|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Towards Flexible All-Carbon Electronics:Flexible Organic Field-Effect Transistors and Inverter Circuits Using Solution-Processed All-Graphene Source/Drain/Gate Electrodes显示文摘Flexible organic field-effect transistors(OFETs)using solution-processable functionalized graphene for all the electrodes(source,drain,and gate)have been fabricated for the first time.These OFETs show performance comparable to corresponding devices using Au electrodes as the source/drain electrodes on SiO2/Si substrates with Si as the gate electrode.Also,these devices demonstrate excellent flexibility without performance degradation over severe bending cycles.Furthermore,inverter circuits have been designed and fabricated using these all-graphene-electrode OFETs.Our results demonstrate that the long-sought dream for all-carbon and flexible electronics is now much closer to reality. | Yongsheng Chen Yanfei Xu Kai Zhao Xiangjian Wan Jiachun Deng Weibo Yan | 2010 | Nano Research2010，3，10： | 5 |
| 2 | Interventional effect of hirudin on the expression of microtubule-associated protein 2 in peripheral tissue of hematom of model rats with acute intracerebral hemorrhage显示文摘BACKGROUND: It is suspected that dissociation, destruction or synthetic disorder of microtubule-associated protein 2 (MAP-2) may participate in secondary injury of intracerebral hemorrhage (ICH), and the reason may be related to thrombin in high concentration after ICH; therefore, the mechanism should be studied further. OBJECTIVE: To explore the effect of hirudin on expression of MAP-2 in peripheral tissue of hematom after ICH and changes of water content in brain tissue and analyze pathogenesis of thrombin in secondary injury after ICH. DESIGN: Completely randomized grouping design and controlled animal study. SETTING: Department of Neurology, the First Affiliated Hospital of Jilin University. MATERIALS: The experiment was carried out in the Neurological Laboratory of the First Affiliated Hospital of Jilin University from April 2003 to April 2004. A number of 80 healthy Wistar rats, of both genders, aged 3-4 months, weighing 250-350 g, were randomly divided into 8 groups: normal control group, 6-hour ICH group, 1-day ICH group, 2-day ICH group, 3-day ICH group, 7-day ICH group, 3-day hirudin group and 7-day hirudin group with 10 in each group. Five rats from each group were selected to measure their water content, and the others were undertaken immunohistochemical stain. Hirudin was produced by Sigma Company, USA, and MAP-2 rabbit-rat polyclonal antibody was provided by Fuzhou Maixin Biotechnology Company Limited. METHODS: ① Model establishing and grouping intervention: Rats in simple ICH group were collected their blood from tails and then inserted with 50 μL non-anticoagulant auto-arterial blood into the cauda of the putamen in right brain within 5 minutes. Rats in hirudin groups were inserted with 10 U hirudin (which was diluted with saline to 20 μL) into local hematom regions within 5 minutes, and the needle was pulled out after 10 minutes. Rats in normal control group were untouched. ② Water content in peripheral tissue of hematom: Based on the ratio between dry weight and wet weight, brain tissue at bleeding side and in right frontal lobe was selected to measure dry and wet weights so as to calculate the water content [(wet weight - dry weight)/wet weight] × 100%. ③ Positive expression of MAP-2: Based on immunohistochemical stain, positive MAP-2 cells were regarded as neurons and they were buffy morphological. Positive rate of MAP-2 was calculated, i.e., percentage of positive cells in each sight to total cells in all sights. ④ Statistical analysis: Data among groups were compared with one-way analysis of variance, averages were compared with SNK-q test by each other, and relation between water content and MAP-2 was analyzed with linear regression technique. MAIN OUTCOME MEASURES: Changes of water content and MAP-2 expression in peripheral tissue of hematom at various time points after ICH and intervention of hirudin. RESULTS: All 80 