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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | The rice OsV4 encoding a novel pentatricopeptide repeat protein is required for chloroplast development during the early leaf stage under cold stress显示文摘Pentatricopeptide repeat(PPR)proteins,characterized by tandem arrays of a 35 amino acid motif,have been suggested to play central and broad roles in modulating the expression of organelle genes in plants.However,the molecular mechanisms of most rice PPR genes remains unclear.In this paper,we isolated and characterized a temperature-conditional virescent mutant,OsV4,in rice(Oryza sativa cultivar Jiahua1(WT,japonica rice variety)).The mutant displays albino phenotype and abnormal chloroplasts at the three leaf stage,which gradually turns green after the four leaf stage at a low temperature(20°C).But the mutant always develops green leaves and well-developed chloroplasts at a high temperature(32°C).Genetic and molecular analyses uncovered that OsV4 encodes a novel chloroplast-targeted PPR protein including four PPR motifs.Further investigations show that the mutant phenotype is associated with changes in chlorophyll content and chloroplast development.The OsV4transcripts only accumulate to high levels in young leaves,indicating that its expression is tissue-specific.In addition,transcript levels of some ribosomal components and plastid-encoded polymerase-dependent genes are dramatically reduced in the albino mutants grown at 20°C.These findings suggest that OsV4 plays an important role during early chloroplast development under cold stress in rice. | Xiaodi Gong Qianqian Su Dongzhi Lin Quan Jiang Jianlong Xu Jianhui Zhang Sheng Teng Yanjun Dong | 2014 | Journal of Integrative Plant Biology2014，56，4： | 19 |
| 3 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 4 | Changes in Extreme Maximum Temperature Events and Population Exposure in China under Global Warming Scenarios of 1.5 and 2.0°C: Analysis Using the Regional Climate Model COSMO-CLM显示文摘We used daily maximum temperature data(1986–2100) from the COSMO-CLM(COnsortium for Small-scale MOdeling in CLimate Mode) regional climate model and the population statistics for China in 2010 to determine the frequency, intensity, coverage, and population exposure of extreme maximum temperature events(EMTEs) with the intensity–area–duration method. Between 1986 and 2005(reference period), the frequency, intensity, and coverage of EMTEs are 1330–1680 times yr^(–1), 31.4–33.3°C, and 1.76–3.88 million km^2, respectively. The center of the most severe EMTEs is located in central China and 179.5–392.8 million people are exposed to EMTEs annually. Relative to 1986–2005, the frequency, intensity, and coverage of EMTEs increase by 1.13–6.84, 0.32–1.50, and15.98%–30.68%, respectively, under 1.5°C warming; under 2.0°C warming, the increases are 1.73–12.48, 0.64–2.76,and 31.96%–50.00%, respectively. It is possible that both the intensity and coverage of future EMTEs could exceed the most severe EMTEs currently observed. Two new centers of EMTEs are projected to develop under 1.5°C warming, one in North China and the other in Southwest China. Under 2.0°C warming, a fourth EMTE center is projected to develop in Northwest China. Under 1.5 and 2.0°C warming, population exposure is projected to increase by23.2%–39.2% and 26.6%–48%, respectively. From a regional perspective, population exposure is expected to increase most rapidly in Southwest China. A greater proportion of the population in North, Northeast, and Northwest China will be exposed to EMTEs under 2.0°C warming. The results show that a warming world will lead to increases in the intensity, frequency, and coverage of EMTEs. Warming of 2.0°C will lead to both more severe EMTEs and the exposure of more people to EMTEs. Given the probability of the increased occurrence of more severe EMTEs than in the past, it is vitally important to China that the global temperature increase is limited within 1.5°C. | Mingjin ZHAN Xiucang LI Hemin SUN Jianqing ZHAI Tong JIANG Yanjun WANG | 2018 | Journal of Meteorological Research2018，32，1： | 11 |
