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| 1 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 2 | Integrated approach to colorectal anastomotic leakage: Communication, infection and healing disturbances显示文摘Colorectal anastomotic leakage(CAL) remains a major complication after colorectal surgery. Despite all efforts during the last decades, the incidence of CAL has not decreased. In this review, we summarize the available strategies regarding prevention, prediction and intervention of CAL and categorize them into three categories: communication, infection and healing disturbances. These three major factors actively interact during the onset of CAL. We aim to provide an integrated approach to CAL based on its etiology. The intraoperative air leak test, intraoperative endoscopy, radiological examinations and stoma construction mainly aim to detect and to prevent communication between the intra- and extra-luminal content. Other strategies including postoperative drainage, antibiotics, and infectious-parameter evaluation are intended to detect and prevent anastomotic or peritoneal infection. Most currently available interventions for CAL focus on the control of communication and infection, while strategies targeting the healing disturbances such as lifestyle changes, oxygen therapy and evaluation of metabolic biomarkers still lack wide clinical application. This simplified categorization may contribute to an integrated understanding of CAL. We strongly believe that this integrated approach should be taken into consideration during clinical practice. An integrated approach to CAL could contribute to a better understanding of the etiology of CAL and eventually better patient outcome. | Cloe L Sparreboom Zhou-Qiao Wu Jia-Fu Ji Johan F Lange | 2016 | World Journal of Gastroenterology2016，22，32： | 9 |
| 3 | Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study显示文摘 | Toru Furukawa Günter Kl?ppel N. Volkan Adsay Jorge Albores-Saavedra Noriyoshi Fukushima Akira Horii Ralph H. Hruban Yo Kato David S. Klimstra Daniel S. Longnecker Jutta Lüttges G. Johan A. Offerhaus Michio Shimizu Makoto Sunamura Arief Suriawinata Kyoichi | 2005 | Virchows Archiv2005，，5： | 3 |
| 4 | 瑞典东南部一个人工景观镶嵌体内集水区的碳收支:有助于一个核废料埋藏点的安全评估显示文摘生态系统的物质收支有助于评价一个景观中可与生物体结合的污染物质的运输和累积,因为物质和能量流动最终决定环境中污染物质分配的速率。本研究比较生态系统的性质,如净初级生产量(NPP)、物质接收和进入到人类食物源的通量,这对于描述瑞典东南部的一个较大集水区域内14个集水区中可与生物体结合的放射性核素的通量和累积可能是重要的。作为有机物质的一个替代变量,碳收支主要基于碳库和通量的局地估计,这些值已通过地理信息系统(GIS),分配于一个具有不同植被类型和管理体制的景观镶嵌体中。净初级生产量以一个接近于2的因子而变化(432~709g C/m^2·a),而生态系统净生产量因集水区不同而在-124~159g C/m^2·a之间变化。碳接受主要发生于植被,而土壤有机碳库基本是碳源。大型食草动物平均消费地上部分绿色组织生产量的4.5%。当集水区存在耕地时,从农作物进入到人类的碳通量最高,按递减顺序,接着是来自于牛奶和牛肉的通量,然后是来自于打猎和浆果/真菌采摘的通量。这些结果可用于估计植被对放射性核素的潜在吸收情况,以及可与生物体结合的放射性核素对人类的潜在暴露水平。 | Anders Lfgren Sofia Miliander Johan Truvé Tobias Lindborg 马爱进 | 2006 | AMBIO-人类环境杂志2006，35，8： | 2 |
| 5 | Methodology for pharmacokinetic/pharmacodynemic data analysis显示文摘 | Johan L Gabrielsson Daniel L Weiner | 1999 | PSTT1999，2，： | 1 |
