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| 1 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
| 2 | Effects of maize root exudates and organic acids on the desorption of phenanthrene from soils显示文摘The eects of maize root exudates and low-molecular-weight-organic anions (LMWOAs) on the desorption of phenanthrene from eight artificially contaminated soils were evaluated. A significant negative correlation was observed between the amounts of phenanthrene desorbed and the soil organic carbon (SOC) contents (P < 0.01), and the inuences of soil pH and clay content on phenanthrene desorption were insignificant (P > 0.1). Neither maize root exudates nor oxalate and citrate anions inuenced desorption of phenanthrene with the addition of NaN3. A faster phenanthrene desorption occurred without the addition of NaN3 in the presence of maize root exudates than oxalate or citrate due to the enhanced degradation by root exudates. Without the addition of NaN3, oxalate or citrate at dierent concentrations could inhibit phenanthrene desorption to dierent extents and the inhibiting eect by citrate was more significant than by oxalate. This study leads to the conclusion that maize root exudates can not enhance the desorption under abiotic condition with the addition of NaN3 and can promote the desorption of phenanthrene in soils without the addition of NaN3. | ZHU Yanhong, ZHANG Shuzhen, HUANG Honglin, WEN Bei State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. | 2009 | Journal of Environmental Sciences2009，21，7： | 14 |
| 3 | Occurrence and distribution of antibiotic resistance genes in the sediments of the East China Sea bays显示文摘The coastal area of the East China Sea has experienced rapid urbanization and industrialization in China since 1980 s, resulting in severe pollution of its environments.Antibiotic resistance genes(ARGs) are regarded as a kind of emerging pollutant with potential high risk. The sediment samples were collected from Hangzhou Bay(HB),Xiangshan Bay(XB), and Taizhou Bay(TB) to investigate the spatial occurrence and distribution of 27 ARGs and class I integron–integrase gene(intI1) in the coastal area of the East China Sea. The PCR results showed the frequent presence of 11 ARGs and intI1 in the sediments of the three bays. The qPCR results further showed that sulfonamide resistance was the most prevalent ARG type and antibiotic target replacement and protection were the most important resistance mechanisms in the sediments. Regarding the subtype of ARGs, sulI, tetW, and dfrA13 were the most abundant ARGs, in which sulI was higher in TB(based on both the absolute and relative abundances) and dfrA13 was higher in HB(based on the relative abundances). The network analysis revealed that intI1 had significant correlations with tetC, sulI, sulII, and blaPSE-1. Oil was the key connected factor, which had positive connections with sulI, sulII, and blaPSE-1. In addition, the joint effect of heavy metals and nutrients & organic pollutants might be crucial for the fate of ARGs in the coastal sediments. | Jiayu Chen Zhiguo Su Tianjiao Dai Bei Huang Qinglin Mu Yongming Zhang Donghui Wen | 2019 | Journal of Environmental Sciences2019，31，7： | 13 |
| 4 | Performance and comparison of assessment models to predict 30-day mortality in patients with hospital-acquired pneumonia显示文摘Background:Hospital-acquired pneumonia(HAP)is the most common hospital-acquired infection in China with substantial morbidity and mortality.But no specific risk assessment model has been well validated in patients with HAP.The aim of this study was to investigate the published risk assessment models that could potentially be used to predict 30-day mortality in HAP patients in non-surgical departments.Methods:This study was a single-center,retrospective