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| 1 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 2 | 世界家庭医生组织(WONCA)研究论文摘要汇编——有氧运动缓解产后抑郁效果的系统性综述与荟萃分析显示文摘背景当前英美国家尚无运动方法治疗产后抑郁方面的专门指导,而且国际上在此方面的指导也不尽相同。目的评价有氧运动治疗产后抑郁的效果。设计与场所本研究为系统性综述及荟萃分析,无研究地点。方法使用计算机检索MEDLINE、EMBASE、Cochrane Library、Psyc INFO、Sport Discus、Scr Clinical Trials.gov以及World Health Organization International Clinical Trials Registry Platform数据库,收集评估产妇分娩后1年内抑郁状况的随机对照试验、有氧运动和常规护理或者其他护理方式改善产后抑郁效果的比较研究的摘要及全文。使用Cochrane协作组推荐使用的偏倚风险评估工具对纳入的文献进行偏倚风险评估。对纳入的文献进行荟萃分析。对纳入文献之间存在的异质性进行预设亚组分析。结果共纳入13篇文献,包括1 734例患者。整体来看,有氧运动可以显著缓解产后抑郁[SMD=-0.44,95%CI=(-0.75,-0.12)]。异质性分析发现,有氧运动干预效果在可能患有抑郁的产妇间及一般产妇间不存在统计学差异;只采用有氧运动取得的干预效果与采用有氧运动结合其他方式取得的干预效果不存在统计学差异;群体有氧运动与配置有氧运动咨询的干预效果不存在统计学差异。结论本项系统性综述为有氧运动具有缓解产后抑郁的效果提供了证据支持。群体运动、研究对象自己选择运动方式、运动结合其他干预方式均是有效缓解产后抑郁的方法。但是由于纳入文献存在显著异质性和高偏倚风险,故此研究结果应谨慎参考。 | PRITCHETT R V DALEY A J JOLLY K 本刊编辑部 | 2017 | 中国全科医学2017，20，30： | 12 |
| 3 | Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis显示文摘During sepsis,neutrophil activation induces endothelial cell(EC)dysfunction partly through neutrophil extracellular trap(NET)release.The triggering receptor expressed on myeloid cell-1(TREM-1)is an orphan immune receptor that amplifies the inflammatory response mediated by Toll-like receptor-4(TLR4)engagement.Although the key role of TLR4 signaling in NETosis is known,the role of TREM-1 in this process has not yet been investigated.Here,we report that TREM-1 potentiates NET release by human and murine neutrophils and is a component of the NET structure.In contrast,pharmacologic inhibition or genetic ablation of TREM-1 decreased NETosis in vitro and during experimental septic shock in vivo.Moreover,isolated NETs were able to activate ECs and impair vascular reactivity,and these deleterious effects were dampened by TREM-1 inhibition.TREM-1 may,therefore,constitute a new therapeutic target to prevent NETosis and associated endothelial dysfunction. | Amir Boufenzer Kevin Carrasco Lucie Jolly Benjamin Brustolin Elisa Di-Pillo Marc Derive Sébastien Gibot | 2021 | Cellular & Molecular Immunology2021，18，2： | 9 |
| 4 | sTREM-1 is a specific biomarker of TREM-1 pathway activation显示文摘TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and platelets.TREM-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3]. | Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden Tom van der Poll Alexandre Mebazaa Pierre-François Laterre Sebastien Gibot Amir Boufenzer Marc Derive | 2021 | Cellular & Molecular Immunology2021，18，8： | 8 |
| 5 | Color and texture fusion:application to aerial image segmentation and GIS updating显示文摘 | Jolly M P D Gupta A | 2000 | Image and Vision Computing2000，18，10： | 2 |
| 6 | Perils of Rib Fractures显示文摘 | Sharma Om P Oswanski Michael F Jolly Shashank Lauer Sherry K Dressel Rhonda Stombaugh Heather A | 2008 | The American Surgeon2008，，4： | 2 |
