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| 1 | Virus-Encoded microRNAs: Future Therapeutic Targets?显示文摘The discovery of microRNAs (miRNAs) is a remarkable breakthrough in the field of molecular genetics, as miRNAs are key actors which regulate gene expression in diverse cellular processes from unicellular yeast to human. The recent discovery of virus-encoded miRNAs indicates that viruses also use this fundamental mode of gene regulation. Research into viral miRNAs function demonstrates that some miRNAs play an important role in regulating both the viral life cycle and the interaction between viruses and their hosts. The first in vivo “antagomir” study provides an exciting first step towards miRNA therapy, and the potential for ultimately designing molecular medicines based on the modulation of miRNAs seems good. | Peng Qi Jinxiang Han Yanqin Lu Chuanxi Wang Fanfeng Bu | 2006 | Cellular & Molecular Immunology2006，3，6： | 12 |
| 2 | TXNDC5 synergizes with HSC70 to exacerbate the inflammatory phenotype of synovial fibroblasts in rheumatoid arthritis through NF-κB signaling显示文摘The upregulated expression of thioredoxin domain-containing protein 5(TXNDC5)is associated with rheumatoid arthritis in patients and model mice.However,the underlying mechanism by which TXNDC5 influences the pathological activation of rheumatoid arthritis synovial fibroblasts(RASFs)remains unknown.In this study,we show that TXNDC5 expression in RASFs and their cytokine production are significantly upregulated in response to LPS,TNF-αand IL-6,but suppressed by transfection with TXNDC5-siRNA.TXNDC5 is further validated as the direct target of NF-κB signaling.Mechanistically,TXNDC5 directly interacts with heat shock cognate 70 protein(HSC70)to sequester it in the cytoplasm,and HSC70 silencing exerts the same effects as TXNDC5 on the biological activity of RASFs(for example,decreased cell viability,invasion and cytokine production).Furthermore,HSC70 activates NF-κB signaling by destabilizing IκBβprotein in the absence of LPS or facilitating its nuclear translocation in the presence of LPS.Importantly,TXNDC5 can also regulate the activity of NF-κB signaling in a HSC70-IκBβ-dependent manner.Taken together,by linking HSC70 and NF-κB signaling,TXNDC5 plays a pro-inflammatory role in RASFs,highlighting a potential approach to treat RA by blocking the TXNDC5/HSC70 interaction. | Lin Wang Hongyan Dong Guanhua Song Rui Zhang Jihong Pan Jinxiang Han | 2018 | Cellular & Molecular Immunology2018，15，7： | 5 |
| 3 | Phase 1 studies comparing safety, tolerability, pharmacokinetics and pharmacodynamics of HLX01(a rituximab biosimilar) to reference rituximab in Chinese patients with CD20-positive B-cell lymphoma显示文摘Objective: This study aimed to compare the pharmacokinetic, pharmacodynamic and safety profiles of HLX01(a rituximab biosimilar) and reference rituximab sourced from China(Mab Thera?;rituximab-CN).Methods: Here we report the results of two phase 1 studies. In the phase 1 a, open-label, dose-escalation study(NCT03218072, CTR20140400), eligible patients received 250, 375 and 500 mg/m^(2) HLX01 sequentially at 7-day intervals, after confirming no dose-limiting toxicity(DLT). In the phase 1 b, double-blind study(NCT02584920,CTR20140764), eligible patients were given a single dose of 375 mg/m^(2) HLX01 or rituximab-CN. The primary endpoints included safety and tolerability parameters for the phase 1 a and the area under the plasma concentrationtime curve from time zero to day 91(AUC0-91 d) for the phase 1 b study. Equivalence was concluded if 90%confidence interval(90% CI) for the geometric least squares mean ratio(GLSMR) fell in the pre-specified equivalence criteria(80%-125%).Results: Between June 20, 2014 and January 5, 2015, 12 patients were enrolled in the phase 1 a