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| 1 | Allodynia limits the usefulness of intraspinal neural stem cell grafts,directed differentiation improves outcome显示文摘 | Christoph PH Niklas AV Johan AL | 2005 | Nature Neuroscience2005，8，： | 1 |
| 2 | Identification, Cloning, and Expression of the Scytalidium acidophilum XYL1 Gene Encoding for an Acidophilic Xylanase 显示文摘 | Ballaa Bassam AL Wouters Johan Dogne Sophie | 2006 | Biosci Biotechnol Biochem2006，70，1： | 1 |
| 3 | An aggregatepublic health indicator to represent the impact ofmultiple environmental exposures 显示文摘 | Augustinus E M Johan M M Erik L e t al | 1999 | Epidemiology1999，10，： | 1 |
| 4 | Chemometries in metabonomics 显示文摘 | Johan T Elaine H Torbjorn L el al | 2007 | Protenome2007，6，： | 1 |
| 5 | lnhalational nickel earbonyl poisoning in wast processing workers 显示文摘 | SEET R C JOHAN A TEO C E el al | 2005 | Chest2005，128，1： | 1 |
| 6 | International Results with the Boston Type I Keratoprosthesis显示文摘 | Anthony J. Aldave Virender S. Sangwan Sayan Basu Samar K. Basak Anna Hovakimyan Ofelya Gevorgyan Soliman Al Kharashi Mohanna Al Jindan Radhika Tandon Jeena Mascarenhas Boris Malyugin Ma. Dominga B. Padilla Quresh Maskati Nisheeta Agarwala Johan Hutauruk M | 2012 | Ophthalmology2012，，8： | 1 |
| 7 | Water-incrude oil emulsion from the norwegian continental shelf显示文摘 | JOHAN S LI Ming-yuan AL FRED A C | 1995 | Colloids and Surfaces1995，96，： | 1 |
| 8 | Inte-grating Water Management and SpatialPlanning 显示文摘 | Woltjer Johan and Al Niels | 2007 | the American PlanningAssociations2007，，： | 1 |
| 9 | Reassessment of historical sections from the Paleogene marine margin of the Congo Basin reveals an almost complete absence of Danian deposits显示文摘The early Paleogene is critical for understanding global biodiversity patterns in modern ecosystems. During this interval, Southern Hemisphere continents were largely characterized by isolation and faunal endemism following the breakup of Gondwana. Africa has been proposed as an important source area for the origin of several marine vertebrate groups but its Paleogene record is poorly sampled, especially from sub-Saharan Africa. To document the early Paleogene marine ecosystems of Central Africa, we revised the stratigraphic context of sedimentary deposits from three fossil-rich vertebrate localities: the Landana section in the Cabinda exclave(Angola), and the Manzadi and Bololo localities in western Democratic Republic of Congo.We provide more refined age constraints for these three localities based on invertebrate and vertebrate faunas, foraminiferal and dinoflagellate cyst assemblages, and carbon isotope records. We find an almost complete absence of Danian-aged rocks in the Landana section, contrary to prevailing interpretations over the last half a century(only the layer 1, at the base of the section, seems to be Danian). Refining the age of these Paleocene layers is crucial for analyzing fish evolution in a global framework, with implications for the early appearance of Scombridae(tunas and mackerels) and Tetraodontiformes(puffer fishes). The combination of vertebrate fossil records from Manzadi and Landana sections suggests important environmental changes around the K/Pg transition characterized by an important modification of the ichthyofauna. A small faunal shift may have occurred during the Selandian. More dramatic is the distinct decrease in overall richness that lasts from the Selandian to the Ypresian. The Lutetian of West Central Africa is characterized by the first appearance of numerous cartilaginous and bony fishes. Our analysis of the ichthyofauna moreover indicates two periods of faunal exchanges: one during the Paleocene, where Central Africa appears to have been a source for the European marine fauna, and another during the Eocene when Europe was the source of the Central Africa fauna. These data indicate that Central Africa has had connections with the Tethyian realm. | Floréal Solé Corentin Noiret Delphine Desmares Sylvain Adnet Louis Taverne Thierry De Putter Florias Mees Johan Yans Thomas Steeman Stephen Louwye Annelise Folie Nancy J.Stevens Gregg F.Gunnell Daniel Baudet Nicole Kitambala Yaya Thierry Smith | 2019 | Geoscience Frontiers2019，10，3： | 0 |
| 10 | Statins markedly potentiate aminopeptidase inhibitor activity against(drug-resistant)human acute myeloid leukemia cells显示文摘Aim: This study aimed to decipher the molecular mechanism underlying the synergistic effect of inhibitors of the mevalonate-cholesterol pathway (i.e., statins) and aminopeptidase inhibitors (APis) on APi-sensitive and -resistant acute myeloid leukemia (AML) cells.Methods: U937 cells and their sublines with low and high levels of acquired resistance to (6S)-[(R)-2-((S)-Hydroxy-hydroxycarbamoyl-methoxy-methyl)-4-methyl-pentanoylamino]-3,3 dimethyl-butyric acid cyclopentyl ester (CHR2863), an APi prodrug, served as main AML cell line models. Drug combination effects were assessed with CHR2863 and in vitro non-toxic concentrations of various statins upon cell growth inhibition, cell cycle effects, and apoptosis induction. Mechanistic studies involved analysis of Rheb prenylation required for mTOR activation.Results: A strong synergy of CHR2863 with the statins simvastatin, fluvastatin, lovastatin, and pravastatin was demonstrated in U937 cells and two CHR2863-resistant sublines. This potent synergy between simvastatin and CHR2863 was also observed with a series of other human AML cell lines (e.g., THP1, MV4-11, and KG1), but not with acute lymphocytic leukemia or multiple solid tumor cell lines. This synergistic activity was: (i) specific for APis (e.g., CHR2863 and Bestatin), rather than for other cytotoxic agents;and (ii) corroborated by enhanced induction of apoptosis and cell cycle arrest which increased the sub-G1 fraction. Consistently, statin potentiation of CHR2863 activity was abrogated by co-administration of mevalonate and/or farnesyl pyrophosphate, suggesting the involvement of protein prenylation;this was experimentally confirmed by impaired Rheb prenylation by simvastatin.Conclusion: These novel findings suggest that the combined inhibitory effect of impaired Rheb prenylation and CHR2863-dependent mTOR inhibition instigates a potent synergistic inhibition of statins and APis on human AML cells. | Gerrit Jansen Marjon Al Yehuda G.Assaraf Sarah Kammerer Johan van Meerloo Gert J.Ossenkoppele Jacqueline Cloos Godefridus J.Peters | 2023 | Cancer Drug Resistance2023，6，3： | 0 |
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