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| 1 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 3 | The role of computational methods in the identification of bioactive compounds显示文摘 | Glick M Jacoby E | 2011 | Curr Opin Chem Biol2011，15，4： | 1 |
| 4 | Treatment delay in pa- tients undergoing primary percutaneous coronary interventionfor ST-elevation myocardial infarction: a key process analysis of patient and program factors显示文摘 | Parikh SV Jacobi JA Chu E | 2008 | Am Heart J2008，155，2： | 1 |
| 5 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 6 | Influence of tempera- ture and rainfall on the development of tobacco black shank 显示文摘 | Jacobi W R Main C E Powell N T | 1983 | Phytopathology1983，73，2： | 1 |
| 7 | Some results of S - transform analysis of the transient planetary - scale wind oscillations in the lower thermosphere显示文摘 | Potnyagin Y Merzlyakov E Jacobi C | 1999 | Earth Planets and Space1999，51，4： | 1 |
| 8 | Detremination of glycoforms of hunman chorinic gonadotropin-core fragment by matri-assisted 1aster desorptional ionization time-of-f1ight mass spectrometry显示文摘 | Jacoby E S | 2000 | Clin Chem2000，46，11： | 1 |
| 9 | Moderate controlled hypotension with sodium nitroprusside does not improve surgical conditions or decrease blood loss in endoscopic sinus surgery显示文摘 | Jacobi K E Boehm B E Rickauer A G | 2000 | J Clin Anesth2000，12，3： | 1 |
| 10 | qnrB,another plasmid-mediated gene for quionlone resistanee显示文摘 | Jacoby G A Walsh K E Mills D M | 2006 | Antimierob Agents Chemother2006，50，4： | 1 |
| 11 | The critical care clinical pharmacist:evo-lution of an essential team member显示文摘 | Horn E Jacobi J | 2006 | Crit Care Med2006，34，3： | 1 |
| 12 | 7 cause anosmia 显示文摘 | Weiss J Pyrski M Jacobi E Bufe B Willnecker V Schick B et aL Loss-of-function mutations in sodi- um channel Nay1 | 2011 | Nature2011，472，7342： | 1 |
| 13 | Detremination of Glycoforms ofhuman chorinic Gonadotropin β-core Fragment by matri-assisted laster desorptional ionization time-of-flight mass spectrome-try显示文摘 | E S Jacoby | 2000 | Clin Chem2000，46，11： | 1 |
| 14 | Conditioning 'Kensington' mango with hot air alleviates hot water disinfestation injuries 显示文摘 | Jacobi K Giles J MacRae E | 1995 | HortScience1995，30，： | 1 |
| 15 | qnrB, another plasmid - mediated gene for quinolone resistance 显示文摘 | Jacoby G A K E Walsh D M Mills | 2006 | Antimicrob Agents Che- mother2006，50，4： | 1 |
| 16 | Potomac River stream flow since 1730 as reconstruction tree rings显示文摘 | Cook E R Jacoby G C | 1983 | Journal of Climate and Applied Meteorology1983，22，： | 1 |
| 17 | Antibody targeting of cell-bound MUCl SEA domain kills tumor cells显示文摘 | Pichinuk E Benhar I Jacobi O | 2012 | Cancer Res2012，72，13： | 1 |
| 18 | Internal phosphorus loading in a shallow eutrophic lake显示文摘 | JACOBY J M LYNCH D D WELCH E B | 1982 | Water Research1982，16，6： | 1 |
| 19 | Influence of temperature and rainfall on the development of tobacco black shank 显示文摘 | Jacobi W R Main C E Powell N T | 1983 | Phytopathology1983，73，： | 1 |
| 20 | Effect of fruit maturity on quality and physiology of high-humidity hot air-treated 'Kensington' mango (Mangifera indica Linn)显示文摘 | Jacobi K K Wong L S Giles J E | 1995 | Postharvest Biology and Technology1995，5，： | 1 |
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