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| 1 | Isatin hybrids and their anti-tuberculosis activity显示文摘Tuberculosis(TB) is one of the most common and even fatal infectious diseases known to mankind.Millions of new cases are reported every year over the world,and one-third of the world's population is potentially infected with mycobacteria tuberculosis(MTB).Research to develop novel anti-TB drugs led to the identification of several isatin-based antimycobacterial agents,among which a number of potential candidates displayed excellent antimycobacterial activity and were found to be free of cytotoxicity.This review outlines the advances in the application of isatin hybrids as antimycobacterial agents and the critical aspects of design and structure-activity relationship of these derivatives. | Zhi Xu Shu Zhang Chuan Gao Jing Fan Feng Zhao Zao-Sheng Lv Lian-Shun Feng | 2017 | Chinese Chemical Letters2017，28，2： | 10 |
| 2 | 靛红类化合物的抗疟疾活性显示文摘疟疾是全球性传染病,每年约有5亿人罹患疟疾,死亡近百万。尽管临床上使用的抗疟药物对药敏型疟疾疗效显著,但是耐药疟原虫的出现使得这类药物的疗效逐年下降。因此,有必要研发新型抗疟药。靛红具有多种生物活性,广泛存在于药物分子中。近年来的研究表明,靛红类化合物具有潜在的抗疟疾活性,引起了药物化学家的极大兴趣。本文将归纳近年来靛红类化合物在抗疟疾领域的研究进展,并讨论这类化合物的构-效关系,为更合理的设计抗疟新药提供理论帮助。 | 冯连胜 王世浩 宋旭峰 徐志 强敏 | 2017 | 国外医药(抗生素分册)2017，38，5： | 2 |
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