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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination显示文摘Ubiquitination 调整主人免疫的许多方面并且因此是为传染代理人的一个普通目标。最近的研究表明了细菌的病原体 Legionella pneumophila 的方面受动器家庭的成员攻击不要求主人 ubiquitination 机械的 E1 和 E2 酶的新奇 ubiquitination 机制与 endoplasmic 蜂窝胃联系的几小 GTPases。在这种情况中, ubiquitin 被一项 mono-ADP-ribosyltransferase 活动被 ADP-ribosylation 首先在 Arg 42 激活;中介然后被也住在 SdeA 以内的一项 phosphodiesterase 活动劈开,有到经由一个 phosphoribosyl 连接器的底层蛋白质的丝氨酸残余的 ubiquitin 的附件的伴随物。这里,我们证明方面的效果被 SidJ 反对,一个受动器由位于为方面家庭(SdeC, SdeB 和 SdeA ) 的三个成员编码的地点的基因编码了。SidJ 由劈开连接 phosphoribosylated ubiquitin 到蛋白质底层的 phosphodiester 契约颠倒修改方面的底层的 ubiquitination。SidJ 也显示古典 deubiquitinase 活动但是不要求催化半胱氨酸残余。进一步, SidJ 的这些 deubiquitinase 活动为它在 L 的角色是必要的。pneumophila 感染。最后, SidJ 的活动为高效地在细菌的举起以后在一些小时以内在感染的房间减少许多 ubiquitinated Rab33b 被要求。我们的结果作为工作在方面受动器的活动强加时间的规定的 ubiquitin-deconjugating 酶建立 SidJ。SidJ 可能在表明串联的未来研究是重要的由这唯一的 ubiquitination 调停了,潜在地也在真核细胞的房间调整细胞的过程的。 | Jiazhang Qiu Kaiwen Yu Xiaowen Fei Yao Liu Emesto S Nakayasu Paul D Piehowski Jared B Shaw Kedar Puva Chittaranjan Das Xiaoyun Liu Zhao-Qing Luo | 2017 | Cell Research2017，27，7： | 2 |
| 4 | Myocarditis:Current trends in diagnosis and treatment显示文摘 | Jared W Magnani G William D | 2006 | Circulation2006，113，6： | 1 |
| 5 | Spel ing-sound consistency effects in di-syl abic word naming显示文摘 | Chateau D Jared D | | 0，，： | 1 |
| 6 | Vitamin D Status and Cardiovascular Health : a 2009 update 显示文摘 | Erin D Michos Jared P Reis Michal L Melamed | 2010 | The Open Clinical Chemistry Journal2010，3，： | 1 |
| 7 | Analysis of fatal crashes in Georgia work zones显示文摘 | DANIEL J DIXON K JARED D | 2000 | Transportation Research Record:Journal of the Transportation Re- search Board2000，1715，1： | 1 |
| 8 | China's environment in a globalizing world显示文摘 | Liu J G Jared D | 2005 | Nature2005，435，： | 1 |
| 9 | Serum vitamin D,parathyroid hormone levels,and carotid atherosclerosis显示文摘 | Jared P Reis Denise von Muhlen Erin D Michos | | 0，，207： | 1 |
| 10 | Serum vi- tamin D parathyroid hormone levels and carotid atherosclerosis 显示文摘 | Jared P Reis Denise Von Mtlhlen Erin D Michos | 2009 | Atheroselerosis2009，20，7： | 1 |
| 11 | Genetic and moleeular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics显示文摘 | Jares P Colomer D Campo E | 2007 | Nat Rev Caneer2007，7，10： | 1 |
| 12 | Myocarditis:current trends in diagnossis and treatment显示文摘 | Magnani G William D | 2006 | Circulation2006，113，6： | 1 |
| 13 | Ore Fluid Properties and Sources from Quartz - Associated Gold at the Betze - Post Carlin - Type Gold Deposit, Nevada, United States 显示文摘 | Jared D L Cline J S | 2012 | Economic Geology2012，，107： | 1 |
| 14 | Genetic and molecular pathogene- sis of mantle cell lymphoma: perspectives for new targeted ther- apeutics 显示文摘 | Jares P Colomer D Campo E | 2007 | Nat Rev Cancer2007，7，10： | 1 |
| 15 | Asymmetric pri- cing of implied systematic volatility in the cross-section of expected returns 显示文摘 | JARED D R JAMES S D DAVID R P | 2011 | Journal of Futures Markets2011，31，1： | 1 |
| 16 | Myocarditis: current t rends in diagnosis and t reatment 显示文摘 | Jared W Magnani G William D | 2006 | Circulation2006，113，6： | 1 |
| 17 | Homophone effects in lexical decision显示文摘 | Pexman P M Luper S J Jared D | 2001 | Journal of Experimental Psychology:Learning Memory and Cognition2001，27，： | 1 |
| 18 | Use ofpeptides from p21 (Warfl/Cipl) to investigate PCNA function in xenopus egg ectraets显示文摘 | Mattock H Jares P Zheleva D | 2001 | Exp Cell Res2001，23，11： | 1 |
| 19 | Implementation of length expanding inflatable penile prosthesis is not sufficient to prevent postsurgical penile shortening显示文摘Asingle armed,prospective,two-center study was conducted,with an aim of evaluating the effectiveness of the AMS 700 LGX cylinders in maintaining or increasing penile length postimplantation.The LGX has the unique ability to expand in length with inflation.Only 23.1%(6)of the patients were able to maintain stretched penile length.We now recommend leaving the implant inflated 60%-80%in the immediate postoperative setting for approximately 6 weeks.Then we teach pump training with deflation at around 6 weeks,prior to a maximum inflation protocoldaily.Further studies would be required to validate if these interventions have significantly increased the number of patients who maintain or gain stretched penile length. | Jared J Wallen SriGita K Madiraju Run Wang Gerard D Henry | 2019 | Asian Journal of Andrology2019，21，1： | 1 |
| 20 | Correlation between the fractal dimension of the electrode surface and the EIS of the zinc anodic dissolution for different kinds of galvanized steel显示文摘 | Giménez-Romero D García -Jare? o J J Vicente F | 2004 | Electrochemistry Communications2004，6，： | 1 |
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