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| 1 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 2 | Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain显示文摘Inflammatory orofacial pain,in which substance P (SP) plays an important role,is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs).SGC activation is emerging as the key mechanism underlying inflammatory pain through different signalling mechanisms,including glial fibrillary acidic protein (GFAP) activation,phosphorylation of mitogen-activated protein kinase (MAPK) signalling pathways,and cytokine upregulation.However,in the TG,the mechanism underlying SP-mediated orofacial pain generated by SGCs is largely unknown.In this study,we investigated whether SP is involved in inflammatory orofacial pain by upregulating interleukin (IL)-1β and tumour necrosis factor (TNF)-α from SGCs,and we explored whether MAPK signalling pathways mediate the pain process.In the present study,complete Freund’s adjuvant (CFA) was injected into the whisker pad of rats to induce an inflammatory model in vivo.SP was administered to SGC cultures in vitro to confirm the effect of SP.Facial expression analysis showed that pre-injection of L703,606 (an NK-1 receptor antagonist),U0126 (an inhibitor of MAPK/extracellular signal-regulated kinase [ERK] kinase [MEK] 1/2),and SB203580 (an inhibitor of P38) into the TG to induce targeted prevention of the activation of the NK-1 receptor and the phosphorylation of MAPKs significantly suppressed CFA-induced inflammatory allodynia.In addition,SP promoted SGC activation,which was proven by increased GFAP,p-MAPKs,IL-1β and TNF-α in SGCs under inflammatory conditions.Moreover,the increase in IL-1β and TNF-α was suppressed by L703,606,U0126 and SB203580 in vivo and in vitro.These present findings suggested that SP,released from TG neurons,activated SGCs through the ERK1/2 and P38 pathways and promoted the production of IL-1β and TNF-α from SGCs,contributing to inflammatory orofacial pain associated with peripheral sensitization. | Yanyan Zhang Ning Song Fei Liu Jiu Lin Mengke Liu Chaolan Huang Daqing Liao Cheng Zhou Hang Wang Jiefei Shen | 2019 | International Journal of Oral Science2019，11，3： | 6 |
| 3 | Receptor tyrosine kinases positively regulate BACE activity and Amyloid-β production through enhancing BACE internalization显示文摘Amyloid-β (AP) peptide, the primary constituent of senile plaques in Alzheimer's disease (AD), is generated byβ-secretase- and γ-secretase-mediated sequential proteolysis of the amyloid precursor protein (APP). The aspartic pro-tease, β -site APP cleavage enzyme (BACE), has been identified as the main P-secretase in brain but the regulation of itsactivity is largely unclear. Here, we demonstrate that both BACE activity and subsequent Aβ production are enhancedafter stimulation of receptor tyrosine kinases (RTKs), such as the receptors for epidermal growth factor (EGF) and nervegrowth factor (NGF), in cultured cells as well as in mouse hippocampus. Furthermore, stimulation of RTKs also inducesBACE internalization into endosomes and Golgi apparatus. This enhancement of BACE activity and Aβ production uponRTK activation could be specifically inhibited by Src family kinase inhibitors and by depletion of endogenous c-Src withRNAi, and could be mimicked by over-expressed c-Src. Moreover, blockage of BACE internalization by a dominantnegative form of Rab5 also abolished the enhancement of BACE activity and Aβ production, indicating the requirementof BACE internalization for the enhanced activity. Taken together, our study presents evidence that BACE activity andAβ production are under the regulation of RTKs and this is achieved via RTK-stimulated BACE internalization, andsuggests that an aberration of such regulation might contribute to pathogenic Aβ production. | Lin Zou Zhu Wang Li Shen Guo Bin Bao Tian Wang Jiu Hong Kang Gang Pei | 2007 | Cell Research2007，17，5： | 5 |
