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| 1 | Metasurfaces for manipulating terahertz waves显示文摘Terahertz(THz)science and technology have attracted significant attention based on their unique applications in non-destructive imaging,communications,spectroscopic detection,and sensing.However,traditional THz devices must be sufficiently thick to realise the desired wave-manipulating functions,which has hindered the development of THz integrated systems and applications.Metasurfaces,which are two-dimensional metamaterials consisting of predesigned meta-atoms,can accurately tailor the amplitudes,phases,and polarisations of electromagnetic waves at subwavelength resolutions,meaning they can provide a flexible platform for designing ultra-compact and high-performance THz components.This review focuses on recent advancements in metasurfaces for the wavefront manipulation of THz waves,including the planar metalens,holograms,arbitrary polarisation control,special beam generation,and active metasurface devices.Such ultra-compact devices with unique functionality make metasurface devices very attractive for applications such as imaging,encryption,information modulation,and THz communications.This progress report aims to highlight some novel approaches for designing ultra-compact THz devices and broaden the applications of metasurfaces in THz science. | Xiaofei Zang Bingshuang Yao Lin Chen Jingya Xie Xuguang Guo Alexei VBalakin Alexander P.Shkurinov Songlin Zhuang | 2021 | Light(Advanced Manufacturing)2021，2，2： | 4 |
| 2 | Antimicrobial Chlorinated Carbazole Alkaloids from the Sponge-Associated Actinomycete Streptomyces diacarni LHW51701显示文摘Four new chlorinated carbazole alkaloids,chlocarbazomycins(CCBs)A-D,were isolated from sponge associated bacterium Streptomyces diacarni LHW51701.Their structures were elucidated via spectroscopic techniques(including HRESIMS,ID&2D NMR),and X-ray crystallographic analysis.Structurally,the 4-chloro coupled with 3-methoxyl substituents in the tricycle nucleus of CCBs A-D and the A/-methoxyl group of CCB-D are rare in naturally occurred tricyclic carbazole alkaloids.Moreover,CCBs A-D do not bear the typical Cl poro-alkyl and C2 meto-methyl side chains of bacterial tricycle carbazoles,suggesting a novel mechanism of aromatic ring formation in biosynthesis.The biological evaluation showed that CCB-C possessed inhibitory activities against pathogenic microorganisms including methicillin-resistant Staphylococcus aureus(MRSA),Mycobacterium smegmatis,Bacillus mycoides,and Candida albicans. | Yijia Cheng Nannan Chen Jing Li Jun-Cheng Su Jingya Yang Cui-Xian Zhang Hou-Wen Lin Yongjun Zhou | 2021 | Chinese Journal of Chemistry2021，39，5： | 3 |
| 3 | Berry syndrome: a rare cardiac malformation with extra-cardiac findings显示文摘Dear Editor,Berry syndrome is a rare combination of congenital cardiac malformations characterized by four abnormal features;namely,an aortopulmonary window(APW),aortic origin of the right pulmonary artery,hypoplasia or interruption of the aortic arch,with an intact ventricular septum.The disease was first reported by Berry in 1982,who estimated the incidence within the population with congenital cardiac malformations to be 0.046%(Berry et al.,1982).Until recently, | Jingya Li Ya Yang Xiaomin Duan Lanzhong Jin Lin Zheng Xin Zhang Haiyan Wei Yan Sun Xiaolin Zhang Pei Li Jiao Yang Ning Ma Fangyun Wang | 2017 | Science China(Life Sciences)2017，60，7： | 3 |
| 4 | Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function显示文摘The AMP-activated protein kinase(AMPK)is a central regulator of energy homeostasis.Although much has been learned on how low energy status and glucose starvation activate AMPK,how AMPK activity is properly controlled in vivo is still poorly understood.Here we report that UHRF1,an epigenetic regulator highly expressed in proliferating and cancer cells,interacts with AMPK and serves to suppress AMPK activity under both basal and stressed conditions.As a nuclear protein,UHRF1 promotes AMPK nuclear retention and strongly suppresses nuclear AMPK activity toward substrates H2B and EZH2.Importantly,we demonstrate that UHRF1 also robustly inhibits AMPK activity in the cytoplasm compartment,most likely as a consequence of AMPK nucleocytoplasmic shuttling.Mechanistically,we found that UHRF1 has no obvious effect on AMPK activation by upstream kinases LKB1 and