study.In total,223 patients diagnosed with HAP from 2012 to 2017 were included in this study.Clinical and laboratory data during the initial 24 hours after HAP diagnosis were collected to calculate the pneumonia severity index(PSI);consciousness,urea nitrogen,respiratory rate,blood pressure,and age≥65 years(CURB-65);Acute Physiology and Chronic Health Evaluation II(APACHE II);Sequential Organ Failure Assessment(SOFA);and Quick Sequential Organ Failure Assessment(qSOFA)scores.The discriminatory power was tested by constructing receiver operating characteristic(ROC)curves,and the areas under the curve(AUCs)were calculated.Results:The all-cause 30-day mortality rate was 18.4%(41/223).The PSI,CURB-65,SOFA,APACHE II,and qSOFA scores were significantly higher in non-survivors than in survivors(all P<0.001).The discriminatory abilities of the APACHE II and SOFA scores were better than those of the CURB-65 and qSOFA scores(ROC AUC:APACHE II vs.CURB-65,0.863 vs.0.744,Z=3.055,P=0.002;APACHE II vs.qSOFA,0.863 vs.0.767,Z=3.017,P=0.003;SOFA vs.CURB-65,0.856 vs.0.744,Z=2.589,P=0.010;SOFA vs.qSOFA,0.856 vs.0.767,Z=2.170,P=0.030).The cut-off values we defined for the SOFA,APACHE II,and qSOFA scores were 4,14,and 1.Conclusions:These results suggest that the APACHE II and SOFA scores determined during the initial 24 h after HAP diagnosis may be useful for the prediction of 30-day mortality in HAP patients in non-surgical departments.The qSOFA score may be a simple tool that can be used to quickly identify severe infections. | Jia-Ning Wen Nan Li Chen-Xia Guo Ning Shen Bei He | 2020 | Chinese Medical Journal2020，，24： | 7 |
| 5 | Metabolism pathways of arachidonic acids:mechanisms and potential therapeutic targets显示文摘The arachidonic acid(AA)pathway plays a key role in cardiovascular biology,carcinogenesis,and many inflammatory diseases,such as asthma,arthritis,etc.Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2),which is in turn further metabolized by cyclooxygenases(COXs)and lipoxygenases(LOXs)and cytochrome P450(CYP)enzymes to a spectrum of bioactive mediators that includes prostanoids,leukotrienes(LTs),epoxyeicosatrienoic acids(EETs),dihydroxyeicosatetraenoic acid(diHETEs),eicosatetraenoic acids(ETEs),and lipoxins(LXs).Many of the latter mediators are considered to be novel preventive and therapeutic targets for cardiovascular diseases(CVD),cancers,and inflammatory diseases.This review sets out to summarize the physiological and pathophysiological importance of the AA metabolizing pathways and outline the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD and cancer.progression will provide valuable insight for developing new therapeutic drugs for CVD and anti-cancer agents such as inhibitors of EETs or 2J2.Thus,we herein present a synopsis of AA metabolism in human health,cardiovascular and cancer biology,and the signaling pathways involved in these processes.To explore the role of the AA metabolism and potential therapies,we also introduce the current newly clinical studies targeting AA metabolisms in the different disease conditions. | Bei Wang Lujin Wu Jing Chen Lingli Dong Chen Chen Zheng Wen Jiong Hu Ingrid Fleming Dao Wen Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 7 |
