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| 1 | Dispersion stability of thermal nanofluids显示文摘Thermal nanofluids, the engineered fluids with dispersed functional nanoparticles, have exhibited extraordinary thermophysical properties and added functionalities, and thus have enabled a broad range of important applications. The poor dispersion stability of thermal nanofluids, however, has been considered as a longexisting issue that limits their further development and practical application. This review overviews the recent efforts and progresses in improving the dispersion stability of thermal nanofluids such as mechanistic understanding of dispersion behavior of nanofluids, examples of both water-based and oil-based nanofluids,strategies to stabilize nanofluids, and characterization techniques for dispersion behavior of nanofluids. Finally,on-going research needs, and possible solutions to research challenges and future research directions in exploring stably dispersed thermal nanofluids are discussed. | Fan Yu Yingying Chen Xingbo Liang Jiale Xu Chiahsun Lee Qi Liang Peng Tao Tao Deng | 2017 | Progress in Natural Science:Materials International2017，27，5： | 5 |
| 2 | Effectiveness of tonifying-kidney and regulating-liver therapy on diminished ovarian reserve: a systematic review and Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To evaluate the effectiveness of the Traditional Chinese Medicine tonifying-kidney and regulating-liver therapy on diminished ovarian reserve(DOR).METHODS: The literature was comprehensively searched up to August 2019 using four Chinese and three English electronic databases to extract randomized clinical trials(RCTs) comparing Traditional Chinese Medicine tonifying-kidney and regulating-liver prescriptions(combined with hormone therapy or not) with Western Medicine. Data quality evaluation was conducted using the Cochrane risk of bias tool. Meta-analysis was conducted using Revman 5.3 software with effect estimates presented as mean difference(MD), risk ratio(RR), and95% confidence interval(CI).RESULTS: A total of nine RCTs with 512 participants were extracted and eligible for Meta-analysis.There were no significant differences between Chinese medicine and Western Medicine on basal serum follicle-stimulating hormone(FSH) level(MD0.11, 95% CI-0.52 to 0.74, 392 participants, seven trials), anti-Müllerian hormone level(MD 0.48, 95%CI-0.62 to 1.58, 95 participants, two trials), and the FSH and luteinizing hormone ratio(MD 0.01,95% CI-0.95 to 0.96, 115 participants, two trials).Chinese medicine was more effective at improving Traditional Chinese Medicine symptom scores(TCMSS)(MD-2.39, 95% CI-3.83 to-0.94, 160 participants, three trials), effective rate of TCMSS(RR1.18, 95% CI 1.02 to 1.36, 160 participants, three trials), antral follicle count(AFC)(MD 0.55, 95% CI 0.05 to 1.04, 155 participants, three trials), and FSH levels at 3 months post-treatment(MD-4.77, 95% CI-6.09 to-3.45, 137 participants, two trials).CONCLUSION: Compared with Western Medicine,tonifying-kidney and regulating-liver therapy is more effective at relieving symptoms and improving AFC and FSH at 3 months post-treatment. | Liu Liuqing Liu Yanfeng Yang Ming Xu Guiqin Li Ruiqi Xu Xiuli Pan Xue Liang Jialing | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 3 |
| 3 | Quantified assessment of deep brain stimulation on Parkinson’s patients with task fNIRS measurements and functional connectivity analysis:a pilot study显示文摘Background:Deep brain stimulation(DBS)has proved effective for Parkinson’s disease(PD),but the identification of stimulation parameters relies on doctors’subjective judgment on patient behavior.Methods:Five PD patients performed 10-meter walking tasks under different brain stimulation frequencies.During walking tests,a wearable functional near-infrared spectroscopy(fNIRS)system was used to measure the concentration change of oxygenated hemoglobin(ΔHbO_(2))in prefrontal cortex,parietal lobe and occipital lobe.Brain functional connectivity and global efficiency were calculated to quantify the brain activities.Results:We discovered that both the global and regional brain efficiency of all patients varied with stimulation parameters,and the DBS pattern enabling the highest brain efficiency was optimal for each patient,in accordance with the clinical assessments and DBS treatment decision made by the doctors.Conclusions:Task fNIRS assessments and brain functional connectivity analysis promise a quantified and objective solution for patient-specific optimization of DBS treatment.Trial registration:Name:Accurate treatment under the multidisciplinary cooperative diagnosis and treatment model of Parkinson’s disease.Registration number is ChiCTR1900022715.Date of registration is April 23,2019. | Ningbo Yu Siquan Liang Jiewei Lu Zhilin Shu Haitao Li Yang Yu Jialing Wu Jianda Han | 2021 | Chinese Neurosurgical Journal2021，7，3： | 1 |
