010，29，2： | 8 |
| 14 | Progression of diabetic retinopathy: the Beijing Eye Study显示文摘当在工作人口 worldwide.This 学习的视觉缺陷和盲目的一个领先的原因试图估计频率并且在北京眼睛学习是的基于人口的 setting.Methods 在题目把医生的前进的因素与已知的糖尿病联系了,背景糖尿病的 retinopathy (医生)出现了基于的学习在更大的北京执行了的一张人口在在场的 2001 和 2006 .The ,调查在 2001 与已知的糖尿病 mellitus 包括了所有题目,参予了后续 e ( 30 ) 51 使遭到在 2001 显示出医生的症状并且是在 2006,36 的 re-examined ( 21.2 )使遭到(与在基线在场的医生一起的 18 个题目,与在 2006 的最新诊断的医生一起的 18 个题目)在 follow-up.Progression 期间显示出医生的前进医生与农村区域被联系(机会比率(或): 5.43 , P0.001 )并且自我报导的动脉的高血压( OR:3.85 , P0.023 ) .In 非进步的亚群,医生的存在与教育的不同层次被联系(中学,中学,学院或更高, OR:0. | TU Ying XU Liang WEI Wen-bin WANG Shuang WANG Ya-xing Jost B Jonas | 2011 | Chinese Medical Journal2011，，22： | 7 |
| 15 | Recent results of laparoscopic surgery in inflammatory bowel disease显示文摘Inflammatory bowel diseases are an ideal indication for the laparoscopic surgical approach as they are basically benign diseases not requiring lymphadenectomy and extended mesenteric excision;well-established surgical procedures are available for the conventional approach.Inflammatory alterations and fragility of the bowel and mesentery,however,may demand a high level of laparoscopic experience.A broad spectrum of operations from the rather easy enterostomy formation for anal Crohn’s disease(CD)to restorative proctocolectomies for ulcerative colitis(UC)may be managed laparoscopically.The current evidence base for the use of laparoscopic techniques in the surgical therapy of inflammatory bowel diseases is presented.CD limited to the terminal ileum has become a common indication for laparoscopic surgical therapy.In severe anal CD, laparoscopic stoma formation is a standard procedure with low morbidity and short operative time.Studies comparing conventional and laparoscopic bowel resections,have found shorter times to first postoperative bowel movements and shorter hospital stays as well as lower complication rates in favour of the laparoscopic approach.Even complicated cases with previous surgery,abscess formation and enteric fistulas may be op-erated on laparoscopically with a low morbidity.In UC, restorative proctocolectomy is the standard procedure in elective surgery.The demanding laparoscopic approach is increasingly used,however,mainly in major centers; its feasibility has been proven in various studies.An increased body mass index and acute inflammation of the bowel may be relative contraindications.Short and longterm outcomes like quality of life seem to be equivalent for open and laparoscopic surgery.Multiple studies have proven that the laparoscopic approach to CD and UC is a safe and successful alternative for selected patients. The appropriate selection criteria are still under investigation.Technical considerations are playing an important role for the complexity of both diseases. | Hermann Kessler Jonas Mudter Werner Hohenberger | 2011 | World Journal of Gastroenterology2011，17，9： | 7 |