study. The pharmacokinetics of HLX01 showed dose proportionality and accumulation to steady state. HLX01 was well tolerated, with no serious adverse events(AEs), discontinuations or DLTs. Between November 8, 2014 and August13, 2015, 87 eligible patients were enrolled in the phase 1 b study, including 43 who received HLX01 and 44 who were treated with rituximab-CN. The equivalence endpoint was met with GLSMR for AUC0-91 d being 89.6%(90% CI: 80.4%-99.8%). AEs, anti-drug antibodies, and CD19+ and CD20+ B lymphocyte counts were similar between the HLX01 and rituximab-CN treatment groups.Conclusions: Treatment with HLX01 was safe and well tolerated in Chinese patients with B-cell lymphoma.HLX01 and rituximab-CN have similar pharmacokinetic, pharmacodynamic and safety profiles. | Yuankai Shi Qingyuan Zhang Xiaohong Han Yan Qin Xiaoyan Ke Hang Su Li Liu Jinxiang Fu Jie Jin Jifeng Feng Xiaonan Hong Xiaohong Zhang Depei Wu Bin Jiang Xiaodong Dong | 2021 | Chinese Journal of Cancer Research2021，33，3： | 5 |
| 4 | Study on the quantitative structureactivity relation-ship of C-10 substituted artemisinin(QHS)’s derivatives using rough set theory显示文摘The structure-activity relationship study of C-10 substituted artemisinin (QHS) derivatives that are used as antimalarial was performed with the RS (rough sets) method. An RS process is a concise nonlinear process, and it has broad application foreground in the data mining of nonlinear life courses. In this work, initially the parameters of C-10 substituted QHS’s derivatives were computed with the quantum chemistry method, and the information table was constructed from the parameters (condition attributes) and biological activity (decision attributes). Based on the analysis of rough set theory, the core and reduction of attributes sets were obtained. Then the decision rules were extracted and the struc-ture-activity relationship was analyzed. As a nonlinear system, RS theory can extract the special rela-tion in the database. It has the advantage of being nonlinear over multiple linear regression (MLR), principal component analysis (PCA), partial least square (PLS), etc., and the advantage of obtaining results with unambiguous physical meanings over artificial neuron networks (ANNs), etc. The result obtained in this study is instructive to the study of pharmacodynamics, resistance mechanism of QHS and development of QHS’s derivatives. | LIU Hao QU LingBo GAO HongBin WANG JinXiang HAN LiPing XIANG BingRen | 2008 | Science China Chemistry2008，51，10： | 5 |
| 5 | Measurement of Neutron Capture Cross Section for ^(180)Hf | Chen Jinxiang Shi Zhaomin Tang Guoyou Zhang Guohui Institute of Heavy Ion Physics,Peking University,Beijing 100871Lu Hanlin Han Xiaogang Huang Xiaolong China Institute of Atomic Energy,P.O.Box 275(3),Beijing 102413 | 1997 | Chinese journal of nuclear physics1997，，2： | 3 |
| 6 | The interfering hypothesis of channels and collat- erals :the channels and collateral is a whole network of solidar- ity by the electromagnetic radiation interfering beams within hu- man body显示文摘 | Han Jinxiang | 2012 | Cell Biochem Biophys2012，62，： | 1 |
| 7 | Quantum:may be a new-found me- ssenger in biological systems显示文摘 | Han Jinxiang Yang Meina | 2011 | Bio Science Trends2011，5，3： | 1 |
| 8 | Mathematical model of biological order state or syndrome in traditional Chinese medicine:based on electromagnetic radiation within the human body显示文摘 | Han Jinxiang Huang Jinzhao | 2012 | Cell Biochem Biophys2012，62，： | 1 |
| 9 | Quantum: May be a new - found messenger in biological systems 显示文摘 | Jinxiang Han Meina Yang | 2011 | Bioscicnce trends2011，5，3： | 1 |
| 10 | Circulating microRNA-21 as noninvasive predictive biomarker for response in cancer immunotherapy显示文摘 | Zhiyu Wang Jinxiang Han Yazhou Cui Kaixi Fan Xiaoyan Zhou | 2013 | Medical Hypotheses2013，，1： | 1 |