| 4 | Determining the biological zero for gonadal development razor clams Sinonovacula constricta (lamarck 1818) in Zhejiang,China显示文摘The biological zero of gonadal development and the effective accumulated temperature of one and two-year-old razor clams Sinonovacula constricta(Lamarck 1818)were studied in Sanmen County,Zhejiang Province,China between April 2016 to October 2017,using a new variety named“Shen-Zhe No.1”.The biological zero was determined by using the rule of effective accumulated temperature and the linear regression method,which was confirmed using a histological analysis of the full gonadal development cycle.The results showed that the biological zero of gonadal reproduction of 1-year-old and 2-year-old S.constricta was the same:20.8℃.When the temperature reached 20–21℃,analysis of the histological sections indicated that more than half of the S.constricta individuals initiated gonadal development.The average effective accumulated temperature over two years was 806 d℃.This study contributes to our understanding of the regulation and control of gonadal maturation,suggesting that changes in the spawning and breeding season during one-year of farming using the new variety of razor clam could provide an economic benefit to industrialized large-scale spat production.The results demonstrated that the razor clam S.constricta is a typical clam of the accumulative temperature mature oviposition type.In addition,although S.constricta does not display hypothermy,it requires a lower temperature for gonadal maturity and spawning. | Baobao Xue Delong Meng Hao Li Wei Liang Donghong Niu Jiale Li Heding Shen | 2021 | Aquaculture and Fisheries2021，6，1： | 1 |
| 5 | Double adaptive selection strategy for MOEA/D显示文摘Since most parameter control methods are based on prior knowledge, it is difficult for them to solve various problems.In this paper, an adaptive selection method used for operators and parameters is proposed and named double adaptive selection(DAS) strategy. Firstly, some experiments about the operator search ability are given and the performance of operators with different donate vectors is analyzed. Then, DAS is presented by inducing the upper confidence bound strategy, which chooses suitable combination of operators and donates sets to optimize solutions without prior knowledge. Finally, the DAS is used under the framework of the multi-objective evolutionary algorithm based on decomposition, and the multi-objective evolutionary algorithm based on DAS(MOEA/D-DAS) is compared to state-of-the-art MOEAs. Simulation results validate that the MOEA/D-DAS could select the suitable combination of operators and donate sets to optimize problems and the proposed algorithm has better convergence and distribution. | GAO Jiale XING Qinghua FAN Chengli LIANG Zhibing | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 1 |
| 6 | Ga-In liquid metal nanoparticles prepared by physical vapor deposition显示文摘Controlled synthesis and appropriate characterization of nanoscale particles of gallium-based liquid metals are critical to fulfilling their broad range of applications in the field of flexible, stretchable, and printable micro-/nanoelectronics. Herein, we report a new way to synthesize surfactant-free gallium-indium nanoparticles with controlled particle size on a variety of substrates through a facile physical vapor deposition method. It was found that with prolonged deposition time the liquid metal nanoparticles gradually grew from near-monodispersed small particles with a diameter of ~25 nm to bimodal distributed particles. A nucleation, growth, ripening and merging process was proposed to explain the observed evolution of particle size. Atomic force microscopy measurement indicates that the fabricated liquid metal nanoparticles demonstrate elastic deformation with a certain range of loads and the scanned particle size is dependent on the applied loads. We further investigated the gradual breaking process of the core-shell structured liquid metal nanoparticles, which was evidenced by multiple kinks on the force-separation curve. This work presents a new bottom-up approach to prepare nanoscale liquid metal particles and demonstrates that atomic force microscopy is a suitable technique to characterize the synthesized liquid metal nanoparticles. | Fan Yu Jiale Xu Huiqin Li Zizhao Wang Limin Sun Tao Deng Peng Tao Qi Liang | 2018 | Progress in Natural Science:Materials International2018，28，1： | 1 |
| 7 | MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN显示文摘 | Changju Qu Zhihui Liang JiaLing Huang Ruiying Zhao Chunhui Su Sumei Wang Xudan Wang Rong Zhang Mong-Hong Lee Huiling Yang | 2012 | Cell Cycle2012，，4： | 1 |
