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| 1 | Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose- induced hepatic mitochondrial dysfunction显示文摘Catalpol, iridoid glycoside,被显示了由 rescuing mitochondrial 功能,而是详细机制遗体施加血糖过低的效果不清楚还。在这研究,在糖尿病的条件下面的肝的线粒体上的 catalpol 的效果和机制进一步被检验。catalpol 的口头的管理显著地在高脂肪的导致食谱、导致 streptozotocin 的糖尿病的老鼠减少了血葡萄糖, triglyceride,和胆固醇层次。另外, catalpol 在源于糖尿病的肝 mitochondrial ATP 内容稀释了减少。而且,拥有一种长尺寸的线粒体的数字在对待 catalpol 的老鼠被增加。有趣地, mitochondrial 功能的导致 catalpol 的恢复与减少的分裂蛋白质 1 被联系并且 dynamin 相关的蛋白质象增加的 mitofusin 一样的 1 个表达式在肝的 1 个表达式。在 HepG2 房间, catalpol 减轻了 ATP 内容和 mitochondrial 膜潜力的减少,并且反应的氧种类形成的增加由高葡萄糖导致了。当房间与 catalpol 被对待时,线粒体的管状的特征被维持的米托特拉克·格林污点表演。Catalpol 也减少了分裂蛋白质 1 并且 dynamin 相关的蛋白质 1 表情和增加的 mitofusin 在 HepG2 房间的 1 表情。现在的结果建议 catalpol 能改善在一名糖尿病患者下面的肝的 mitochondrial 机能障碍状态,和这可能与它 mitochondrial 的规定有关熔化和分裂事件。 | Zhimeng Xu Luyong Zhang Xiaojie Li Zhenzhou Jiang Lixin Sun Guolin Zhao Guohua Zhou Heran Zhang Jing Shang Tao Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 2 | Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer:a multicenter randomized controlled trial显示文摘Background:The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial,and more high-level clinical evidence is needed.This study aimed to evaluate the outcome of extended pancreatoduodenectomy(EPD)with retroperitoneal nerve resection in pancreatic head cancer.Methods:This multicenter randomized trial was performed at 6 Chinese highvolume hospitals that enrolled patients between October 3,2012,and September 21,2017.Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments(preoperative chemotherapy or chemoradiation)within three months were randomly assigned to undergo standard pancreatoduodenectomy(SPD)or EPD,with the latter followed by dissection of additional lymph nodes(LNs),nerves and soft tissues 270◦on the right side surrounding the superior mesenteric artery and celiac axis.The primary endpoint was overall survival(OS)by intention-to-treat(ITT).The secondary endpoints were disease-free survival(DFS),mortality,morbidity,and postoperative pain intensity.Results:TheR1 ratewas slightly lower with EPD(8.46%)thanwith SPD(12.56%).The morbidity and mortality rates were similar between the two groups.The median OS was similar in the EPD and SPD groups by ITT in the whole study cohort(23.0 vs.20.2 months,P=0.100),while the median DFS was superior in the EPD group(16.1 vs.13.2 months,P=0.031).Patients with preoperative CA19–9<200.0 U/mL had significantly improved OS and DFS with EPD(EPD vs.SPD,30.8 vs.20.9 months,P=0.009;23.4 vs.13.5 months,P<0.001).The EPD group exhibited significantly lower locoregional(16.48%vs.35.20%,P<0.001)andmesenteric LNrecurrence rates(3.98%vs.10.06%,P=0.022).The EPD group exhibited less back pain 6 months postoperation than the SPD group.Conclusions:EPD for pancreatic head cancer did not significantly improve OS,but patients with EPD treatment had significantly improved DFS.In the subgroup analysis,improvements in bothOS and DFS in the EPD armwere observed in patients with preoperative CA19–9<200.0 U/mL.EPD could be used as an effective surgical procedure for patients with pancreatic head cancer,especially those with preoperative CA19–9<200.0 U/mL. | Qing Lin Shangyou Zheng Xianjun Yu Meifu Chen Yu Zhou Quanbo Zhou Chonghui Hu Jing Gu Zhongdong Xu LinWang Yimin Liu Qingyu Liu MinWang Guolin Li He Cheng Dongkai Zhou Guodong Liu Zhiqiang Fu Yu Long Yixiong Li Weilin Wang Renyi Qin Zhihua Li Rufu Chen | 2023 | Cancer Communications2023，43，2： | 3 |
| 3 | A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats显示文摘Remifentanil is widely used to control intraoperative pain. However, its analgesic effect is limited by the generation of postoperative hyperalgesia. In this study, we investigated whether the impairment of transmembrane protein 16C(TMEM16C)/Slack is required for a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptor(AMPAR) activation in remifentanil-induced postoperative hyperalgesia. Remifentanil anesthesia reduced the paw withdrawal threshold from 2 h to 48 h postoperatively,with a decrease in the expression of TMEM16C and Slack in the dorsal root ganglia(DRG) and spinal cord.Knockdown of TMEM16C in the DRG reduced the expression of Slack and elevated the basal peripheral sensitivity and AMPAR expression and function. Overexpression of TMEM16C in the DRG impaired remifentanilinduced ERK1/2 phosphorylation and behavioral hyperalgesia. AMPAR-mediated current and neuronal excitability were downregulated by TMEM16C overexpression in the spinal cord. Taken together, these findings suggest that TMEM16C/Slack regulation of excitatory synaptic plasticity via GluA1-containing AMPARs is critical in the pathogenesis of remifentanil-induced postoperative hyperalgesia in rats. | Yize Li Linlin Zhang Jing Li Chunyan Wang Yi Chen Yuan Yuan Keliang Xie Guolin Wang Yonghao Yu | 2021 | Neuroscience Bulletin2021，37，5： | 2 |
