|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Protective action of glutamine in rats with severe acute liver failure显示文摘BACKGROUND Severe acute liver failure(SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver function.Thioacetamide(TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2(Nrf2) activates the antioxidant protection of cells. Studies have evidenced the involvement of inflammatory mediators in conditions of oxidative stress.AIM To evaluate the antioxidant effects of glutamine on Nrf2 activation and NFκBmediated inflammation in rats with TAA-induced IHAG.METHODS Male Wistar rats(n = 28) were divided into four groups: control,control+glutamine, TAA, and TAA + glutamine. Two TAA doses(400 mg/kg)were administered intraperitoneally, 8 h apart. Glutamine(25 mg/kg) was administered at 30 min, 24 h, and 36 h. At 48 h, blood was collected for liver integrity analysis [aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP)]. The liver was harvested for histology and assessment of oxidative stress [thiobarbituric acid-reactive substances(TBARS), catalase(CAT), glutathione peroxidase(GPx), glutathione S-transferase(GST), glutathione(GSH), Nrf2, Kelch-like ECH-associated protein 1(Keap1),NADPH quinone oxidoreductase1(NQO1), superoxide dismutase(SOD)] and inflammatory process.RESULTS TAA caused disruption of the hepatic parenchyma, with inflammatoryinfiltration, massive necrosis, and ballooning degeneration. Glutamine mitigated this tissue damage, with visible regeneration of hepatic parenchyma; decreased TBARS(P < 0.001), GSH(P < 0.01), IL-1β, IL6, and TNFα levels(P <0.01) in hepatic tissue; and decreased blood levels of AST, ALT, and ALP(P <0.05). In addition, CAT, GPx, and GST activities were restored in the glutamine group(P<0.01, P <0.01, and P <0.001, respectively vs TAA alone). Glutamine increased expression of Nrf2(P < 0.05), NQO1, and SOD(P < 0.01), as well as levels of IL-10(P <0.001), while decreasing expression of Keap1, TLR4, NFκB(P < 0.001), COX-2 and iNOS,(P < 0.01), and reducing NO_2 and NO_3 levels(P < 0.05).CONCLUSION In the TAA experimental model of IHAG, glutamine activated the Nrf2 pathway,thus promoting antioxidant protection, and blunted the NFκB-mediated pathway, reducing inflammation. | Elizangela G Schemitt Renata M Hartmann Josieli R Colares Francielli Licks Jéferson O Salvi Cláudio A Marroni Norma P Marroni | 2019 | World Journal of Hepatology2019，11，3： | 5 |
| 2 | What is the ideal approach for emergent pericardiocentesis using point-of-care ultrasound guidance?显示文摘BACKGROUND:Traditionally performed using a subxiphoid approach,the increasing use of point-of-care ultrasound in the emergency department has made other approaches(parasternal and apical)for pericardiocentesis viable.The aim of this study is to identify the ideal approach for emergency-physician-performed ultrasound-guided pericardiocentesis as determined by ultrasound image quality,distance from surface to pericardial fl uid,and likely obstructions or complications.METHODS:A retrospective review of point-of-care cardiac ultrasound examinations was performed in two urban academic emergency departments for the presence of pericardial eff usions.The images were reviewed for technical quality,distance of eff usion from skin surface,and predicted complications.RESULTS:A total of 166 pericardial effusions were identified during the study period.The mean skin-to-pericardial fl uid distance was 5.6 cm(95%confi dence interval[95%CI]5.2-6.0 cm)for the subxiphoid views,which was signifi cantly greater than that for the parasternal(2.7 cm[95%CI 2.5-2.8 cm],P<0.001)and apical(2.5 cm[95%CI 2.3-2.7 cm],P<0.001)views.The subxiphoid view had the highest predicted complication rate at 79.7%(95%CI 71.5%-86.4%),which was signifi cantly greater than the apical(31.9%;95%CI 21.4%-44.0%,P<0.001)and parasternal(20.2%;95%CI 12.8%-29.5%,P<0.001)views.CONCLUSIONS:Our results suggest that complication rates with pericardiocentesis will be lower via the parasternal or apical approach compared to the subxiphoid approach.The distance from skin to fl uid collection is the least in both of these views. | Lori Stolz Elaine Situ-LaCasse Josie Acuña Matthew Thompson Nicolaus Hawbaker Josephine Valenzuela Uwe Stolz Srikar Adhikari | 2021 | World Journal of Emergency Medicine2021，12，3： | 2 |
| 3 | Design of division specific primers of Ralstonia solanacearum and application to the identification of European isolates显示文摘 | Boudazin G Claire Le Roux A Josi K | 1999 | European Journal of Plant Pathology1999，105，4： | 1 |
| 4 | A wireless controller to enhance dynamic performance of parallel invertel in distributed generation systems 显示文摘 | JOSEP M GUERRERO LUIS GARCA DE VICU 1 A JOSI MATAS | 2004 | IEEE Transactions on Power Electronics2004，19，5： | 1 |