| 8 | Compact MPPC-based coded aperture imaging camera for dual-particle detection显示文摘Purpose Fast neutrons and gamma-ray imaging detection is an effective way to detect and identify radioactive material in the field of nuclear security.A compact coded aperture imaging(CAI)camera was designed to be sensitive to both gamma and neutron radiation based on plastic scintillators and multi-pixel photon counters(MPPC).Methods MPPCs coupling with the 13×13 pixelated plastic scintillators one-to-one were utilized to reduce the scale of the CAI system while maintaining good positional performance.The symmetric charge division(SCD)circuit was adopted to reduce the 169 signals output from the MPPC array to 26.Each waveform was collected and processed with four Domino Ring Sampler 4(DRS4)chips and two 16-channel analog-to-digital converter(ADC)modules.As the pulse shapes of fast neutrons would be broadened after elastic scattering multiple times in the scintillators,the Anger-Logic method was applied to eliminate multiple elastic scattering events so that good pulse shape discrimination(PSD)performance can be achieved.Results The imaging and detection ability of the camerawas evaluated using the 241Am-Be(5.9×10^(5) n/s)neutron source and 137Cs(370 MBq)gammasource.The camera can be used to detect fast neutrons(0.5–10 MeV)and gammarays(0.2–2.5MeV).Furthermore,it can implement efficient neutron/gamma PSD capabilities in the mixed-field environment.The figure of merit(FOM)of the camera calculated at 400keVee energy cut is 0.93.Conclusion A compact MPPC-based CAI camera was designed to detect and discriminate fast neutrons and gamma rays.Its good PSD performance was well suited to distinguish fast neutrons from gamma rays in a dual-particle environment.The portable design makes it promising for complex monitoring scenarios in nuclear security. | Jing Guo Xiaoyu Pang Jiale Cai Daowu Li Xiaoming Wang Xuanhou Hu Yue Yu Shuangquan Liu Xiuzuo Liang Yiwen Zhang Lei Shuai Long Wei | 2021 | Radiation Detection Technology and Methods2021，5，1： | 1 |
| 9 | Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing显示文摘Severe combined immunodeficiency(SCiD)encompasses a range of inherited disorders that lead to a profound deterioration of the immune system.Among the pivotal genes associated with SCID,RAG1 and IL2RG play crucial roles.IL2RG is essential for the development,differentiation,and functioning of T,B,and NK cells,while RAG1 critically contributes to adaptive immunity by facilitating V(D)J recombination during the maturation of lymphocytes.Animal models carrying mutations in these genes exhibit notable deficiencies in their immune systems. | Xiao Zheng Chunhui Huang Yingqi Lin Bofeng Han Yizhi Chen Caijuan Li Jiawei Li Yongyan Ding Xichen Song Wei Wang Weien Liang Jianhao Wu Jiaxi Wu Jiale Gao Chengxi Wei Xudong Zhang Zhuchi Tu Sen Yan | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 10 | Characteristics of air-water flow in an emptying tank under different conditions显示文摘This paper experimentally studied the features of air-water flow during the emptying of a water-filled prismatic tank with a bottom orifice under different conditions.The experiments were conducted with both circular and elliptical orifices,with and without ventilation.The evolution of bubbles,water pressure variation,and water level change with time were recorded in the experiments and analyzed.Based on the results,the evolution of bubbles could be mainly divided into three stages of formation,deformation,and decomposition.Ventilation was found important to the emptying process,with which the drainage efficiency was much higher than that under the unventilated condition.Additionally,under the unventilated condition,the drainage efficiency with the circular orifice was slightly higher than that with the elliptical orifice. | Jialing Liang Yiyi Ma Yi Zheng | 2021 | Theoretical & Applied Mechanics Letters2021，11，6： | 0 |
| 11 | Epigenetic and transcriptional activation of the secretory kinase FAM20C as an oncogene in glioma显示文摘Gliomas are the most prevalent and aggressive malignancies of the nervous system.Previous bioinformatic studies have revealed the crucial role of the secretory pathway kinase FAM20C in the prediction of glioma invasion and malignancy.However,little is known about the pathogenesis of FAM20C in the regulation of glioma.Here,we construct the full-length transcriptome atlas in paired gliomas and observe that 22 genes are upregulated by full-length transcriptome and differential APA analysis.Analysis of ATAC-seq data reveals that both FAM20C and NPTN are the hub genes with chromatin openness and differential expression.Further,in vitro and in vivo studies suggest that FAM20C stimulates the proliferation and metastasis of glioma cells.Meanwhile,NPTN,a novel cancer suppressor gene,counteracts the function of FAM20C by inhibiting both the proliferation and migration of glioma.The blockade of FAM20C by neutralizing antibodies results in the regression of xenograft tumors.Moreover,MAX,BRD4,MYC,and REST are found to be the potential trans-active factors for the regulation of FAM20C.Taken together,our results uncover the oncogenic role of FAM20C in glioma and shed new light on the treatment of glioma by abolishing FAM20C. | Bo Gong Yi Liang Qian Zhang Huan Li Jialing Xiao Liang Wang Han Chen Wenjie Yang Xiaoqing Wang Yi Wang Zongze He | 2023 | Journal of Genetics and Genomics2023，50，6： | 0 |
