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| 1 | Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration显示文摘In this review,we summarise the evidence for a role of the ribonuclease angiogenin in the pathophysiology of neurodegenerative disorders,with a specific focus on Parkinson’s disease(PD).Angiogenin is a stress-induced,secreted ribonuclease with both nuclear and cytosolic activities.Loss-of-function mutations in the angiogenin gene(ANG)have been initially discovered in familial cases of amyotrophic lateral sclerosis(ALS),however,variants in ANG have subsequently been identified in PD and Alzheimer’s disease.Delivery of angiogenin protein reduces neurodegeneration and delays disease progression in in vitro and in vivo models of ALS and in vitro models of PD.In the nucleus,angiogenin promotes ribosomal RNA transcription.Under stress conditions,angiogenin also translocates to the cytosol where it cleaves non-coding RNA into RNA fragments,in particular transfer RNAs(tRNAs).Stress-induced tRNA fragments have been proposed to have multiple cellular functions,including inhibition of ribosome biogenesis,inhibition of protein translation and inhibition of apoptosis.We will discuss recent evidence of tRNA fragment accumulation in PD,as well as their potential neuroprotective activities. | Jochen H M Prehn Elisabeth Jirstrom | 2020 | Acta Pharmacologica Sinica2020，41，4： | 2 |
| 2 | Converting an Esterase into an Epoxide Hydrolase 显示文摘 | Jochens H Stiba K Savile C | 2009 | Angew Chem Int Ed Engl2009，48，19： | 1 |
| 3 | Thermostabilization of an esterase by alignment-guided focused directed evolution显示文摘 | Jochens H Aerts D Bornscheuer U T | 2010 | Protein Engineering Design and Selection2010，23，12： | 1 |
| 4 | Hurz Reliability considerations of NDT by probability of detection (POD) determination u- sing ultrasound phased array显示文摘 | JOCHEN H | 2013 | Engineering Failure Analysis2013，5，： | 1 |
| 5 | Improvements of AE technique using wavelet algorithms,coherence functions and automatic data analysis显示文摘 | Christian U Grosse Florian Finck Jochen H Kurz | 2004 | Construction and Building Materials2004，18，： | 1 |
| 6 | High intensity ultrasound-assisted extraction of oil from soybeans显示文摘 | Li H Z Lestcr P Jochen W | 2004 | Food Research International2004，37，7： | 1 |
| 7 | The alpha/beta- hydrolase fold 3DM database (ABHDB) as a tool for protein engineering显示文摘 | Kourist R Jochens H Bartsch S | 2010 | Chembiochem2010，11，12： | 1 |
| 8 | Protein engineering of α/β-hydrolase fold enzymes显示文摘 | Jochens H Hesseler M Stiba K | 2011 | Chembiochem2011，12，10： | 1 |
| 9 | Tryptophan N-glucoside in fruits and fruit juices显示文摘 | Stefanie D Jochen B Markus H | | 0，，10： | 1 |
| 10 | Probabilistic failure assessment of ferritic steels using the master curve approach including constraint effects显示文摘 | Jorg H Jochen H Valérie F | 2007 | Engineering Fracture Mechanics2007，74，： | 1 |
| 11 | Is serological testing tool in la boratory diagnosis of syphilis? Meta-an~ilysis of eight external quality control surveys performed by the Germany infection serol ogy proficiency testing program显示文摘 | Muller I Brade V Jochen H | 2006 | Clinical Microbiology2006，44，4： | 1 |
| 12 | Tregs in infection and vaccinology: Heroesor traitors 显示文摘 | Luciana B Franz P Jochen H | 2012 | Microb Biotechnol2012，5，3： | 1 |
| 13 | Eosinophilic gastroenteritis mimicking idiopathic hypertrophic pyloric stenosis显示文摘 | Barbara H. Hümmer-Ehret W. K. Rohrschneider Krystina Oleszczuk-Raschke Kassa Darge Walter Nützenadel Jochen Tr?ger | 1998 | Pediatric Radiology1998，，： | 1 |
| 14 | Systemic Spread Is an Early Step in Breast Cancer显示文摘 | Yves Hüsemann Jochen B. Geigl Falk Schubert Piero Musiani Manfred Meyer Elke Burghart Guido Forni Roland Eils Tanja Fehm Gert Riethmüller Christoph A. Klein | 2008 | Cancer Cell2008，，1： | 1 |
| 15 | A Proposal to Measure Antimatter Gravity Using Ultracold Antihydrogen Atoms显示文摘 | Jochen Walz Theodor W. H?nsch | 2004 | General Relativity and Gravitation2004，，3： | 1 |
| 16 | Rational assignment of key motifs for function guides in silico enzyme identification显示文摘 | Hohne M Schatzle S Jochens H | 2010 | Nat Chem Biol2010，6，11： | 1 |
| 17 | Wind and wave field measurements using marine X-band radar-image sequences显示文摘 | H eiko Dankert Jochen Horstmann Wolfgang Rosenthal | 2005 | IEEE Joural of Oceanic engineering2005，30，3： | 1 |
| 18 | Safety culture by crm training experiences from 2 trainings and German hospital simulation in healthcare显示文摘 | Wolfgang H Stefan M Jochen V | | 0，，03： | 1 |
| 19 | Analysis of toxic alkaloids in body samples 显示文摘 | JOCHEN B OLAF H D HANS H M | 2009 | Forensic Science International2009，185，： | 1 |
| 20 | The proline 12 alanine substitution in the peroxisome proliferator-activated receptor gamma gene is associated with lower lipoprotein lipase activity in vivo显示文摘 | Jochen S Joerg K Andreas H | 2002 | Diabetes2002，51，： | 1 |
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