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| 1 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 2 | Gastric per-oral endoscopic myotomy: Current status and future directions显示文摘Gastroparesis, or symptomatic delayed gastric emptying in the absence of mechanical obstruction, is a challenging and increasingly identified syndrome. Medical options are limited and the only medication approved by the Food and Drug Administration for treatment of gastroparesis is metoclopramide, although other agents are frequently used off label. With this caveat, first-line treatments for gastroparesis include dietary modifications, antiemetics and promotility agents, although these therapies are limited by suboptimal efficacy and significant medication side effects. Treatment of patients that fail first-line treatments represents a significant therapeutic challenge. Recent advances in endoscopic techniques have led to the development of a promising novel endoscopic therapy for gastroparesis via endoscopic pyloromyotomy, also referred to as gastric per-oral endoscopic myotomy or per-oral endoscopic pyloromyotomy. The aim of this article is to review the technical aspects of the per-oral endoscopic myotomy procedure for the treatment of gastroparesis, provide an overview of the currently published literature, and outline potential next directions for the field. | Alexander Podboy Joo Ha Hwang Linda A Nguyen Patricia Garcia Thomas A Zikos Afrin Kamal George Triadafilopoulos John O Clarke | 2019 | World Journal of Gastroenterology2019，25，21： | 3 |
| 3 | Multicenter evaluation of recurrence in endoscopic submucosal dissection and endoscopic mucosal resection in the colon:A Western perspective显示文摘BACKGROUND While colon endoscopic mucosal resection(EMR)is an effective technique,removal of larger polyps often requires piecemeal resection,which can increase recurrence rates.Endoscopic submucosal dissection(ESD)in the colon offers the ability for en bloc resection and is well-described in Asia,but there are limited studies comparing ESD vs EMR in the West.AIM To evaluate different techniques in endoscopic resection of large polyps in the colon and to identify factors for recurrence.METHODS The study is a retrospective comparison of ESD,EMR and knife-assisted endoscopic resection performed at Stanford University Medical Center and Veterans Affairs Palo Alto Health Care System between 2016 and 2020.Knife-assisted endoscopic resection was defined as use of electrosurgical knife to facilitate snare resection,such as for circumferential incision.Patients≥18 years of age undergoing colonoscopy with removal of polyp(s)≥20 mm were included.The primary outcome was recurrence on follow-up.RESULTS A total of 376 patients and 428 polyps were included.Mean polyp size was greatest in the ESD group(35.8 mm),followed by knife-assisted endoscopic resection(33.3 mm)and EMR(30.5 mm)(P<0.001).ESD achieved highest en bloc resection(90.4%)followed by knife-assisted endoscopic resection(31.1%)and EMR(20.2%)(P<0.001).A total of 287 polyps had follow-up(67.1%).On follow-up analysis,recurrence rate was lowest in knife-assisted endoscopic resection(0.0%)and ESD(1.3%)and highest in EMR(12.9%)(P=0.0017).En bloc polyp resection had significantly lower rate of recurrence(1.9%)compared to non-en bloc(12.0%,P=0.003).On multivariate analysis,ESD(in comparison to EMR)adjusted for polyp size was found to significantly reduce risk of recurrence[adjusted hazard ratio 0.06(95%CI:0.01-0.57,P=0.014)].CONCLUSION In our study,EMR had significantly higher recurrence compared to ESD and knife-assisted endoscopic resection.We found factors including resection by ESD,en bloc removal,and use of circumferential incision were associated with significantly decreased recurrence.While further studies are needed,we have demonstrated the efficacy of ESD in a Western population. | Mike T Wei Margaret J Zhou Andrew A Li Andrew Ofosu Joo Ha Hwang Shai Friedland | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，6： | 2 |
| 4 | Caveolin 1 Expression Correlates with Poor Prognosis and Focal Adhesion Kinase Expression in Gastric Cancer显示文摘 | Nam Kyung Han Lee Byung Lan Park Joo Hyun Kim Jin Han Nayoung Lee Hee Eun Kim Min A Lee Hye Seung Kim Woo Ho | 2012 | Pathobiology2012，，2： | 2 |
| 5 | Valuing Loss Firms 显示文摘 | Peter Joos George A Plesko | 2005 | The Accounting Review2005，80，： | 1 |
| 6 | Elevated MMP - 12 protein levels in induced sputum from patients with COPD 显示文摘 | Demedts I K Morel - Montero A Lebecque S Pacheco Y Cataldo D Joos G F Pauwels R A Brusselle G G | 2006 | Thorax2006，61，6： | 1 |
| 7 | Electromagnetic radiation shielding by intrinsically conducting 显示文摘 | Joo J Epstein A J | 1994 | Applied Physics Letters1994，65，18： | 1 |
| 8 | Nitrile, aldehyde, and halonitroal- kane formation during chlorination/chloramination of pri- mary amines 显示文摘 | Joo S H Mitch W A | 2007 | Environmental Science & Technology2007，41，4： | 1 |
| 9 | Amniotic fluid-derived stem cells in regenerative medicine research 显示文摘 | Joo S Ko IK Atala A | 2012 | Arch Pharm Res2012，35，： | 1 |
| 10 | Development of thermo- stable Candidaantarctica lipase B through novel in silico design of disulfidebridge显示文摘 | LE Q A T JOO J C YOO Y J | 2012 | Biotechnology and Bioengineering2012，109，4： | 1 |
| 11 | Vascular basis of mucosal color显示文摘 | Kleirtheinz J Buchter A Fillies T Joos U | 2005 | Head Face Med2005，1，： | 1 |
| 12 | Mapping and chromosome analysis:the potential of fluorescence in situ hybridization 显示文摘 | Joos S Fink TM Ratsch A | 1994 | Biotechnology1994，35，1： | 1 |
| 13 | Summer drought reduces total and litter-derived soil CO2effluxes in temperate grassland–clues from a 13 C litter addition experiment显示文摘 | Joos O Hagedorn F Heim A | 2010 | Biogeosciences2010，7，： | 1 |
| 14 | Bandwidth allocation with a particle swarm meta-heuristic for Ethernet passive optical networks显示文摘 | Joo U Smith A | 2010 | Computer Communications2010，33，4： | 1 |
| 15 | Single umbilical artery in fetopatho- logical investigations显示文摘 | Joo JG Beke A Papp Z | 2008 | Pathol Res Pract2008，204，11： | 1 |
| 16 | Optimization of an artificial neural network for identifying fishing set positions from VMS data:An example from the Peruvian anchovy purse seine fishery显示文摘 | Joo R Bertrand S Chaigneau A | 2011 | Ecological Modelling2011，222，4： | 1 |
| 17 | The development of a thermostable Ci P(Coprinus cinereus peroxidase)through in silico design显示文摘 | Kim S J Lee J A Joo J C | 2010 | Biotechnology Progress2010，26，4： | 1 |
| 18 | Accounting choice and future performance: the case of R&D accounting in France 显示文摘 | CAZAVAN -JENY A JEANJEAN T JOOS P | 2011 | Journal of Accounting and Public Policy2011，30，2： | 1 |
| 19 | Interleukin-1 be- ta and tumor necrosis factor alpha inhibit migration activity of chondrogenic progenitor cells from non-fibrillated osteoarthrit- ic cartilage显示文摘 | JOOS H WILDNER A HOGREFE C | 2013 | Arthritis Res Therapy2013，15，5： | 1 |
| 20 | Adaptive distance relay setting for lines connecting wind farms显示文摘 | PRADHAN A K JOOS G | 2007 | IEEE Transactions on Energy Conversion2007，22，1： | 1 |
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