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| 1 | 在 laparoscopic 肝外科的快轨道的节目: 理论或事实?显示文摘 AIM:To analyze our results after the introduction of a fast-track(FT) program after laparoscopic liver surgery in our Hepatobiliarypancreatic Unit.METHODS:All patients(43) undergoing laparoscopic liver surgery between March 2004 and March 2010 were included and divided into two consecutive groups:Control group(CG) from March 2004 until December 2006 with traditional perioperative cares(17 patients) and fast-track group(FTG) from January 2007 until March 2010 with FT program cares(26 patients).Primary endpoint was the influence of the program on the postoperative stay,the amount of re-admissions,morbidity and mortality.Secondarily we considered duration of surgery,use of drains,conversion to open surgery,intensive cares needs and transfusion.RESULTS:Both groups were homogeneous in age and sex.No differences in technique,time of surgery or conversion to open surgery were found,but more malignant diseases were operated in the FTG,and then transfusions were higher in FTG.Readmissions and morbidity were similar in both groups,without mortality.Postoperative stay was similar,with a median of 3 for CG vs 2.5 for FTG.However,the 80.8% of patients from FTG left the hospital within the first 3 d after surgery(58.8% for CG).CONCLUSION:The introduction of a FT program after laparoscopic liver surgery improves the recovery of patients without increasing complications or re-admissions,which leads to a reduction of the stay and costs. | Belinda Sánchez-Pérez José Manuel Aranda-Narváez Miguel Angel Suárez-Muoz Moises elAdel-delFresno José Luis Fernández-Aguilar Jose Antonio Pérez-Daga Ysabel Pulido-Roa Julio Santoyo-Santoyo | 2012 | World Journal of Gastrointestinal Surgery2012，4，11： | 18 |
| 2 | Red pigment production by Penicillium purpurogenum GH2 is influenced by pH and temperature显示文摘The combined effects of pH and temperature on red pigment production and fungal morphology were evaluated in a submerged culture of Penicillium purpurogenum GH2, using Czapek-Dox media with D-xylose as a carbon source. An experimental design with a factorial fix was used: three pH values (5, 7, and 9) and two temperature levels (24 and 34 °C) were evaluated. The highest production of red pigment (2.46 g/L) was reached with a pH value of 5 and a temperature of 24 °C. Biomass and red pigment production were not directly associated. This study demon- strates that P. purpurogenum GH2 produces a pigment of potential interest to the food industry. It also shows the feasibility of producing and obtaining natural water-soluble pigments for potential use in food industries. A strong combined effect (p<0.05) of pH and temperature was associated with maximal red pigment production (2.46 g/L). | Alejandro MéNDEZ Catalina PéREZ Julio Cesar MONTAéZ Gabriela MARTíNEZ Cristóbal Noé AGUILAR | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，12： | 4 |
| 3 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 4 | Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey显示文摘 | Juan J. Vila Manuel Pérez-Miranda Enrique Vazquez-Sequeiros Monder Abu-Suboh Abadia Antonio Pérez-Millán Ferrán González-Huix Joan Gornals Julio Iglesias-Garcia Carlos De la Serna José R. Aparicio José C. Subtil Alberto álvarez Felipe de la Morena Jesús G | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 5 | Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most lethal malignant tumours worldwide.The mortality-to-incidence ratio is up to 91.6%in many countries,representing the third leading cause of cancer-related deaths.Systemic drugs,including the multikinase inhibitors sorafenib and lenvatinib,are first-line drugs used in HCC treatment.Unfortunately,these therapies are ineffective in most cases due to late diagnosis and the development of tumour resistance.Thus,novel pharmacological alternatives are urgently needed.For