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| 1 | Endovascular stent-induced alterations in host artery mechanical environments and their roles in stent restenosis and late thrombosis显示文摘Cardiovascular stent restenosis remains a major challenge in interventional treatment of cardiovascular occlusive disease.Although the changes in arterial mechanical environment due to stent implantation are the main causes of the initiation of restenosis and thrombosis,the mechanisms that cause this initiation are still not fully understood.In this article,we reviewed the studies on the issue of stent-induced alterations in arterial mechanical environment and discussed their roles in stent restenosis and late thrombosis from three aspects:(i)the interaction of the stent with host blood vessel,involve the response of vascular wall,the mechanism of mechanical signal transmission,the process of re-endothelialization and late thrombosis;(ii)the changes of hemodynamics in the lumen of the vascular segment and(iii)the changes of mechanical microenvironment within the vascular segment wall due to stent implantation.This review has summarized and analyzed current work in order to better solve the two main problems after stent implantation,namely in stent restenosis and late thrombosis,meanwhile propose the deficiencies of current work for future reference. | Jinxuan Wang Xuepu Jin Yuhua Huang Xiaolin Ran Desha Luo Dongchuan Yang Dongyu Jia Kang Zhang Jianhua Tong Xiaoyan Deng Guixue Wang | 2018 | Regenerative Biomaterials2018，5，3： | 13 |
| 2 | An Efficient Adaptive Failure Detection Mechanism for Cloud Platform Based on Volterra Series显示文摘Failure detection module is one of important components in fault-tolerant distributed systems,especially cloud platform.However,to achieve fast and accurate detection of failure becomes more and more difficult especially when network and other resources' status keep changing.This study presented an efficient adaptive failure detection mechanism based on volterra series,which can use a small amount of data for predicting.The mechanism uses a volterra filter for time series prediction and a decision tree for decision making.Major contributions are applying volterra filter in cloud failure prediction,and introducing a user factor for different QoS requirements in different modules and levels of IaaS.Detailed implementation is proposed,and an evaluation is performed in Beijing and Guangzhou experiment environment. | LIN Rongheng WU Budan YANG Fangchun ZHAO Yao HOU Jinxuan | 2014 | China Communications2014，11，4： | 6 |
| 3 | Flexibility improvement evaluation of hydrogen storage based on electricity-hydrogen coupled energy model显示文摘To achieve carbon neutrality by 2060,decarbonization in the energy sector is crucial.Hydrogen is expected to be vital for achieving the aim of carbon neutrality for two reasons:use of power-to-hydrogen(P2H)can avoid carbon emissions from hydrogen production,which is traditionally performed using fossil fuels;Hydrogen from P2H can be stored for long durations in large scales and then delivered as industrial raw material or fed back to the power system depending on the demand.In this study,we focus on the analysis and evaluation of hydrogen value in terms of improvement in the flexibility of the energy system,particularly that derived from hydrogen storage.An electricity-hydrogen coupled energy model is proposed to realize the hourly-level operation simulation and capacity planning optimization aiming at the lowest cost of energy.Based on this model and considering Northwest China as the region of study,the potential of improvement in the flexibility of hydrogen storage is determined through optimization calculations in a series of study cases with various hydrogen demand levels.The results of the quantitative calculations prove that effective hydrogen storage can improve the system flexibility by promoting the energy demand balance over a long term,contributing toward reducing the investment cost of both generators and battery storage and thus the total energy cost.This advantage can be further improved when the hydrogen demand rises.However,a cost reduction by 20%is required for hydrogen-related technologies to initiate hydrogen storage as long-term energy storage for power systems.This study provides a suggestion and reference for the advancement and planning of hydrogen storage development in regions with rich sources of renewable energy. | Chen Jin Jinyu Xiao Jinming Hou Xiaoqing Wu Jinxuan Zhang Ershun Du | 2021 | Global Energy Interconnection2021，4，4： | 3 |