CAMKK2 but inhibits AMPK activity by acting as a bridging factor targeting phosphatase PP2A to dephosphorylate AMPK.Hepatic overexpression of UHRF1 showed profound effects on glucose and lipid metabolism in wild-type mice but not in those with the liver-specific knockout of AMPKα1/α2,whereas knockdown of UHRF1 in adipose tissue led to AMPK activation and reduced sizes of adipocytes and lipogenic activity,highlighting the physiological significance of this regulation in glucose and lipid metabolism.Thus,our study identifies UHRF1 as a novel AMPK gate-keeper with critical roles in cellular metabolism. | Xiang Xu Guangjin Ding Caizhi Liu Yuhan Ding Xiaoxin Chen Xiaoli Huang Chen-Song Zhang Shanxin Lu Yunpeng Zhang Yuanyong Huang Zhaosu Chen Wei Wei Lujian Liao Shu-Hai Lin Jingya Li Wei Liu Jiwen Li Sheng-Cai Lin Xinran Ma Jiemin Wong | 2022 | Cell Research2022，32，1： | 3 |
| 5 | Development of T. aestivum L.eH. californicum Alien Chromosome Lines and Assignment of Homoeologous Groups of Hordeum californicum Chromosomes显示文摘Hordeum californicum(2n=2x=14, HH) is resistant to several wheat diseases and tolerant to lower nitrogen. In this study, a molecular karyotype of H. californicum chromosomes in the Triticum aestivum L. cv. Chinese Spring(CS)eH. californicum amphidiploid(2n=6x=56, AABBDDHH) was established. By genomic in situ hybridization(GISH) and multicolor fluorescent in situ hybridization(FISH) using repetitive DNA clones(pTa71, pTa794 and pSc119.2) as probes, the H. californicum chromosomes could be differentiated from each other and from the wheat chromosomes unequivocally. Based on molecular karyotype and marker analyses, 12 wheatealien chromosome lines, including four disomic addition lines(DAH1, DAH3, DAH5 and DAH6), five telosomic addition lines(MtH7L,MtH1 S, MtH1 L, DtH6 S and DtH6L), one multiple addition line involving H. californicum chromosome H2, one disomic substitution line(DSH4) and one translocation line(TH7S/1BL), were identified from the progenies derived from the crosses of CSeH. californicum amphidiploid with common wheat varieties. A total of 482 EST(expressed sequence tag) or SSR(simple sequence repeat) markers specific for individual H. californicum chromosomes were identified, and 47, 50, 45, 49, 21, 51 and 40 markers were assigned to chromosomes H1, H2, H3, H4, H5, H6 and H7, respectively. According to the chromosome allocation of these markers, chromosomes H2,H3, H4, H5, and H7 of H. californicum have relationship with wheat homoeologous groups 5, 2, 6, 3, and 1, and hence could be designated as 5Hc, 2Hc, 6Hc, 3Hcand 1Hc, respectively. The chromosomes H1 and H6 were designated as 7Hcand 4Hc, respectively, by referring to SSR markers located on rye chromosomes. | Yuhui Fang Jingya Yuan Zhangjun Wang Haiyan Wang Jin Xiao Zhixi Yang Ruiqi Zhang Zengjun Qi Weigang Xu Lin Hu Xiu-E Wang | 2014 | Journal of Genetics and Genomics2014，41，8： | 2 |
| 6 | Dual-layered metasurfaces for asymmetric focusing显示文摘Asymmetric transmission,defined as the difference between the forward and backward transmission,enables a plethora of applications for on-chip integration and telecommunications.However,the traditional method for asymmetric transmission is to control the propagation direction of the waves,hindering further applications.Metasurfaces,a kind of two-dimensional metamaterials,have shown an unprecedented ability to manipulate the propagation direction,phase,and polarization of electromagnetic waves.Here we propose and experimentally demonstrate a metasurface-based directional device consisting of a geometric metasurface with spatially rotated microrods and metallic gratings,which can simultaneously control the phase,polarization,and propagation direction of waves,resulting in asymmetric focusing in the terahertz region.These dual-layered metasurfaces for asymmetric focusing can work in a wide bandwidth ranging from 0.6 to 1.1 THz.The flexible and robust approach for designing broadband asymmetric focusing may open a new avenue for compact devices with potential applications in encryption,information processing,and communication. | BINGSHUANG YAO XIAOFEI ZANG ZHEN L LIN CHEN JINGYA XIE YIMING ZHU SONGLIN ZHUANG | 2020 | Photonics Research2020，8，6： | 2 |