rats were involved in the final analysis. ① Water content: Water content was increased at day 1, reached peak at day 3 and decreased at day 7. It was (72.31±0.32)%, (77.42±0.53)%, (78.44±0.28)%, (74.10±0.13)%, (74.85±0.51)% and (70.07±0.36)%, respectively in 1-day, 2-day, 3-day and 7-day ICH groups and 3-day and 7-day hirudin groups, which was higher than that in normal control group (63.85±0.41, q=-4.684 3 to -7.262 0, P < 0.05); that in 2-day and 3-day ICH groups was higher than that in 7-day ICH group (q=-3.053 4, -3.727 0, P < 0.05); and that in 3-day and 7-day ICH groups was higher than that in hirudin groups at the same time points (q=-2.965 6, -2.726 4, P < 0.05). ② Positive expression of MAP-2: Positive expression of MAP-2 was decreased at 6 hours after ICH, reached the lowest value at day 3 and increased at day 7. Positive rate was (78.60±0.42)%, (60.56±0.74)%, (44.60±0.26)%, (25.45±0.85)%, (32.55±0.64)%, (37.69±0.76)%, (41.75±0.68)%, respectively in 6-hour, 1-day, 2-day, 3-day and 7-day ICH groups and 3-day and 7-day hirudin groups, which was lower than that in normal control group [(96.50±0.33)%, q= -3.074 5 to -8.128 5, P < 0.05]. In addition, positive cells of MAP-2 disappeared plentifully at 3-7 days after ICH, stain of positive cells were light, and only stain of plasma was positive. That in 3-day and 7-day hirudin groups was higher than that in ICH groups at the same time points (q= -3.391 8, -2.967 9, P < 0.05). Moreover, positive cells of MAP-2 was formed slightly but deeply stained. ③ Results of linear regression: Water content was negatively related to MAP-2 changes at 7 days after ICH (r= -0.894 9, P < 0.01), i.e., water content was increased with decrease of MAP-2 expression. CONCLUSION: The deterioration of MAP-2 may be involved in the pathogenesis of thrombin within the first week after ICH, and the local administration of hirudin can protect neurons. | Jiachun Feng Ying Zhang Fang Deng | 2006 | Neural Regeneration Research2006，1，3： | 2 |
| 3 | A microRNA-135a/b binding polymorphism in CD133 confers decreased risk and favorable prognosis of lung cancer in Chinese by reducing CD133 expression显示文摘 | Mei Cheng Lei Yang Rongrong Yang Xiaorong Yang Jieqiong Deng Bolan Yu Dongsheng Huang Shuxu Zhang Hui Wang Fuman Qiu Yifeng Zhou Jiachun Lu | 2013 | Carcinogenesis2013，，10： | 1 |
| 4 | Genetic susceptibility loci of lung cancer are associated with malignant risk of pulmonary nodules and improve malignancy diagnosis based on CEA levels显示文摘Objective:The heightened prevalence of pulmonary nodules(PN)has escalated its significance as a public health concern.While the precise identification of high-risk PN carriers for malignancy remains an ongoing challenge,genetic variants hold potentials as determinants of disease susceptibility that can aid in diagnosis.Yet,current understanding of the genetic loci associated with malignant PN(MPN)risk is limited.Methods:A frequency-matched case-control study was performed,comprising 247 MPN cases and 412 benign NP(BNP)controls.We genotyped 11 established susceptibility loci for lung cancer in a Chinese cohort.Loci associated with MPN risk were utilized to compute a polygenic risk score(PRS).This PRS was subsequently incorporated into the diagnostic evaluation of MPNs,with emphasis on serum tumor biomarkers.Results:Loci rs10429489G>A,rs17038564A>G,and rs12265047A>G were identified as being associated with an increased risk of MPNs.The PRS,formulated from the cumulative risk effects of these loci,correlated with the malignant risk of PNs in a dose-dependent fashion.A high PRS was found to amplify the MPN risk by 156%in comparison to a low PRS[odds ratio(OR)=2.56,95%confidence interval(95%CI),1.40−4.67].Notably,the PRS was observed to enhance the diagnostic accuracy of serum carcinoembryonic antigen(CEA)in distinguishing MPNs from BPNs,with diagnostic values rising from 0.716 to 0.861 across low-to high-PRS categories.Further bioinformatics investigations pinpointed rs10429489G>A as an expression quantitative trait locus.Conclusions:Loci rs10429489G>A,rs17038564A>G,and rs12265047A>G