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| 1 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 2 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 3 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 4 | The effects of epithelial cell supernatant on contractions of isolated canine tracheal smooth muscle显示文摘 | Barnett K Jacoby D B Nadel J A | 1988 | Am Rev Respir Dis1988，138，4： | 2 |
| 5 | An experimental study of flow and heat transfer in sinusoidal wavy passages显示文摘 | Rush T A Newell T A Jacobi A M | 1999 | Int J Heat Mass Transfer1999，42，9： | 2 |
| 6 | A functional classification scheme for beta-lactamases and its correlation with molecular structure 显示文摘 | Bush K Jacoby G A Medeiros A A | 1995 | Antimicrob Agents Chemother1995，39，： | 2 |
| 7 | Plamid determined AmpC type beta lactamases 显示文摘 | Philippon A Arlet G Jacoby GA | 2002 | Antimierob Agents Chemother2002，46，5： | 1 |
| 8 | Fluoroquinolone- modifying enzyme: a new adaptation of a common aminoglyco- side acetyltransferase 显示文摘 | Robicsek A Strahilevitz J Jacoby G A | 2006 | Nat Med2006，12，1： | 1 |
| 9 | Fluoroquinolonemodifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase显示文摘 | Robicsek A J Strahilevitz G A Jacoby | 2006 | Nat Med2006，12，1： | 1 |
| 10 | Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States 显示文摘 | Wang M G Sahm D F Jacoby G A | 2004 | Antimicrob Agents Chemother2004，48，4： | 1 |
| 11 | Plasmid-determined AmpC- type beta-lactamases显示文摘 | Philippon A Arlet G Jacoby GA | 2002 | Antimierob Agents Chemother2002，46，1： | 1 |
| 12 | Plasmid-determi-ned AmpC-type beta-lactamases显示文摘 | Philippon A Arlet G Jacoby G A | 2002 | Antimicrob Agent Chemother2002，46，： | 1 |
| 13 | Direct mass spectrometric studies of the destructionof harzardous wastes显示文摘 | Jacoby W A Nimlos N R Blake D M | 1993 | Envion Sci Technol1993，27，： | 1 |
| 14 | Plasmid-determined AmpC-tye β-lactmamses 显示文摘 | Philippon A Arlet G Jacoby GA | 2002 | Antimicrob Agents Clemother2002，46，1： | 1 |
| 15 | Determination of eicesanoid and cytokine production in salvaged blood, stored red blood cell con- centrates, and whole blood 显示文摘 | Jacobi KE Wanke C Jacobi A | 2000 | J Clin Anesth2000，12，2： | 1 |
| 16 | The worhlwide emergence of plas- mid-mediated quinoloue resistance显示文摘 | Robicsek A Jacoby C A | 2006 | Lancet Infect Dis2006，6，10： | 1 |
| 17 | Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial显示文摘 | de Jager CA Oulhaj A Jacoby R | 2012 | Int J Geriatr Psychiatry2012，27，6： | 1 |
| 18 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 19 | Cognitive and clini- cal outcomes of homocysteine lowering B-vitamin treat- ment in mild cognitive impairment; a randomized controlled trial显示文摘 | De Jager C'A Oulhaj A Jacoby R | 2012 | Int JUeriatr Psychiatry2012，，27： | 1 |
| 20 | Pneumoperitoneum with carbon dioxide stimulates growth of malignant colonic cells显示文摘 | Jacobi C A Sabat R Bohm B | 2007 | Surgery2007，121，1： | 1 |
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