| 7 | Predictors of Postoperative Complications After Trimodality Therapy for Esophageal Cancer显示文摘 | Jingya Wang Caimiao Wei Susan L. Tucker Bevan Myles Matthew Palmer Wayne L. Hofstetter Stephen G. Swisher Jaffer A. Ajani James D. Cox Ritsuko Komaki Zhongxing Liao Steven H. Lin | 2013 | International Journal of Radiation Oncology Biology Physics2013，，5： | 1 |
| 8 | Quantifying the Interfractional Displacement of the Gastroesophageal Junction During Radiation Therapy for Esophageal Cancer显示文摘 | Jingya Wang Steven H. Lin Lei Dong Peter Balter Radhe Mohan Ritsuko Komaki James D. Cox George Starkschall | 2012 | International Journal of Radiation Oncology Biology Physics2012，，2： | 1 |
| 9 | PIF4 and HOOKLESS1 Impinge on Common Transcriptome and Isoform Regulation in Thermomorphogenesis显示文摘High temperature activates the transcription factor PHYTOCHROME-INTERACTING FACTOR4(PIF4)to stimulate auxin signaling,which causes hypocotyl elongation and leaf hyponasty(thermomorphogenesis).HOOKLESS1(HLS1)is a recently reported positive regulator of thermomorphogenesis,but the molecular mechanisms by which HLS1 regulates thermomorphogenesis remain unknown.In this study,we initially compared PIF4-and/or HLS1-dependent differential gene expression(DEG)upon high-temperature treatment.We found that a large number of genes are coregulated by PIF4 and HLS1,especially genes involved in plant growth or defense responses.Moreover,we found that HLS1 interacts with PIF4 to form a regulatory module and that,among the HLS1-PIF4-coregulated genes,27.7%are direct targets of PIF4.We also identified 870 differentially alternatively spliced genes(DASGs)in wild-type plants under high temperature.Interestingly,more than half of these DASG events(52.4%)are dependent on both HLS1 and PIF4,and the spliceosome-defective mutant plantsexhibit a hyposensitive response to high temperature,indicating that DASGs are required for thermomorphogenesis.Further comparative analyses showed that the HLS1/PIF4-coregulated DEGs and DASGs exhibit almost no overlap,suggesting that high temperature triggers two distinct strategies to control plant responses and thermomorphogenesis.Taken together,these results demonstrate that the HLS1-PIF4 module precisely controls both transcriptional and posttranscriptional regulation during plant thermomorphogenesis. | Huanhuan Jin Jingya Lin Ziqiang Zhu | 2020 | Plant Communications2020，1，2： | 1 |
| 10 | Spin-decoupled metalens with intensity-tunable multiple focal points显示文摘The control of spin electromagnetic(EM)waves is of great significance in optical communications.Although geometric metasurfaces have shown unprecedented capability to manipulate the wavefronts of spin EM waves,it is still challenging to independently manipulate each spin state and intensity distribution,which inevitably degrades metasurface-based devices for further applications.Here we propose and experimentally demonstrate an approach to designing spin-decoupled metalenses based on pure geometric phase,i.e.,geometric metasurfaces with predesigned phase modulation possessing functionalities of both convex lenses and concave lenses.Under the illumination of left-/right-handed circularly polarized(LCP or RCP)terahertz(THz)waves,these metalenses can generate transversely/longitudinally distributed RCP/LCP multiple focal points.Since the helicity-dependent multiple focal points are locked to the polarization state of incident THz waves,the relative intensity between two orthogonal components can be controlled with different weights of LCP and RCP THz waves,leading to the intensity-tunable functionality.This robust approach for simultaneously manipulating orthogonal spin states and energy distributions of spin EM waves will open a new avenue for designing multifunctional devices and integrated communication systems. | BINGSHUANG YAO XIAOFEI ZANG YANG ZHU DAHAI YU JINGYA XIE LIN CHEN SEN HAN YIMING ZHU SONGLIN ZHUANG | 2021 | Photonics Research2021，9，6： | 1 |