| 4 | Microstructure Evolution and Dynamic Softening Mechanism of 00Cr22Ni5Mo3N DSS During Hot Compression显示文摘Through plane strain compression,hot ductility of 00Cr22Ni5Mo3N DSS is studied under plane strain condition,and the dynamic softening mechanism is investigated through microstructure observation under TEM.The results show that the deformation temperature can markedly influence the peak stress of 00Cr22Ni5Mo3N specimens.And being different from DSS softening mechanism generally reported,ferrite can be softened through dynamic recovery and recrystallization,but austenite can be softened only through dynamic recovery during hot deformation.The unfavourable effect of N on softening capacity of austenite is greater than that of Ni. | SONG Zhi gang WU Jiu LIN Xiu-ji WANG Li-xin LI Guo-ping ZHENG Wen-jie | 2011 | Journal of Iron and Steel Research(International)2011，18，7： | 5 |
| 5 | Early Changes of Peripheral Blood Lymphocyte Subpopulations in Patients with Occupational 2,4-dinitrophenol Poisoning显示文摘2,4-dinitrophenol(DNP),an organic compound which frequently used in industry,is considered to have high toxicity.This study aimed to investigate the early changes of lymphocyte subpopulations in patients with occupational 2,4-DNP poisoning.Totally 9 patients with acute occupational 2,4-DNP poisoning and 30 healthy volunteers as | JIANG Jiu Kun FANG Wen GU Lin Hui LU Yuan Qiang | 2016 | Biomedical and Environmental Sciences2016，29，12： | 4 |
| 6 | Optimal control on special Euclidean group via natural gradient algorithm显示文摘Considering the optimal control problem about the control system of the special Euclidean group whose output only depends on its input is meaningful in practical applications. The optimal control considered here is described as the output matrix is as close as possible to the target matrix by adjusting the system input.The geodesic distance is adopted as the measure of the difference between the output matrix and the target matrix, and the trajectory of the control input obtained in the process is achieved. Furthermore, some numerical simulations are shown to illustrate our outcomes based on the natural gradient descent algorithm for optimizing the control system of the special Euclidean group. | Chunhui LI Erchuan ZHANG Lin JIU Huafei SUN | 2016 | Science China(Information Sciences)2016，59，11： | 4 |
| 7 | Effect of Hypertonic Versus Isotonic Saline Resuscitation on Heme Oxygenase-1 Expression in Visceral Organs Following Hemorrhagic Shock in Rats显示文摘To compare the early effects of hypertonic and isotonic saline resuscitation on heme oxygenase-1 (HO-1) expression in organs of rats with hemorrhagic shock. Rats were randomly divided into hypertonic saline resuscitation (HTS), normal saline resuscitation (NS) and sham groups. | LU Yuan Qiang GU Lin Hui JIANG Jiu Kun MOU Han Zhou | 2013 | Biomedical and Environmental Sciences2013，26，8： | 4 |
| 8 | Effect of amide type modified rapeseed oil as lubricating additive on friction and wear behavior of steel-steel and steel-aluminum alloy systems显示文摘A new type of environmentally friendly lube additive-amide type modified rapeseed oil was synthesized and characterized by infrared spectrum. Its effect on the friction and wear behavior of steel-steel and steel-aluminum alloy systems were investigated with a four-ball machine and an Optimol SRV friction and wear tester respectively.The morphographies of the worn surfaces were analyzed by means of scanning electron microscopy(SEM). The worn surfaces of the 2024Al alloy block were analyzed by means of X-ray photoelectron spectroscopy(XPS). The results show that the modified rapeseed oil as additives can obviously decrease the wear rate and friction coefficient of steel pair and steel-aluminum frictional pair. Its lubrication mechanism is inferred that a high strength complex protection films form on the worn surface of the Al alloy due to the adsorption or tribochemistry reaction of a long chain additive molecule and high reaction activity of N element. | FANG Jian-hua CHEN Bo-shui LIU Wei-min DONG Lin WANG Jiu | 2004 | 中国有色金属学会会刊:英文版2004，14，z1： | 1 |
