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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Challenges and Development Prospects of Ultra-Long and Ultra-Deep Mountain Tunnels显示文摘1. Introduction Social development has led to the placement of high standards on ultra-long and ultra-deep mountain tunnels. Disasters may be encountered during the construction and maintenance of such mountain tunnels due to high geostress, high geotemperature, high hydraulic pressure, and special adverse strata, in addition to various other problems caused by engineering activities. To deal with uncertain geological conditions during mountain tunnel construction, comprehensive geological prediction, refined monitoring, and dynamic design and construction methods based on information technology should be adopted. For the operation and maintenance of ultra-long tunnels, the concepts of dynamic evacuation rescue, active protection, energy conservation, and environmental protection should be fully embodied in order to address significant problems related to ventilation, rescue situations, and energy consumption. Moreover, integrated construction and maintenance should be carried out to achieve digital sensing and intelligent maintenance. | Hehua Zhu Jinxiu Yan Wenhao Liang | 2019 | Engineering2019，5，3： | 16 |
| 3 | 尖镰孢菌和禾谷镰孢菌引起的大豆根腐病生物防治研究显示文摘以大豆与禾谷类作物轮作体系中引起大豆根腐病的尖镰孢菌(F.oxysporum)和禾谷镰孢菌(F.graminea-rum)为研究对象,测试分离于大豆和小麦根部及根际土壤的生防菌对2种病原菌防治效果。结果表明:拮抗试验中所测试的生防菌对2种镰孢菌抑菌效果差异不显著,生防菌HJ-ZT1、HJ-MM7、HJ-ZT2、CH-Tr14、HJ-MM8和CH-Tr18的抑菌率显著高于CH-Tr51、HJ-MM35、HJ-MM9和ACM941。温室条件下生防菌处理对尖镰孢菌和禾谷镰孢菌2种病原菌的防效及对大豆的促生作用均存在差异,CH-Tr12、ACM941、SB24+HJ-MM7和化学药剂对尖镰孢菌防效效果较好,并很大程度促进植株生长;生防菌CH-Tr14、HJ-MM7和CH-Tr12对禾谷镰孢菌防治效果较好。田间试验中,生防菌处理ACM941+HJ-MM7使大豆增产10%,CH-Tr14增产9%,CH-Tr12增产8%,与化学对照增产6%差异不显著。 | 张红骥 Allen G. Xue Jinxiu Zhang 许艳丽 于德才 | 2011 | 大豆科学2011，30，1： | 13 |
| 4 | Regeneration of commercial selective catalyst reduction catalysts deactivated by Pb and other inorganic elements显示文摘The regeneration of commercial SCR(Selective Catalyst Reduction) catalysts deactivated by Pb and other elements was studied.The deactivated catalyst samples were prepared by chemical impregnation with mixed solution containing K_2SO_4,Na_2SO_4,CaSO_4,Pb(NO_3)_2and NH_4H_2PO_4.A novel method combining Ethylenediaminetetraacetic acid disodium salt(EDTA-2Na) and H_2SO_4solution(viz.catalysts treated by dilute EDTA-2Na and H_2SO_4 solution in sequence) was used to recover the activity of deactivated samples,and the effect was compared with single H_2SO_4,oxalic acid,acetic acid,EDTA or HNO_3 solutions.The surface structure,acidity and reducibility of samples were characterized by N_2adsorption–desorption,inductively coupled plasma optical emission spectrometer(ICP-OES),scanning electron microscopy(SEM),X-ray diffraction(XRD),X-ray fluorescence(XRF),H-2-temperature programmed section(H_2-TPR),NH3-temperature programmed desorption(NH3-TPD) and in situ DRIFTS.Impurities caused a decrease of specific surface area and surface reducibility,as well as Br?nsted acid sites,and therefore led to severe deactivation of the SCR catalyst.The use of an acid solution alone possibly eliminated the impurities on the deactivated catalyst to some extent,and also increased the specific surface area and Br?nsted acid sites and promoted the surface reducibility,thus recovered the activity partially.The combination of EDTA-2Na and H_2SO_4 could remove most of the impurities and improve the activity significantly.The removal of Pb should be an important factor for regeneration.Due to a high removal rate for Pb and other impurities,the combination of EDTA-2Na and H_2SO_4 solutions provided the best efficiency. | Yanke Yu Jinxiu Wang Jinsheng Chen Xinjiang He Yujing Wang Kai Song Zongli Xie | 2016 | Journal of Environmental Sciences2016，28，9： | 11 |
