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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Immunostimulation in crustaceans:does it really protect against infection显示文摘 | VALERI J S JANET H B CHRIS HAUTON | 2003 | Fish & Shellfish Immunology2003，，15： | 1 |
| 3 | Shareholder activism and middle management equity Incentives 显示文摘 | JANET H MARLER CHRISTOPHE FAUGERE | 2010 | Corporate Governance: An International Review2010，18，4： | 1 |
| 4 | Characterization of novel gene, wosA, regulating FlhDC expression in Proteus mlrabilis显示文摘 | Janet K H Philip N R | 2008 | Bacteri- ol2008，3，： | 1 |
| 5 | Loss of PTEN expression as a prognostic marker for tongue cancer显示文摘 | Janet IL Jean-Charles S Khaled A H | 2001 | Arch Otolaryngol2001，127，14： | 1 |
| 6 | Compensation strategy: Does business strategy influence compensation in high -technology finns? 显示文摘 | YOSHIO Y JANET H M | 2006 | Strategic Management Journal2006，27，6： | 1 |
| 7 | Comparison of PCR- based molecular marker analyses of Musa breeding populations 显示文摘 | Crouch JH Crouch HK Constandt H Van Gysel A Breyne P Van Montagu M Janet RL Ortiz R | 1999 | Mol Breed1999，5，： | 1 |
| 8 | Signaling pathways in vascular development 显示文摘 | Janet R Lorraine H | 2002 | Annu Rev Cell Dev Biol2002，18，： | 1 |
| 9 | Changes in glutathione S-transferase activity in DDT resistant natural Mexican populations of Anopheles albimanus under different insecticide resistance management strategies显示文摘 | Patricia R P Américo D R Janet H | 2006 | Pesticide Biochemistry and Physiology2006，86，2： | 1 |
| 10 | Calcium phosphate cement containing resorbable fibers for short-term reinforcement and macroporosity显示文摘 | HOCKIN H K X JANET B Q | 2002 | Biomaterials2002，23，： | 1 |
| 11 | Compassion satisfaction, burn out, and compassion fatigue among emergency nurses compared with nurses in other selected inpatient Specialties 显示文摘 | Crystal H Janet C David R | 2010 | J Emerg Nurs2010，36，5： | 1 |
| 12 | A specific antibody to the carbohydrate recognition domain of the asialoglycoprotein receptor RHL1 subunit Does not react with RHL2/3 but blocks ligand binding显示文摘 | Zeng Fuyue Janet A Oka Paul H Weigel | 1998 | Biochemical and Biophysical Research Communications1998，249，： | 1 |
| 13 | Effects of differentwhiskers on the reinforcement of dental resin composites 显示文摘 | Hockin H K Xu Janet B Quinn douglas T Smith | 2003 | Dental Materials2003，19，： | 1 |
| 14 | A novel approach in model- based mapping of soil water conditions at forest sites 显示文摘 | Kai S Karl H F Janet H | 2009 | Forest Ecology and Management2009，72，8： | 1 |
| 15 | Ammonium fixation and availability in vermiculite显示文摘 | ALLISON F E ROLLER E M JANET H D | 1953 | Soil Sci1953，75，： | 1 |
| 16 | Interspecies variation of Kitasatospora recifensis endophytic from yam bean produ-cing thermostable amylases in alternative media显示文摘 | Yong H P Jin W B Janete M A | 2007 | World Journal of Microbiology and Biotechnology2007，23，12： | 1 |
| 17 | 8 - hydroxydeooxyguanosine in DNA from leukocytes of healthy adults: relationship with cigarette smoking, environmental tobacco smoke, alcohol and coffee consumption显示文摘 | Albert AK Anton J Janet H | 1999 | Mutation Res1999，439，： | 1 |
| 18 | Cauliflower mosaic virus protein P6 is a suppressor of RNA silencing 显示文摘 | Andrew J L Janet L Justin H | 2007 | Journal of General Virology2007，88，： | 1 |
| 19 | Mechanisms of action of arsenic trioxide 显示文摘 | WILSON H HYMAN M JANET S | 2002 | Cancer Res2002，62，14： | 1 |
| 20 | The toxicity of microcystin-LR in mice following 7 days of inhalation exposure显示文摘 | JANET M B JULIE A H KATHLEEN R | 2005 | Toxicon2005，45，： | 1 |
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