| 11 | Atrial of arbidol hydrochloride in adults with COVID-19显示文摘Background: To date, there is no effective medicine to treat coronavirus disease 2019 (COVID-19), and the antiviral efficacy of arbidol in the treatment for COVID-19 remained equivocal and controversial. The purpose of this study was to evaluate the efficacy and safety of arbidol tablets in the treatment of COVID-19.Methods: This was a prospective, open-label, controlled and multicenter investigator-initiated trial involving adult patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients were stratified 1:2 to either standard-of-care (SOC) or SOC plus arbidol tablets (oral administration of 200 mg per time, three times a day for 14 days). The primary endpoint was negative conversion of SARS-CoV-2 within the first week. The rates and 95% confidential intervals were calculated for each variable.Results: A total of 99 patients with laboratory-confirmed SARS-CoV-2 infection were enrolled;66 were assigned to the SOC plus arbidol tablets group, and 33 to the SOC group. The negative conversion rate of SARS-CoV-2 within the first week in patients receiving arbidol tablets was significantly higher than that of the SOC group (70.3% [45/64]vs. 42.4% [14/33];difference of conversion rate 27.9%;95% confidence interval [CI], 7.7%-48.1%;P=0.008). Compared to those in the SOC group, patients receiving arbidol tablets had a shorter duration of clinical recovery (median 7.0 daysvs. 12.0 days;hazard ratio [HR]: 1.877, 95% CI: 1.151-3.060,P=0.006), symptom of fever (median 3.0 daysvs. 12.0 days;HR: 18.990, 95% CI: 5.350-67.410,P<0.001), as well as hospitalization (median 12.5 daysvs. 20.0 days;P<0.001). Moreover, the addition of arbidol tablets to SOC led to more rapid normalization of declined blood lymphocytes (median 10.0 daysvs. 14.5 days;P > 0.05). The most common adverse event in the arbidol tablets group was the elevation of transaminase (5/200, 2.5%), and no one withdrew from the study due to adverse events or disease progression.Conclusions: SOC plus arbidol tablets significantly increase the negative conversion rate of SARS-CoV-2 within the first week and accelerate the recovery of COVID-19 patients. During the treatment with arbidol tablets, we find no significant serious adverse events. | Jingya Zhao Jinnong Zhang Yang Jin Zhouping Tang Ke Hu Hui Sun Mengmeng Shi Qingyuan Yang Peiyu Gu Hongrong Guo Qi Li Haiying Zhang Chenghong Li Ming Yang Nian Xiong Xuan Dong Juanjuan Xu Fan Lin Tao Wang Chao Yang Bo Huang Jingyi Zhang hi Chen Qiong He Min Zhou Jieming Qu | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 12 | New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort study显示文摘A new definition of metabolic dysfunction-associated fatty liver disease(MAFLD)has recently been proposed.We aim to examine the associations of MAFLD,particularly its discordance from non-alcoholic fatty liver disease(NAFLD),with the progression of elevated brachial-ankle pulse wave velocity(baPWV)and albuminuria in a community-based study sample in Shanghai,China.After 4.3 years of follow-up,778 participants developed elevated baPWV and 499 developed albuminuria.In comparison with the non-MAFLD group,the multivariable adjusted odds ratio(OR)of MAFLD group for new-onset elevated baPWV was 1.25(95%confidence interval(CI)1.01–1.55)and 1.35(95%CI 1.07–1.70)for albuminuria.Participants without NAFLD but diagnosed according to MAFLD definition were associated with higher risk of incident albuminuria(OR 1.77;95%CI 1.07–2.94).Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher risk of elevated baPWV or albuminuria.In conclusion,MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body mass index,waist circumference,and hip circumference.Individuals without NAFLD but diagnosed as MAFLD had high risk of albuminuria,supporting that MAFLD criteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver patients. | Jialu Wang Shanshan Liu Qiuyu Cao Shujing Wu Jingya Niu Ruizhi Zheng Lizhan Bie Zhuojun Xin Yuanyue Zhu Shuangyuan Wang Hong Lin Tiange Wang Min Xu Jieli Lu Yuhong Chen Yiping Xu Weiqing Wang Guang Ning Yu Xu Mian Li Yufang Bi Zhiyun Zhao | 2022 | Frontiers of Medicine2022，16，5： | 0 |
| 13 | Deformation of the Shirenshan Block in the North Qinling显示文摘Objective The Qinling orogenic belt is a typical complex continental orogenic belt which has experienced multiperiod tectonic evolution and where some important tectonic belts formed.The Luoluan fault is one of the most important belts,which is the boundary fault of the North China Plate and the Qinling orogenic belt.The Shirenshan block is located in the north section between Luanchuan and Fangcheng of the Luoluan fault.The north part | WANG Jingya REN Shenglian LI Jiahao LI Quanzhong SONG Chuanzhong LI Longmin LIN Shoufa HUANG Yonglong HAN Xu LI Zhenqiang | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 0 |
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