| 5 | The Epitope Study on the SARS-CoV Nucleocapsid Protein显示文摘The nucleocapsid protein (N protein) has been found to be an antigenic protein in a number of coronaviruses. Whether the N protein in severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is antigenic remains to be elucidated. Using Western blot and Enzyme-linked Immunosorbent Assay (ELISA),the recombinant N proteins and the synthesized peptides derived from the N protein were screened in sera from SARS patients. All patient sera in this study displayed strong positive immunoreactivities against the recombinant N proteins,whereas normal sera gave negative immunoresponses to these proteins, indicating that the N protein of SARS-CoV is an antigenic protein. Furthermore, the epitope sites in the N protein were determined by competition experiments, in which the recombinant proteins or the synthesized peptides competed against the SARS-CoV proteins to bind to the antibodies raised in SARS sera. One epitope site located at the C-terminus was confirmed as the most antigenic region in this protein. A detailed screening of peptide with ELISA demonstrated that the amino sequence from Codons 371 to 407 was the epitope site at the C-terminus of the N protein. Understanding of the epitope sites could be very significant for developing an effective diagnostic approach to SARS. | Shuting Li, Liang Lin, Hao Wang, Jianning Yin, Yan Ren, Zhe Zhao, Jie Wen, Cuiqi Zhou, Xumin Zhang, Xiaolei Li, Jingqiang Wang, Zhengfeng Zhou, Jinxiu Liu, Jianmin Shao, Tingting Lei, Jianqiu Fang, Ningzhi Xu, and Siqi LiuBeijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China & Beijing Proteomics Institute, Beijing 101300, China | 2003 | Genomics, Proteomics & Bioinformatics2003，1，3： | 9 |
| 6 | Effects of environment lighting on the growth,photosynthesis,and quality of hydroponic lettuce in a plant factory显示文摘Leafy vegetable production under controlled environment using artificial lighting has many advantages over conventional greenhouses and open-field production.However,high initial investment and operation costs are restricting the wide application of this technology.In order to design an optimal artificial lighting environment for lettuce production,effects of different combinations of light intensity,photoperiod,and light quality on growth,quality,photosynthesis,and energy use efficiency of lettuce(Lactuca sativa L.cv Ziwei)were investigated under a closed plant factory.Lettuce transplants were grown under photosynthetic photon flux density(PPFD)at 150μmol/m^(2)·s,200μmol/m^(2)·s,250μmol/m^(2)·s,and 300μmol/m^(2)·s provided by fluorescent lamps(FL)with a red to blue ratio(R:B ratio)of 1.8 and light-emitting diode(LED)lamps with R:B ratio of 1.2 and 2.2,in combination with photoperiod of 12 and 16 h/d.In order to examine the“long term”photosynthetic characteristics,net photosynthetic rates of hydroponic lettuce leaves were continuously measured for 2 d(15^(th) and 16^(th) day after transplanting)before harvest.There was no difference in leaf fresh weight(FW)between PPFD of 250μmol/m^(2)·s and 300μmol/m^(2)·s with photoperiod of 16 h/d,regardless of light quality,and same results showed in contents of nitrate,soluble sugar,and vitamin C,respectively.The results of continuous measurements of net photosynthetic rate of lettuce leaves before harvest indicated that plants grown at PPFD of 250μmol/m^(2)·s had consistently higher compared to those grown at PPFD of 300μmol/m^(2)·s.Combining the results from growth,photosynthesis,quality,and energy consumption,it can be concluded that PPFD at 250μmol/m^(2)·s with photoperiod of 16 h/d under LED with R:B ratio of 2.2 is a suitable light environment for maximum growth and high quality of commercial lettuce(cv.Ziwei)production under indoor controlled environment. | Xin Zhang Dongxian He Genhua Niu Zhengnan Yan Jinxiu Song | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 8 |