| 16 | Evidence or eminence in abdominal surgery: Recent improvements in perioperative care显示文摘Repeated surveys from Europe, the United States, Australia, and New Zealand have shown that adherence to an evidence-based perioperative care protocol, such as Enhanced Recovery After Surgery(ERAS), has been generally low. It is of great importance to support the implementation of the ERAS protocol as it has been shown to improve outcomes after a number of surgical procedures, including major abdominal surgery. However, despite an increasing awareness of the importance of structured perioperative management, the implementation of this complex protocol has been slow. Barriers to implementation involve both patient- and staff-related factors as well as practice-related issues and resources. To support efficient and successful implementation, further educational and structural measures have to be made on a national or regional level to improve the standard of general health care. Besides postoperative morbidity, biological and physiological variables have been quite commonly reported in previous ERAS studies. Little information, however, has been obtained on cost-effectiveness, long-term outcomes, quality of life and patient-related outcomes, and these issues remain important areas of research for future studies. | Josefin Segelman Jonas Nygren | 2014 | World Journal of Gastroenterology2014，20，44： | 7 |
| 17 | Robot impedance control and passivity analysis with inner torque and velocity feedback loops显示文摘阻抗控制是一种生长得很好的技术在机器人学控制相互作用力量。然而,有一个内部环的阻抗控制的真实实现可以受不了几限制。特别地,稳定的僵硬的可行范围和抑制的值能被内部控制环的带宽强烈影响(例如,一个转矩环) 象由过滤和采样频率一样。这份报纸提供这些方面怎么象系统的被动一样影响阻抗参数的稳定性区域的广泛的分析。这将被模拟和试验性的数据支持。而且,为基于一个内部转矩环设计联合阻抗控制器的方法论和一个积极速度反馈环将被介绍。速度反馈的目标是增加(给限制保存稳定性) 没有一个复杂控制器的需要的转矩环的带宽。 | Michele FOCCHI Gustavo A. MEDRANO-CERDA Thiago BOAVENTURA Marco FRIGERIO Claudio SEMINI Jonas BUCHLI Darwin G. CALDWELL | 2016 | Control Theory and Technology2016，14，2： | 6 |
| 18 | 跨筛板压力差与青光眼相关关系的研究:邯郸眼病研究显示文摘目的评价中国农村成年人群估算跨筛板压力差(TLCPD)与青光眼视神经损害的相关关系。设计以人群为基础的横断面研究。研究对象中国农村30岁及以上成年人群。方法对邯郸眼病研究I期6830例30岁以上受试者进行问卷、全身及眼部检查和血液、尿液实验室检查。眼科检查包括:视力检查、验光、裂隙灯检查、眼压、视野、晶状体、眼底检查、散瞳下眼底视神经立体照相,眼部A超,HRT-Ⅱ等。利用HRT-Ⅱ获得视盘的全周参数;引入非侵入测量颅内压(CSFP)研究得出的CSFP估算公式:CSFP(mmHg)=0.44×体质指数(BMI)(kg/m^2)+0.16×舒张压(DBP)(mmHg)-18×年龄(岁)-1.91。TLCPD:眼压-估算的CSFP。单因素及多因素分析分析非青光眼人群及原发性开角型青光眼(POAG)人群中估算筛板压力差、估算CSFP与全身系统及眼部参数的相关关系;评价该人群青光眼患病或青光眼特征性视神经损害定量参数与筛板压力差的关系。主要指标POAG及原发性闭角型青光眼(PACG)患者估算CSFP,估算TLCPD。结果 6450人(87.5%)的血压、身高、体重数据可用于数据分析。原发性开角型青光眼(POAG)组及非青光眼组相比,POAG组估算CSFP明显偏低,眼压、估算TLCPD明显偏高(P<0.001)。多因素分析中,校准其他混杂因素,POAG患病分别与较高的TLCPD(P<0.001;β:0.08;B:4.12;95%CI:2.24,6.02)、较低的估算CSFP(P=0.01;β:-0.05;B:-2.37;95%CI:-4.23,-0.51)显著相关。将TLCPD与眼压置于同一模型中,POAG患病与TLCPD增高显著相关(P<0.001;OR:1.290;95%CI:1.204,1.383),而非眼压(P=0.321);盘沿面积与TLCPD相关(P=0.028;β:-0.034;B:-0.003;95%CI:-0.005^-0.000),眼压被剔除(P=0.398);原发性闭角型青光眼(PACG)患病与眼压显著相关(P=0.02;OR:1.38;95%CI:1.05,1.71),而非TLCPD(P=0.46)。结论与PACG相比,TLCPD与POAG患病及视神经损害的关联强于眼压。这表明较低的CSFP在POAG发病机制中可能起到重要作用。 | 张青 王宁利 Jonas Jost B. 杨一佺 王亚星 梁远波 王凤华 杨迪亚 解晓斌 | 2016 | 眼科2016，25，4： | 6 |
| 19 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 20 | New endoscopic approaches in IBD显示文摘Recent advances in endoscopic imaging techniques have revolutionized the diagnostic approach of patients with inflammatory bowel disease(IBD).New,emerging endoscopic imaging techniques visualized a plethora of new mucosal details even at the cellular and subcellular level.This review offers an overview about new endoscopic techniques,including chromoendoscopy,magnification endoscopy,spectroscopy,confocal laser endomicroscopy and endocytoscopy in the face of IBD. | Helmut Neumann Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员