| 9 | Experimental Study and Calculation of Fire Resistance of Concrete - Filled Hollow Steel Columns 显示文摘 | Xiao - Ling Zhao You - Fu Yang and Jiu - Bin Feng | 2003 | Journal of Structural Engineering ASCE2003，129，3： | 1 |
| 10 | Numerical Analysis on Convection Heat Transfer in a Spirally Fluted and Field Synergy Principle Analysis显示文摘 | Yu Jiu Yang Yang Wen Hao Wu Yan Yang Lin Wei Liu Li Jun Liu Qian | 2011 | Advanced Materials Research . 2011 (308)2011，，308： | 1 |
| 11 | Insulin-like signaling pathway functions in integrative response to an olfactory and a gustatory stimuli in Caenorhabditis elegans显示文摘Animals integrate various environmental stimuli within the nervous system to generate proper behavioral responses.However,the underlying neural circuits and molecular mechanisms are largely unknown.The insulinlike signaling pathway is known to regulate dauer formation,fat metabolism,and longevity in Caenorhabditis elegans(C.elegans).Here,we show that this highly conserved signaling pathway also functions in the integrative response to an olfactory diacetyl and a gustatory Cu^(2+) stimuli.Worms of wild-type N2 Bristol displayed a strong avoidance to the Cu^(2+) barrier in the migration pathway to the attractive diacetyl.Mutants of daf-2(insulin receptor),daf-18(PTEN lipid phosphatase),pdk-1(phosphoinositide-dependent kinase),akt-1/-2(Akt/PKB kinase)and sgk-1(serum-and glucocorticoidinducible kinase)show severe defects in the elusion from the Cu^(2+) .Mutations in DAF-16,a forkhead-type transcriptional factor,suppress the integrative defects of daf-2 and akt-1/-2 mutants.We further report that neither cGMP nor TGFβpathways,two other dauer formation regulators,likely plays a role in the integrative learning.These results suggest that the insulin-like signaling pathway constitutes an essential component for sensory integration and decision-making behavior plasticity. | Ya-Ming Jiu Yang Yue Song Yang Lin Liu Jun-Wei Yu Zheng-Xing Wu Tao Xu | 2010 | Protein & Cell2010，1，1： | 1 |
| 12 | Research on the preparation of ceramic tritium breeders in SICCAS显示文摘 | Zhaoyin Wen Xiangwei Wu Xiaogang Xu Jiu Lin Zhonghua Gu | 2010 | Fusion Engineering and Design2010，，7： | 1 |
| 13 | Continuous selection and fixed point theorems显示文摘 | YU Zemn Tsuen LIN Lai Jiu | 2003 | Nonlinear Anal2003，52，2： | 1 |
| 14 | Kinematic positioning with GPS carrier phases by two types of wide laning显示文摘 | WU Jiu LIN Xiuguo | 1997 | Navigation ION1997，44，4： | 1 |
| 15 | Vector-virus mutual- ism accelerates population increase of an invasive whitefly 显示文摘 | Jiu Min Zhou Xueping Tong Lin | 2007 | PLoS ONE2007，2，1： | 1 |
| 16 | Slit–Robo GTPase‐Activating Proteins are Differentially Expressed in Murine Dorsal Root Ganglia: Modulation by Peripheral Nerve Injury显示文摘 | Zhi‐BingChen Hai‐YingZhang Jiu‐HongZhao WeiZhao DanZhao Lin‐FengZheng Xian‐FangZhang Xiao‐PingLiao Xi‐NanYi | 2012 | Anat Rec2012，，4： | 1 |