| 5 | Visual Space Perception and Visually Directed Action显示文摘 | Jack M Loomis Naofumi Fujita Josi A Da Silva Sergio S Fukusima | 1992 | Journal of Experimental Psychology:Human Perception and Performance (S0096-1523)1992，18，4： | 1 |
| 6 | Cell proliferation of human fibroblasts on alumina and hydroxyapatite-based ceramics with different surface treatments 显示文摘 | DELFINO CAR1NA S BRESSIANI JOSI C BRESSIANI ANA H A | 2010 | International Journal of Applied Ceramic Technology2010，7，2： | 1 |
| 7 | Competitive particle growth:a tool to control the parti- cle size distribution for the synthesis of high solids content low viscosity latexes 显示文摘 | INS DE F A MARIZ JOSE R LEIZA JOSI C DE LA CAL | 2011 | Chemical Engineering Journal2011，168，2： | 1 |
| 8 | New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes显示文摘 | Libby Gillian Donnelly Louise A Donnan Peter T Alessi Dario R Morris Andrew D Evans Josie M M | 2009 | Diabetes Care2009，，： | 1 |
| 9 | Role of the support on the activity of silica-supported TiO2 photocatalysts: Structure of the TiO2/SBA-15 photocatalysts显示文摘 | MAP JA-JOSI~ L M RAFAEL V G JOSI~ A | 2005 | Catalysis Today2005，101，： | 1 |
| 10 | Effect of processing parameters on the mechanical properties of in situ compatibilized polybutylene terephthalate/acrylonitrile-butadiene-styrene blends显示文摘 | JOSI D A ELIAS H J | 2012 | J Appl Polym Sci2012，124，： | 1 |
| 11 | Biochemical changes and quality loss during chilled storage of farmed turbot (Psetta maxima)显示文摘 | SANTIAGO P A CARMEN P JOSI~ M G | 2005 | Food Chemistry2005，90，3： | 1 |
| 12 | Melatonin prevents oxidative stress,inflammatory activity,and DNA damage in cirrhotic rats显示文摘BACKGROUND Cirrhosis is an important health problem characterized by a significant change in liver parenchyma.In animals,this can be reproduced by an experimental model of bile duct ligation(BDL).Melatonin(MLT)is a physiological hormone synthesized from serotonin that has been studied for its beneficial properties,including its antioxidant potential.AIM To evaluate MLT’s effects on oxidative stress,the inflammatory process,and DNA damage in an experimental model of secondary biliary cirrhosis.METHODS Male Wistar rats were divided into 4 groups:Control(CO),CO+MLT,BDL,and BDL+MLT.MLT was administered(20 mg/kg)daily beginning on day 15 after biliary obstruction.On day 29 the animals were killed.Blood samples,liver tissue,and bone marrow were collected for further analysis.RESULTS BDL caused changes in biochemical and histological parameters and markers of inflammatory process.Thiobarbituric acid(0.46±0.01)reactive substance levels,superoxide dismutase activity(2.30±0.07)and nitric oxide levels(2.48±0.36)were significantly lower(P<0.001)n the groups that received MLT.DNA damage was also lower(P<0.001)in MLT-treated groups(171.6±32.9)than the BDL-only group(295.5±34.8).Tissue damage and the expression of nuclear factor kappa B,interleukin-1β,Nrf2,NQO1 and Hsp70 were significantly lower in animals treated with MLT(P<0.001).CONCLUSION When administered to rats with BDL-induced secondary biliary cirrhosis,MLT effectively restored the evaluated parameters. | Josieli R Colares Renata M Hartmann Elizângela G Schemitt Sandielly R B Fonseca Marilda S Brasil Jaqueline N Picada Alexandre S Dias Aline F Bueno Cláudio A Marroni Norma P Marroni | 2022 | World Journal of Gastroenterology2022，28，3： | 1 |
| 13 | Probiotics in aquaculture: The need, principles and mechanisms of action and screening processes 显示文摘 | Kesarcodi-Watson A Kaspar H Josie Lategan M | 2008 | Aquaculture2008，274，1： | 1 |
| 14 | Acute toxicity of oxytetracycline and florfenicol to the microalgae Tetrasel- mis chuii and to the crustacean Anemia parthenogenetica 显示文摘 | CARLA S BRUNO A JOSI~ M | 2007 | Ecotoxic and Environ Safety2007，67，： | 1 |
| 15 | Degumming of corn oil/hexane miscella using a ceramic membrane显示文摘 | M~RCIA P JOSI~ C LIRENY A | 2008 | Journal of Food Engineering2008，86，4： | 1 |
| 16 | Experimental implementation of the gyrator transform显示文摘 | RODRIGO JOSI A ALIEVA TATIANA CALVO MARIA L | 2007 | Journal of the Optics Society of America2007，24，10： | 1 |
| 17 | Pharmacokinetie behaviour of R-( + )- and S-( - )- amlodipine after single enantiomer administration显示文摘 | LUKSA J JOSI D KREMSER M KOITAR A MILUTINOVI S | 1997 | J Chromatogr: B1997，703，1： | 1 |
| 18 | Multi-stage phase retrieval algorithm based up- on the gyrator transfonn显示文摘 | RODRIGO JOSI A DUADI HAMOOTAL ALIEVA TATI- ANA | 2009 | Optics Express2009，18，2： | 1 |
| 19 | Modeling a city's image: the case of Granada显示文摘 | TEODORO LUQUE-MARTtNEZ SALVADOR DEL BARRIO-GARC JOSI ANGEL IB /IEZ-ZAPATA | 2007 | Cities2007，24，5： | 1 |
| 20 | Reference current computation for active power filters by running DFT techniques 显示文摘 | JOSIE M JOSIE A ANTONIO G | 2010 | IEEE Trans on Power Delivery2010，25，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员