| 5 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 6 | Immobilization of Papain in Biosilica Matrix and Its Catalytic Property显示文摘一个新奇方法通过 papain 导致的一个 biomimetic silicification 过程为 papain 固定被开发。由在一个硅石先锋答案孵化 papain, papain 硅石合成很快形成了, papain 被包含。封装效率和恢复活动分别地是 82.60% 和 83.09% 。与面对另外的猛抛硅石的种类在 biosilica 矩阵使不能调动的酶和 biomolecules 相比,这个 papain 封装过程,一条 biomimetic 途径,由它在温和条件(在中立附近的 pH 和周围的温度) 下面的 autosilification 活动的认识到的高封装效率。而且,包含的 papain 展览提高了热, pH,再循环并且存储稳定性。运动分析证明 biomimetic 硅石矩阵显著地没妨碍底层的集体运输或产品的版本。 | ZHOU Liya WANG Cui JIANG Yanjun GAO Jing | 2013 | Chinese Journal of Chemical Engineering2013，21，6： | 8 |
| 7 | PIF1 and RVE1 form a transcriptional feedback loop to control light-mediated seed germination in Arabidopsis^FA显示文摘The phytochrome B (phyB) photoreceptor plays a major role that inputs light signals to regulate seed dormancy and germination. PHYTOCHROME-INTERACTING FACTOR1 (PIF1) is a key transcription factor repressing phyB-mediated seed germination, while REVEILLE1 (RVE1) factor functions as a curial regulator in controlling both seed dormancy and ger-mination. However, the relationship between the PIF1-and RVE1-modulated signaling pathways remains mostly unknown. Here, we find that PIF1 physically interacts with RVE1. Genetic analysis indicates that RVE1 inhibition on seed germination requires PIF1;re-ciprocally, the repressive effect of PIF1 is partially de-pendent on RVE1. Strikingly, PIF1 and RVE1 directly bind to the promoter and activate the expression of each other. Furthermore, PIF1 and RVE1 coordinately regulate the transcription of many downstream genes involved in abscisic acid and gibberellin pathways. Moreover, PIF1 enhances the DNA-binding ability and transcriptional repression activity of RVE1 in regulating GIBBERELLIN 3-OXIDASE2, and RVE1 promotes PIF1's DNA-binding ability in modulating ABSCISIC ACID-INSENSITIVE3 expression. Thus, this study demon-strates that PIF1 and RVE1 form a transcriptional feedback loop that coordinately inhibits seed germi-nation, providing a mechanistic understanding of how phyB-mediated light signal is transduced to the seeds. | Liwen Yang Zhimin Jiang Yanjun Jing Rongcheng Lin | 2020 | Journal of Integrative Plant Biology2020，62，9： | 7 |
| 8 | Enzyme@silica nanoflower@metal-organic framework hybrids: A novel type of integrated nanobiocatalysts with improved stability显示文摘一个新奇综合 nanobiocatalyst 系统基于 enzyme@silica,有改进稳定性的 nanoflower@metal 器官的框架(enzyme@SNF@ZIF-8 ) 结构第一次被制作。这个系统的通用性作为模型酶用青霉素 G acylase (针网阵列) 和过氧化氢酶(猫) 被验证。多微孔的 ZIF-8 层能被改变 ZIF-8 涂层周期的数字控制,它与不同 ZIF-8 层厚度生产 PGA@SNF@ZIF-8 nanobiocatalysts。在第二个 ZIF-8 涂层周期以后, PGA@SNF@ZIF-8 (2 ) 结构与一同类并且 well-intergrown ZIF-8 层被形成,它拥有优秀机械、化学的稳定性。而且, PGA@SNF@ZIF-8 (2 ) 表演与在硅石 nanoflowers (PGA@SNF ) 上使不能调动的免费针网阵列和针网阵列相比改进了 thermal/storage 稳定性和可重用性。获得的基于猫的 nanobiocatalysts (CAT@SNF@ZIF-8 (2 )) 也显示出优秀催化性能。 | Yingjie Du Jing Gao Huajiao Liu Liya Zhou Ying He Zhihong Huang Yanjun Jiang | 2018 | Nano Research2018，11，8： | 5 |
| 9 | Preparation of cross-linked enzyme aggregates of nitrile hydratase ES-NHT-118 from E.coli by macromolecular cross-linking agent显示文摘Cross-linked enzyme aggregates(CLEAs) of nitrile hydratase(NHase) ES-NHT-118 from Escherichia coli were prepared by using ammonium sulfate as precipitating agent followed by cross-linking with dextran polyaldehyde for the first time. In this process, egg white was added as protein feeder for facilitating the formation of CLEAs. The optimal conditions of the immobilization process were determined. Michaelis constants(Km) of free NHase and NHase CLEAs were also determined. The NHase CLEAs exhibited increased stability at varied pH and temperature conditions compared to its free counterpart. When exposed to high concentrations of acrylamide, NHase CLEAs also exhibited effective catalytic activity. | Liya Zhou Haixia Mou Jing Gao Li Ma Ying He Yanjun Jiang | 2017 | Chinese Journal of Chemical Engineering2017，25，4： | 5 |
| 10 | SET8 is involved in the regulation of hyperglycemic memory in human umbilical endothelial cells显示文摘 | Xiangyuan Chen Qichao Wu Hui Jiang Jiaqiang Wang Yanjun Zhao Yajun Xu Minmin Zhu1 | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 5 |