| 6 | Chevrier's Field Mouse(Apodemus chevrieri) and Père David's Vole(Eothenomys melanogaster) in China Carry Orthohepeviruses that form Two Putative Novel Genotypes Within the Species Orthohepevirus C显示文摘Hepatitis E virus(HEV)is the prototype of the family Hepeviridae and the causative agent of common acute viral hepatitis.Genetically diverse HEV-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential.In this study,we tested 278 specimens collected from seven wild small mammal species in Yunnan province,China,for the presence and prevalence of orthohepevirus by broad-spectrum reverse transcription(RT)-PCR.HEV-related sequences were detected in two rodent species,including Chevrier’s field mouse(Apodemus chevrieri,family Muridae)and Père David’s vole(Eothenomys melanogaster,family Cricetidae),with the infection rates of 29.20%(59/202)and 7.27%(4/55),respectively.Further four representative full-length genomes were generated:two each from Chevrier’s field mouse(named Rd HEVAc14 and Rd HEVAc86)and Père David’s vole(Rd HEVEm40 and Rd HEVEm67).Phylogenetic analyses and pairwise distance comparisons of whole genome sequences and amino acid sequences of the gene coding regions showed that orthohepeviruses identified in Chinese Chevrier’s field mouse and Père David’s vole belonged to the species Orthohepevirus C but were highly divergent from the two assigned genotypes:HEV-C1 derived from rat and shrew,and HEV-C2 derived from ferret and possibly mink.Quantitative real-time RT-PCR demonstrated that these newly discovered orthohepeviruses had hepatic tropism.In summary,our work discovered two putative novel genotypes orthohepeviruses preliminarily named HEVC3 and HEV-C4 within the species Orthohepevirus C,which expands our understanding of orthohepevirus infection in the order Rodentia and gives new insights into the origin,evolution,and host range of orthohepevirus. | Bo Wang Wen Li Ji-Hua Zhou Bei Li Wei Zhang Wei-Hong Yang Hong Pan Li-Xia Wang Thomas Bock Zheng-Li Shi Yun-Zhi Zhang Xing-Lou Yang | 2018 | Virologica Sinica2018，33，1： | 6 |
| 7 | Toxic effects of chlortetracycline on maize growth,reactive oxygen species generation and the antioxidant response显示文摘The toxicity of chlortetracycline (CTC) on maize (Zea mays L.) growth and reactive oxygen species (ROS) generation was studied.The root and shoot lengths and fresh weights of maize seedlings were inhibited by CTC treatment (p < 0.05).Root length was more sensitive than other parameters with the EC 10 value of 0.064 mg/L.The spin trapping technique followed by electron paramagnetic resonance (EPR) analysis was used to quantify the ROS production.The ROS generated in maize roots after exposure to CTC was identified as hydroxyl radical (·OH).The EPR signal intensity correlated positively with the logarithm of CTC concentrations exposed (p < 0.05).The dynamic changes of malondialdehyde (MDA) contents and the antioxidative enzyme activities in maize roots were also determined.As compared to the control group,CTC was found to significantly increase MDA content.Treatment of maize roots with the ·OH scavenger sodium benzoate (SB) reduced the MDA content and enhanced the antioxidative enzyme activities.The results demonstrated the harmfulness of CTC at high dose to maize in the early developmental stage,and clarified that the inducement of ·OH is one of the mechanisms of CTC toxicity. | Bei Wen Yu Liu Peng Wang Tong WU Shuzhen Zhang Xiaoquan Shan Jingfen Lu | 2012 | Journal of Environmental Sciences2012，24，6： | 6 |
| 8 | G-protein beta 3 subunit polymorphisms and essential hypertension: a case-control association study in northern Han Chinese显示文摘ObjectiveTo 探索在三多型性之间的协会[ C825T , C1429T 和 G (编码 3 子单元( GNB3 )和由执行盒子控制的高血压在北汉中国 population.MethodsWe 学习的 G 蛋白质贝它的基因的-350)A]招募了 731 个高血压的病人和 673 个控制题目(计算力量价值是 > ;0.8 ) 。Genotyping 被执行识别 C825T, C1429T 和 G (用 TaqMan 试金的 -350)A 多型性。比较突变而产生之遗传并且在盒子和控制之间的 genotypic 频率被使用 chi 平方测试做。逻辑回归分析被执行在不同基因模型下面调查在 GNB3 基因的三多型性之间的关系(添加剂,主导、后退的模型) C825T , C1429T 和 G 的 .ResultsThe 遗传型分发和等位基因频率( -350)A 多型性没在高血压的病人和控制题目之间显著地不同,当完整的样品被估计时或当样品被性成层时。没有重要协会在 C825T, C1429T 和 G 之间被观察(-350)A 多型性和在任何基因模型的必要高血压的风险。连接不平衡仅仅在 C825T 和 C1429T 多型性之间被检测。Haplotype 分析没 hypertension.ConclusionsOur 学习的风险建议了的显著地增加的三估计的 haplotypes 观察那任何一个 GNB3 基因多型性[C825T, C1429T 和 G (-350)A] 显著地没用北汉汉语与必要高血压被联系人口。 | Mei LI Bei ZHANG Chuang LI Jie-Lin LIU Li-Juan WANG Ya LIU Zuo-Guang WANG Shao-Jun WEN | 2015 | Journal of Geriatric Cardiology2015，12，2： | 4 |