| 7 | 中国商用车领域的铂族金属需求依然强劲(英文/中文)显示文摘2020年以来中国商用车市场发生了很多变化,近期卡车销量从疫情萧条中大幅反弹,物流、基建以及排放标准升级共同推动了2020年商用车市场需求,对铂族金属的需求更加有利,对铂金需求的预期增长似乎比对钯金需求更有保障。 | Matthew TURNER David JOLLIE 曲艺 | 2020 | 贵金属2020，41，S01： | 2 |
| 8 | Review on cochlear implant electrode array tip fold-over and scalar deviation显示文摘Objective: Determine the occurrence rate of cochlear implant (CI) electrode tip fold-over and electrode scalar deviation as reported in patient cases with different commercial electrode types. Data-sources: PubMed search for identifying peer-reviewed articles published till 2018 on CI electrode tip fold-over and scalar deviation. Key-words for searching were “Cochlear electrode tip fold-over”,“Cochlear electrode scalar position” and “Cochlear electrode scalar location”. Articles-selection: Only if electrode related issues were investigated in patient cases. 38 articles met the inclusion-criteria. Results: 13 articles on electrode tip fold-over issue covering 3177 implanted ears, out of which 50 ears were identified with electrode tip fold-over with an occurrence rate of 1.57%. Out of 50 ears, 43 were implanted with pre-curved electrodes and the remaining 7 with lateral-wall electrodes. One article reported on both tip fold-over and scalar deviation. 26 articles reported on the electrode scalar deviation covering an overall number of 2046 ears out of which, 458 were identified with electrode scalar deviation at a rate of 22.38%. After removing the studies that did not report on the number of electrodes per electrode type, it was 1324 ears implanted with pre-curved electrode and 507 ears with lateral-wall electrode. Out of 1324 pre-curved electrode implanted ears, 424 were reported with scalar deviation making an occurrence rate of 32%. Out of 507 lateral-wall electrode implanted ears, 43 were associated with scalar deviation at an occurrence rate of 6.7%. Conclusion: This literature review revealing the fact of higher rate of electrode insertion trauma associated with pre-curved electrode type irrespective of CI brand is one step closer to obsolete it from the clinical practice in the interest of patient's cochlear health. | Anandhan Dhanasingh Claude Jolly | 2019 | Journal of Otology2019，14，3： | 2 |
| 9 | The Impact of a Statewide Pre-Hospital STEMI Strategy to Bypass Hospitals Without Percutaneous Coronary Intervention Capability on Treatment Times显示文摘 | Emil L. Fosbol Christopher B. Granger James G. Jollis Lisa Monk Li Lin Barbara L. Lytle Ying Xian J. Lee Garvey Greg Mears Claire C. Corbett Eric D. Peterson Seth W. Glickman | 2013 | Circulation2013，，5： | 2 |