| 12 | Identification of oleic acid as an endogenous ligand of GPR3显示文摘Although GPR3 plays pivotal roles in both the nervous system and metabolic processes,such as cold-induced thermogenesis,its endogenous ligand remains elusive.Here,by combining structural approach(including cryo-electron microscopy),mass spectrometry analysis,and functional studies,we identify oleic acid(OA)as an endogenous ligand of GPR3.Our study reveals a hydrophobic tunnel within GPR3 that connects the extracellular side of the receptor to the middle of plasma membrane,enabling fatty acids to readily engage the receptor.Functional studies demonstrate that OA triggers downstream Gs signaling,whereas lysophospholipids fail to activate the receptor.Moreover,our research reveals that cold stimulation induces the secretion of OA in mice,subsequently activating Gs/cAMP/PKA signaling in brown adipose tissue.Notably,brown adipose tissues from Gpr3 knockout mice do not respond to OA during cold stimulation,reinforcing the significance of GPR3 in this process.Finally,we propose a“born to be activated and cold to enhance”model for GPR3 activation.Our study provides a starting framework for the understanding of GPR3 signaling in cold-stimulated thermogenesis. | Yangjie Xiong Zhenmei Xu Xinzhi Li Yuqin Wang Jing Zhao Na Wang Yaning Duan Ruixue Xia Zhengbin Han Yu Qian Jiale Liang Anqi Zhang Changyou Guo Asuka Inoue Yu Xia Zheng Chen Yuanzheng He | 2024 | Cell Research2024，34，3： | 0 |
| 13 | A Review on Electrospinning as Versatile Supports for Diverse Nanofibers and Their Applications in Environmental Sensing显示文摘Rapid industrialization is accompanied by the deterioration of the natural environment.The deepening crisis associated with the ecological environment has garnered widespread attention toward strengthening environmental monitoring and protection.Environmental sensors are one of the key technologies for environmental monitoring,ultimately enabling environmental protection.In recent decades,micro/nanomaterials have been widely studied and applied in environmental sensing owing to their unique dimensional properties.Electrospinning has been developed and adopted as a facile,quick,and effective technology to produce continuous micro-and nanofiber materials.The technology has advanced rapidly and become one of the hotspots in the field of nanomaterials research.Environmental sensors made from electrospun nanofibers possess many advantages,such as having a porous structure and high specific surface area,which effectively improve their performance in environmental sensing.Furthermore,by introducing functional nanomaterials(carbon nanotubes,metal oxides,conjugated polymers,etc.)into electrospun fibers,synergistic effects between different materials can be utilized to improve the catalytic activity and sensitivity of the sensors.In this review,we aimed to outline the progress of research over the past decade on electrospinning nanofibers with different morphologies and functional characteristics in environmental sensors. | Jialing Song Xuanhao Lin Liang Ying Ee Sam Fong Yau Li Manhong Huang | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
| 14 | High Solar Energy Absorption and Human Body Radiation Reflection Janus Textile for Personal Thermal Management显示文摘A large of energy consumption is required for indoor and outdoor personal heating to ameliorate the comfortable and healthy conditions.Main personal thermal management strategy is to reflect mid-infrared human body radiation for human surface temperature(THS)regulation.We demonstrate a visible Janus light absorbent/reflective air-layer fabric(Janus A/R fabric)that can passively reflect radiative heating meanwhile can actively capture the solar energy.A series of azobenzene derivatives functionalized with alkyl tails are reported to co-harvest the solar and phase-change energy.The THS covered by Janus A/R fabric can be heated up to~3.7°C higher than that covered by air-layer fabric in cold environment(5°C).Besides,integrating the thermo-and photo-chromic properties is capable of monitoring comfort THS and residue energy storage enthalpy,respectively.According to the colour monitors,intermittent irradiation approach is proposed to prolong comfortable-THS holding time for managing energy efficiently. | Liang Fei Weidong Yu Jialing Tan Yunjie Yin Chaoxia Wang | 2023 | Advanced Fiber Materials2023，5，3： | 0 |