| 11 | Present Situation of the Anti-Fatigue Processing of High-Strength Steel Internal Thread Based on Cold Extrusion Technology:A Review显示文摘The adoption of cold-extrusion forming for internal thread net forming becomes an important component of anti-fatigue processing with the development of internal thread processing towards high performance, low cost and low energy consumption. It has vast application foreground in the field of aviation, spaceflight, high speed train and etc. The internal thread processing and anti-fatigue manufacture technology are summarized. In terms of the perspective of processing quality and fatigue serving life, the advantages and disadvantages of the processing methods from are compared. The internal thread cold-extrusion processing technology is investigated for the purpose of improving the anti-fatigue serving life of internal thread. The superiorities of the plastic deformation law and surface integrity of the metal layer in the course of cold extrusion for improving its stability and economy are summed up. The proposed research forecasts the development tendency of the internal thread anti-fatigue manufacturing technology. | Hong MIAO Cheng JIANG Sixing LIU Shanwen ZHANG Yanjun ZHANG | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 5 |
| 12 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 13 | Propofol attenuates high glucose-induced P66shc expression in human umbilical vein endothelial cells through Sirt1显示文摘Perioperative hyperglycemia is a common metabolic disorder in clinic settings.Hyperglycemia leads to endothelial inflammation,endothelial cell apoptosis,and dysfunction,thus resulting in endothelial injury.Propofol(2,6-diisopropylphenol)is a widely used intravenous anesthetic in clinic settings.Our previous study indicated that propofol inhibits mitochondrial reactive oxygen species(ROS)production via down-regulation of phosphatase A2(PP2A)expression,inhibition of Ser36-p66shc dephosphorylation and mitochondrial translocation,thus improving high glucose-induced endothelial injury.The expression of p66shc was inhibited by propofol in hyperglycemic human umbilical vein endothelial cells(HUVECs).However,the mechanism by which propofol inhibits p66shc expression in hyperglycemic HUVECs is still obscure.In the present study,we mainly examined how propofol inhibited high glucose-induced p66shc expression in HUVECs.Compared with 5 mM glucose treatment,high glucose increased p66shc expression and decreased sirt1 expression,which was inhibited by propofol treatment.Moreover,EX527(a sirt1 inhibitor)reversed the effect of propofol against high glucose-induced p66shc expression.However,EX527 did not reverse the effects of propofol against high glucose-induced ROS accumulation,endothelial inflammation,and apoptosis.Furthermore,when cells were incubated with propofol,EX527,and FTY720(a PP2A activator)simultaneously,the effects of propofol against high glucose-induced ROS accumulation,inflammation,and apoptosis were reversed.Our results suggested that propofol inhibited high glucose-induced p66shc expression via upregulation of sirt1 expression in hyperglycemic HUVECs.Moreover,propofol protects against high glucose-mediated ROS accumulation and endothelial injury via both inhibition of p66shc expression and dephosphorylation of Ser36-p66shc. | Jing Wang Jie Qi Qichao Wu Hui Jiang Yuehao Yin Yan Huanx Yanjun Zhao Minmin Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 5 |
| 14 | A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro显示文摘Highly virulent porcine epidemic diarrhea virus(PEDV)strains re-emerged and circulated in China at the end of 2010,causing significant economic losses in the pork industry worldwide.To understand the genetic dynamics of PEDV during its passage in vitro,the PEDV G2 strain FJzzl was serially propagated in Vero cells for up to 200 passages.The susceptibility and adaptability of the FJzzl strain increased gradually as it was serially passaged in vitro.Sequence analysis revealed that amino acid(aa)changes were mainly concentrated in the S glycoprotein,which accounted for 72.22%-85.71%of all aa changes.A continuous aa deletion(^(55)I^(56)G^(57)E→^(55)K^(56)Δ^(57)Δ)occurred in the N-terminal domain of S1(Sl-NTD).To examine how the aa changes affected its virulence,FJzzl-F20 and FJzzl-F200 were selected to simultaneously evaluate their pathogenicity in suckling piglets.All the piglets in the