|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Isatin hybrids and their anti-tuberculosis activity显示文摘Tuberculosis(TB) is one of the most common and even fatal infectious diseases known to mankind.Millions of new cases are reported every year over the world,and one-third of the world's population is potentially infected with mycobacteria tuberculosis(MTB).Research to develop novel anti-TB drugs led to the identification of several isatin-based antimycobacterial agents,among which a number of potential candidates displayed excellent antimycobacterial activity and were found to be free of cytotoxicity.This review outlines the advances in the application of isatin hybrids as antimycobacterial agents and the critical aspects of design and structure-activity relationship of these derivatives. | Zhi Xu Shu Zhang Chuan Gao Jing Fan Feng Zhao Zao-Sheng Lv Lian-Shun Feng | 2017 | Chinese Chemical Letters2017，28，2： | 10 |
| 2 | Potassium phthalimide:An efficient and green organocatalyst for the synthesis of 4-aryl-7-(arylmethylene)-3,4,6,7-tetrahydro-1Hcyclopenta[d]pyrimidin-2(5H)-ones/thiones under solvent-free conditions显示文摘An efficient synthesis of Biginelli-type compounds using potassium phthalimide as a green,mild,and commercially available organocatalyst in a one-pot,multi-component cyclocondensation reaction of cyclopentanone,aldehydes,and urea/thiourea is reported.The present methodology is a green approach to access 4-aryl-7-(aryImethylene)-3,4,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-2(5H)-ones/thiones.It offers several merits such as simple operational procedures,no use of hazardous organic solvents,and cheap and environmentally friendly solid basic catalyst. | Hamzeh Kiyani Maryam Ghiasi | 2014 | Chinese Chemical Letters2014，25，2： | 3 |
| 3 | A simple and efficient approach to one-pot synthesis of mono- and bis-N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates catalyzed by InCl_3显示文摘An efficient and straightforward procedure has been developed for the synthesis of highly substituted mono- and bis-N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates via a one-pot, four-component domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of InCl3(20 mol%) in MeOH at ambient temperature. The salient advantages of this method are mild reaction conditions, environmentally benign, high to excellent yields, shorter reaction times, easy operation and no column chromatographic separation. | Seyed Sajad Sajadikhah Malek Taher Maghsoodlou Nourallah Hazeri | 2014 | Chinese Chemical Letters2014，25，1： | 1 |
| 4 | Excited-state charge coupled proton transfer reaction via the dipolar functionality of salicylideneaniline显示文摘Based on design and synthesis of salicylideneaniline derivatives(1a-1d),we demonstrate a prototypical system to investigate the excited-state intramolecular charge transfer(ESICT) coupled excited-state intramolecular proton transfer(ESIPT) reaction via the dipolar functionality of the molecular framework. In solid and aprotic solvents 1a-1d exist mainly as E conformers that possess an intramolecular sixmembered -ring hydrogen bond.Compounds 1a-1c exhibit a unique proton-transfer tautomer emission, while compound 1d exhibits remarkable dual emission due to the different solvent-polarity environment between ESICT and ESIPT states.Time-dependent density functional theory(TDDFT) calculations are reported on these Schiff bases in order to rationalize their electronic structure and absorption spectra. | Tzu-Chien Fang Hsing-Yang Tsai Ming-Hui Luo Che-Wei Chang Kew-Yu Chen | 2013 | Chinese Chemical Letters2013，24，2： | 1 |
| 5 | Potential anti-tubercular agents:Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones显示文摘A series of indazol-2-yl(pyridin-4-yl)methanones,4 were acquired from 2,6-bisbenzylidene cyclohexanones,3 and anti-tubercular drug(isoniazid),and their anti-tubercular impacts were screened.Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay,the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL,comparable to standard drugs(streptomycin,MIC,6.25 u.g/mL,pyrazinamide,isoniazid and ciprofloxacin with MICs of 3.125 μg/mL). | Ayyakannu Arumugam Napoleon Fazlur-Rahman Nawaz Khan Euh Duck Jeong Eun Hyuk Chung | 2015 | Chinese Chemical Letters2015，26，5： | 0 |
| 6 | Synthesis,characterization and antibacterial screening of some novel 1,2,4-triazine derivatives显示文摘A new series of 1, 2, 4-triazine derivatives possessing indole nucleus were synthesized with an aim to explore their effect on in vitro growth of microorganisms causing microbial infection. In vitro antimicrobial activity was performed against S. aureus, S. epidermidis, P. mirabilis and E. coli using disk diffusion method. The MIC was detected using the double dilution method. The results were compared by calculating percent inhibition area/mg of the compounds with the standard drug 'Ciprofloxacin'.Selected compounds were evaluated for toxic effects using human hepatocellular carcinoma(HepG2) cell line by MTT-assay. Results revealed that some compounds of the series were found to exhibit better activity with less toxicity than | Mohammad Arshad Abdul Roouf Bhat Kwon Kang Hoi Inho Choi Fareeda Athar | 2017 | Chinese Chemical Letters2017，28，7： | 0 |
| 7 | 靛红亚胺衍生物的抗菌活性研究进展显示文摘靛红亚胺衍生物是一类重要的杂环化合物,可作为药物合成的前体。自被发现以来,人们对其抗菌活性进行了大量研究。本文综述了2010年至2020年报道的关于靛红亚胺衍生物抗菌活性的研究结果,并对结构与活性之间的关系及作用机理进行探讨,以期为合理设计更有效的靛红亚胺衍生物提供依据。 | 陈哲 沈光海 金瑛 | 2021 | 吉林医药学院学报2021，42，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员