| 4 | Enhanced catalysis of ultrasmall Au-MoS_2 clusters against reactive oxygen species for radiation protection显示文摘Ionizing radiation produces excessive reactive oxygen species(ROS) which impose detrimental effects on biological systems. Thus, it is important to explore clinically safe and efficacious radioprotection agents to scavenge ROS and reduce the risks of radiotherapy. Recently, emerging catalytic nanomaterials such as sulfide nanomaterials have shown capability of clearing ROS in vivo by unique electron transfers between atoms, but their catalytic activities are yet suboptimal. As such, there is an unmet need to improve catalytic properties for stronger antioxidant activities and radiation protection. Herein, we prepared ultrasmall Au-MoS_2 clusters(~2.5 nm) and they showed enhanced catalytic properties via gold intercalation facilitating increased active sites and synergistic effects. Electrocatalysis results revealed that the catalytic activity of Au-MoS_2 towards H2O_2 was superior to ultrasmall MoS_2 without Au. As a result, we found that improving the electrocatalytic property of Au-MoS_2 can effectively enhance corresponding antioxidant activities and radioprotection effects in vivo. In addition, Au-MoS_2 also showed significant radioprotection in vitro and dramatically reduced the excess of radiation-induced adverse ROS. It also rescued radiation-induced DNA damages and protected the bone marrow hematopoietic system from ionizing radiation. | Peixian Bian Jinxuan Zhang Junying Wang Jiang Yang Jingya Wang Haile Liu Yuanming Sun Meixian Li Xiao-Dong Zhang | 2018 | Science Bulletin2018，63，14： | 2 |
| 5 | An unstructured FEM model based on Boussinesq equations and its application to the calculation of multidirectional wave run-up in a cylinder group显示文摘 | Shuxue Liu Zhongbin Sun Jinxuan Li | 2011 | Applied Mathematical Modelling2011，，9： | 2 |
| 6 | ROS-responsive biomimetic nanoparticles for potential application in targeted anti-atherosclerosis显示文摘The development of nanomedicines provides new opportunities for the treatment of atherosclerosis(AS)due to their great advantages such as the improved drug solubility,enhanced bioavailability and reduced side effects.Despite these advantages,nanomedicines are still facing some challenges.The problems remain in the short circulation life,lack of specific targeting and poor drug release controllability.In order to overcome the shortages of conventional nanomedicines,the combination of biomimetic strategy with smart nanoagents has been proposed.In light with the high reactive oxygen species(ROS)level in AS microenvironment and the fact that macrophages play a critical role in the pathogenesis of AS,we fabricated ROS-responsive biomimetic nanoparticles(NPs),which camouflaged macrophage membrane(MM)on ROS-responsive NPs loaded with rapamycin(RNPs)for potential application in AS therapy.The resulting ROSresponsive biomimetic NPs(MM/RNPs)exhibited favorable hydrodynamic size with negative surface charge,retained the functional proteins from MM,and showed ROS-responsive drug release.Because of the biomimetic camouflaging on surface,MM/RNPs could effectively escape from macrophages uptake and target to inflammatory endothelial cells.Meanwhile,MM/RNPs could inhibit the proliferation of macrophages and smooth muscle cells in vitro.Furthermore,the MM-coated NPs were found to be nontoxic in both cytotoxicity assay and in vivo toxicity evaluation.Consequently,these results demonstrated that MM/RNPs could be a potential candidate of drug delivery system for safe and effective anti-AS applications. | Dan Tang Yi Wang Andy Wijaya Boyan Liu Ali Maruf Jinxuan Wang Jianxiong Xu Xiaoling Liao Wei Wu Guixue Wang | 2021 | Regenerative Biomaterials2021，8，4： | 2 |
| 7 | The existence of a positive solution for a singular couled system of nonliear fractional differential equations显示文摘 | ] BAI Chuanzhi FANG Jinxuan | 2004 | Appl Math Comp2004，150，： | 1 |
| 8 | Detecting deformations in uncompacted strata by fiber Bragg grating sensors incorporated into GFRP 显示文摘 | Chai Jing Liu Jinxuan Qiu Biao | 2011 | Tunnelling and Underground Space Technology2011，26，1： | 1 |
| 9 | Some properties of sequences of gen- eralized fuzzy integrable functions显示文摘 | FANG Jinxuan | 2007 | Fuzzy Sets and Systems2007，158，： | 1 |
| 10 | Theoretical and expe- rimental study on fiber Bragg grating sensing of rock strata settle- ment deformation 显示文摘 | Liu Jinxuan Chai Jing Wei Shiming | 2008 | Journal of Coal Science and Engineering2008，14，3： | 1 |
| 11 | Existence of multiple positive solutions for nonlinear m-point boundary value prohlem显示文摘 | Chuanzhi Bai Jinxuan Fang | 2003 | J Math Anal Appl2003，281，1： | 1 |
| 12 | A set of new separation axioms in L-fuzzy topological spaces显示文摘 | Fang Jinxuan Ren Bailin | 1998 | Fuzzy Sets and Systems1998，96，： | 1 |
| 13 | Direct laser patterning of two-dimensional lateral transition metal disulfide-oxide-disulfide heterostructures for ultrasensitive sensors显示文摘Two-dimensional(2D)heterostructures based on the combination of transition metal dichalcogenides(TMDs)and transition metal oxides(TMOs)have aroused growing attention due to their integrated merits of both components and multiple functionalities.However,nondestructive approaches of constructing TMD-TMO heterostructures are still very limited.Here,we develop a novel type of lateral TMD-TMO heterostructure(NbS2-Nb2O5-NbS2)using a simple lithography-free,direct laser-patterning technique.The perfect contact of an ultrathin TMO channel(Nb2O5)with two metallic TMDs(NbS2)electrodes guarantee strong electrical signals in a two-terminal sensor.Distinct from sensing mechanisms in separate TMOs or TMDs,this sensor works based on the modulation of surface conduction of the ultrathin