| 7 | INFLUENCE OF PREPARATIVE HISTORY ON STRUCTURE AND PROPERTIES OF SODIUM ALUMINATE SOLUTIONS显示文摘It has been found that samples of sodium aluminate solutions with the same composition but different preparative history may have difTerent structure and physico-chemical properties.The structure of sodium-bearing aluminate solutions change very slowly during the storage after preparation.Sodium aluminate solutions contain several ammunium-bearing anisons such as Al(OH)^(-)_(4),Al(OH)^(3-)_(6)and[(HO)_(3)Al-O-Al(OH)_(3)]^(2-),etc.These anions can convert to each other but the reactions are very slow owing to the formation or breakage of covalent Al-O bond.Hence the ratio between these anions approaches equilibrium very slowly after the preparation,and the structure or properties of these solution samples before equilibrium is reached depend on their preparative histosive. | Chen Nianyi Liu Miaoxiu Yang Jinxiu Chi Likuan | 1992 | Transactions of Nonferrous Metals Society of China1992，2，2： | 8 |
| 8 | Radiative forcing and global warming potential of perfluorocarbons and sulfur hexafluoride显示文摘We developed two radiation parameterizations with different resolutions(17-band and 998-band) for perfluorocarbons(PFCs) and sulfur hexafluoride(SF6) using the updated High-resolution Transmission Molecular Absorption(HITRAN) 2004 database and the correlated k-distribution method.We analyzed the impacts of the two radiation schemes on heating rates.Then we studied their instantaneous radiative efficiency,stratospheric adjusted radiative efficiency,global warming potential(GWP),and global temperature potential(GTP),for both clear-and all-sky conditions using a high-resolution radiation scheme.We found that the stratosphere-adjusted radiative efficiencies of C2F6,CF4,and SF6 for the whole sky were 0.346,0.098,and 0.680 W m-2 ppbv-1,respectively.Radiative forcing from the industrial revolution to 2005 was 0.001,0.007,and 0.004 W m-2,re-spectively;and was predicted to rise to 0.008,0.036,and 0.037 W m-2,respectively,by 2100,according to emission scenarios provided by the IPCC.The GWPs of C2F6,CF4,and SF6 are 17035,7597,and 31298,respectively,for a time horizon of 100 years relative to CO2.Their GTPs of pulse and sustained emissions,GTPP and GTPS,are 22468,10052,and 40935 and 16498,7355,and 30341,respectively,for a 100-year time horizon. | ZHANG Hua WU JinXiu SHEN ZhongPing | 2011 | Science China Earth Sciences2011，54，5： | 8 |
| 9 | A novel two-stage extended Kalman filter algorithm for reaction flywheels fault estimation显示文摘This paper investigates the problem of two-stage extended Kalman filter(TSEKF)-based fault estimation for reaction flywheels in satellite attitude control systems(ACSs). Firstly, based on the separate-bias principle, a satellite ACSs with actuator fault is transformed into an augmented nonlinear discrete stochastic model; then, a novel TSEKF is suggested such that it can simultaneously estimate satellite attitude information and actuator faults no matter they are additive or multiplicative; finally, the proposed approach is respectively applied to estimating bias faults and loss of effectiveness for reaction flywheels in satellite ACSs, and simulation results demonstrate the effectiveness of the proposed fault estimation approach. | Chen Xueqin Sun Rui Jiang Wancheng Jia Qingxian Zhang Jinxiu | 2016 | Chinese Journal of Aeronautics2016，29，2： | 7 |
| 10 | Development and application of genotyping technologies显示文摘With the completion of Human Genome Project,International HapMap Project and the publication of copy number variation in human genome,a great number of accurate,rapid,and cost-effective technologies for SNP analysis have been developed,promoting the research of the complex diseases.This article presents a review of widely used genotyping techniques,and the progress and prospect in the study of complex diseases in terms of the projects and achievements of Chinese National Human Genome Center at Shanghai(CHGCs). | SHI JinXiu,WANG Ying & HUANG Wei Shanghai-MOST Key Laboratory of Health and Disease Genomics,Chinese National Human Genome Center at Shanghai,Shanghai 201203,China | 2009 | Science China(Life Sciences)2009，52，1： | 6 |