| 9 | Comparison study of slag corrosion resistance of MgO–MgAl_(2)O_(4),MgO–CaO and MgO–C refractories under electromagnetic field显示文摘To illuminate the corrosion behavior of MgO-based refractories under electromagnetic field(EMF),herein,the slag corrosion and penetration resistance of MgO–MgAl_(2)O_(4),MgO–CaO,and MgO–C refractories were investigated using the rotary immersion slag resistance test at 1873 K for 1 h.The results showed that the order of the good slag resistance of as-tested refractories was MgO–C>MgO–CaO>MgO–MgAl_(2)O_(4).The EMF accelerated the corrosion and penetration of slag to the refractories,which caused the molten slag to be easier into the refractories by natural convection and Marangoni effect.In addition,the MgO–C refractories did not show an overwhelming advantage in slag resistance because EMF impeded the formation of the dense protection layer.Consequently,in view of the present results,the MgO–C refractories are still the most promising slag line material for refining furnace among MgO–MgAl_(2)O_(4),MgO–CaO,and MgO–C refractories. | Xin‑ming Ren Bei‑yue Ma Shi‑ming Li Hong‑xia Li Guo‑qi Liu Wen‑gang Yang Fan Qian Shi‑xian Zhao Jing‑kun Yu | 2021 | Journal of Iron and Steel Research(International)2021，28，1： | 4 |
| 10 | Chronic obstructive pulmonary disease assessment test score correlated with dyspnea score in a large sample of Chinese patients显示文摘 | ZHOU Qing-tao MEI Jing-jing HE Bei HUANG Shao-guang SHI Yi WEN Fu-qiang ZHAO Ming-wu | 2013 | Chinese Medical Journal2013，，1： | 4 |
| 11 | Differences in cocaine-induced place preference persistence, locomotion and social behaviors between C57BL/6J and BALB/cJ mice显示文摘C57BL/6J and BALB/cJ mice display significant differences in sociability and response to drugs,but the phenotypic variability of their susceptibility to cocaine is still not well known.In this study,the differences between these two mice strains in the persistence of cocaine-induced conditioned place preference(CPP),as well as the locomotion and social behaviors after the 24-hour withdrawal from a four-day cocaine(20 mg/kg/day) administration were investigated.The results showed that the cocaine-induced CPP persisted over two weeks in C57BL/6J mice,while it diminished within one week among BALB/cJ mice.After 24-hours of cocaine withdrawal,high levels of locomotion as well as low levels of social interaction and aggressive behavior were found in C57BL/6J mice,but no significant changes were found in BALB/cJ mice,indicating that cocaine-induced CPP persistence,locomotion and social behavior are not consistent between these two strains,and that overall C57BL/6J mice are more susceptible to cocaine than BALB/cJ mice at the tested doses. | Jian-Li WANG Bei WANG Wen CHEN | 2014 | Zoological Research2014，35，5： | 3 |
| 12 | Influence of organic amendments on the sorption of pentachlorophenol on soils显示文摘The influence of pH on the sorption of pentachlorophenol (PCP) onto three organic amendments, char, humic acid (HA) and peat, and the effect of organic amendments on PCP sorption to three kinds of soils were evaluated. The sorption of PCP on these sorbents fitted the Freundlich model well, suggesting that PCP sorption isotherms were nonlinear with exponential coefficient (N) value lower than 1. The PCP sorption capacity on three organic amendments and the N values increased with decreasing pH. The sorption capacities were in the order: char > HA > peat. Organic amendments resulted in an enhancement of sorption capacities of soils. The N values of PCP sorption on soils were decreased by char amendment and increased by HA and peat amendments. This study demonstrated that application of traditional organic amendments led to the enhancement of PCP sorption by soils. This information may aid both in predicting environmental fates of hydrophobic ionizable organic compounds and in developing remediation strategies for them. | LI Ruijuan, WEN Bei, ZHANG Shuzhen, PEI Zhiguo, SHAN Xiaoquan State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences,Beijing 100085, China | 2009 | Journal of Environmental Sciences2009，21，4： | 3 |