TMO(Nb2O5)channel through an adsorbed layer of water molecules.The sensor thus exhibits high selectivity and ultrahigh sensitivity for room-temperature detection of NH3(ΔR/R=80%at 50 ppm),superior to the reported NH3 sensors based on 2D materials,and a positive temperature coefficient of resistance as high as 15%–20%/℃.Bending-invariant performance and high reliability are also demonstrated in flexible versions of sensors.Our work provides a new strategy of lithography-free processing of novel TMD-TMO heterostructures towards high-performance sensors,showing great potential in the applications of future portable and wearable electronics. | Bolun Wang Hao Luo Xuewen Wang Enze Wang Yufei Sun Yu-Chien Tsai Jinxuan Dong Peng Liu Huanglong Li Yong Xu Sefaattin Tongay Kaili Jiang Shoushan Fan Kai Liu | 2020 | Nano Research2020，13，8： | 1 |
| 14 | Existence of multiple positive solutions for nonlinear m-point boundary-value problems显示文摘 | Bai Chuanzhi Fang Jinxuan | 2003 | Appl Math Compu2003，140，： | 1 |
| 15 | 1 H NMR and multivariate data analysis of the relationship between the age and quality of duck meat显示文摘 | Chunli Liu Daodong Pan Yangfang Ye Jinxuan Cao | 2013 | Food Chemistry2013，，2： | 1 |
| 16 | Existence of multiple positive solutions for nonlinear m-point boundary value problems 显示文摘 | Bai Chuanzhi Fang Jinxuan | 2003 | Appl Math Copmut2003，140，： | 1 |
| 17 | trans-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis显示文摘The transport and metabolism of lipids in cerebrovascular endothelial cells(ECs)have been hypothesized to regulate blood-brain barrier(BBB)maturation and homeostasis.Long-chain polyunsaturated fatty acids(LCPUFAs)as the important lipids components of cell membranes are essential for the development and function of BBB,but the direct links of lipid metabolism and ECs barrier function remain to be established.Here,we comprehensively characterize the transcriptomic phenotype of developmental cerebrovascular ECs in single-cell resolution and firstly find that trans-2-enoyl-CoA reductase(Tecr),a verylong-chain fatty acid synthesis,is highly expressed during barriergenesis and decreased after BBB maturation.EC-specific knockout of Tecr compromises angiogenesis due to delayed vascular sprouting.Importantly,EC-specific deletion of Tecr loss restrictive quality of vascular permeability from neonatal stages to adulthood,with high levels of transcytosis,but maintains the vascular tight junctions.Moreover,lipidomic analysis shows that the expression of Tecr in ECs is associated with the containing of omega-3 fatty acids,which directly suppresses caveolae vesicles formation.These results reveal a protective role for Tecr in BBB integrity and suggest that Tecr as a novel therapeutic target in the central nervous system(CNS)diseases associated with BBB dysfunction. | Jinxuan Wang Jianxiong Xu Guangchao Zang Tao Zhang Qi Wu Hongping Zhang Yidan Chen Yi Wang Weixi Qin Shuang Zhao Erdai Qin Juhui Qiu Xiaojuan Zhang Lin Wen Yeqi Wang Guixue Wang | 2022 | Research2022，，3： | 1 |
| 18 | The variational principle and fixed point theorems in certain topological spaces显示文摘 | | 1996 | J Math Anal Appl1996，202，： | 1 |
| 19 | Dynamic Mechanical Properties and Energy Dissipation Characteristics of Frozen Soil Under Passive Confined Pressure显示文摘Impact compression tests on frozen soil samples with different freezing temperatures and subjected to passive confined pressure were performed using a split Hopkinson pressure bar at different loading strain rates.The three-dimensional stress-strain curves of the frozen soil samples under the corresponding conditions were obtained.The experimental results showed that,when the frozen soil was loaded to its elastic limit,shear failure occurred,the bearing capacity of pore ice was lost,and the thawed soil functioned as the main stress-bearing body.Nevertheless,the capacity of frozen soil to withstand hydrostatic pressure continued to increase.The dynamic mechanical properties of the frozen soil under passive confined pressure were observed to be strongly related to the loading strain rate and freezing temperature.As the loading strain rate increased,the secant modulus,elastic modulus,and strength(including the shear strength)of the frozen soil increased,whereas its Poisson^ratio and coefficient of lateral pressure decreased.As the freezing temperature decreased,the secant modulus,elastic modulus,and shear strength of the frozen soil increased;however,its Poisson5s ratio and coefficient of lateral pressure decreased.When the frozen soil was subjected to impact loading under passive confined pressure,energy dissipation occurred due to plastic deformation,mesoscopic damage evolution,and ice-water phase transition.When shear failure occurred,the absorption energy per unit volume of frozen soil increased as the freezing temperature decreased and the loading strain rate increased. | Jinxuan Jia Huaiping Tang Huijian Chen | 2021 | Acta Mechanica Solida Sinica2021，34，2： | 1 |
| 20 | Some properties of sequences of generalized fuzzy integrable functions显示文摘 | FANG Jinxuan | 2007 | Fuzzy Sets and Systems2007，158，： | 1 |
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