instance,immune checkpoint inhibitors have provided new approaches targeting cells of the immune system.Furthermore,monoclonal antibodies against programmed cell death-1 have shown benefits in HCC patients.In addition,drug combinations,including first-line treatment and immunotherapy,as well as drug repurposing,are promising novel therapeutic alternatives.Here,we review the current and novel pharmacological approaches to fight HCC.Preclinical studies,as well as approved and ongoing clinical trials for liver cancer treatment,are discussed.The pharmacological opportunities analysed here should lead to significant improvement in HCC therapy. | Fernanda Villarruel-Melquiades María Eugenia Mendoza-Garrido Claudia M García-Cuellar Yesennia Sánchez-Pérez Julio Isael Pérez-Carreón Javier Camacho | 2023 | World Journal of Gastroenterology2023，29，17： | 2 |
| 6 | Cerebral white matter is highly vulnerable to ischemia显示文摘 | Leonardo P Julio HG Jorge AG | 1996 | Stroke1996，27，9： | 2 |
| 7 | Is nasogastric or na- sojejunal decompression necessary after gastrectomy? A prospective randomized trial显示文摘 | Carr~re N Seulin P Julio CH | 2007 | World J Surg2007，31，1： | 1 |
| 8 | Determination of Tryptophan by High-performance Liquid Chromatography of Alkaline Hydrolysates With Spectrophotometric Detection 显示文摘 | Maria M Y Justo P Julio G C etal | 2004 | Food Chemistry(S0308-8146)2004，85，2： | 1 |
| 9 | Is nasogasic or nasod unadde-compression necessary after gasectomy A prospective randomized trial显示文摘 | Carrere N Seulin P Julio CH | 2007 | World J Sug2007，31，1： | 1 |
| 10 | Blow-up for a non-local diffusion problem with Neumann boundary conditions and a reaction term显示文摘 | Mayte Pérez-Llanos Julio D. Rossi | 2008 | Nonlinear Analysis2008，，4： | 1 |
| 11 | Plasma and tissue glutamine response to acute and chronic supplementation with L-glutamine and L-alanyl-L-glutamine in rats 显示文摘 | Marcelo M R Julio T Rogerio G P | 2004 | Nutrition Res2004，24，4： | 1 |
| 12 | The spectrum of acute renal failure in the intensive care unit compared with that seen in other settings显示文摘 | Eduardo J Julio P | 1998 | Kid Int1998，53，166： | 1 |
| 13 | Modeling changes of sensory attributes for individual and mixed fresh-cut leafy vegetables显示文摘 | Andrea M P Julio C M Daniel R G | 2005 | Postharvest Biology and Technology2005，，3： | 1 |
| 14 | In hindsight, life flows from left to right显示文摘 | Julio Santiago Antonio Román Marc Ouellet Nieves Rodríguez Pilar Pérez-Azor | 2010 | Psychological Research PRPF2010，，1： | 1 |
| 15 | Is nasogastric or nasojejunal decompression necessary after gastrectomy? A prospective random- ized triM显示文摘 | Carrere N Seulin P Julio CH | 2007 | World J Surg2007，31，1： | 1 |
| 16 | Fermentation of cellobiose to ethanol by industrial Saccharomyces strains carrying theβ-glucosidase gene (BGL1) from Saccharomycopsis fibuligera显示文摘 | Leontina G I (A)lvaro L Julio P Julia M N | | 0，，： | 1 |
| 17 | Cerebral white matter is highly vulnerable to ischemia显示文摘 | Julio H G Jorge A G | 1996 | Stroke1996，27，9： | 1 |
| 18 | Efficient and automated start-up of a pilot reactor for nitritation of reject water: From batch granulation to high rate continuous operation显示文摘 | Josep A. Torà Eduard Moliné Julián Carrera Julio Pérez | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 19 | Is nasogastric or nasojejunal decomprssion necessary after gastrectomy?A prospective randomized trial显示文摘 | Carrère N Seulin P Julio CH | 2007 | World J Surg2007，31，1： | 1 |
| 20 | The combination of fructooligosaccharides and resistant starch shows prebiotic additive effects in rats显示文摘 | Maria Elena Rodríguez-Cabezas Desirée Camuesco Belén Arribas Natividad Garrido-Mesa Mònica Comalada Elvira Bailón Margarita Cueto-Sola Pilar Utrilla Eduardo Guerra-Hernández Carlos Pérez-Roca Julio Gálvez Antonio Zarzuelo | 2010 | Clinical Nutrition2010，，6： | 1 |
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