| 10 | 环境变化背景下北极生物的多样性、分布及其适应性显示文摘生物个体是对气候变化和紫外线B(UV-B)辐射变化产生反应的基础,而且这种反应会在各种时间尺度上发生。北极地区的动物、植物以及微生物种类的多样性从表面上看是低的,而且从北方针叶林到极地荒漠逐渐减少,但其原始物种却很丰富。与这种物种多样性随纬向梯度减少的趋势相反,一些空间分布范围很广的单一优势物神的优势度则呈增长趋势。全球气候变暖可能会减少该地区的物种多样性,并限制到这些物种的分布范围,尤其是在该地区生物分布的北部边缘,一些极地特有的动物和植物种类会面临着灭绝的危险。最有可能侵入苔原地带的物种是那些目前生存在极地外缘的北方地区生物。许多植物都具有自身的特征使它们能够在以下环境中生存;短暂的无冰雪覆盖的生长季节,低的太阳高度角,永久冻结地带及低的土壤温度,贫乏的养分获取条件以及极少的物理扰动。以上这些特征有些可能会限制当地物种对气候变暖的反应,但其最主要的因素是这些物种与那些潜在的入侵物种相比缺乏竞争能力。北极地区陆生动物拥有许多适应特性,这使它们能够适应北极地区剧烈的温度变化。许多动物通过冬眠或迁移来逃避极地地区的恶劣天气和资源短缺。北极地区动物生存的生物环境则相对简单:几乎没有天敌、竞争者、疾病、寄生生物,但同时食物资源也很短缺。极地陆生动物可能对由气候变化带来的温暖而干旱的夏季非常不适应,这种变化将会影响到动物的迁移路线、途中栖息地,并会改变冬季积雪的状况和冻融的循环过程。气候变化还会改变动物繁殖和发育的季节,并会引来新的竞争者、捕食者、寄生生物以及疾病等。极地微生物也能很好地适应该地区的气候:一些微生物甚至在-39℃的低温下还能进行代谢活动。蓝藻细菌和藻类生物有着很广泛的适应策略,这能够使它们避免(至少可以减少)紫外线的伤害。微生物能够忍受许多环境条件,而且其生长周期很短,这些特点将使它们能很快适应新的生存环境。与此形成对比的是,极地植物和动物很可能通过改变其分布范围而不是积极的生物进化来适应环境的变暧。 | Terry V.Callaghan Lars Olof Bjrn Yuri Chernov Terry Chapin Torben R.Christensen Brian Huntley Rolf A.Ims Margareta Johansson Dyanna Jolly Sven Jonasson Nadya Matveyeva Nicolai Panikov Walter Oechel Gus Shaver Josef Elster Heikki Henttonen Kari Laine Kari Taulavuori Erja Taulavuori Christoph Zckler 何永涛 | 2004 | AMBIO-人类环境杂志2004，33，B11： | 2 |
| 11 | Phenotypic plasticity in prostate cancer: role of ntrinsically disordered proteins显示文摘 | Steven M Mooney Mohit Kumar Jolly Herbert Levine Prakash Kulkarni | 2016 | Asian Journal of Andrology2016，18，5： | 2 |
| 12 | Comparison of effectiveness of enoxaparin versus unfractionated heparin to reduce silent and Clinical- ly apparent acute myocardial infarction in patients presenting with non -ST- segment elevation acute coronary syndrome 显示文摘 | Jolly S Tan M Mendelsohn A | 2007 | Am J Cardiol2007，99，2： | 1 |
| 13 | Hyperuricemia and associated disease 显示文摘 | Becker MA Jolly M | 2006 | Rheum Dis Clin North Am2006，32，2： | 1 |
| 14 | Chlamydia trachomatis omplgenotypic diversity and concordance with sexual network data显示文摘 | Cabral T Jolly AM Wylie JL | 2003 | J Infect Dis2003，187，2： | 1 |
| 15 | Human aflatoxicosis in developing countries:a review of toxicology,exposure,potential health consequences,and interventions显示文摘 | Williams JH Phillips TD Jolly PE | 2004 | Am J Clin Nutr2004，80，5： | 1 |
| 16 | 显示文摘 | Jolly M R Bender J W | 1999 | J Intell Mater Syst Struct1999，513，： | 1 |
| 17 | Newly discovered fossil hominid skull from the Afar depression, Ethiopia显示文摘 | Conroy GC Jolly CJ Cramer D | 1978 | Nature1978，276，： | 1 |
| 18 | Effects of dietary n-3 fatty acids on T cell activation and T cell receptor-mediated signaling in a murine model显示文摘 | McMurray DN Jolly CA Chapkin RS | 2000 | J Infect Dis2000，182，： | 1 |
| 19 | Apoptotic pathways in pemphigus显示文摘 | Bektas M Jolly P Rubenstein DS | 2010 | Dermatol Res Pract2010，，2010： | 1 |
| 20 | Flashover of contaminated insulators with cy- lindrical symmetry under DC conditions显示文摘 | Jolly D C Poole C D | 1979 | IEEE Transactions on Electrical Insulation1979，14，2： | 1 |
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