| 11 | Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China显示文摘Objective: Care HPV is a human papillomavirus(HPV) DNA test for low-resource settings(LRS).This study assesses optimum triage strategies for care HPV-positive women in LRS.Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid(VIA),liquid-based cytology and HPV testing by physician-and self-collected care HPV,and physician-collected Hybrid Capture 2(HC2).Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary.HPV-positivity was defined as ≥1.0 relative light units/cutoff(RLU/CO) for both care HPV and HC2.Primary physician-HC2,physician-care HPV and self-care HPV and in sequential screening with cytology,VIA,or increased HPV test-positivity performance,stratified by age,were assessed for cervical intraepithelial neoplasia(CIN) grade 2/3 or worse(CIN2/3+) detection.Results: The sensitivities and specificities of primary HPV testing for CIN2+ were: 83.8%,88.1% for physiciancare HPV; 72.1%,88.2% for self-care HPV; and 97.1%,86.0% for HC2.Physician-care HPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2+ versus 80.9% with cytology triage.Self-care HPV testpositive women with VIA triage was 26.5% versus 66.2% with cytology triage.The sensitivity of HC2 test-positive women with VIA triage was 38.2% versus 92.6% with cytology triage.The sensitivity of physician-care HPV testing for CIN2+ decreased from 83.8% at ≥1.0 RLU/CO to 72.1% at ≥10.00 RLU/CO,while the sensitivity of selfcare HPV testing decreased from 72.1% at ≥1.0 RLU/CO to 32.4% at ≥10.00 RLU/CO; similar trends were seen with age-stratification.Conclusions: VIA and cytology triage improved specificity for CIN2/3 than no triage.Sensitivity with VIA triage was unsuitable for a mass-screening program.VIA provider training might improve this strategy.Cytology triage could be feasible where a high-quality cytology program exists.Triage of HPV test-positive women by increased test positivity cutoff adds another LRS triage option. | Margaret Wang Shangying Hu Shuang Zha o Wenhua Zhang Qinjing Pan Xun Zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui Zhao | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 12 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 13 | D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP显示文摘 | Fengjing Jia Jiayi Wang Jinxiu Peng Ping Zhao Ziqing Kong Kairong Wang Wenjin Yan Rui Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 5 |
| 14 | The effect of slight to minor biodegradation on C_6 to C_7 light hydrocarbons in crude oils: a case study from Dawanqi Oilfield in the Tarim Basin,NW China显示文摘Light hydrocarbons(LHs) are one of the main petroleum fractions in crude oils, and carry much information regarding the genetic origin and alteration of crude oils. But secondary alterations—especially biodegradation—have a significant effect on the composition of LHs in crude oils. Because most of the LHs affected in oils underwent only slight biodegradation(rank 1 on the biodegradation scale), the variation of LHs can be used to describe more the refined features of biodegradation. Here,23 crude oils from the Dawanqi Oilfield in the Tarim Basin, NW China, eleven of which have been biodegraded to different extents, were analyzed in order to investigate the effect of slight to minor biodegradation on C_6–C_7 LHs.The study results showed that biodegradation resulted in the prior depletion of straight-chained alkanes, followed by branched alkanes. In slight and minor biodegraded oils,such biodegradation scale could not sufficiently affect C_6–C_7cycloalkanes. For branched C_6–C_7 alkanes, generally,monomethylalkanes are biodegraded earlier than dimethylalkanes and trimethylalkanes, which indicates that branched alkanes are more resistant to biodegradation, with the increase of substituted methyl groups on parent rings.The degree of alkylation is one of the primary controlling factors on the biodegradation of C_6–C_7 LHs. There is a particular case: although 2,2,3-trimethylbutane has a relative higher alkylation degree, 2,2-dimethylpentane is more resistant to biodegradation than 2,2,3-trimethylbutane. 