| 13 | Modeling the transport of TiO 2 nanoparticle aggregates in saturated and unsaturated granular media: Effects of ionic strength and pH显示文摘 | Jing Fang Mei-jia Xu Deng-jun Wang Bei Wen Jing-yi Han | 2012 | Water Research2012，，： | 2 |
| 14 | Stability of titania nanoparticles in soil suspensions and transport in saturated homogeneous soil columns显示文摘 | Jing Fang Xiao-quan Shan Bei Wen Jin-ming Lin Gary Owens | 2008 | Environmental Pollution2008，，4： | 2 |
| 15 | Selected dark sides of biomass-derived biochars as environmental amendments显示文摘With the rapid increase in the application of biochars as amendments, studies are needed to clarify the possible environmental risks derived from biochars to use safely the biomass resources. This work reported selected dark sides of maize straw-and swine manurederived biochars pyrolyzed at 300 and 500°C. During the pyrolysis processes, total heavy metals in the biochars were enriched greatly accompanying with considerable emission of the heavy metals into atmosphere and the trends became increasingly obvious with pyrolysis temperature. Meanwhile, the biochars showed distinctly decreased available heavy metals compared with raw feedstocks, which could be mainly attributed to the sorption by the inorganics in the biochars. The water-and acid-washing treatments significantly increased the releasing risks of heavy metals from biochars into the environments. Electron paramagnetic resonance analysis indicated that persistent free radicals, emerged strongly in the biochars as a function of the aromatization of biomass feedstocks, were free from the influence of water-, acid-, or organic-washing of the biochars and could remain stable even after aged in soils for 30 days. Dissolved biochars, highly produced during pyrolysis processes, showed distinct properties including lower molecular weight distribution while higher aromaticity compared with soil dissolved organic carbon.The results of this study provide important perspectives on the safe usage of biochars as agricultural/environmental amendments. | Zien Chen Lei Luo Diyi Xiao Jitao Lv Bei Wen Yibing Ma Shuzhen Zhang | 2017 | Journal of Environmental Sciences2017，29，4： | 2 |
| 16 | Analysis of mechanisms of Shenhuang Granule in treating severe COVID-19 based on network pharmacology and molecular docking显示文摘Objective:Severe cases of coronavirus disease 2019(COVID-19)are expected to have a worse prognosis than mild cases.Shenhuang Granule(SHG)has been shown to be a safe and effective treatment for severe COVID-19 in a previous randomized clinical trial,but the active chemical constituents and underlying mechanisms of action remain unknown.The goal of this study is to explore the chemical basis and mechanisms of SHG in the treatment of severe COVID-19,using network pharmacology.Methods:Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry was employed to screen chemical constituents of SHG.Putative therapeutic targets were predicted by searching traditional Chinese medicine system pharmacology database and analysis platform,Swiss Target Prediction,and Gene Expression Omnibus(GEO)databases.The target protein–protein interaction network and enrichment analysis were performed to investigate the hub genes and presumptive mechanisms.Molecular docking and molecular dynamics simulations were used to verify the stability and