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| 1 | Toxic effects of chlortetracycline on maize growth,reactive oxygen species generation and the antioxidant response显示文摘The toxicity of chlortetracycline (CTC) on maize (Zea mays L.) growth and reactive oxygen species (ROS) generation was studied.The root and shoot lengths and fresh weights of maize seedlings were inhibited by CTC treatment (p < 0.05).Root length was more sensitive than other parameters with the EC 10 value of 0.064 mg/L.The spin trapping technique followed by electron paramagnetic resonance (EPR) analysis was used to quantify the ROS production.The ROS generated in maize roots after exposure to CTC was identified as hydroxyl radical (·OH).The EPR signal intensity correlated positively with the logarithm of CTC concentrations exposed (p < 0.05).The dynamic changes of malondialdehyde (MDA) contents and the antioxidative enzyme activities in maize roots were also determined.As compared to the control group,CTC was found to significantly increase MDA content.Treatment of maize roots with the ·OH scavenger sodium benzoate (SB) reduced the MDA content and enhanced the antioxidative enzyme activities.The results demonstrated the harmfulness of CTC at high dose to maize in the early developmental stage,and clarified that the inducement of ·OH is one of the mechanisms of CTC toxicity. | Bei Wen Yu Liu Peng Wang Tong WU Shuzhen Zhang Xiaoquan Shan Jingfen Lu | 2012 | Journal of Environmental Sciences2012，24，6： | 6 |
| 2 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 3 | 3D-QSAR study on phenoxy-alkylamine compounds of α_1-adrenoceptor antagonist显示文摘The study of three-dimensional quantitative structure-activity relationship (3D-QSAR) of DDPH and its derivatives that have been known with their activity parameters has been developed using the comparative molecular field analysis (CoMFA) method. Here, (+)-DDPH crystal structure was selected as the active conformation model and comparisons between the influences of different charge calculation methods and grid setup were conducted. The coefficients of cross-validation (q2) and regression (r2) are 0.481 and 0.997, respectively. The standard error (SE) is 0.102. The research result suggests that the steric field makes more contributions to the activity than the electrostatic field. This model can help us not only in improving our understanding of the receptor-ligand interactions, but also in predicting the activity of derivatives and designing new compounds with better potency. | FANG Hao, LU Jingfen, XIA Lin & ZHANG LineDepartment of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China State Key Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, China | 2001 | Chinese Science Bulletin2001，46，4： | 1 |
| 4 | Membrane transport of vanadium compounds and the interaction with the erythrocyte membrane 显示文摘 | Xiaogai Yang Kui Wang Jingfen Lu | 2003 | Coordination Chemistry Reviews2003，237，： | 1 |
| 5 | Studies of antioxidant activity of natural products with EPR methods显示文摘 | Lu Jingfen Muteliefu Gulinuer Li Tingfeng | 2007 | Chinese Journal of Magnetic Resonance2007，，27： | 1 |
| 6 | EPR and UV-vis studies of biomimetic complexes of molybdoenzyme and tungstoenzyme显示文摘The Mo(Ⅴ) and W(Ⅵ) complexes of (NH3CH2- CH2NH2)3[Mo(Ⅴ)O2(OC6H4O)2] (1), (NH3CH2CH2NH2)2.5 [Mo(Ⅴ) 0.5W(Ⅵ)0.5O2(OC6H4O)2] (2) and (NH3CH2CH2NH2)2- [W(Ⅵ)O2(OC6H4O)2] (3) were synthesized by choosing cate-chol ligand which shows a good reductive property and tak-ing advantage of EMo > EW. Their EPR and UV-vis spectra were compared with the oxidized UV-vis spectra of xanthine dehydrogenase from chicken liver and xanthine oxidase from milk and the EPR spectrum of flavoenzyme from milk. | LU Xiaoming LIU Shuncheng MAO Xi YE Zhaohui LU Jingfen | 2003 | Chinese Science Bulletin2003，48，7： | 0 |
| 7 | Phylogeny of SARS-CoV as inferred from complete genome comparison显示文摘SARS-CoV, as the pathogeny of severe acute respiratory syndrome (SARS), is a mystery that the origin of the virus is still unknown even a few isolates of the virus were completely sequenced. To explore the genesis of SARS-CoV, the FDOD method previously developed by us was applied to comparing complete genomes from 12 SARS-CoV isolates to those from 12 previously identified coronaviruses and an unrooted phylogenetic tree was constructed. Our results show that all SARS-CoV isolates were clustered into a clique and previously identified coronaviruses formed the other clique. Meanwhile, the three groups of coronaviruses depart from each other clearly in our tree that is consistent with the results of prevenient papers. Differently, from the topology of the phylogenetic tree we found that SARS-CoV is more close to group 1 within genus coronavirus. The topology map also shows that the 12 SARS-CoV isolates may be divided into two groups determined by the association with the SARS-CoV from the Hotel M in Hong Kong that may give some information about the infectious relationship of the SARS. | QI Zhen HU Yu LI Wei CHEN Yanjun ZHANG Zhihua SUN Shiwei LU Hongchao ZHANG Jingfen BU Dongbo LING Lunjiang CHEN Runsheng | 2003 | Chinese Science Bulletin2003，48，12： | 0 |
| 8 | Interfacial Characters of Organophosphoric and Phosphonic Acid Extraction Systems显示文摘Dynamic interracial characters are investigated for solvent extraction system of metals by organophosphoric or phosphonicacid.The relationship between interfacial characters and kinetic parameters shows that the dynamic interfacial properties are im-portant to mass transfer processes in liquid-liquid extraction.The authors develop a two-film adsorption model,which may offera basis for researching interfacial activity in mass transfer process. | Yu, Qiang Yu, Jingfen Lu, Jiufang Teng, Teng | 1989 | Rare Metals1989，9，2： | 0 |
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