FJzzl-F20-infected group showed typical diarrhea at 24 h postinfection,and the piglets died successively by 48 h postinfection.However,the clinical signs of the piglets in the FJzzl-F200-infected group were significantly weaker,and no deaths occurred.The FJzzl-F200-infected group also showed a lower level of fecal viral shedding and lower viral loads in the intestinal tissues,and no obvious histopathological lesions.TypeⅠandⅢinterferon were induced in the FJzzl-F200 infection group,together with pro-inflammatory cytokines,such as TNF-α,IL-1βand IL-8.These results indicate that the identified genetic changes may contribute to the attenuation of FJzzl strain,and the attenuated FJzzl-F200 may have the potential for developing PEDV live-attenuated vaccines. | Pengfei Chen Xiongwei Zhao Shuting Zhou Tianxing Zhou Xiangmei Tan Xia Wu Wu Tong Fei Gao Lingxue Yu Yifeng Jiang Hai Yu Zhibiao Yang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，5： | 4 |
| 15 | Simulation and projection of climate change using CMIP6 Muti-models in the Belt and Road Region显示文摘Climate condition over a region is mostly determined by the changes in precipitation,temperature and evaporation as the key climate variables.The countries belong to the Belt and Road region are subjected to face strong changes in future climate.In this paper,we used five global climate models from the latest Sixth Phase of Coupled Model Intercomparison Project(CMIP6)to evaluate future climate changes under seven combined scenarios of the Shared Socioeconomic Pathways and the Representative Concentration Pathways(SSP1-1.9,SSP1-2.6,SSP2-4.5,SSP3-7.0,SSP4-3.4,SSP4-6.0 and SSP5-8.5)across the Belt and Road region.This study focuses on undertaking a climate change assessment in terms of future changes in precipitation,air temperature and actual evaporation for the three distinct periods as near-term period(2021−2040),mid-term period(2041−2060)and long-term period(2081−2100).To discern spatial structure,Köppen−Geiger Climate Classification method has been used in this study.In relative terms,the results indicate an evidence of increasing tendency in all the studied variables,where significant changes are anticipated mostly in the long-term period.In addition to,though it is projected to increase under all the SSP-RCP scenarios,greater increases will be happened under higher emission scenarios(SSP5-8.5 and SSP3-7.0).For temperature,robust increases in annual mean temperature is found to be 5.2°C under SSP3-7.0,and highest 7.0°C under SSP5-8.5 scenario relative to present day.The northern part especially Cold and Polar region will be even more warmer(+6.1°C)in the long-term(2081−2100)period under SSP5-8.5.Similarly,at the end of the twenty-first century,annual mean precipitation is inclined to increase largely with a rate of 2.1%and 2.8%per decade under SSP3-7.0 and SSP5-8.5 respectively.Spatial distribution demonstrates that the largest precipitation increases are to be pronounced in the Polar and Arid regions.Precipitation is projected to increase with response to increasing warming most of the regions.Finally,the actual evaporation is projected to increase significantly with rate of 20.3%under SSP3-7.0 and greatest 27.0%for SSP5-8.5 by the end of the century.It is important to note that the changes in evaporation respond to global mean temperature rise consistently in terms of similar spatial pattern for all the scenarios where stronger increase found in the Cold and Polar regions.The increase in precipitation is overruled by enhanced evaporation over the region.However,this study reveals that the CMIP6 models can simulate temperature better than precipitation over the Belt and Road region.Findings of this study could be the reliable basis for initiating policies against further climate induced impacts in the regional scale. | YanRan Lü Tong Jiang YanJun Wang BuDa Su JinLong Huang Hui Tao | 2020 | Research in Cold and Arid Regions2020，12，6： | 4 |