contribute to MPN risk and augment the diagnostic precision for MPNs based on serum CEA concentrations. | Zhi Li Liming Lu Yibin Deng Amei Zhuo Fengling Hu Wanwen Sun Guitian Huang Linyuan Liu Boqi Rao Jiachun Lu Lei Yang | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 5 | Protective effect of Wnt-5a against amyloid beta-induced memory impairment in rats显示文摘Recent studies suggest that the activation of the Wnt signaling pathway improves memory function in rats.This study investigated the effects of Wnt-5a on amyloid β (Aβ)-induced cognitive impairment.Aβ25-35 was injected into the rat right lateral ventricle to induce Alzheimer's disease-associated pathology,and Wnt-5a was injected as a potential therapeutic treatment.Immunofluorescence staining showed that compared with normal rats,Aβ25-35 significantly decreased postsynaptic density-95 protein expression in the rat hippocampal CA1 region,but Wnt-5a pretreatment blocked this decrease.This study shows that Wnt-5a can reduce Aβ-induced cognitive impairment,and that it has the potential to be a new therapeutic strategy for the treatment of Alzheimer's disease. | Guili Zhang Lu Lu Yaping Ge Fang Deng Ying Zhang Jiachun Feng | 2011 | Neural Regeneration Research2011，6，14： | 0 |
| 6 | Leaky-Wave Antennas for 5G/B5G Mobile Communication Systems:A Survey显示文摘Since leaky-wave antennas(LWAs)have the advantages of high directivity,low loss and structural simplicity,LWAs are very suitable for designing millimeter-wave(mmW)antennas.The purpose of this paper is to review the latest research progress of LWAs for 5G/B5G mobile communication systems.Firstly,the conventional classification and design methods of LWAs are introduced and the effects of the phase constant and attenuation constant on the radiation characteristics are discussed.Then two types of new LWAs for 5G/B5G mobile communication systems including broadband fixed-beam LWAs and frequencyfixed beam-scanning LWAs are summarized.Finally,the challenges and future research directions of LWAs for 5G/B5G mobile communication systems are presented. | HE Yejun JIANG Jiachun ZHANG Long LI Wenting WONG Sai-Wai DENG Wei CHI Baoyong | 2020 | ZTE Communications2020，18，3： | 0 |
| 7 | Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation显示文摘Phosphatidylcholines(PCs)are major phospholipids in the mammalian cell membrane.Structural remodeling of PCs is associated with many biological processes.Lysophosphatidylcholine acyltransferase 3(Lpcat3),which catalyzes the incorporation of polyunsaturated fatty acyl chains into the sn-2 site of PCs,plays an important role in maintaining plasma membrane fluidity.Adipose tissue is one of the main distribution organs of Lpcat3,while the relationship between Lpcat3 and adipose tissue dysfunction during overexpansion remains unknown.In this study,we reveal that both polyunsaturated PC content and Lpcat3 expression are increased in abdominal adipose tissues of high-fat diet-fed mice when compared with chow-diet-fed mice,indicating that Lpcat3 is involved in adipose tissue overexpansion and dysfunction.Our experiments in 3T3-L1 adipocytes show that inhibition of Lpcat3 does not change triglyceride accumulation but increases palmitic acid-induced inflammation and lipolysis.Conversely,Lpcat3 overexpression exhibits anti-inflammatory and anti-lipolytic effects.Furthermore,mechanistic studies demonstrate that Lpcat3 deficiency promotes reactive oxygen species(ROS)generation by increasing NOX enzyme activity by facilitating the translocation of NOX4 to lipid rafts,thereby aggregating 3T3-L1 adipocyte inflammation induced by palmitic acid.Moreover,overexpression of Lpcat3 exhibits the opposite effects.These findings suggest that Lpcat3 protects adipocytes from inflammation during adipose tissue overexpansion by reducing ROS generation.In conclusion,our study demonstrates that Lpcat3 deficiency promotes palmitic acid-induced inflammation in 3T3-L1 adipocytes by enhancing ROS generation. | Jiachun Hu Yan Deng Tingbo Ding Jibin Dong Yuning Liang Bin Lou | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员