| 6 | Invasive aspergillosis in the Inten-sive Care Unit显示文摘 | Wouter M Katrien L Johan M | 2007 | Clinical Infectious Diseases 120072007，，： | 1 |
| 7 | Lensed fiber-array assembly with individu- al fiber fine positioning in the submicrometer range 显示文摘 | Johan H C van Zantvoort Simon G L Plukker Erwin C A Dekkers | 2006 | IEEE Selected Topics in Quantum Electronics2006，12，05： | 1 |
| 8 | Decreasing Time-Trends of Colorectal Cancer in a Large Cohort of Patients With Inflammatory Bowel Disease显示文摘 | Sverre S?derlund Lena Brandt Annika Lapidus Per Karlén Olle Brostr?m Robert L?fberg Anders Ekbom Johan Askling | 2009 | Gastroenterology2009，，5： | 1 |
| 9 | Antifungal effect of dairy propi- onibacteria-contribution of organic acids 显示文摘 | Helen L Hans J Johan S | 2005 | International Journal of Food Microbiology2005，98，： | 1 |
| 10 | The endoxylanases from family 11: computer analysis of protein sequences reveals important structural and phylogenetic relationships显示文摘 | Amalia S Johan W Christophe L | 2002 | Journal of Biotechnology2002，95，2： | 1 |
| 11 | Neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS)显示文摘 | Johan L Dikken Johanna W van Sandick HA Maurits Swellengrebel | | 0，，： | 1 |
| 12 | Effect of Ag particle size on electrical conductivity of isotropically conductive adhesives 显示文摘 | Lilei Y Zonghe L Johan L | 1999 | Electronics Packaging Manufacturing IEEE Transactions on1999，22，4： | 1 |
| 13 | Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27 显示文摘 | JOHANE G HERMAN L JACQUES H | 1997 | J Cell Sci- ence1997，110，3： | 1 |
| 14 | Vitreous:a barrier to nonviral ocular gene therapy显示文摘 | Peeters L Sanders NN Braeckmans K Boussery K Johan Voorde VD Smedt SC | | 0，，10： | 1 |
| 15 | A renewable lignin-lactide copolymer and application in biobased compo- sites显示文摘 | Yi Linchung Johan V O Russell J L | 2013 | Sustainable Chemistry Engineering2013，1，10： | 1 |
| 16 | 瑞典中部法伦地区1000年铜生产对环境的影响显示文摘瑞典中部的法伦地区在铜生产过程中向大气中排放二氧化硫(SO_2)和金属的历史至少有1000年。在17世纪,排放达到高峰,当时,法伦地区铜产量占世界铜供应量的2/3。因此,该地区为研究酸沉降和金属污染的长期效应,包括随后3个世纪降低二氧化硫排放和金属沉降的恢复提供了一个难得的机会。本文对当地二氧化硫的排放进行了1000年的回顾,估算了二氧化硫的大气浓度和干沉降,及对土壤和湖泊的酸化和金属污染。尽管长期以来二氧化硫的沉降超过了临界负荷,但土壤酸化仅局限于矿区西北和东南12km污染最严重的范围内。根据湖泊沉积物中的硅藻分析,14个湖泊中仅有8个为酸化型(0.4~0.8 pH单位)。可能是由于大量的硫酸盐仍然累积在土壤中,以及土地利用方式发生了变化,这些湖泊目前仍处于酸化状态。 | Anna S.Ek Stefan Lfgren Johan Bergholm Ulf Qvarfort 晏维金 | 2001 | AMBIO-人类环境杂志2001，30，2： | 1 |
| 17 | DNA methylation and diet in cancer显示文摘 | Johanning G L Heimburger D C Piyathilake C J | 2002 | J Nutr2002，132，12： | 1 |
| 18 | Sacral and presacral tumor:problems in diagnosis and management显示文摘 | Johan AF James L McGauley | 1989 | Neuro Surgery1989，25，6： | 1 |
| 19 | An electrorheological study on the behavior of water-in-crude oil emulsions under influence of a DC electric field and different flow conditions 显示文摘 | Simone L Andreas H Johan S | 2008 | Journal of Dispersion Science and Technology2008，29，： | 1 |
| 20 | Wavelet-based power quantification approaches 显示文摘 | Johan L J Driesen Ronnie J M Belmans | 2003 | IEEE Transactions on Power Delivery2003，52，4： | 1 |
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