2,2-Dimethylpentane is the most resistant to biodegradation in branched C_6–C_7 alkanes. Furthermore, the 2-methylpentane/3-methylpentane and 2-methylhexane/3-methylhexane ratios decreased steadily with increasing biodegradation,which implies that isomers of bilateral methyl groups are more prone to bacterial attack relative to mid-chain isomers. The position of the alkyls on the carbon skeleton is also one of the critical factors controlling the rate of biodegradation. With increasing biodegradation, Mango's LH parameters K1 values decrease and K2 values increase,the values of n-heptane and isoheptane decrease, and the indices of methylcyclohexane and cyclohexane increase.LH parameters should be applied cautiously for the biodegraded oils. Because biodegraded samples belong to slight or minor biodegraded oils, the values of n-heptane and isoheptane from Dawanqi Oilfield can better reflect and determine the ‘‘Biodegraded'' zone. When the heptane value is 0–21 and the isoheptane value is 0–2.6, the crude oil in Dawanqi Oilfield is defined as the ‘‘Biodegraded'' zone. | Lu Yang Chunming Zhang Meijun Li Jing Zhao Xuening Qi Jinxiu Du | 2016 | Acta Geochimica2016，35，2： | 5 |
| 15 | Upregulation of miR-489-3p and miR-630 inhibits oxaliplatin uptake in renal cell carcinoma by targeting OCT2显示文摘Renal cell carcinoma(RCC) is one of the most common malignant tumors affecting the urogenital system, accounting for 90% of renal malignancies. Traditional chemotherapy options are often the front-line choice of regimen in the treatment of patients with RCC, but responses may be modest or limited due to resistance of the tumor to anticarcinogen. Downregulated expression of organic cation transporter OCT2 is a possible mechanism underlying oxaliplatin resistance in RCC treatment. In this study, we observed that mi R-489-3 p and mi R-630 suppress OCT2 expression by directly binding to the OCT2 30-UTR. Meanwhile, via 786-O-OCT2-mi RNAs stable expression cell models, we found that mi RNAs could repress the classic substrate 1-methyl-4-phenylpyridinium(MPP+), fluorogenic substrate N,N-dimethyl-4-(2-pyridin-4-ylethenyl) aniline(ASP+), and oxaliplatin uptake by OCT2 both in vitro and in xenografts. In 33 clinical samples, mi R-489-3 p and mi R-630 were significantly upregulated in RCC, negatively correlating with the OCT2 expression level compared to that in adjacent normal tissues, using tissue microarray analysis and q PCR validation. The increased binding of c-Myc to the promoter of pri-mi R-630, responsible for the upregulation of mi R-630 in RCC, was further evidenced by chromatin immunoprecipitation and dual-luciferase reporter assay. Overall, this study indicated that mi R-489-3 p and mi R-630 function as oncotherapy-obstructing micro RNAs by directly targeting OCT2 in RCC. | Lu Chen Le Chen Zhiyuan Qin Jinxiu Lei Sheng Ye Kui Zeng Hua Wang Meidan Ying Jianqing Gao Su Zeng Lushan Yu | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 5 |
| 16 | Effects of light quality on growth and development of cucumber seedlings in controlled environment显示文摘Conventional light sources have been successfully used to cultivate a wide variety of horticultural crops.However,they are of limited use due to uncontrollability of spectra and energy inefficiency.Light-emitting diodes(LEDs)emerged with tremendous potential in controlled environment agriculture due to their energy efficiency,longevity,and spectral specificity,but the effects of different types of LEDs on plant growth and development must be examined.In this study,cucumber(Cucumis sativus L.cv.Zhongnong 26)seedlings were grown under four different lighting treatments that each delivered a photosynthetic photon flux density of 200μmol/m2·s at plant canopy including triphosphate fluorescent lamps(TF),high-frequency fluorescent lamps(HF),white LEDs(WL),and red and blue LEDs(RBL).Cucumber seedlings were grown in a growth chamber at(25.0±1.5)℃with 12-hour light and 12-hour dark for 30 days after sowing,and data were subsequently collected.Seedlings