| 16 | Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord显示文摘Activation of inflammatory responses regulates the transmission of pain pathways through an integrated network in the peripheral and central nervous systems.The immunopotentiator thymosin alpha-1(Tal)has recently been reported to have anti-inflammatory and neuroprotective functions in rodents.However,how Tα1 affects inflammatory pain remains unclear.In the present study,intraperitoneal injection of Tal attenuated complete Freund's adjuvant(CFA)-induced pain hypersensitivity,and decreased the up-regulation of pro-inflammatory cytokines(TNF-α,IL-1β,and IL-6)in inflamed skin and the spinal cord.We found that CFA-induced peripheral inflammation evoked strong microglial activation,but the effect was reversed by Tα1.Notably,Tα1 reversed the CFA-induced up-regulation of vesicular glutamate transporter(VGLUT)and down-regulated the vesicular γ-aminobutyric acid transporter(VGAT)in the spinal cord.Taken together,these results suggest that Tα1 plays a therapeutic role in inflammatory pain and in the modulation of microgliainduced pro-inflammatory cytokine production in addition to mediation of VGLUT and VGAT expression in the spinal cord. | Yunlong Xu Yanjun Jiang Lin Wang Jiahua Huang Junmao Wen Hang Lv Xiaoli Wu Chaofan Wan Chuanxin Yu Wenjie Zhang Jiaying Zhao Yinqi Zhou Yongjun Chen | 2019 | Neuroscience Bulletin2019，35，4： | 4 |
| 17 | Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice显示文摘Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia. | Yanjun Liu Bing Chen Yirong Cai Yuan Han Ying Xia Nanqi Li Bingqian Fan Tianjie Yuan Junli Jiang Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 18 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
| 19 | Projection of temperature and precipitation under SSPs-RCPs Scenarios over northwest China显示文摘Climate change significantly affects the environmental and socioeconomic conditions in northwest China.Here we evaluate the ability of five general circulation models(GCMs)from 6th phase of the Coupled Model Inter-comparison Project(CMIP6)to reproduce regional temperature and precipitation over northwest China from 1961 to 2014,and project the future temperature and precipitation during 2021 to 2100 under SSPs-RCPs(SSP1-1.9,SSP1-2.6,SSP2-4.5,SSP3-7.0,SSP4-3.4,SSP4-6.0 and SSP5-8.5).The results show that the CMIP6 models can simulate temperature better than precipitation.Projections show that the annual mean temperature will further increase under different SSPs-RCPs scenarios in the 21st century.Future climate changes in the near-term(2021-2040),mid-term(2041-2060)and long-term(2081-2100)are analyzed relative to the reference period(1995-2014).In the long term,warming will be significantly higher than the near and mid-terms.In the long term,annual mean temperature will increase by 1.4℃,1.9℃,3.3℃,5.5℃,2.7℃,3.8℃ and 6.0℃ under SSP1-1.9,SSP1-2.6,SSP2-4.5,SSP3-7.0,SSP4-3.4,SSP4-6.0 and SSP5-8.5,respectively.Spatially,warming in the Junggar Basin will be higher than those in the Tarim Basin.Seasonally,the maximum warming zone will be in the mountainous areas of Tarim Basin during spring and autumn,in the southern basin during winter,and in the east during summer.Precipitation shows an increasing trend under different SSPs-RCPs in the 21st century.In the long term,increase in precipitation will be significantly higher than in the near and mid-terms.Increase in annual precipitation in the long term will be 4.1% under SSP1-1.9,13.9% under SSP1-2.6,28.4% under SSP2-4.5, 35.2% under SSP3-7.0, 6.9% under SSP4-3.4, 8.9% under SSP4-6.0, and 27.3% under SSP5-8.5 relative to the reference period of 1995-2014. Spatially, precipitation increase will be higher in the south than the north, especially higher in mountainous regions than the basin under SSP2-4.5, SSP3-7.0, and SSP5-8.5. Seasonally, highest increase can be expected for winter, followed by spring, with significant increase in mountainous regions of southern Tarim Basin. Summer precipitation will reduce in Tian Shan and basins but will significantly increase in the northern margin of the Kunlun Mountain. | Jiancheng QIN Buda SU Hui TAO Yanjun WANG Jinlong HUANG Tong JIANG | 2021 | Frontiers of Earth Science2021，15，1： | 3 |
| 20 | Interaction of Caffeine with Bovine Serum Albumin: Determination of Binding Constants and the Binding Site by Spectroscopic Methods显示文摘 | Wu, Qiong Jiang, Fenglei Li, Chaohong Hu, Yanjun Liu, Yi | 2011 | Chinese Journal of Chemistry2011，29，3： | 3 |
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