|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anti-rods/rings autoantibody generation in hepatitis Cpatients during interferon-α/ribavirin therapy显示文摘Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon. | Gerson Dierley Keppeke S John Calise Edward KL Chan Luis Eduardo C Andrade | 2016 | World Journal of Gastroenterology2016，22，6： | 4 |
| 2 | SmaB-world overlay P2P networks: construction, management and handling of dynamic flash crowds显示文摘 | Hui Ken Y K Lui John C S Yan David K Y | 2006 | Computer Networks2006，50，15： | 1 |
| 3 | A game-theoretic analysis of the implications of overlay network Iraffic on ISP peering 显示文摘 | Jessie Hui Wang Dah Ming Chiu John C S Lui | 2008 | Computer Networks (S1389-1286)2008，52，15： | 1 |
| 4 | DCAR: distributed cod- ing-aware muting in wireless networks 显示文摘 | Le Jilin Lui John C S Chiu Dah Ming | 2010 | 11 1 1 Transactions on Mobile Computing2010，9，4： | 1 |
| 5 | Agame-theoreticanalysis of the implications of overlay network trafficon ISP peering显示文摘 | JessieHui Wang Dah Ming Chiu John C S Lui | 2008 | Computer Networks (S1389-1286)2008，52，15： | 1 |
| 6 | DCAR: dsitributed coding-aware routing in wireless networks显示文摘 | LE J L JOHN LUI C S CHIU D M | 2010 | IEEE Transactions on Mobile Com- puting2010，9，4： | 1 |
| 7 | Carotid artery endarterectomy in patients with symptomatic non-stenotic carotid artery disease显示文摘Object We sought to determine the safety and efficacy in secondary stroke prevention of carotid endarterectomy(CEA)in patients with symptomatic non-stenotic carotid artery disease(SyNC).Methods This was a single-centre retrospective case series.All patients who underwent CEA for unilateral anterior circulation cerebrovascular events with ipsilateral<50%carotid stenosis from 2002 to 2020 were included.Imaging hallmarks including the degree of luminal stenosis and the presence of various vulnerable plaque characteristics(eg,intraplaque haemorrhage(IPH)on MR angiography,ulceration or low-density plaque on CT angiography)were assessed.The presence of vulnerable plaque characteristics was compared between arteries ipsilateral to the ischaemic event and contralateral arteries.The prevalence of perioperative/intraoperative complications,as well as recurrent ischaemic events at follow-up was determined.Results Thirty-two patients were included in the analysis,of which 25.0%were female.Carotid arteries ipsilateral to an ischaemic event had a significantly higher prevalence of IPH when compared with contralateral arteries(80.0%vs 0.0%;p<0.001).There were no intraoperative complications.One patient(3.1%)developed symptoms of transient ipsilateral ischaemia 1 day following CEA which resolved without treatment.In a median follow-up of 18.0 months(IQR 5.0-36.0),only one patient(3.1%)experienced a transient neurologic deficit with complete resolution(annualised rate of recurrent stroke after CEA of 1.5%for a total follow-up of 788 patient-months following CEA).All other patients(31/32,96.9%)were free of recurrent ischaemic events.Conclusion CEA appears to be safe and well-tolerated in patients with SyNC.Additional studies with larger cohorts and longer follow-up intervals are needed in order to determine the role of CEA in this patient population. | Valentina Nardi John C Benson Anthony S Larson Waleed Brinjikji Luca Saba Fredric B Meyer Giuseppe Lanzino Amir Lerman Luis E Savastano | 2022 | Stroke & Vascular Neurology2022，7，3： | 1 |
| 8 | A muhiobjective modeling approach to locating incinerators 显示文摘 | LUI'S A A JOAO C R John C | 2009 | Socio -Economic Planning Sciences2009，，43： | 1 |
| 9 | Hack-Proof Synchronization Protocol for Multi-Player Online Games显示文摘 | Yeung S F Lui John C S | 2009 | Multimedia Tools and Applications2009，，： | 1 |
| 10 | Scheduling and data layout policies for a near-line multimedia storage architecture 显示文摘 | SIU-WAH LAU JOHN C S LUI | 1997 | Multimedia Systems1997，，5： | 1 |
| 11 | An Efficient Partitioning Algorithm for Distributed Virtual Environment Systems显示文摘 | John C S Lui M F Chan | 2002 | IEEE Transactions on Parallel and Distributed Systems2002，13，3： | 1 |
| 12 | An efficient partitioning algorithm for distributed virtual environment systems显示文摘 | JOHN C LUI S CHAN M F | 2002 | IEEE Transaction on Parallel and Distributed Systems2002，13，3： | 1 |
| 13 | Secure Overlay Cloud Storage with File Assured Deletion 显示文摘 | Yang Tang Patrick P C Lee John C S Lui | 2010 | Computer Science and Engi- neering Monday2010，，11： | 1 |
| 14 | An efficient partitioning algorithm for distributed virtual environment systems显示文摘 | JOHN C LUI S CHAN M F | 2002 | IEEE Trans on Parallel and Distributed Systems2002，13，2： | 1 |
| 15 | An Efficient Partition Algorithm for Distributed Virtual Environment Systems显示文摘 | John C S Lui | 2002 | IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS2002，13，3： | 1 |
| 16 | Small world overlay P2P networks 显示文摘 | Ken Y K Hui John C S Lui | 2006 | Computer Networks2006，50，： | 1 |
| 17 | A game theoretic approach to provide incentive and service differentiation in P2P networks显示文摘 | Richard T B Ma Sam C M Lee John C S Lui | 2004 | Performance Evaluation Review2004，32，1： | 1 |
| 18 | Secure overlaycloud storage with access control and assured deletion显示文摘 | Tang Yang Lee Patrick P C Lui John C S | 2012 | IEEETransactions on Dependable and Secure Computing2012，9，6： | 1 |
| 19 | An efficient partitioning algorithm for distributed virtual environment systems显示文摘 | M F Chan | 2002 | IEEE Trans on Parallel and Distributed Systems2002，13，3： | 1 |
| 20 | P2P Computing Systems显示文摘 | JOHN C S LUI DAN RUBENSTEIN VISH AL MISRA | 2006 | Performance Evaluation2006，63，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员