grown under the WL were 45%,12%,and 40%taller than those grown under the TF,HF and RBL,respectively.The leaf area was 23%smaller under the TF than under the HF.The shoot dry weight was 16%-22%lower under the TF than under the other lighting treatments.The transplants grown under the RBL had the lowest root dry weight and root to shoot ratio.The seedling quality index was similar among all the lighting treatments.The LEDs treatment yielded more total dry weight with unit electric power compared to the fluorescent lamps.The chlorophyll content was 13%-15%higher in plants grown under the HF and WL than that under the TF and RBL.Plants grown under the WL and RBL had greater photosynthetic rate,transpiration rate,and stomatal conductance than those grown under the TF and HF.It was concluded that high quality cucumber seedlings can be efficiently produced under the broad-spectrum WL that emit a reasonable amount of blue,green and red light,and the lack of green light and/or high ratio of red to blue light under the RBL may cause undesired plant attributes. | Song Jinxiu Meng Qingwu Du Weifen He Dongxian | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 4 |
| 17 | FeOOH quantum dots decorated graphene sheet:An efficient electrocatalyst for ambient N2 reduction显示文摘Electrochemical N2 reduction offers a promising alternative to the Haber-Bosch process for sustainable NH3 synthesis at ambient conditions,but it needs efficient catalysts for the N2 reduction reaction(NRR).Here,we report that FeOOH quantum dots decorated graphene sheet acts as a superior catalyst toward enhanced electrocatalytic N2 reduction to NH3 under ambient conditions.In 0.1 M LiClO4,this hybrid attains a large NH3 yield rate and a high Faradaic efficiency of 27.3µg·h^−1·mg−1cat.and 14.6%at−0.4 V vs.reversible hydrogen electrode,respectively,rivalling the current efficiency of all Fe-based NRR electrocatalysts in aqueous media.It also shows strong durability during the electrolytic process. | Xiaojuan Zhu Jinxiu Zhao Lei Ji Tongwei Wu Ting Wang Shuyan Gao Abdulmohsen Ali Alshehri Khalid Ahmed Alzahrani Yonglan Luo Yimo Xiang Baozhan Zheng Xuping Sun | 2020 | Nano Research2020，13，1： | 4 |
| 18 | Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine显示文摘Background:The clinical features of keloids consist of aberrant proliferation,secretion,differentiation and apoptosis of keloid dermis-derived fibroblasts(KFBs).Notably,the apoptosis rate of KFBs is lower than the proliferation rate.Though the anti-fibrotic effect of adipose-derived stem cells(ADSCs)on keloids has become a hot topic of research,the exact anti-fibrotic mechanism of the paracrine effect remains unclear.This study aimed to find out how the conditioned medium of ADSCs(ADSC-CM)exerts an anti-fibrotic effect in KFBs.Methods:KFBs and ADSCs were extracted and cultured.Then,ADSC-CM was prepared.Whether ADSC-CM could inhibit KFB growth and induce apoptosis was verified by the use of a cell counting kit-8,an 5-Ethynyl-2-deoxyuridine(Edu)kit and flow cytometry.The expressions of cyclooxygenase-1(COX-1),COX-2,caspase 3 and B-cell lymphoma-2(Bcl-2)in ADSC-CM-cultured KFBs were tested by real-time PCR and western blotting.To clarify the role of COX-2 in ADSC-CM-induced KFB apoptosis,a specific COX-2 inhibitor,celecoxib,was applied to KFBs cultured in ADSC-CM.Moreover,we tested the production of arachidonic acid(AA)and prostaglandin E2(PGE2)by ELISA.Then,we established a keloid transplantation model in a nude mouse to validate the therapeutic effect in vivo.Results:The proliferation ability of KFBs cultured in ADSC-CM was found to be weakened and apoptosis was significantly increased.Caspase 3 expression was significantly upregulated and Bcl-2 was downregulated in ADSC-CM-cultured KFBs.Furthermore,ADSC-CM strikingly elevated COX-2 mRNA and protein expressions,but COX-1 expression was unaltered.COX-2 inhibitors reduced ADSC-CM-induced apoptosis.Additionally,COX-2 inhibition blocked the elevation of caspase 3 and reversed the decrease in Bcl-2 expression.ADSC-CM increased PGE2 levels by 1.5-fold and this effect was restrained by COX-2 inhibition.In the nude mouse model,expressions of AA,COX-2 and PGE2 were higher in the translated keloid tissues after ADSC-CM injection than in the controls.Conclusions:We showed activation of the COX-2/PGE2 cascade in KFBs in response to ADSC-CM.By employing a specific COX-2 inhibitor,COX-2/PGE2 cascade activation played a crucial role in mediating the ADSC-CM-induced KFB apoptosis and anti-proliferation effects. | Jinxiu Yang Shiyi Li Leren He Minliang Chen | 2021 | Burns & Trauma2021，9，1： | 4 |