interaction between the key chemical constituents of SHG and COVID-19 protein targets.Results:Forty-five chemical constituents of SHG were identified along with 131 corresponding therapeutic targets,including hub genes such as HSP90AA1,MMP9,CXCL8,PTGS2,IFNG,DNMT1,TYMS,MDM2,HDAC3 and ABCB1.Functional enrichment analysis indicated that SHG mainly acted on the neuroactive ligand-receptor interaction,calcium signaling pathway and c AMP signaling pathway.Molecular docking showed that the key constituents had a good affinity with the severe acute respiratory syndrome coronavirus 2 protein targets.Molecular dynamics simulations indicated that ginsenoside Rg4 formed a stable protein-ligand complex with helicase.Conclusion:Multiple components of SHG regulated multiple targets to inhibit virus invasion and cytokine storm through several signaling pathways;this provides a scientific basis for clinical applications and further experiments. | Xiang-ru Xu Wen Zhang Xin-xin Wu Hong-qiang Yang Yu-ting Sun Yu-ting Pu Bei Wang Wei Peng Li-hua Sun Quan Guo Shuang Zhou Bang-jiang Fang | 2022 | Journal of Integrative Medicine2022，20，6： | 2 |
| 17 | A comparison of the rhizosphere-based method with DTPA, EDTA, CaCl 2 , and NaNO 3 extraction methods for prediction of bioavailability of metals in soil to barley显示文摘 | Mu-Hua Feng Xiao-Quan Shan Shuzhen Zhang Bei Wen | 2005 | Environmental Pollution2005，，2： | 1 |
| 18 | Determina tion of pentachlorophenol in wastewater irrigated soils and incubated earthworms 显示文摘 | LIU Ying WEN Bei SHAN Xiao-quan | 2006 | Talanta2006，69，： | 1 |
| 19 | Significant Polymorphisms of Vitamin D Receptor Gene(rs2189480 and rs3847987) Related to the Risk of Type 2 Diabetes in Henan Rural Area显示文摘Type 2 diabetes mellitus (T2DM) accounts for 90% of all diabetes cases and results in severe complications. It is a multifactorial metabolic disorder that results from a combination of resistance to insulin action and an inadequate compensatory insulin secretory response. The interaction between multiple genetic and environmental determinants has been considered to contribute to the pathogenesis of T2DM[1]. | HAN Han ZHAO Ming Xu WANG Yan WANG Jun REN Bing Nan GE Hui Na WANG Teng SUN Bei Bei BA Yue LI Wen Jie | 2019 | Biomedical and Environmental Sciences2019，32，1： | 1 |
| 20 | Thermal and combustion behavior of Al-MnO_(2) nanothermite with poly(vinylidene fluoride-co-hexafluoropropylene) energetic binder显示文摘Fluoropolymers get increasing attention in energetic materials application due to the high fluorine content.To explore the effect of poly(vinylidene fluoride-co-hexafluoropropylene)(P(VDF-HFP))on Al/MnO_(2) nanothermite,the samples with different contents are prepared and characterized by SEM,TGDSC,XRD,and their ignition and combustion behavior are tested and recorded.The results show that P(VDF-HFP)as an energetic binder can combine the nanothermite components together,even exist in the gaps.The integrity of energetic materials has been improved.Thermal analysis shows that the addition of P(VDF-HFP)greatly changes the thermal reaction processes,and the exothermic peaks appear early,but the utilization of fuel and oxidizer is not efficient from the XRD results.Furthermore,the appropriate addition of P(VDF-HFP)can directly reduce the ignition energy threshold and increase the combustion time,which is necessary for the potential ignition charge application.The possible reasons for above phenomena are discussed and analyzed.This research provides a reference for improvement of thermitebased ignition charge formulation. | Jia-xing Song Tao Guo Miao Yao Jia-lin Chen Wen Ding Feng-li Bei Xiao-nan Zhang Qin Yin Jun-yi Huang Chang-hao Li | 2021 | Defence Technology(防务技术)2021，17，4： | 1 |
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