| 15 | Uphill or downhill?Cropland use change and its drivers from the perspective of slope spectrum显示文摘The continuous decrease of low-slope cropland resources caused by construction land crowding poses huge threat to regional sustainable development and food security.Slope spectrum analysis of topographic and geomorphic features is considered as a digital terrain analysis method which reflects the macro-topographic features by using micro-topographic factors.However,pieces of studies have extended the concept of slope spectrum in the field of geoscience to construction land to explore its expansion law,while research on the slope trend of cropland from that perspective remains rare.To address the gap,in virtue of spatial analysis and geographically weighted regression(GWR)model,the cropland use change in the Yangtze River Basin(YRB)from 2000 to 2020 was analyzed and the driving factors were explored from the perspective of slope spectrum.Results showed that the slope spectrum curves of cropland area-frequency in the YRB showed a first upward then a downward trend.The change curve of the slope spectrum of cropland in each province(municipality)exhibited various distribution patterns.Quantitative analysis of morphological parameters of cropland slope spectrum revealed that the further down the YRB,the stronger the flattening characteristics,the more obvious the concentration.The province experienced the greatest downhill cropland climbing(CLC)was Shannxi,while province experienced the highest uphill CLC was Zhejiang.The most common cropland use change type in the YRB was horizontal expansion type.The factors affecting average cropland climbing index(ACCI)were quite stable in different periods,while population density(POP)changed from negative to positive during the study period.This research is of practical significance for the rational utilization of cropland at the watershed scale. | PAN Sipei LIANG Jiale CHEN Wanxu PENG Yelin | 2024 | Journal of Mountain Science2024，21，2： | 0 |
| 16 | Genome-edited rabbits:Unleashing the potential of a promising experimental animal model across diverse diseases显示文摘Animal models are extensively used in all aspects of biomedical research,with substantial contributions to our understanding of diseases,the development of pharmaceuticals,and the exploration of gene functions.The field of genome modification in rabbits has progressed slowly.However,recent advancements,particularly in CRISPR/Cas9-related technologies,have catalyzed the successful development of various genome-edited rabbit models to mimic diverse diseases,including cardiovascular disorders,immunodeficiencies,agingrelated ailments,neurological diseases,and ophthalmic pathologies.These models hold great promise in advancing biomedical research due to their closer physiological and biochemical resemblance to humans compared to mice.This review aims to summarize the novel gene-editing approaches currently available for rabbits and present the applications and prospects of such models in biomedicine,underscoring their impact and future potential in translational medicine. | Yang Han Jiale Zhou Renquan Zhang Yuru Liang Liangxue Lai Zhanjun Li | 2024 | Zoological Research2024，45，2： | 0 |
| 17 | Revolutionizing diabetic wound healing:The power of microneedles显示文摘Diabetic wounds significantly affect patient quality of life.Microneedles are a promising treatment to accelerate wound healing owing to their high drug-loading capacity and efficient drug delivery;however,few studies to date have comprehensively reviewed microneedles for diabetic wound healing.This up-to-date review summarizes the research progress in microneedles for diabetic wound healing,including manufacturing materials and techniques,structures,designs,release mechanisms,delivery substances,and their specific effects.This study showed that most microneedles designed for diabetic wounds are made of synthetic polymers and/or natural materials using polydimethylsiloxane micromolding.The geometric structure and design directly influence penetration ability and drug delivery capacity.Microneedles can deliver antibiotics,hypoglycemic agents,traditional Chinese medicines,metal ions,growth factors,exosomes,stem cells,and microorganisms,thus promoting diabetic wound healing through diverse mechanisms,such as antibacterial,anti-inflammatory,antioxidant,hypoglycemic,and angiogenic activities,at different stages of the healing process.In conclusion,microneedles are promising drug delivery systems for the treatment of diabetic wounds. | Chun Liang Ren Wang Tian He Dongsheng Chen Guangliang Zhang Xiangye Yin Hongyu Wang Jiale Xie Yujing Li Youbai Chen | 2023 | Chinese Journal Of Plastic and Reconstructive Surgery2023，5，4： | 0 |
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