| 19 | The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population显示文摘The norepinephrine transporter plays an important role in the pathophysiology and pharmacological treatment of major depressive disorder.Consequently,the norepinephrine transporter gene is an attractive candidate in major depressive disorder research.In the present study,we evaluated the depression symptoms of subjects with major depressive disorder,who were all from the North of China and of Han Chinese origin,using the Hamilton Depression Scale.We examined the rela-tionship between two single nucleotide polymorphisms in the norepinephrine transporter,rs2242446 and rs5569,and the retardation symptoms of major depressive disorder using quantitative trait testing with the UNPHASED program.rs5569 was associated with depressed mood,and the GG genotype may be a risk factor for this;rs2242446 was associated with work and interest,and the TT genotype may be a risk factor for loss of interest.Our findings suggest that rs2242446 and rs5569 in the norepinephrine transporter gene are associated with the retardation symptoms of depression in the Han Chinese population. | Xinrong Li Ning Sun Yong Xu Yanfang Wang Suping Li Qiaorong Du Juyi Peng Jinxiu Luo Kerang Zhang | 2012 | Neural Regeneration Research2012，7，25： | 3 |
| 20 | Development of high-resolution chloroplast markers for intraspecific phylogeographic studies of Phaeocystis globosa显示文摘Phaeocystis globosa is an important harmful algal bloom causative species distributing widely in temperate and tropical coastal waters in the world.The morphological,physiological,and biochemical characteristics are different among geographic strains,which can not be distinguished with nuclear ribosomal DNA markers at present.Therefore,the genetic distance and phylogeographic relationships of nuclear 28S rDNA D1–D2 and ITS regions,and three chloroplast intergenic spacers(petN-trnS1,trnM1-psbA,and rbcS-rpl27)were analyzed and compared among 13 strains of P.globosa isolated from the Pacific Ocean and Atlantic Ocean in this study.In addition,the nucleotide polymorphisms of 28S rDNA D1–D2,ITS,and rbcS-rpl27 regions were evaluated in two P.globosa strains.The various levels of nucleotide polymorphism were in the nuclear 28S rDNA D1–D2 region and ITS region,but no polymorphism was in the chloroplast rbcS-rpl27 intergenic spacer.A reasonable intraspecific phylogeographic relationship was presented by rbcS-rpl27 intergenic spacer,which had the strongest distinction to geographic strains compared to those of 28S rDNA D1–D2 and ITS regions.In the phylogenetic tree of rbcS-rpl27 intergenic spacer,the two strains from the North Sea of the Atlantic Ocean were divided firstly from the species of P.globosa,and then formed an independent clade,while the other Atlantic strains and all of Pacific strains joined up to build the other clade.It was implied that at least two genetically distant populations of P.globosa existed in the Atlantic coastal regions.This study provided a high-resolution chloroplast marker to analyze intraspecific phylogeographic populations of P.globosa,and preliminarily clarified the genetic relationships of the Pacific and Atlantic strains of P.globosa. | Qingchun ZHANG Zhuang NIU Jinxiu WANG Chao LIU Fanzhou KONG Xiaokun HU Jiayu ZHAO Rencheng YU | 2021 | Journal of Oceanology and Limnology2021，39，2： | 3 |
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