| 11 | Proteomic Analysis of Pancreatic Ductal Adenocarcinoma Compared with Normal Adjacent Pancreatic Tissue and Pancreatic Benign Cystadenoma显示文摘 | Yazhou Cui Mei Tian Meijuan Zong Mujian Teng Yu Chen Jun Lu Jinbo Jiang Xiaoyong Liu Jinxiang Han | 2009 | Pancreatology . 2009 (1-2)2009，，1： | 1 |
| 12 | A Transient Three-plasmid Expression System for the Production of Hepatocytes Targeting Retroviral Vectors显示文摘制动火箭指向病毒的向量到特定的房间通过修改鼠科的白血病病毒(MLV ) 的表面蛋白质被尝试,但是在许多情况中,蛋白质功能被影响,并且完成指向的交货是困难的。在这研究,我们试试制动火箭到基于的工程师 ecotropic Moloney 鼠科的白血病病毒( MoMLV )病毒的向量 totransduce hepatocytes.A 妄想的信封( Env )表示原生质标志被构造包含在 pgag-pol 的 Env.Following simultaneoustransfection 的N终点熔化到 aa+1 的肝炎 B 病毒 PreS2 肽, pLEGFP 和妄想的 env 原生质标志进 293T 细胞,有约 104 传染 units/ml 的 titer 的没有助手的 retrovirusstocks 在假类型向量显示出的 48 hpost-transfection.These 被完成制动火箭病毒的正常宿主范围,感染 hostNIH 3T3 细胞,尽管效率与带 wild-typeecotropic MoMLV 信封的 virions 的相比被减少。另外,结果的假类型病毒能没有 polymerized, transduce 人 hepatomacells 与那些 transductions 比较与相对高的乳头 ers 由 polymerized 人浆液白朊调停了人的浆液白朊。这条途径能有选择地习惯于 targethepatocytes。 | Peng QI Jinxiang HAN Yanqin LU Chuanxi WANG Bo ZHU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，8： | 1 |
| 13 | Index system and methods for comprehensive assessment of cross-border power grid interconnection projects显示文摘With the global economy integration and progress in energy transformation,it has become a general trend to surpass national boundaries to achieve wider and optimal energy resource allocations.Consequently,there is a critical n eed to adopt scie ntific approaches in assessi ng cross-border power grid interconnection projects.First,con sidering the promotion of large-scale renewable energy resources and improvements in system adequacy,a comprehensive assessment index system,including costs,socio-economic benefits,environmental benefits,and technical benefits,is established in this study.Second,a synthetic assessment framework is proposed for cross-border power grid interconnection projects based on the index system comprising cost-benefit analysis,with market and network simulations,iterative methods for indicator weight evaluation,and technique for order preferenee by similarity to an ideal solution(TOPSIS)method for the project rankings.Fin ally,by assessi ng and comparing three cross-border projects betwee n Europe and Asia,the proposed index system and assessment framework have been proved to be effective and feasible;the results of this system can thus support investment decision-making related to such projects in the future. | Teng Zhao Yizhe Jiang Han Jiang Yi Gao Wei Wu Chen Wang Jinxiang Zhu | 2020 | Global Energy Interconnection2020，3，6： | 0 |
| 14 | Recent progress of traditional Chinese medical science based on theory of biophoton显示文摘 | Xiuxiu WANG Jinzhao HUANG Jinxiang HAN Meina YANG Jingxiang PANG Xiaolei ZHAO | 2014 | Frontiers of Optoelectronics2014，7，1： | 0 |
| 15 | Sirt5 desuccinylates Cdc42 to mediate osteoclastogenesis and bone remodeling in mice显示文摘Post-translational modifications(PTMs)play a critical role in bone remodeling,with phosphorylation and acetylation being particularly well characterized.Recently,succinylation,a relatively uncommon PTM on lysine,has received considerable research attention for its influence on several physiological and pathological processes and conditions.1 Several substrates involved in mitochondrial pathways have been validated as substrates for the desuccinylase sirtuin 5(Sirt5),a key regulator of succinylation.2 Bone is one of the most metabolically active organs,but the role of succinylation during bone remodeling is not well characterized. | Yuang Zhanngg Jing Wang Jjing Luan Chuanju Liu Yazhou Cui Jinxiang Han | 2024 | Genes & Diseases2024，11，3： | 0 |
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