| 17 | Nutritional Risk Screening with NRS2002 among Hospitalized Cancer Patients in China显示文摘Objective The Nutritional Risk Screening 2002(NRS 2002)was used to assess the nutritional risk of hospitalized oncology patients in China.This study explored the factors affecting the risk of nutrition to provide a scientific basis for the assessment and treatment of malnutrition in oncology patients.Methods We used the NRS 2002 to evaluate the nutritional risk in 48,831 hospitalized cancer patients.Descriptive statistical methods were used to describe the general patient information.A Chi-squared test was applied to analyze the relationship between NRS 2002 scores and different demographic characteristics,and the NRS 2002 scores of cancer patients with different characteristics were compared by one-way ANOVA.Results Among 48,831 patients,43.3%were women and 57.7%were men,and 36.5%(17,802)of patients were at risk of nutrition(score≥3).The NRS 2002 score was the highest in leukemia patients(2.93±1.28).A one-way ANOVA revealed that the differences in NRS 2002 scores among patients of different gender,ages,TNM stages,education levels,occupations and areas of residence were statistically significant(P<0.001).Male patients had slightly higher NRS 2002 scores than females(2.33 vs.2.17).The lowest NRS 2002 scores were in patients aged 45-59(2.00±1.26)years and the highest scores were in patients aged≥70(2.76±1.43)years.The NRS 2002 score of patients receiving surgery was the highest(2.45±1.41),and patients receiving surgery plus radiotherapy/chemotherapy was the lowest(2.00±1.26).The risk of nutrition was highest in patients who were farmers(2.34±1.37 scores)and lowest in office staff(2.15±1.32 scores).Patients living in rural areas had the highest risk of nutrition(2.32±1.37 scores).There were significant differences in the NRS 2002 scores for different cancer sub-types for different ethnic groups(P<0.05),except for Zhuang individuals(P=0.124).The risk of nutrition was highest in Uyghur patients(3.35±1.33 scores)and lowest in Mongolians(2.04±1.37 scores).Conclusion More attention should be paid to people at high risk of nutrition,such as elderly patients,patients with a high TNM stage,patients receiving surgical treatment,and patients living in rural areas.Active nutritional interventions should be carried out to improve the nutritional status of malnourished patients. | Ming Ming Zhou Tian Tian Wu Yu Han Wang Yuan Lin Zou Ke Di Xu Jiu Wei Cui Zeng Ning Li Jun Qiang Chen Ming Liu Zeng Qing Guo Hong Xia Xu Han Ping Shi Chun Hua Song Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 0 |
| 18 | La2Zr2O7 and MgO co-doped composite Li-Garnet solid electrolyte显示文摘Various solid electrolytes,such as sulfides(10^-3-10^-2 S cm^-1)and oxides(10^-4–10^-3 S cm^-1)are explored and developed to solve the safety problems in commercial Li-ion batteries using liquid flammable electrolytes.Metallic Li anode is required for pursuing high power density(>300 Wh kg^-1)for solid-state batteries[1,2]. | Jiu Lin Linbin Wu Zhen Huang Xiaoxiong Xu Jiheng Liu | 2020 | Journal of Energy Chemistry2020，29，1： | 0 |
| 19 | Local non-equilibrium thermal fluctuation,internal noise and dissipation in gaseous heat conduction systems with high values of Prandtl number显示文摘借助于在这建议的一个随机的模型,为有本地非平衡的系统的纸使热变化激动,著名香农熵被扩大包括经常的温度坡度的边界限制在二个方面外部地控制的热传导过程。同时,为连续 Markov 使用对主人方程的描述处理为一种尺寸有效的随机的熵生产的一个平衡方程有 Prandtl 数字的高值的气体的热传导系统也被建立了。基于它,为两个的一般表情随机的熵生产和变化的熵生产被扩大进一步推出了。在这个形式体系,对从非平衡的驱散的各种随机的贡献热变化和内部噪音变得明确。 | Feng Lin Jiu Li Luo Nan Rong Zhao | 2011 | Chinese Chemical Letters2011，22，5： | 0 |
| 20 | A Novel p.Tyr129His Variant in SIX1 Leads to Dominant,Delayed-onset Hearing Loss with Possible Association with Congenital Anosmia显示文摘SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1]. | PANG Xiu Hong ZHENG Xiao Yong LIN Yun ZHENG Hao XU Jun LIU Dong JIN Chun Yan ZHANG Lu Ping ZHANG Yu Ting CHU Jiu Sheng CHAI Yong Chuan YANG Tao | 2021 | Biomedical and Environmental Sciences2021，34，4： | 0 |
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