| 4 | Studying oily sludge treatment by thermo chemistry显示文摘 | Jing Guolin Chert Tingting Luan Mingming | 2011 | Arabian Journal of Chemistry2011，7，2： | 1 |
| 5 | Treatment of oily sludgeby advanced oxidation process显示文摘 | Guolin Jing Mingming Luan Wenting Du | 2012 | Environ Earth Sci2012，，67： | 1 |
| 6 | Studies on prediction of separation percent in electrodialysis process via BP neural networks and improved BP algorithms显示文摘 | Guolin Jing Wenting Du Yingying Guo | 2012 | Desalination2012，，： | 1 |
| 7 | An effective process for removing organic compounds from oily sludge using soluble metallic salt显示文摘 | JING Guolin LUAN Mingming HAN Chunjie | 2012 | Journal of Industrial and Engineering Chemistry2012，18，4： | 1 |
| 8 | Studying oily sludge treatment by thermo chemistry显示文摘 | Jing Guolin Chen Tingting and Luan Mingming | 2011 | Arabian Journal of Chemistry2011，，10： | 1 |
| 9 | Prospects for development of oily sludge treatment 显示文摘 | JING Guolin LUAN Mingming CHEN Tingting | 2011 | Chemistry and Technology of Fuels and Oils2011，47，4： | 1 |
| 10 | Influence of demulsifier on interfacial film between oil and water 显示文摘 | Kang Wanli?Jing Guolin Zhang Hongyan | 2006 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2006，272，12： | 1 |
| 11 | A Review:Wet Oxidation and Catalytic Wet Oxidation of Industrial Wastewater显示文摘 | Mingming Luan Guolin Jing Xun Xu | 2013 | Recent Patents on Chemical Engineering2013，16，2： | 1 |
| 12 | Influence of Demulsifier on Interfacial Film between Oil and Water 显示文摘 | KANG Wanli JING Guolin ZHANG Hongyan | 2006 | Colloids and Surfaces A:Physicochemicaland Engineering Aspects2006，272，12： | 1 |
| 13 | Studying oily sludge treatment by thermo chemistry显示文摘 | Jing Guolin Chen Tingting Luan Mingming | 2011 | Arabian Journal of Chemistry2011，，10： | 1 |
| 14 | Influence of demulsifier on interracial film between oil and water显示文摘 | Kang Wanli Jing Guolin Zhang Hongyan | 2006 | Colloids and Surfaces A: Physicochemieal and Engineering Aspects2006，272，： | 1 |
| 15 | Studies on prediction of separation percent in electrodialysis process via BP neural networks and improved BP algorithms显示文摘 | Jing Guolin Du Wenting Guo Yingying | 2012 | Desalination2012，，291： | 1 |
| 16 | Study on TDS Removal from Polymer-Flooding Wastewater in Crude Oil:Extraction by Electrodialysis显示文摘 | Jing Guolin Wang Xiaoyu Zhao Hai | | 0，，1： | 1 |
| 17 | Oxidation of oily sludge in supercritical water 显示文摘 | Cui Baochen Cui Fuyi Jing Guolin | 2009 | Journal of Hazardous Materials2009，165，： | 1 |
| 18 | Degradation of malachite green dye by Tenacibaculum sp. HMG1isolated from Pacific deep-sea sediments显示文摘A deep-sea bacterium from the Pacific Ocean identified as Tenacibaculum sp. HMG1 was found to have strong malachite green(MG) degradation activity. The MG tolerance and decolorizing activities of strain HMG1 were confirmed by bacterial growth and high-performance liquid chromatography(HPLC) analyses. Strain HMG1 was capable of removing 98.8% of the MG in cultures within 12 h and was able to grow vigorously at 20 mg/L MG. A peroxidase gene detected in the genome of strain HMG1 was found to be involved in the MG biodegradation process. The corresponding recombinant peroxidase(r POD) demonstrated high degradative activity at 1 000 mg/L MG. Based on the common candidate intermediates, strain HMG1 was inferred to have one primary MG degradation pathway containing r POD. In addition, five other candidate intermediates of the r POD-MG degradative process were detected. The optimal conditions for MG degradation were determined and showed that strain HMG1 and the r POD enzyme could maintain high bioactivity at a low temperature(20°C), variable p H values(6.0–9.0), higher salinities(100 mmol/L) and other factors, such as multiple metal ions, H_2O_2 and EDTA.MG-tolerant strain Tenacibaculum sp. HMG1 and its peroxidase have prospective applications as environmental amendments for MG degradation during coastal remediation. | QU Wu HONG Guolin ZHAO Jing | 2018 | Acta Oceanologica Sinica2018，37，6： | 1 |
| 19 | Aqueous zinc--polyaniline secondary battery- 显示文摘 | LI Shengqi ZHANG Guolin JING Guolin | 2008 | Synthetic Metals2008，158，： | 1 |
| 20 | 显示文摘 | Kan Jinqing Zhang Shuling Jing Guolin | 2006 | J Appl Polym Sci2006，99，： | 1 |
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